scholarly journals Immunological Indicators of Infl ammation in Late-Life Bipolar Disorder

Psychiatry ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 22-33
Author(s):  
L. V. Androsova ◽  
E. S. Shipilova ◽  
A. N. Simonov ◽  
I. N. Otman ◽  
T. P. Klyushnik ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Elderly Patients ◽  
Blood Plasma ◽  
Bipolar Disorders ◽  
The Elderly ◽  
Affective States ◽  
Immune Markers ◽  
Leukocyte Elastase ◽  
Immunological Parameters ◽  
Bipolar Affective Disorders

The aim of the study was to determine the immune markers of infl ammation in the blood plasma of the elderly patients with bipolar affective disorders (BD) in relation to the clinical specifi cities of the disease. Patients and methods: 134 blood samples from the elderly patients aged from 52 to 88 years old (mean age 66.7 ± 7.7 years) with diagnose of bipolar disorder were examined. Infl ammatory markers in the blood plasma were determined as follows: the enzymatic activity of leukocyte elastase (LE) and the functional activity of the D1-proteinase inhibitor (D1-PI), as well as the level of autoantibodies (aAB) to S100b and myelin basic protein (MBP), and the protease inhibitor index (PII), which was the ratio of LE and D1-PI activity and characterized the activity of the proteolytic system as the most important component of infl ammation. Cluster analysis was used to reveal immunotypes. Results and discussion: а signifi cant increase in D1-PI and the level of aAB to S100b was revealed in elderly patients diagnosed with bipolar disorders, as well as low proteolytic activity of infl ammation (according to PII). Immune markers of infl ammation in different types of affective episodes (depressions, manias, mixed affective states) and in therapeutic remission did not differ from each other. Immunological parameters in elderly patients with bipolar disorders depended on the severity degree of the affective disorder. A relationship was found between the severity of depression and the level of aAB to S100b; the difference between mania and hypomania in terms of LE and PII activity was shown; in mixed affective states immunological parameters differed from the control only in moderate disorders. Remission with residual symptoms differed from asymptomatic therapeutic remission in terms of LE and PII activity. The two identifi ed clusters (immunotypes) differed in the activity of LE and PII. Conclusion: the results indicated the participation of infl ammation in the pathogenesis of bipolar disorder, and the isolated immunotypes confi rmed the clinical diversity of the disease. The study of the pathogenetic signifi cance of infl ammation and the identifi cation of various immunotypes was aimed at search for new therapy targets, taking into account the contribution of infl ammation.

Evolution of the Elderly Admissions in an Acute Psychiatric Unit over the Last Decade

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
R. Touzon ◽  
P. Rico-Villademoros ◽  
E. Garnica
Keyword(s):  
Bipolar Disorder ◽  
Elderly Patients ◽  
Medical Records ◽  
Depressive Disorders ◽  
Bipolar Disorders ◽  
The Elderly ◽  
Psychiatric Unit ◽  
Population Pyramid

Aims:To describe and then compare the admissions of elderly in the last decade, to see if there have been significant changes regarding both the diagnosis and the number of admissions.Methods:Medical records of patients over 70 years admitted in an acute psychiatric unit in the course of 1997 and 2007 have been reviewed. the number of admissions in elderly patients is compared to the number of admissions in any age. Diagnosis in the elderly between 1997 and 2007 is also compared.Results:In the last decade the percentage of patients over 70 who enter our unit has increased. with regard to their diagnoses, depressive disorders and the "others" category have decreased, increasing, however, the bipolar disorder, dementia and other psychoses.Conclusions:Since the population pyramid tends towards older ages, it seems logical that the number of admissions in elderly patients increase, as it has been shown in our research.The fall in the diagnosis of “others” and the rise of diagnosis such as Dementia, Bipolar disorders and other psychosis might be due to a better diagnosis of these pathologies.

scholarly journals Predicting the Risk of Depression in the Elderly by Immunological Indicators Research

Psychiatry ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 26-32
Author(s):  
A. N. Simonov ◽  
T. P. Klyushnik ◽  
L. V. Androsova ◽  
T. P. Safarova
Keyword(s):  
Mathematical Model ◽  
Enzymatic Activity ◽  
Blood Plasma ◽  
Functional Activity ◽  
Depressive Disorders ◽  
The Elderly ◽  
Control Group ◽  
Correct Prediction ◽  
Continuous Variables ◽  
Immunological Parameters

