The Effect of Sex Discordance on Blood Transfusion Reactions

ObjectivesBlood transfusion is a life-saving procedure and is also associated with a range of risks including the occurrence of symptoms of acute transfusion reactions (ATRs). Very few studies in sub-Saharan Africa have reported on ATRs. The present study addresses this gap in the literature by documenting the prevalence of and factors associated with ATRs in the Democratic Republic of Congo (DRC).DesignThis is a cross-sectional descriptive and analytical study using blood bank data from a general referral hospital.SettingCentre Hospitalier Mère-Enfant (CHME) Monkole, a general referral hospital in Kinshasa, DRC.ParticipantsGeneral population who have received blood transfusion in CHME Monkole between 2014 and 2019.ResultsThe data set included a total of 7166 patients; 3153 (44%) men and 4013 (56%) women. The overall prevalence of symptoms of ATRs was 2.6%; the lowest prevalence was in 2017 (2.34%) and highest in 2018 (2.95%) and 2019 (2.94%). The documented symptoms included 74 (39.6%) cases of dyspnoea/respiratory distress, 60 (32.1%) cases of fever, 36 (19.2%) cases of pruritus/urticaria and 17 (9.1%) cases of vomiting. None of the studied factors was associated with symptoms of ATRs.ConclusionSymptoms of ATRs were not uncommon in the studied population. Dyspnoea and respiratory distress, fever and pruritus/urticaria were the most common symptoms of ATRs. This study highlights the need for a clinical and biological surveillance to detect, prevent and manage ATRs in the context of the DRC.

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Fatal blood transfusion reactions, An analysis

American Journal of Forensic Medicine & Pathology ◽

10.1097/00000433-198106000-00010 ◽

1981 ◽

Vol 2 (2) ◽

pp. 143-150 ◽

Cited By ~ 13

Author(s):

Frank R. Camp ◽

W. Patrick Monaghan

Keyword(s):

Blood Transfusion ◽

Transfusion Reactions

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Efficacy of Oral Acetaminophen and Intravenous Chlorpheniramine Maleate versus Placebo to Prevent Red Cell Transfusion Reactions in Children and Adolescent with Thalassemia: A Prospective, Randomized, Double-Blind Controlled Trial

Anemia ◽

10.1155/2018/9492303 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Piya Rujkijyanont ◽

Chalinee Monsereenusorn ◽

Pimpat Manoonphol ◽

Chanchai Traivaree

Keyword(s):

Blood Transfusion ◽

Controlled Trial ◽

Febrile Reaction ◽

Chlorpheniramine Maleate ◽

Clinical Trial Registry ◽

Double Blind ◽

Urticarial Rash ◽

To Receive ◽

Transfusion Reactions ◽

Rbc Transfusion

Background. Thalassemia is a common congenital hemolytic disorder. In severe cases, regular blood transfusion is essentially required. The role of premedications to prevent transfusion reactions is varied among institutions with no standard guideline. Objective. To prospectively compare the risk of transfusion reactions in thalassemia patients premedicated with acetaminophen and chlorpheniramine maleate (CPM) versus placebo prior to blood transfusion. Material and Method. A randomized, double-blinded, placebo-controlled transfusion reaction study of 147 eligible patients was analyzed. All administered red blood cell (RBC) products were leukoreduced blood products. Patients were monitored and followed for the development of transfusion reactions for 24 hours after RBC transfusion. Results. A total of 73 patients randomized to receive active drugs consisting of acetaminophen and CPM were compared to 74 patients receiving placebo. The overall incidences of febrile reaction and urticarial rash were 6.9% and 22% in the patients randomized to receive active drugs comparing with 9.5% and 35.2% in the patients receiving placebo with no significant differences between two groups. However, delayed development of urticarial rash at 4-24 hours after RBC transfusion was significantly higher in female and patients receiving placebo. Conclusion. Administration of premedications in thalassemia patients receiving RBC transfusion without a history of transfusion reactions does not decrease the overall risk of transfusion reactions. However, the use of CPM might be beneficial to prevent delayed urticarial rash in those patients especially in females (Thai Clinical Trial Registry (TCTR) study ID: 20140526001).

