Blood Transfusion Reactions

Author(s):  
Sajit Varghese
BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e045081
Author(s):  
Patou Masika Musumari ◽  
Samclide Mutindu Mbikayi ◽  
Kriengkrai Srithanaviboonchai ◽  
Teeranee Techasrivichien ◽  
Arunrat Tangmunkongvorakul ◽  
...  

ObjectivesBlood transfusion is a life-saving procedure and is also associated with a range of risks including the occurrence of symptoms of acute transfusion reactions (ATRs). Very few studies in sub-Saharan Africa have reported on ATRs. The present study addresses this gap in the literature by documenting the prevalence of and factors associated with ATRs in the Democratic Republic of Congo (DRC).DesignThis is a cross-sectional descriptive and analytical study using blood bank data from a general referral hospital.SettingCentre Hospitalier Mère-Enfant (CHME) Monkole, a general referral hospital in Kinshasa, DRC.ParticipantsGeneral population who have received blood transfusion in CHME Monkole between 2014 and 2019.ResultsThe data set included a total of 7166 patients; 3153 (44%) men and 4013 (56%) women. The overall prevalence of symptoms of ATRs was 2.6%; the lowest prevalence was in 2017 (2.34%) and highest in 2018 (2.95%) and 2019 (2.94%). The documented symptoms included 74 (39.6%) cases of dyspnoea/respiratory distress, 60 (32.1%) cases of fever, 36 (19.2%) cases of pruritus/urticaria and 17 (9.1%) cases of vomiting. None of the studied factors was associated with symptoms of ATRs.ConclusionSymptoms of ATRs were not uncommon in the studied population. Dyspnoea and respiratory distress, fever and pruritus/urticaria were the most common symptoms of ATRs. This study highlights the need for a clinical and biological surveillance to detect, prevent and manage ATRs in the context of the DRC.


Anemia ◽  
2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Piya Rujkijyanont ◽  
Chalinee Monsereenusorn ◽  
Pimpat Manoonphol ◽  
Chanchai Traivaree

Background. Thalassemia is a common congenital hemolytic disorder. In severe cases, regular blood transfusion is essentially required. The role of premedications to prevent transfusion reactions is varied among institutions with no standard guideline. Objective. To prospectively compare the risk of transfusion reactions in thalassemia patients premedicated with acetaminophen and chlorpheniramine maleate (CPM) versus placebo prior to blood transfusion. Material and Method. A randomized, double-blinded, placebo-controlled transfusion reaction study of 147 eligible patients was analyzed. All administered red blood cell (RBC) products were leukoreduced blood products. Patients were monitored and followed for the development of transfusion reactions for 24 hours after RBC transfusion. Results. A total of 73 patients randomized to receive active drugs consisting of acetaminophen and CPM were compared to 74 patients receiving placebo. The overall incidences of febrile reaction and urticarial rash were 6.9% and 22% in the patients randomized to receive active drugs comparing with 9.5% and 35.2% in the patients receiving placebo with no significant differences between two groups. However, delayed development of urticarial rash at 4-24 hours after RBC transfusion was significantly higher in female and patients receiving placebo. Conclusion. Administration of premedications in thalassemia patients receiving RBC transfusion without a history of transfusion reactions does not decrease the overall risk of transfusion reactions. However, the use of CPM might be beneficial to prevent delayed urticarial rash in those patients especially in females (Thai Clinical Trial Registry (TCTR) study ID: 20140526001).


2019 ◽  
Vol 64 (2) ◽  
pp. 222-233
Author(s):  
I. A. Pashkova

Introduction. Screening and identification of anti-erythrocyte alloimmune antibodies in recipients is an important and necessary step in their testing before blood transfusion.Aim. To formulate algorithms that could facilitate the process of pre-transfusion immunohematological testing.General findings. Such a testing allows the development of post-transfusion reactions and complications to be avoided. The presence of alloantibodies of various specificities and autoantibodies in the test blood may complicate pre-transfusion testing and require the use of additional methods (adsorption, elution, etc.). The author has proposed an effective system of algorithms for conducting immunohematological studies, which can be used to identify patients at risk of developing immune post-transfusion complications and ensure an individual selection of compatible donor blood-transfusion products.


2018 ◽  
Vol 29 (4) ◽  
pp. 275-278
Author(s):  
M. Borhany ◽  
N. Anwar ◽  
H. Tariq ◽  
N. Fatima ◽  
A. Arshad ◽  
...  

1980 ◽  
Vol 8 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Bryan Rush ◽  
Newton L. Y. Lee

Due to the sophistication of red cell compatibility testing, the majority of transfusion reactions are non-haemolytic in origin. This paper reviews the clinical presentation of these reactions, emphasising that blood transfusion reaction must always be considered in the differential diagnosis when a patient develops unexpected complications during his hospital stay. Fever, allergic reactions, respiratory distress, hypotension and jaundice may all be manifestations of a transfusion reaction.