Objective: to construct a mathematical model that predicts the state of depression by immunological parameters in the blood plasma of older people to further predict the development of the disease.Patients and methods: 55 hospitalized patients of late age (mean age 69.2 ± 6.9 years) with a depressive episode were included in the study. The control group consisted of 41 elderly people (average age 66.6 ± 6.2 years) without depressive disorders. The activity of inflammatory and autoimmune markers in the blood plasma of patients and control groups was determined: the enzymatic activity of leukocyte elastase (LE), the functional activity of the α1-proteinase inhibitor (α1-PI), the level of autoantibodies to neuro-specific antigens S100B and the myelin basic protein (MBP). Statistical data processing was performed using the R (R version 3.2.4) and STATA (version 12.1) programs. We used point-bead-correlation to measure the strength and direction of the relationship between the binary variable and continuous variables and logistic regression to predict the probability of occurrence of events of interest by the values of one or more independent variables (predictors).Results: in patients with depressive disorders, a statistically significant increase in the functional activity of α1-PI (p ≤ 0.05) and the level of autoantibodies to the neurospecific S100B antigen (p ≤ 0.05) was revealed compared with the control. LE activity and MBP level did not differ from the control (p = 0.12 and p = 0.1, respectively). Based on immunological parameters in elderly patients with depression, a mathematical model is constructed. The accuracy of the correct prediction of outcomes using the model as a whole was 83.33%, which indicates a high predictive efficiency of this model.Conclusion: the results of mathematical analysis obtained in this work indicate that immunological parameters such as the functional activity of α1-PI and S100B are statistically significantly associated with the likelihood of depression in the elderly. Indicators such as enzymatic activity of LE and the level of autoantibodies to MBP did not have a statistically significant effect on the desired probability. 

Bipolar Affective Disorders: Diagnostic and Treatment Situation in Lithuania

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
V. Adomaitiene ◽  
A. Kunigeliene ◽  
K. Dambrauskiene ◽  
V. Danileviciute
Keyword(s):  
Bipolar Disorder ◽  
Depressive Symptoms ◽  
Affective Disorders ◽  
Bipolar Disorders ◽  
Male Population ◽  
Female Population ◽  
Bipolar Ii Disorder ◽  
Treatment Situation ◽  
Bipolar Ii ◽  
Bipolar Affective Disorders

Introduction:Bipolar disorder is one of the most important psychiatric diseases. This is a lifelong illness which increases disability, bad social, employment, and functional outcomes. Bipolar disorder causes dramatic mood swings - from overly “high” and irritable to sad and hopeless, often with periods of normal mood between. Bipolar I disorder is characterized by a history of at least one manic episode, with or without depressive symptoms. Bipolar II disorder is characterized by the presence of both depressive symptoms and a less severe form of mania.Objective:To review diagnostic and treatment situation of bipolar affective disorders in Lithuania.Method:A review of bipolar affective disorders in Lithuania: the prevalence of bipolar disorders, the differences between genders, the clinical features between genders.Results:Studies have suggested, that the prevalence of bipolar disorder in Lithuania is 1 % of population. The rates of bipolar disorder: in 2003 was 1131 cases, in 2004 - 1133 cases, in 2005 - 1147 cases, in 2006 - 1255 cases, in 2007 - 1257 cases. Distribution of bipolar disorders between males and females: males - 35,88 %, females - 64,12 %.Conclusion:The rates of Bipolar I disorder are equal between female and male population, but bipolar II disorder is more frequent in female population (bipolar depression, mixed manic disorder). Bipolar disorder with alcohol and drug abuse are very common among male population. Bipolar disorders are very common with somatic disease (thyroid disease, migraine, obesity of medication), anxiety disorders are more frequent in female population.

scholarly journals MARKERS OF INFLAMMATION IN THE BLOOD PLASMA OF PATIENTS WITH FRONTOTEMPORAL DEMENTIA

2019 ◽  
Vol 19 (1S) ◽  
pp. 10-12
Author(s):  
L V Androsova ◽  
S A Zozulya ◽  
N M Mikhailova ◽  
Ya B Fedorova ◽  
T P Klyushnik
Keyword(s):  
Blood Plasma ◽  
Frontotemporal Dementia ◽  
Significant Variation ◽  
Control Group ◽  
C Reactive Protein ◽  
Leukocyte Elastase ◽  
Immunological Parameters ◽  
Inflammatory Reactions ◽  
Reactive Protein ◽  
Markers Of Inflammation

The aim of this work was to identify several markers of inflammation in the blood of patients with frontotemporal dementia (FTD). 34 patients were surveyed with FTD. The control group consisted of 35 age- and sex- matched healthy people. Blood plasma was used for immunological studies. The enzymatic activity of leukocyte elastase (LE) and the functional activity of the α1-proteinase inhibitor (α1-PI) were determined by a spectrophotometric method, the concentration of interleukin-6 (IL-6) and C-reactive protein (CRP) were measured by ELISE. A statistically significant increase in α1-PI activity (p < 0.0001) was detected in patients with FTD; no difference from control was found for other indicators. There is a significant variation in all indicators, i.e. both increase and decrease of values compared to the control group. According to the level of LE activity, two immunophenotypes were identified. 73.5% of patients with FTD have an immunophenotype characteristic of patients with endogenous psychosis and 26.5% of patients have an immunophenotype similar to Alzheimer’s disease. The data obtained indicate the involvement of inflammatory reactions in the development of FTD and the heterogeneity of this disease as assed by immunological parameters.

