scholarly journals A review: Gastroretentive drug delivery system (grdds)

2015 ◽  
Vol 3 (01) ◽  
Author(s):  
Meenakshi Jassal ◽  
Ujjwal Nautiyal ◽  
Jyotsana Kundlas ◽  
Devendra Singh
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Delivery ◽  
Special Focus ◽  
Gastric Residence Time ◽  
Novel Approach ◽  
Floating System ◽  
Absorption Window ◽  
Gastro Retentive

One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System). GRDDSs can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site.The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits, demerits and applications of gastroretentive drug delivery systems.

scholarly journals A review on gastroretentive drug delivery system

2016 ◽  
Vol 4 (2) ◽  
pp. 01-10
Author(s):  
Shailaja Pant ◽  
Ashutosh Badola ◽  
Preeti Kothiyal
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Specific Drug ◽  
Site Specific ◽  
Gastric Residence Time ◽  
Gastro Intestinal Tract ◽  
Novel Drug ◽  
Absorption Window ◽  
Gastro Retentive

Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. This approach is useful particularly for the drugs which have narrow absorption window in the upper part of gastro intestinal tract. In this review we have been discussed various approaches of gastro retentive drug delivery system, such as floating and non-floating systems.

scholarly journals A Comprehensive Review on Floating Drug Delivery System (FDDS)

2020 ◽  
Vol 10 (6) ◽  
pp. 174-182
Author(s):  
Aishwarya Rajendra Bhosale ◽  
Jitendra V Shinde ◽  
Rajashree S. Chavan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Gastric Emptying Rate ◽  
Principal Mechanism ◽  
Pharmaceutical Dosage Form ◽  
Floating Drug Delivery ◽  
Floating System ◽  
Floating Drug Delivery System

The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS. Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.

scholarly journals Floating Drug Delivery System

2021 ◽  
Vol 11 (3-S) ◽  
pp. 125-130
Author(s):  
Sanjay Thakur ◽  
Krishnappa Ramya ◽  
Deepak Kumar Shah ◽  
Khadga Raj
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Special Focus ◽  
Duration Of Action ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Tablet ◽  
Floating Drug Delivery System ◽  
Absorption Window

Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, method of preparation, mechanism of action advantages and disadvantages.  Keywords: Floating drug delivery system, Sustained release, controlled release, Floating tablet, Evaluation, Application, Gastro-retentive drug delivery system.

Suitable Polymers in Floating Gastro-Retentive Drug Delivery

2020 ◽  
pp. 371-382
Author(s):  
Kaustubh Gavali ◽  
Preeti Karade
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Floating Drug Delivery ◽  
Effect Of Food ◽  
Multiple Unit ◽  
Novel Drug ◽  
Absorption Window ◽  
Gastro Retentive

Gastro-retentive drug delivery is novel drug delivery system which is emerged for controlled and targeted delivery of drug especially when target site lies in or near the stomach. The drug with absorption window in stomach, locally acting drug in stomach, etc. are the best suitable candidate for this drug delivery system. It can be formulated in various types like floating, expandable & unfoldable, Raft forming, swelling system Bio adhesive, High density system etc. The gastro-retentive form can be used in various dosage forms like tablet, capsule, microsphere, granules, powders, pills and laminated films according to the need. It can be also formulated as single unit and multiple unit dosage form but sometime this gastro-retention is unpredictable due to effect of pH, gastric mobility, effect of food etc. This review mainly focuses on the floating drug delivery its types, polymer used in floating drug delivery and application.

scholarly journals Development and Evaluation of Gastro-retentive Floating Tablet of Rilpivirine Hydrochloride for the Treatment of HIV

2020 ◽  
Vol 10 (3-s) ◽  
pp. 43-46
Author(s):  
Dipali Trivedi ◽  
Arti Majumdar ◽  
Neelesh Malviya
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Residence Time ◽  
Delivery System ◽  
Research Work ◽  
Water Soluble ◽  
Gastric Residence Time ◽  
Floating Drug Delivery ◽  
Gastro Retentive

