PO 18067 - Application of 5% lidocaine patch to painful surgical scars

Introduction: Chronic postoperative pain, defined as persistent pain at the surgical incision site 3 months after a procedure, is a common complaint in orthopedic practice. Almost 50% of patients who undergo orthopedic surgery are presumably affected by this complaint. The objective of this study is to evaluate the lidocaine patch 5% as a method for neuropathic pain treatment after orthopedic surgery compared with therapeutic massage performed over the incisions. Methods: This is a prospective, randomized clinical trial of 37 patients who underwent orthopedic surgery from January 2015 to February 2017. All individuals were assessed using the pain visual analog scale (VAS) and the 36-Item Short Form Survey (SF-36) quality of life questionnaire at treatment onset and at 30, 60 and 90 days of treatment. Results: Both groups showed improvement in pain, although the group using the patch showed a greater reduction of pain over time. There were no significant differences in the parameters assessed by the SF-36: physical functioning, physical role functioning, vitality, emotional role functioning, social role functioning, general health perceptions or mental health. The main advantage of the patch lay in the degree of patient satisfaction, which was significantly higher than that of massage, most likely because the patch is easily applied and generates a psychological effect as a drug therapy. Conclusion: The lidocaine patch and massage are effective treatment methods for reducing scar pain that show similar results. The patch is associated with an improvement in the degree of patient satisfaction.

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TL 18166 - Evaluation of quality of life and radiological parameters after hallux valgus correction

Scientific Journal of the Foot & Ankle ◽

10.30795/scijfootankle.2019.v13.1077 ◽

2019 ◽

Vol 13 (Supl 1) ◽

pp. 97S

Author(s):

Henrique Mansur ◽

Vinicius Trindade Cardoso ◽

Isnar Moreira de Castro Júnior

Keyword(s):

Quality Of Life ◽

Hallux Valgus ◽

Social Role ◽

Short Form ◽

Role Functioning ◽

Significance Level ◽

Radiological Parameters ◽

Sf 36 ◽

Correction Surgery

Introduction: The outcome of hallux valgus correction surgery is usually evaluated based on parameters of interest to the surgeon; however, the outcomes considered important by patients differ from those analyzed by physicians. Our objective is to evaluate the quality of life of patients undergoing hallux valgus correction and to assess the maintenance of radiographic parameters over time. Methods: The study included 38 patients who underwent hallux valgus correction surgery using different osteotomy techniques (scarf, chevron, arciform, proximal chevron and chevron-Akin) from January 2010 to December 2012. The patients were evaluated radiographically at 3 different times (preoperatively and 1 and 5 years postoperatively) and filled out the 36-Item Short Form Survey (SF-36) for the assessment of quality of life. Statistical analysis was performed using the paired Student’s t-test and the nonparametric Wilcoxon signed-rank and Friedman tests, with a maximum significance level of 5%. Results: Among the main findings of the SF-36 questionnaire, the sections on which the patients reported the best results were emotional role functioning, physical functioning and social role functioning, and the final mean score was 74.9. The metatarsophalangeal and intermetatarsal angles and medial eminence showed significant decreases during the postoperative period (p<0.05), and only 1 patient presented loss of joint congruence. Conclusion: Different surgical osteotomy techniques used to correct moderate and severe hallux valgus improved the patients’ radiological parameters and quality of life.

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Innate Immunity Stimulation During COVID-19 Pandemic: Challenge

10.21203/rs.3.rs-1106959/v1 ◽

2021 ◽

Author(s):

beniamino palmieri ◽

antonio manenti ◽

MARIA VADALA'

Keyword(s):

