scholarly journals Decreased Liver Tissue Wasting following High-Intensity Interval Training through Apoptosis Signaling Suppression in Breast Tumor–Bearing Female Mice

2020 ◽  
Vol 13 (2) ◽  
pp. 49-58
Author(s):  
Fereshteh Ahmadabadi ◽  
Marziyeh Saghebjoo ◽  
ریحانه هوشیار ◽  
◽  
◽  
...  
Keyword(s):  
High Intensity ◽  
Breast Tumor ◽  
Liver Tissue ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Female Mice ◽  
Tumor Bearing ◽  
High Intensity Interval

scholarly journals The effect of eight weeks of high intensity interval training and crocin consumption on the apoptotic genes expression in the liver tissue of male rats under chronic doxorubicin induction

2020 ◽  
pp. 323-335
Keyword(s):  
High Intensity ◽  
Liver Tissue ◽  
Training Session ◽  
Interval Training ◽  
Male Rats ◽  
Maximum Speed ◽  
High Intensity Interval Training ◽  
Male Wistar Rats ◽  
Irreversible Effects ◽  
High Intensity Interval

Background and Aim: The use of doxorubicin (Dox) in chemotherapy has irreversible effects on liver tissue. Therefore, the role of exercise activities and the use of antioxidants consumption on the mechanism of apoptosis induced by (Dox are not yet fully understood. Therefore, the aim of the present study was to investigate the effect of High Intensity Interval Training (HIIT) and crocin consumption on liver tissue apoptosis in male rats under chronic Dox induction. Materials and Methods: In this experimental study, 40 male Wistar rats (mean weight 200±20 g)and age range of 8 weeks divided into five groups including; 1: healthy control groups, 2: Dox (2 mg/kg in 7 doses), 3: Dox+crocin (10 mg/kg), 4: Dox+HIIT, and 5: Dox+HIIT+crocin. The training groups ran for 8 weeks, 5 days a week, at 2-minute intervals and with an intensity of 80 to 90% of the maximum speed. 48 hours after the last training session, liver biopsy were performed to assess the fibrosis and expression of Bax and Bcl-2 genes by (Real time-PCR) method. The results of statistical analysis were analyzed using by one-way (ANOVA), at p≤0.05. Results: Dox significantly increased Bax expression compared to Bax/Bcl-2 and also decreased Bcl-2 expression in liver tissue of the patient groups (p=0.001). In contrast, crocin and the combination of exercise and crocin decreased Bax expression compared to Bax/Bcl-2 and increased Bcl-2 expression in experimental groups compared to Dox group (p=0.001). Conclusion: It seems the high intensity interval training with consumption of crocin has significant effect on the decrease of apoptosis in liver tissue in male rats subjected to chronic doxorubicin injection.

scholarly journals Comparing the Effect of Two Methods of High-Intensity Interval Training (HIIT) and High-Intensity Continuous Training (HICT) on Damage and Antioxidant Indices of Liver in Male Wistar Rats

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Aghaali Ghasemnian ◽  
Mozhgan Usefpour ◽  
Ahmad Rahmani ◽  
Zeinab Iddehloei
Keyword(s):  
Superoxide Dismutase ◽  
High Intensity ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Interval Training ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Male Wistar Rats ◽  
High Intensity Interval

Background: Nowadays, one of the widely used training methods is high-intensity interval training (HIIT). In addition, researchers have stated that long-term, high-intensity training is associated with the production of free radicals in the body. Free radicals also damage liver cells, resulting in increased liver enzymes. Objectives: The objective of this study was to investigate the effect of HIIT, compared to high-intensity continuous training (HICT), on damage and antioxidant indices of the liver in male Wistar rats. Methods: Twenty-two adult male rats were randomly divided into three groups of control (n = 6), HIIT (n = 8), and HICT (n = 8). Training protocols included HIIT and HICT on a treadmill for eight weeks (five days in a week). Standard water and food were provided for rats ad libitum. Forty-eight hours after the last training session, blood and tissue samples were collected, and serum enzymes were measured by the methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) method. The level of enzyme activity of superoxide dismutase in the liver tissue was measured by Randox Commercial Kit (Cat. No. SD 126). One-way analysis of variance (ANOVA) and Tukey’s post hoc tests were used to analyze the data. Results: The results showed that eight weeks of HIIT and HICT had no effect on the alanine aminotransferase (ALT) level (P = 0.14), but eight weeks of HIIT significantly decreased the serum aspartate aminotransferase (AST) level compared to the control group (P = 0.04). The level of liver superoxide dismutase (SOD) enzyme activity significantly increased in the HIIT and HICT groups compared to the control group (P = 0.001). HICT also led to a significant increase in the SOD level compared to HIIT (P = 0.03). Conclusions: The research results suggested that eight weeks of HIIT led to a significant reduction in serum AST levels, and HIIT had a lower effect on the increased SOD activity in liver tissue compared to HICT. It might be stated that HIIT is safer than HICT, and it has fewer destructive effects on liver tissue.

