Rauwolfia Serpentina

Keyword(s):  
Tetrahedron ◽  
1985 ◽  
Vol 41 (20) ◽  
pp. 4577-4580 ◽  
Author(s):  
Salimuzzaman Siddiqui ◽  
S.Imtiaz Haider ◽  
S.Salman Ahmad ◽  
B.S. Siddiqui
Keyword(s):  

Author(s):  
Darsi Phebe Sarah Koti Ratnam

The aim of the present study was to investigate the presence of phyto chemical, antimicrobial activities and micro propagation of the selected medicinal plants i.e. Rauwolfia serpentina, Adhatoda vasica and Alstonia scholaris. These endemic plants belong to Apocynaceae and were collected from higher altitudes of Eastern Ghats, Lambasingi forest region, Andhra Pradesh India. To determine the total phenolic and flavonoid contents, Soxhlet apparatus was used for this study. Solvents used were in this study are water, ethyl acetate, chloroform and methanol. Among them the solvent methanolic extract of Rauwolfia serpentina (57.15±1.2) and Alstonia scholaris (55.06±0.7) showed high content of saponins. The test microrganism which were studied against the efficacy of selected medicinal plant extracts were, two bacterial strians i.e., Streptococcus pyogenes, Pseudomonas aeruginosa and two fungal strains Aspergillus niger and Vibrio cholera. The antimicrobial activity was proved that the methanol extracts was found to be maximum antimicrobial growth inhibition. The simple and effective protocol was developed to propagate the Rauwolfia plant from nodal explants. Maximum no of 95% plantlets regenerated successfully. These propagated plantlets were hardened to survive in vivo conditions.


2020 ◽  
Vol 42 (6) ◽  
pp. 875-875
Author(s):  
Erum Shireen Erum Shireen ◽  
Wafa Binte Ali Wafa Binte Ali ◽  
Maria Masroor Maria Masroor ◽  
Shamim A Qureshi Shamim A Qureshi ◽  
Sehrish Kiran Sehrish Kiran ◽  
...  

Rauwolfia Serpentina is a medicinal herb used for hypertension and psychotic disorders. In this study neuroprotective effects of Rauwolfia serpentina plant extract following the exposure to acute immobilization (2h) stress in rats were investigated. The extract of the plant administered orally at non-sedative dose 30mg/kg before immobilization (2h) to observe stress induced behavioral deficits. Neuroprotective efficacy of extract was assessed in terms of alteration in activities of antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT). We also monitored leptin, corticosterone and glucose levels in plasma to obtain an imminent role of Rauwolfia serpentina. Animals were orally administered with Rauwolfia serpentina (30mg/kg) while controls receive saline (1ml/kg). Each group was subdivided into stressed and unstressed groups. Behavioral deficits were monitored in the open field and light dark activity box. Animals were decapitated; plasma samples were collected for CAT, SOD, corticosterone, leptin and glucose estimation. Orally administered Rauwolfia serpentina attenuates stress induced behavioral deficits and rise antioxidant enzymes levels. Plant extract also prevents the stress-induced increase in corticosterone but glucose levels do not manifest any significant change. Immobilization stress (2h) induced decrease of plasma leptin levels were reversed by Rauwolfia serpentina. Therefore, the present study suggests that Rauwolfia serpentina has potentiality to antagonize undesirable effects of immobilization stress (2h) by reducing stress perception and inhibitory effects of stress on the activity of hypothalamic pituitary adrenal (HPA) axis and animal behaviors. Despite an apparent role of Rauwolfia serpentina the mechanism of action at molecular level causing the acute anxiolytic effects of oral administration of plant extract remains to be determined.


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