Innate Immunity ◽

Social Role ◽

Short Form ◽

Bodily Pain ◽

Evidence Based ◽

Complete Regression ◽

Role Functioning ◽

Double Blind ◽

Sf 36 ◽

Oncologic Patients

Abstract AIM: We report an open spontaneous anecdotical retrospective survey of Corynebacterium parvum administration to 4000 fragile immune-depressed and multimorbid patients treated with a killed C. parvum strain to enhance the innate immunity integrating the adaptative immune response for a long standing antinfectious resistance. METHODS: 4000 patients (1900 men and 2100 women) with mild, moderate or chronic disease, appealing to our Second Opinion Medical Consultation Network, signed an informed consent and were injected subcutaneously with C.parvum. The treatment was followed up at 6 months after therapy, filling the short form of the medical outcome health survey questionnaire (SF-36), directly by the patients or its parents and monitoring the health regularly via telemedicine (Skype, WhatsApp, mail, etc) or physician’s visit.RESULTS: The main efficacy endpoints, as assessed by the SF-36 questionnaire, are significant improvements in the mental and physical role functioning score (p< 0.02), in general health, in social role functioning (p < 0.02), vitality (p < 0.03), and a significant reduction in bodily pain (p< 0.03). There was a quick (48-72 hours) symptoms improvement and/or complete regression of the herpetic eruptions observed in 1000 affected patients and of herpetic neuralgia (reduced in 80% of cases), also full recovery or frequency reduction (30%) of recurrent cystitis and prostatitis in 120 affected patients, and last, but not least, a life quality improvement in 100 oncologic patients of overall 200 cases. A significant increase in the lymphocyte count (p<0.01), mainly Helper and Killer lymphocytes, was noted after 6 months by Parvulan injection vs. the baseline.The asymptomatic SARS-CoV-2 patients, incidentally, enrolled in our survey, were tested at sixth months for antibodies against SARS-CoV-2 and 14 patients occurred high level of SARS-CoV-2 antibodies. The incubating Covid infections in the Parvulan injected patients even if rail and multi-morbid recovered in a short term (48-96 hours) and with benign clinical course, usually no need of further drugs administration except for the variants, which lasted on average one week and required some antipyretics, and low dose steroid for a few days.CONCLUSIONS: Our results confirm that C.parvum is quite safe and effective to support immune-compromised patients when epidemic or pandemic events rise the life risk and any kind of infections and complications rate.Further double-blind placebo evidence-based studies are urgently required, and our numerically substantial not sponsored spontaneous observation aims exclusively to promote further evidence based double blind institutional studies.

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Translation and Validation of the Thai Version of the Wisconsin Quality of Life Questionnaire (TH WISQoL) for Kidney Stone Patients

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.11.11450 ◽

2020 ◽

Vol 103 (11) ◽

pp. 1194-1199

Keyword(s):

Quality Of Life ◽

Internal Consistency ◽

Kidney Stone ◽

Convergent Validity ◽

Large Scale ◽

Short Form ◽

Outcome Measurement ◽

Life Questionnaire ◽

Sf 36

Objective: To develop and validate a Thai version of the Wisconsin Quality of Life (TH WISQoL) Questionnaire. Materials and Methods: The authors developed the TH WISQoL Questionnaire based on a standard multi-step process. Subsequently, the authors recruited patients with kidney stone and requested them to complete the TH WISQoL and a validated Thai version of the 36-Item Short Form Survey (TH SF-36). The authors calculated the internal consistency and interdomain correlation of TH WISQoL and compared the convergent validity between the two instruments. Results: Thirty kidney stone patients completed the TH WISQoL and the TH SF-36. The TH WISQoL showed acceptable internal consistency for all domains (Cronbach’s alpha 0.768 to 0.909). Interdomain correlation was high for most domains (r=0.698 to 0.779), except for the correlation between Vitality and Disease domains, which showed a moderate correlation (r=0.575). For convergent validity, TH WISQoL demonstrated a good overall correlation to TH SF-36, (r=0.796, p<0.05). Conclusion: The TH WISQoL is valid and reliable for evaluating the quality of life of Thai patients with kidney stone. A further large-scale multi-center study is warranted to confirm its applicability in Thailand. Keywords: Quality of life, Kidney stone, Validation, Outcome measurement

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Influence of painless one-eye blindness on depression, anxiety and quality of life in glaucoma patients with a normal fellow eye

BMC Ophthalmology ◽

10.1186/s12886-021-01845-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Gábor Holló ◽

Nikolett Gabriella Sándor ◽

Péter Kóthy ◽

Anna Géczy

Keyword(s):

