Lung pathology and causes of death among hospitalized adult patients with HIV infection: pathological analysis

2019 ◽  
Vol 0 (2) ◽  
pp. 24-34
Author(s):  
I.V. Liskina ◽  
L.М. Zagaba ◽  
О.D. Nikolaeva
2020 ◽  
Vol 98 (6) ◽  
pp. 15-21
Author(s):  
E. B. Tsybikovа ◽  
I. M. Son ◽  
A. V. Vlаdimirov

The objective: to study changes in the structure of mortality from tuberculosis and HIV infection in Russia from 2000 to 2017.Subjects and methods. The data of the Federal State Statistics Service on the mortality of the Russian population from tuberculosis and HIV infection (standardized ratio per 100,000 population) for 2000-2017 were studied. Data on the structure of patients with TB/HIV co-infection were obtained from Form no. 61 of the federal statistical monitoring for 2017.Results. In Russia, there has been a steady decrease in the mortality rate from tuberculosis, the value of which in 2017 reached 5.9 per 100,000 people. At the same time, the average values of the mortality rate from tuberculosis have shifted towards the older age groups reaching maximum values in the age group of 45 years and older. On the contrary, the analysis of mortality from HIV infection (2006-2017) detected its unprecedented increase from 1.6 to 12.6 per 100,000 population. The maximum concentration of mortality from HIV infection was observed in young age groups (35-44 years old). The increase in mortality from HIV infection was accompanied by a change in the structure of mortality from infectious diseases: the proportion of tuberculosis decreased from 79.1% (2000) to 27.4% (2017), and the proportion of HIV infection increased from 0.1% ( 2000) to 57.2% (2017). Currently, in Russia, mortality from HIV infection in young age groups has taken a leading position in the structure of causes of death from infectious diseases, displacing mortality from tuberculosis.


Author(s):  
Jason Fischer ◽  
Lianne McLean

This chapter highlights the increasing use of point-of-care ultrasound (PoCUS) in children. The size and body habitus of infants and children are often ideal for sonographic visualization and make PoCUS an ideal imaging modality for paediatric patients. PoCUS applications that have been traditionally used for adult patients are increasingly being adopted for the care of children. Paediatric-specific applications are also being developed for problems common and unique to paediatrics. Focused abdominal scans for appendicitis, intussusception, and pyloric stenosis are now frequently used in patients presenting with abdominal pain or vomiting. PoCUS can differentiate lung pathology and is helpful in the assessment of suspected skull fractures in non-verbal infants. Ongoing integration of PoCUS into shock, trauma, and triage algorithms support its increasing role in paediatric emergency and critical care.


2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 11545-11545
Author(s):  
Xin Liu ◽  
Xiaowei Zhang ◽  
Huijie Wang ◽  
Chunmeng Wang ◽  
Yong Chen ◽  
...  

AIDS ◽  
2000 ◽  
Vol 14 (10) ◽  
pp. 1401-1407 ◽  
Author(s):  
James G. Hakim ◽  
Innocent T. Gangaidzo ◽  
Robert S. Heyderman ◽  
Jens Mielke ◽  
Ebbah Mushangi ◽  
...  

2020 ◽  
Author(s):  
Maged Makhoul ◽  
Samuel Heuts ◽  
Abdulrahman Mansouri ◽  
Fabio Silvio Taccone ◽  
Amir Obeid ◽  
...  

Abstract Background Timing and causes of hospital mortality in adult patients undergoing veno-arterial extracorporeal membrane oxygenation (V-A ECMO) have been poorly described. Aim of the current review was to investigate the timing and causes of death of adult patients treated with V-A ECMO, and subsequently define the “V-A ECMO gap”, which represents the patients who are successfully weaned of ECMO but eventually die during hospital stay.Methods A systematic search was performed using electronic MEDLINE and EMBASE databases through PubMed. Studies reporting on adult V-A ECMO patients from January 1993 to October 2018 were screened. Timing, rates and causes of in-hospital mortality were analyzed.Results Sixty studies with 9,181 patients were included in this systematic review. Overall mortality was 37.6% during V-A ECMO support (reported by 60 studies) and 28.9% (57 studies) after weaning. Finally, 32.6% were discharged from hospital (60 studies). Most common causes of death on ECMO were multiple organ failure (MOF, 49.8%), followed by cardiac failure (20.6%) and neurological causes (15.7%). Most common causes of death after weaning were MOF (55.3%), followed by neurological complications (12.6%), persistent heart failure (10.7%) and pulmonary infections (6.8%).Conclusions More than one-third of adult V-A ECMO patients die during ECMO therapy. Additionally, almost one half of successfully weaned patients still decease during hospital stay, defining the “V-A ECMO gap”. Underreporting and lack of uniformity in reporting of important parameters remains problematic in ECMO research. Future studies should uniformly define timing and causes of death in V-A ECMO patients to better understand the effectiveness and complications of this therapy. Systematic review registration PROSPERO 2019 number CRD42019130815


2019 ◽  
pp. 48-53
Author(s):  
V. M. Svistushkin ◽  
E. V. Sinkov ◽  
G. L. Shumkova ◽  
E. L. Amelina ◽  
S. A. Krasovsky

Among diseases of ENT organs at patients with the CF prevails chronic rhinosinusitis. Stagnation of the infected dense slime in the paranasal sinus and violation of nasal breath aggravates weight of a course of lung pathology. Timely inspection and treatment of pathology of the top airways at patients with CF is necessary. In surgical treatment method of a choice is expanded FESS. This technique allows to keep anatomy of a facial skeleton and to provide a drainage the paranasal sinus. Supervision by the ENT specialist and conservative treatment of a chronic rhinosinusitis has to is carried out during all life of the patient with CF. Continuous use of local mukolitichesky and antibacterial therapy is necessary. As method of delivery of medicines the compressor inhaler with the mode for the chronic rhinosinusitis can serve.


2005 ◽  
Vol 39 (6) ◽  
pp. 950-955 ◽  
Author(s):  
Walter A Eyer-Silva ◽  
Carlos Alberto Basílio-de-Oliveira ◽  
Mariza G Morgado

OBJECTIVE: Studies on the aspects of HIV infection in small Brazilian municipalities are invaluable to appropriately design control strategies, better allocate resources, and improve health care services. The objective of the study was to assess the clinical and epidemiological aspects of HIV infection in a small municipality. METHODS: A descriptive study was carried out in Miracema, a small municipality in the northwestern area of the state of Rio de Janeiro, Brazil, between July 1999 and December 2003. All HIV-infected adult patients followed up at the local HIV/AIDS Program were included. Clinical and epidemiologic characteristics were prospectively assessed through standardized questionnaires. RESULTS: A total of 65 adult patients who attended the local HIV/AIDS Program were analyzed. Most (34) were women (male to female ratio: 0.9). An absolute predominance of patients who were born in Miracema or neighboring municipalities (94%), lived in Miracema (90.7%), were single (70.8%), attributed the acquisition of HIV infection to unprotected heterosexual intercourse (72.3%) and had a past history of snorting cocaine (27.7) was found Central nervous system disorders (including five cases of cryptococcal meningitis) and acute pulmonary pneumocystosis-like respiratory failure were major causes of morbidity. Most patients (56.9%) were at presented in advanced stages of HIV infection. CONCLUSIONS: The predominance of patients on advanced stages of HIV infection suggest the existence of a large pool of undiagnosed cases in the community. A major feature of the cohort was an inverted male to female ratio. Further investigations over a broader geographic area are urgently needed for better understanding the clinical and epidemiological characteristics of HIV infection in small Brazilian municipalities and rural areas.


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