Besides enormous improvements in drug delivery, oral route has been highly and effectively utilized route of administration. Floating drug delivery that is also known to be low density system is advancement in the class of gastro-retentive drug delivery system. In the present research work, floating drug delivery of Rilpivirine hydrochloride was developed by overcoming various limitations and troubles associated with the drug including poor absorption in intestinal pH and degradation when comes in contact with higher pH environment. [2] Prepared formulations were evaluated for various parameters like friability, hardness, thickness, drug content analysis, floating properties and in-vitro drug release study. Based on the evaluation, concluded that floating drug delivery system is a non-toxic as well as cost-effective technique for the rationale of enhancing bioavailability and absorption of poorly water soluble drugs. The improvement in gastric residence time is a clear sign. It can be able to use in the future for more acidic soluble drugs to enhance solubility and absorption. Keywords: Floating drug delivery, gastric residence time, Rilpivirine, effervescent, NNRTI.

scholarly journals FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM CONTAINING COMBINATION OF GLIPIZIDE AND METFORMIN HYDROCHLORIDE

2016 ◽  
Vol 9 (6) ◽  
pp. 235
Author(s):  
Vidya Peter
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Dissolution ◽  
Oral Drug ◽  
Metformin Hydrochloride ◽  
Special Focus ◽  
Content Uniformity ◽  
Drug Bioavailability ◽  
Gastro Retentive

The purpose of gastro-retentive drug delivery systems was special focus on the principle mechanism of floatation to achieve gastric retention. The objective is to develop a gastro-retentive drug delivery system of Glipizide and Metformine hydrochloride is to overcome the biggest problem in oral drug delivery is low and erratic drug bioavailability. Glipizide and Metformine hydrochloride are used for the treatment of diabetes mellitus. Seven formulations containing retardant material and alkalizing agent were prepared with solubilizing agent in different ratio. The ability of various polymers to retain the drug when used in different concentrations was investigated. It was found that sodium bicarbonate reacts with HCl and produce CO2 which creates pores in tablet and elevates swelling by wetting polymer. So it helps in maintaining the buoyancy. The release rate could be modified by varying the polymer ratio, concentration of alkalizing and solubilizing agent. The prepared tablets were evaluated for general appearance, content uniformity, hardness, friability, buoyancy and in vitro dissolution studies.

scholarly journals Gastro-retentive drug delivery system: A better approach of drug delivery system

2021 ◽  
Vol 4 (1) ◽  
pp. 025-034
Author(s):  
Rajiv Kumar ◽  
Rohit Kumar Chopra ◽  
Harpreet Singh ◽  
Parminder Nain ◽  
RK Dhawan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Systemic Circulation ◽  
Oral Route ◽  
Site Specific ◽  
System A ◽  
Floating System ◽  
Important System ◽  
Gastro Retentive

The oral route is the best and most popular route for the administration of drugs in the systemic circulation. There are number of drugs which are given through the oral route. Gastro-retentive drug delivery system is very important system for the drug delivery system. The gastro-retentive drugs prolonged the drug time in the git and also improve their their bioavailability. These are widely used for site specific for the treatment of git disorders and diseases. There are number of approaches for gastro retentive drug delivery system such as floating system, mucoadhesive system, swelling system, high density system etc. In this review we discussed about approaches and various perspectives of gastro retentive drug delivery system.

A Review on Emerging Floating Drug Delivery System

2016 ◽  
Vol 6 (4) ◽  
Author(s):  
Christe Mary M ◽  
Sasikumar Swamiappan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stomach Contents ◽  
Gastric Fluid ◽  
Dosage Forms ◽  
Gastric Residence Time ◽  
Advantages And Disadvantages ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages and disadvantages, application of FDDS and factors affecting the gastric retension time.

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