Quality Of Life ◽

Social Role ◽

Bodily Pain ◽

Control Group ◽

Life Questionnaire ◽

Ophthalmological Examination ◽

Role Functioning ◽

Everyday Functioning ◽

Fellow Eye

Abstract Background For clinical practice it is important to evaluate and compare anxiety, depression and quality of life of glaucoma patients with painless one-eye blindness and a normal fellow eye to unaffected age-matched individuals from a similar environment. Methods Twenty-eight stable glaucoma patients (age, mean ± SD: 69.0 ± 13.3 years) with one normal and one painless blind eye, and 26 controls (age: 67.0 ± 14.0 years) completed the standard Hungarian adaptations of the Beck Depression Inventory, Beck Anxiety Inventory, Spielberger-Trait Anxiety Inventory, Hopelessness Scale, and Quality of Life Questionnaire SF-36 with the assistance of trained psychologist interviewers within 3 months after a detailed ophthalmological examination. Results The groups did not differ in age, gender distribution, number of children, grandchildren and people in their household (p ≥ 0.235). The best corrected visual acuity (BCVA) of the diseased eye was minimal (median: 0.00), while BCVA of their better eye (median: 1.0) did not differ from that of the control group (p ≥ 0.694). Compared to the control group, the patients’ scores were significantly higher for depression (p ≤ 0.01), cognitive and psychophysiological symptoms of anxiety (p ≤ 0.05) and hopelessness (p ≤ 0.013), and lower (worse) for physical function, vitality, general health and bodily pain (p ≤ 0.045). No difference was found between the groups for mental health, physical role functioning, emotional role functioning and social role functioning (p ≥ 0.117). Conclusion Our results show that patients with glaucoma-related one-eye blindness may require regular psychological support even when the visual performance of the fellow eye is fully maintained on the long run, and the patients’ everyday functioning is normal.

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Quality of life in patients with Charcot-Marie-Tooth disease type 1A

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20130045 ◽

2013 ◽

Vol 71 (6) ◽

pp. 392-396 ◽

Cited By ~ 2

Author(s):

Juliana B. Taniguchi ◽

Valeria M.C. Elui ◽

Flavia L. Osorio ◽

Jaime E.C. Hallak ◽

Jose A.S. Crippa ◽

...

Keyword(s):

Quality Of Life ◽

Short Form ◽

Control Group ◽

Life Questionnaire ◽

Charcot Marie Tooth ◽

Social And Emotional ◽

Charcot Marie Tooth Disease ◽

Sf 36 ◽

And Gender

We assessed the functional impairment in Charcot-Marie-Tooth resulting from 17p11.2-p12 duplication (CMT1A) patients using the Short-Form Health Survey (SF-36), which is a quality of life questionnaire. Twenty-five patients of both genders aged ≥10 years with a positive molecular diagnosis of CMT1A were selected. Age- and gender-matched Control Group (without family history of neuropathy), and the sociodemographic and professional conditions similar to the patients' group were selected to compare the SF-36 results between them. The results showed that the majority quality of life impairments in CMT1A patients occurred in the social and emotional domains. Functional capacity also tended to be significantly affected; other indicators of physical impairment were preserved. In conclusion, social and emotional aspects are mostly neglected in the assistance provided to CMT1A Brazilian patients, and they should be better understood in order to offer global health assistance with adequate quality of life as a result.

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Novel Pre-Mastectomy Permanent Implant Reconstruction

Journal of Clinical Review & Case Reports ◽

10.33140/jcrc.06.02.04 ◽

2021 ◽

Vol 6 (2) ◽

Keyword(s):

Patient Satisfaction ◽

Breast Reconstruction ◽

Short Form ◽

Tissue Expander ◽

Silicone Implants ◽

Life Questionnaire ◽

Dermal Substitute ◽

Breast Cancer Patients ◽

Permanent Implant ◽

Implant Reconstruction

Background: Breast reconstruction has been shown to have significant psychosocial benefits for breast cancer patients. Multiple techniques have been used to improve patient satisfaction, aesthetic outcomes, and decrease complications. However, while these techniques are advantageous, they have some significant disadvantages. We are presenting a novel two-stage, pre-mastectomy permanent implant reconstruction (PPIR) technique in an attempt to overcome some of these disadvantages. Methods: Five patients met the essential criteria: they underwent PPIR by insertion of silicone implants three weeks before a proposed mastectomy. The Short Form-36 quality of life questionnaire and the Michigan Breast Reconstruction Outcomes Survey were used before and after the surgery to assess outcome and patient satisfaction. Paired sample t-tests were used to compare changes in the survey scores for various psychosocial subscales and to determine whether score changes after reconstruction were significant. Result: Five patients underwent seven breast reconstructions using PPIR. None of the patients experienced surgical complications (e.g. mastectomy flap complication, wound dehiscence, surgical site infection, or implant-related complications). The PPIR technique resulted in improved psychosocial outcomes and body image with high patient satisfaction. Conclusion: Pre-mastectomy permanent implant reconstruction is a promising potential technique with good aesthetic outcome and patient satisfaction that carries no tissue expander complications and eliminates multiple clinic visits and the usage of a dermal substitute.