2019 ◽  
Vol 3 (15) ◽  
pp. 2298-2306 ◽  
Author(s):  
Lars Thurn ◽  
Agneta Wikman ◽  
Magnus Westgren ◽  
Pelle G. Lindqvist

Abstract Postpartum hemorrhages with blood transfusions are increasing in many high-resource countries. Currently, up to 3% of all women receive blood transfusion postpartum. Most blood transfusions are safe and, in many cases, are lifesaving, but there are significant concerns about adverse reactions. Pregnancy is associated with higher levels of leukocyte antibodies and has a modulating effect on the immune system. Our objective was to investigate whether blood transfusions postpartum are accompanied by an increased risk for transfusion reactions (TRs) compared with transfusions given to nonpregnant women. We included all women who gave birth in Stockholm County, Sweden between 1990 and 2011. Data from the Swedish National Birth Registry were linked to the Stockholm Transfusion Database and included information on blood components administered and whether a TR occurred in women who received blood transfusions postpartum. Background controls were nonpregnant women who received blood transfusions during the study period. The study cohort consisted of 517 854 women. Of these, 12 183 (2.4%) received a blood transfusion. We identified 96 events involving a TR postpartum, giving a prevalence of 79 per 10 000 compared with 40 per 10 000 among nonpregnant women (odds ratio, 2.0; 95% confidence interval, 1.6-2.5). Preeclampsia was the single most important risk factor for TRs (odds ratio, 2.1; 95% confidence interval, 1.7-2.6). We conclude that special care should be taken when women with preeclampsia are considered for blood transfusion postpartum, because our findings indicate that pregnancy is associated with an increased risk for TRs.


1949 ◽  
Vol 10 (2) ◽  
pp. 188-188 ◽  
Author(s):  
Sloan J. Wilson

2020 ◽  
Vol 10 (31) ◽  
pp. 65-73
Author(s):  
Amanda Azevedo Bastos da Silva Santos ◽  
Josilene Da Costa Teixeira ◽  
Luana Do Carmo da Silva Pereira ◽  
Amanda Lorena de Araújo Silva

Descrever por meio de uma revisão integrativa da literatura o conhecimento dos enfermeiros sobre reações transfusionais. Trata-se de uma pesquisa descritiva, qualitativa cujo levantamento bibliográfico ocorreu em outubro de 2019. As bases de dados utilizadas foram PubMed, SciELO, BDEnf e LILACS. Foram identificadas 459 publicações, das quais 56 disponíveis no formato completo, excluíram-se produções duplicadas, que não atendem aos critérios de inclusão e artigos de outras bases de dados que não as supracitadas, restando 08 artigos, como amostra final. Os dados foram organizados em um quadro, com a identificação do artigo com base em sua referência e a sumarização de seus resultados. Conclui-se que há fragilidade no conhecimento dos profissionais de enfermagem e falta de estudos voltados para a temática, e com isso, incorrendo em negligência e, por conseguinte, riscos à saúde do paciente, prejudicando a qualidade da assistência à saúde.Descritores: Reação transfusional, Enfermagem, Transfusão de Sangue. Knowledge of nurses about transfusion reactions: integrative reviewAbstract: Describe, through an integrative literature review, the knowledge of nurses about transfusion reactions. This is a descriptive, qualitative research, which bibliographic survey took place in October 2019. The databases used were PubMed, SciELO, BDEnf and LILACS. Were identified 459 publications, of which 56 were available in full format, were excluded duplicate productions that don’t attend the inclusion criteria and articles from other databases than those mentioned above, leaving 8 articles as final sample. The data were organized in a table, with the identification of the article based on its reference and a summary of its results. In conclusion, there is a fragility in the knowledge of nursing professionals and a lack of studies focused on the theme, and therefore, incurring negligence and, consequently, risks for the patient's health, impairing the quality of health care.Descriptors: Transfusion Reaction, Nursing, Blood Transfusion. Conocimiento de enfermeras sobre reacciones de transfusión: revisión integrativaResumen: Describir, a través de una revisión integradora, el conocimiento de enfermeros sobre las reacciones transfusionales. Esta es una investigación descriptiva, cualitativa cuya encuesta bibliográfica se realizó en octubre de 2019. Las bases de datos utilizadas fueron PubMed, SciELO, BDEnf y LILACS. Se identificaron 459 publicaciones, de los cuales 56 disponibles en formato completo, se excluyeron las producciones duplicadas, que no cumplen con los criterios de inclusión y los artículos de bases de datos distintas a las mencionadas anteriormente, dejando 8 artículos como muestra final. Los datos se organizaron en un quadro, con la identificación del artículo en función de su referencia y resumen de sus resultados. Se concluye que existe fragilidad en el conocimiento de los profesionales de enfermería y falta de estudios centrados en el tema, y con esto, incurrir en negligencia y, por lo tanto, riesgos para la salud del paciente, perjudicando la calidad de la atención al salud.Descriptores: Reacción a la Transfusión, Enfermería, Transfusión Sanguínea.


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