High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools

2019 ◽  
Vol 180 ◽  
pp. 49-62 ◽  
Author(s):  
Kenneth Ladd Seldeen ◽  
Yonas Z. Redae ◽  
Ramkumar Thiyagarajan ◽  
Reem Nagi Berman ◽  
Merced Marie Leiker ◽  
...  
Keyword(s):  
Physical Performance ◽  
High Intensity ◽  
Interval Training ◽  
Assessment Tools ◽  
High Intensity Interval Training ◽  
Female Mice ◽  
Frailty Assessment ◽  
High Intensity Interval

scholarly journals Comparing the Effect of Two Methods of High-Intensity Interval Training (HIIT) and High-Intensity Continuous Training (HICT) on Damage and Antioxidant Indices of Liver in Male Wistar Rats

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Aghaali Ghasemnian ◽  
Mozhgan Usefpour ◽  
Ahmad Rahmani ◽  
Zeinab Iddehloei
Keyword(s):  
Superoxide Dismutase ◽  
High Intensity ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Interval Training ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Male Wistar Rats ◽  
High Intensity Interval

Background: Nowadays, one of the widely used training methods is high-intensity interval training (HIIT). In addition, researchers have stated that long-term, high-intensity training is associated with the production of free radicals in the body. Free radicals also damage liver cells, resulting in increased liver enzymes. Objectives: The objective of this study was to investigate the effect of HIIT, compared to high-intensity continuous training (HICT), on damage and antioxidant indices of the liver in male Wistar rats. Methods: Twenty-two adult male rats were randomly divided into three groups of control (n = 6), HIIT (n = 8), and HICT (n = 8). Training protocols included HIIT and HICT on a treadmill for eight weeks (five days in a week). Standard water and food were provided for rats ad libitum. Forty-eight hours after the last training session, blood and tissue samples were collected, and serum enzymes were measured by the methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) method. The level of enzyme activity of superoxide dismutase in the liver tissue was measured by Randox Commercial Kit (Cat. No. SD 126). One-way analysis of variance (ANOVA) and Tukey’s post hoc tests were used to analyze the data. Results: The results showed that eight weeks of HIIT and HICT had no effect on the alanine aminotransferase (ALT) level (P = 0.14), but eight weeks of HIIT significantly decreased the serum aspartate aminotransferase (AST) level compared to the control group (P = 0.04). The level of liver superoxide dismutase (SOD) enzyme activity significantly increased in the HIIT and HICT groups compared to the control group (P = 0.001). HICT also led to a significant increase in the SOD level compared to HIIT (P = 0.03). Conclusions: The research results suggested that eight weeks of HIIT led to a significant reduction in serum AST levels, and HIIT had a lower effect on the increased SOD activity in liver tissue compared to HICT. It might be stated that HIIT is safer than HICT, and it has fewer destructive effects on liver tissue.

High-Intensity Interval Training and Hypoglycemia Minimization in Adults with Type 1 Diabetes (HIIT HYPO T1D Study)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 743-P
Author(s):  
ANGELA S. LEE ◽  
KIMBERLEY L. WAY ◽  
NATHAN A. JOHNSON ◽  
STEPHEN M. TWIGG
Keyword(s):  
Type 1 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval

553-P: Differential Effects of High-Intensity Interval Training on Somatosensory and Autonomic Nerve Function in Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 553-P
Author(s):  
GIDON J. BÖNHOF ◽  
ALEXANDER STROM ◽  
MARIA APOSTOLOPOULOU ◽  
DOMINIK PESTA ◽  
MICHAEL RODEN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
High Intensity Interval Training ◽  
Differential Effects ◽  
Autonomic Nerve Function ◽  
High Intensity Interval
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