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Validating the Parkinson’s disease caregiver burden questionnaire (PDCB) in German caregivers of advanced Parkinson’s disease patients

International Psychogeriatrics ◽

10.1017/s1041610219000206 ◽

2019 ◽

Vol 31 (12) ◽

pp. 1791-1800 ◽

Cited By ~ 7

Author(s):

M. Klietz ◽

L. Rippena ◽

F. Lange ◽

A. Tulke ◽

L. Paracka ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Caregiver Burden ◽

Short Form ◽

Assessment Tools ◽

Life Questionnaire ◽

German Version ◽

Advanced Parkinson’S Disease ◽

Adequate Measure ◽

Sf 36

ABSTRACTBackground:Advanced Parkinson’s disease (PD) may place a high burden on patients and their caregivers. Understanding the determinants of caregiver burden is of critical importance. This understanding requires the availability of adequate assessment tools. Recently, the Parkinson’s disease caregiver burden questionnaire (PDCB) has been developed as a PD-specific measure of caregiver burden. However, the PDCB has only been evaluated in a sample of Australian caregivers of patients at a less advanced stage of the disease.Objective:We tested whether a German translation of the PDCB qualifies as an adequate measure of caregiver burden in a German sample of caregivers of advanced patients with PD.Methods:We collected PDCB data from 65 caregivers of advanced patients with PD. Reliability of the scale was assessed and compared against the original version. To validate the German version of the PDCB, we examined the correlations with the caregiver burden inventory (CBI), the short form 36 health survey (SF-36), the Parkinson’s disease quality of life questionnaire 39 (PDQ-39), disease duration, and the amount of caregiving time.Results:The total PDCB score proved to be reliable and to be significantly related to CBI and SF-36 scores. PDCB scores also increased with increasing amounts of caregiving time.Conclusions:The German version of the PDCB appears to be an adequate measure of caregiver burden in caregivers of advanced PD patients.

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Validation of the Multiple Sclerosis International Quality of Life questionnaire

Multiple Sclerosis Journal ◽

10.1177/1352458507080733 ◽

2007 ◽

Vol 14 (2) ◽

pp. 219-230 ◽

Cited By ~ 91

Author(s):

MC Simeoni ◽

P. Auquier ◽

O. Fernandez ◽

P. Flachenecker ◽

S. Stecchi ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Internal Consistency ◽

Discriminant Validity ◽

Short Form ◽

Life Questionnaire ◽

Validity And Reliability ◽

Sf 36 ◽

Quality Of Life Scale

This study aims to validate the Multiple Sclerosis (MS) International Quality of Life (MusiQoL) questionnaire, a multi-dimensional, self-administered questionnaire, available in 14 languages, as a disease-specific quality of life scale that can be applied internationally. A total of 1992 patients with different types and severities of MS from 15 countries were recruited. At baseline and day 21 ± 7, each patient completed the MusiQoL, a symptom checklist and the short-form (SF)-36 QoL questionnaire. Neurologists also collected socio-demographic, MS history and outcome data. The database was randomly divided into two subgroups and analysed according to different patient characteristics. For each model, psychometric properties were tested and the number of items was reduced by various statistical methods. Construct validity, internal consistency, reproducibility and external consistency were also tested. Nine dimensions, explaining 71% of the total variance, were isolated. Internal consistency and reproducibility were satisfactory for all the dimensions. External validity testing revealed that dimension scores correlated significantly with all SF-36 scores, but showed discriminant validity by gender, socio-economic and health status. Significant correlations were found between activity in daily life scores and clinical indices. These results demonstrate the validity and reliability of the MusiQoL as an international scale to evaluate QoL in patients with MS. Multiple Sclerosis 2008; 14: 219—230. http://msj.sagepub.com

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Quality of Life in MAP.3 (Mammary Prevention 3): A Randomized, Placebo-Controlled Trial Evaluating Exemestane for Prevention of Breast Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2013.51.2483 ◽

2014 ◽

Vol 32 (14) ◽

pp. 1427-1436 ◽

Cited By ~ 35

Author(s):