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ALGORITHMS FOR SOLVING PROBLEMS OF PRE-TRANSFUSION IMMUNOHEMATOLOGICAL TESTING

Hematology and Transfusiology ◽

10.35754/0234-5730-2019-64-2-222-233 ◽

2019 ◽

Vol 64 (2) ◽

pp. 222-233

Author(s):

I. A. Pashkova

Keyword(s):

At Risk ◽

Blood Transfusion ◽

Individual Selection ◽

Donor Blood ◽

Effective System ◽

Patients At Risk ◽

Screening And Identification ◽

Transfusion Complications ◽

Transfusion Reactions ◽

Selection Of

Introduction. Screening and identification of anti-erythrocyte alloimmune antibodies in recipients is an important and necessary step in their testing before blood transfusion.Aim. To formulate algorithms that could facilitate the process of pre-transfusion immunohematological testing.General findings. Such a testing allows the development of post-transfusion reactions and complications to be avoided. The presence of alloantibodies of various specificities and autoantibodies in the test blood may complicate pre-transfusion testing and require the use of additional methods (adsorption, elution, etc.). The author has proposed an effective system of algorithms for conducting immunohematological studies, which can be used to identify patients at risk of developing immune post-transfusion complications and ensure an individual selection of compatible donor blood-transfusion products.

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Acute blood transfusion reactions in a tertiary care hospital in Pakistan ‐ an initiative towards haemovigilance

Transfusion Medicine ◽

10.1111/tme.12541 ◽

2018 ◽

Vol 29 (4) ◽

pp. 275-278

Author(s):

M. Borhany ◽

N. Anwar ◽

H. Tariq ◽

N. Fatima ◽

A. Arshad ◽

...

Keyword(s):

Blood Transfusion ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Transfusion Reactions

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Clinical Presentation of Nonhaemolytic Transfusion Reactions

Anaesthesia and Intensive Care ◽

10.1177/0310057x8000800205 ◽

1980 ◽

Vol 8 (2) ◽

pp. 125-131 ◽

Cited By ~ 11

Author(s):

Bryan Rush ◽

Newton L. Y. Lee

Keyword(s):

Differential Diagnosis ◽

Blood Transfusion ◽

Respiratory Distress ◽

Hospital Stay ◽

Clinical Presentation ◽

Allergic Reactions ◽

Red Cell ◽

Transfusion Reaction ◽

Cell Compatibility ◽

Transfusion Reactions

Due to the sophistication of red cell compatibility testing, the majority of transfusion reactions are non-haemolytic in origin. This paper reviews the clinical presentation of these reactions, emphasising that blood transfusion reaction must always be considered in the differential diagnosis when a patient develops unexpected complications during his hospital stay. Fever, allergic reactions, respiratory distress, hypotension and jaundice may all be manifestations of a transfusion reaction.

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Blood Transfusion Reactions

Clinical Pathways in Emergency Medicine ◽

10.1007/978-81-322-2710-6_34 ◽

2016 ◽

pp. 429-435

Author(s):

Sajit Varghese

Keyword(s):

Blood Transfusion ◽

Transfusion Reactions

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Incidence and risk factors of transfusion reactions in postpartum blood transfusions

Blood Advances ◽

10.1182/bloodadvances.2019000074 ◽

2019 ◽

Vol 3 (15) ◽

pp. 2298-2306 ◽

Cited By ~ 3

Author(s):

Lars Thurn ◽

Agneta Wikman ◽

Magnus Westgren ◽

Pelle G. Lindqvist

Keyword(s):

Blood Transfusion ◽

Confidence Interval ◽

Odds Ratio ◽

Adverse Reactions ◽

Study Cohort ◽

Blood Transfusions ◽

Birth Registry ◽

High Resource ◽

Increased Risk ◽

Transfusion Reactions

Abstract Postpartum hemorrhages with blood transfusions are increasing in many high-resource countries. Currently, up to 3% of all women receive blood transfusion postpartum. Most blood transfusions are safe and, in many cases, are lifesaving, but there are significant concerns about adverse reactions. Pregnancy is associated with higher levels of leukocyte antibodies and has a modulating effect on the immune system. Our objective was to investigate whether blood transfusions postpartum are accompanied by an increased risk for transfusion reactions (TRs) compared with transfusions given to nonpregnant women. We included all women who gave birth in Stockholm County, Sweden between 1990 and 2011. Data from the Swedish National Birth Registry were linked to the Stockholm Transfusion Database and included information on blood components administered and whether a TR occurred in women who received blood transfusions postpartum. Background controls were nonpregnant women who received blood transfusions during the study period. The study cohort consisted of 517 854 women. Of these, 12 183 (2.4%) received a blood transfusion. We identified 96 events involving a TR postpartum, giving a prevalence of 79 per 10 000 compared with 40 per 10 000 among nonpregnant women (odds ratio, 2.0; 95% confidence interval, 1.6-2.5). Preeclampsia was the single most important risk factor for TRs (odds ratio, 2.1; 95% confidence interval, 1.7-2.6). We conclude that special care should be taken when women with preeclampsia are considered for blood transfusion postpartum, because our findings indicate that pregnancy is associated with an increased risk for TRs.

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