scholarly journals Maternal blood and amnionic oxytocin receptor gene expression and serum oxytocin levels in preterm birth: a case-control study

2021 ◽  
Vol 48 (2) ◽  
pp. 283
Keyword(s):  
Gene Expression ◽  
Preterm Birth ◽  
Case Control Study ◽  
Receptor Gene ◽  
Maternal Blood ◽  
Case Control ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Receptor Gene Expression ◽  
Control Study

scholarly journals Maternal blood and amnionic oxytocin receptor gene expression and serum oxytocin levels in preterm birth: a case control study

2020 ◽  
Author(s):  
KUMARI ANUKRITI ◽  
KIRAN GULERIA ◽  
VIPIN TYAGI ◽  
AMITA SUNEJA ◽  
BASU DEV BANERJEE
Keyword(s):  
Gene Expression ◽  
Preterm Birth ◽  
Quantitative Polymerase Chain Reaction ◽  
Receptor Gene ◽  
Active Phase ◽  
Maternal Blood ◽  
Oxytocin Receptor ◽  
Maternal Serum ◽  
Oxytocin Receptor Gene ◽  
Gene Expression Studies

BACKGROUND: The oxytocin (OXT)-oxytocin receptor (OXTR) system provides promising candidate gene for studies of genetic contributions to prematurity. OBJECTIVE: Quantification and comparison of oxytocin receptor (OXTR) gene expression and serum OXT levels in the blood and amnion of women delivering preterm and evaluation of the correlation between OXTR gene expression in blood and amnion with serum OXT levels in them. METHODS: 70 pregnant women in spontaneous labor delivering vaginally preterm i.e < 37 weeks and equal number of matched controls delivering spontaneously at term (37-42 weeks) were recruited. Maternal serum OXT levels taken in active stage of labor (i.e 4 cm cervical dilatation) were quantified by ELISA. Gene expression studies in the maternal blood and amnion were done by using real time quantitative polymerase chain reaction (RT-qPCR). RESULTS: The mean serum OXT level in PTL was 48.56 +- 6.97 pg/ml; significantly higher than in controls (43.00 +- 3.96 pg/ml), p<0.001. OXTR gene expression both in maternal blood (2.5 times) and amnion (3.5 times) were significantly higher in PTL. A significant positive correlation was observed between serum OXT levels and OXTR gene expression in amnion (r = -0.190, p = 0.025). CONCLUSIONS: The serum OXT levels and OXTR gene expression in amnion surge significantly in active phase of PTL. Thus, amnion probably links OXT-PTGs autocrine paracrine circuit to facilitate PTL. Future studies are needed to devise better OXTR receptor antagonists preferably acting on amnionic OXTRs to prevent PTL. KEYWORDS: Preterm birth, Preterm labor, Oxytocin, Oxytocin receptor, Placenta, Amnion

Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study

2012 ◽  
Vol 14 (7) ◽  
pp. 500-508 ◽  
Author(s):  
Christiane Montag ◽  
Eva-Maria Brockmann ◽  
Martin Bayerl ◽  
Dan Rujescu ◽  
Daniel J. Müller ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Case Control Study ◽  
Receptor Gene ◽  
Case Control ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Receptor Gene Polymorphisms ◽  
Control Study

scholarly journals Polychlorinated biphenyl exposure alters oxytocin receptor gene expression and maternal behavior in rat model

2015 ◽  
Vol 3 (1) ◽  
pp. e979681 ◽  
Author(s):  
E Nicole Dover ◽  
David E Mankin ◽  
Howard C Cromwell ◽  
Vipaporn Phuntumart ◽  
Lee A Meserve
Keyword(s):  
Gene Expression ◽  
Rat Model ◽  
Maternal Behavior ◽  
Polychlorinated Biphenyl ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Receptor Gene Expression

scholarly journals 799: Does cholesterol exposure of myometrial cells affect oxytocin receptor gene expression and downstream signaling?

2020 ◽  
Vol 222 (1) ◽  
pp. S504-S505
Author(s):  
Ruchira Sharma ◽  
Prodyot Chatterjee ◽  
Xue Xiangying ◽  
Burton Rochelson ◽  
Christine Metz
Keyword(s):  
Gene Expression ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Myometrial Cells ◽  
Downstream Signaling ◽  
Receptor Gene Expression

The role of the endometrial oxytocin receptor in determining the length of the sterile oestrous cycle and ensuring maintenance of luteal function in early pregnancy in ruminants

1994 ◽  
Vol 344 (1309) ◽  
pp. 291-304 ◽  
Keyword(s):  
Gene Expression ◽  
Molecular Mechanisms ◽  
Transmembrane Domain ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Oestrous Cycle ◽  
High Rate ◽  
Endocrine Function ◽  
Oxytocin Receptor Gene ◽  
Receptor Gene Expression

The oxytocin receptor, a seven transmembrane domain, G protein-linked receptor molecule, plays a central role in determining the endocrine function of the ruminant uterine endometrium. During non- pregnant cycles the control of this molecule by circulating steroid hormones leads to regression of the corpora lutea. The kinetics of the mechanisms involved determine the time at which luteolysis occurs, and therefore the length of the oestrous cycle. In pregnancy, secretions of the trophoblast block endometrial oxytocin receptor gene expression and lead to luteal maintenance. An understanding of the molecular mechanisms involved in the steroidal control of oxytocin receptor gene expression will provide an explanation for the relative constancy of oestrous cycle lengths in non-pregnant animals. Unravelling the way in which trophoblast products block expression of the oxytocin receptor gene will lead to a better understanding of the reasons for the high rate of embryonic loss in domestic ruminants.

scholarly journals Oxytocin and Oxytocin Receptor Gene Expression in the Reproductive Tract of the Pregnant Cow: Rescue of Luteal Oxytocin Production at Term1

1995 ◽  
Vol 53 (3) ◽  
pp. 553-560 ◽  
Author(s):  
Richard Ivell ◽  
Werner Rust ◽  
Almuth Einspanier ◽  
Stefan Hartung ◽  
Michael Fields ◽  
...  
Keyword(s):  
Gene Expression ◽  
Reproductive Tract ◽  
Receptor Gene ◽  
Oxytocin Receptor ◽  
Oxytocin Receptor Gene ◽  
Receptor Gene Expression
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