Elizabeth Maunsell ◽

Paul E. Goss ◽

Rowan T. Chlebowski ◽

James N. Ingle ◽

José E. Alés-Martínez ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Postmenopausal Women ◽

Short Form ◽

Change Score ◽

Life Questionnaire ◽

Sf 36 ◽

Health Related Qol ◽

Health Related

Purpose Exemestane, a steroidal aromatase inhibitor, reduced invasive breast cancer incidence by 65% among 4,560 postmenopausal women randomly assigned to exemestane (25 mg per day) compared with placebo in the National Cancer Institute of Canada (NCIC) Clinical Trials Group MAP.3 (Mammary Prevention 3) trial, but effects on quality of life (QOL) were not fully described. Patients and Methods Menopause-specific and health-related QOL were assessed by using the four Menopause-Specific Quality of Life Questionnaire (MENQOL) domains and the eight Medical Outcomes Study Short Form Health Survey (SF-36) scales at baseline, 6 months, and yearly thereafter. MENQOL questionnaire completion was high (88% to 98%) in both groups at each follow-up visit. Change scores for each MENQOL and SF-36 scale, calculated at each assessment time relative to baseline, were compared by using the Wilcoxon rank-sum test. Clinically important worsened QOL was defined as a MENQOL change score increase of more than 0.5 (of 8) points and an SF-36 change score decrease of more than 5 (of 100) points from baseline. Results Exemestane had small negative effects on women's self-reported vasomotor symptoms, sexual symptoms, and pain, which occurred mainly in the first 6 months to 2 years after random assignment. However, these changes represented only a small excess number of women being given exemestane with clinically important worsening of QOL at one time or another; specifically, 8% more in the vasomotor domain and 4% more each in the sexual domain and for pain. No other between-group differences were observed. Overall, slightly more women in the exemestane arm (32%) than in the placebo arm (28%) discontinued assigned treatment. Conclusion Exemestane given for prevention has limited negative impact on menopause-specific and health-related QOL in healthy postmenopausal women at risk for breast cancer.

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The role of folded fibular flap in patients’ reconstruction of mandibular defects: a retrospective clinical study

Scientific Reports ◽

10.1038/s41598-021-03331-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Ning Gao ◽

Kun Fu ◽

Jinghua Cai ◽

Hao Chen ◽

Wei He

Keyword(s):

Quality Of Life ◽

Psychological Health ◽

Short Form ◽

Life Questionnaire ◽

Preoperative Level ◽

Sf 36 ◽

Retrospective Clinical Study ◽

Significant Difference ◽

Fibular Flap

AbstractThis study has analyzed 41 patients with mandibular ameloblastoma who underwent a partial mandibulectomy and reconstruction by folding the free fibular flap. In the preoperative and postoperative (6 months and 24 months after surgery), the Quality of Life (QOL) of these patients was assessed by using the University of Washington Quality of Life Questionnaire (UW-QOL) and the medical outcome study short form-36 (SF-36) questionnaires. SPSS 20.0 statistical software was used to conduct statistical analysis on the base data of the two groups of patients. Independent sample t test was conducted for sf-36 and UW-QOL scores at two time points in each group. The SF-36 survey showed that body pain (54.54 ± 8.10), general health (55.27 ± 7.54), and health changes (58.29 ± 9.60) decreased significantly at 6 months after surgery, but the mean score at 24 months after surgery all exceeded the preoperational level. At 24 months after the surgery, the vitality (80.41 ± 3.74), social function (81.61 ± 4.07), emotional role (82.39 ± 4.07), psychological health (81.66 ± 4.37) and total score (704.00 ± 31.53) all returned to the preoperative level, which was statistically significant compared with 6 months after surgery. However, there was no significant difference compared with the preoperative level. The UW-QOL survey showed that chewing (56.68 ± 7.23), speech (54.54 ± 7.7) and taste (62.29 ± 10.15) have significantly changed at 6 months after the surgery, and the difference was statistically significant at 24 months after surgery. Saliva generation decreased slightly (80.76 ± 3.35) at 6 months after surgery, but quickly returned to the preoperative level (81.59 ± 4.06). The total score of the patients almost recovered to the preoperative level at 24 months after surgery. The folded the fibular flap can not only repair the defects of soft tissue and bone tissue, but also restore the height of the alveolar ridge to, avoid the imbalance of crown and root ratio after implantation and reduce the occurrence of peri-implant inflammation, so that a true functional reconstruction can be realized.

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