106 Precipitating factors in the elderly patients admitted with the diagnosis of heart failure. Are easy to find?

2006 ◽  
Vol 5 (1) ◽  
pp. 25-26
Author(s):  
R VIDALPEREZ ◽  
E ABUASSI ◽  
M PARAMODEVEGA ◽  
P VELOSO ◽  
A VARELAROMAN ◽  
...  
Keyword(s):  
Heart Failure ◽  
Elderly Patients ◽  
The Elderly ◽  
Precipitating Factors

Evaluation of R-CHOP and R-CVP in the treatment of elderly patient with non-Hodgkin lymphoma

MedPharmRes ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 1-6
Author(s):  
Truc Phan ◽  
Tram Huynh ◽  
Tuan Q. Tran ◽  
Dung Co ◽  
Khoi M. Tran
Keyword(s):  
Elderly Patients ◽  
Hodgkin Lymphoma ◽  
B Cell Lymphoma ◽  
Complete Response ◽  
The Elderly ◽  
Free Survival ◽  
Non Hodgkin Lymphoma ◽  
Common Sign ◽  
Related Mortality

Introduction: Little information is available on the outcomes of R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine and prednisone) and R-CVP (rituximab with cyclophosphamide, vincristine and prednisone) in treatment of the elderly patients with non-Hodgkin lymphoma (NHL), especially in Vietnam. Material and methods: All patients were newly diagnosed with CD20-positive non-Hodgkin lymphoma (NHL) at Blood Transfusion and Hematology Hospital, Ho Chi Minh city (BTH) between 01/2013 and 01/2018 who were age 60 years or older at diagnosis. A retrospective analysis of these patients was perfomed. Results: Twenty-one Vietnamese patients (6 males and 15 females) were identified and the median age was 68.9 (range 60-80). Most of patients have comorbidities and intermediate-risk. The most common sign was lymphadenopathy (over 95%). The proportion of diffuse large B cell lymphoma (DLBCL) was highest (71%). The percentage of patients reaching complete response (CR) after six cycle of chemotherapy was 76.2%. The median follow-up was 26 months, event-free survival (EFS) was 60% and overall survival (OS) was 75%. Adverse effects of rituximab were unremarkable, treatment-related mortality accounted for less than 10%. There was no difference in drug toxicity between two regimens. Conclusions: R-CHOP, R-CVP yielded a good result and acceptable toxicity in treatment of elderly patients with non-Hodgkin lymphoma. In patients with known cardiac history, omission of anthracyclines is reasonable and R-CVP provides a competitive complete response rate.

Treatment of bipolar disorder in the elderly: a review of the literature

2017 ◽  
Vol Ano 7 ◽  
pp. 26-36
Author(s):  
Gilberto Sousa Alves ◽  
Felipe Kenji Sudo ◽  
Lucas Briand ◽  
Johannes Pantel
Keyword(s):  
Bipolar Disorder ◽  
The Elderly ◽  
Review Of The Literature

O transtorno afetivo bipolar (TAB) é uma condição potencialmente grave, caracterizada por mudanças de humor e disfunção cognitiva e funcional. O presente artigo revisa as evidências atualizadas das intervenções farmacológicas e não medicamentosas direcionadas ao TAB em idosos. Diretrizes baseadas em evidências, embora sejam úteis na promoção de uma terapia racional e eficaz, ainda são relativamente reduzidas no TAB em idosos. As recomendações atuais para mania aguda incluem o uso de antipsicóticos atípicos (por exemplo, risperidona, quetiapina, olanzapina), lítio (de maneira criteriosa) e a eleição de valproato como terapia padrão ouro. Na depressão aguda do TAB, os agentes de primeira linha em monoterapia podem incluir lítio, lamotrigina, quetiapina e quetiapina de liberação prolongada. No que se refere à escolha do estabilizador de humor ideal, o maior potencial de efeitos colaterais relacionados ao lítio vem desestimulando sua prescrição em indivíduos idosos. A eletroconvulsoterapia, embora limitada pela evidência, pode ser uma opção para casos graves/refratários.

Sign in / Sign up

Export Citation Format

Share Document