scholarly journals Prognostic significance of the number of metastatic lymph nodes in early cervical cancer: a retrospective study

2020 ◽  
Vol 41 (4) ◽  
pp. 536
Keyword(s):  
Cervical Cancer ◽  
Retrospective Study ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Early Cervical Cancer

Comparison of the prognostic significance between the number of metastatic lymph nodes and nodal stage based on their location in patients with gastric cancer.

1993 ◽  
Vol 11 (10) ◽  
pp. 1894-1900 ◽  
Author(s):  
T Ichikura ◽  
S Tomimatsu ◽  
Y Okusa ◽  
K Uefuji ◽  
S Tamakuma
Keyword(s):  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Survival Rate ◽  
Lymph Nodes ◽  
Prognostic Significance ◽  
Cox Proportional Hazards Model ◽  
Depth Of Invasion ◽  
Metastatic Lymph Nodes ◽  
Nodal Stage ◽  
Metastatic Lymph

PURPOSE To determine which is the better prognostic determinant in gastric cancer: number of positive metastatic lymph nodes or current nodal stage. PATIENTS AND METHODS Seven hundred seventy-seven patients who underwent potentially curative resections for gastric cancer were divided into three groups according to the depth of invasion. The influence of the number of positive nodes on their survival rate was analyzed. A multivariate analysis by the Cox proportional hazards model was used to determine independent prognostic factors. RESULTS A decreased survival rate was associated with an increased number of positive nodes in all of the subjects and in each of the three groups. Patients with one to three positive nodes had as good a prognosis as those without nodal involvement when each of the three groups was analyzed separately. Using a multivariate analysis in the patients with four or more positive nodes, we found that the number of positive nodes was the most important prognostic determinant (P < .0001), followed by the depth of invasion (P < .02), and that the nodal stage was not significantly prognostic. Further multivariate analysis in the patients with one to three positive nodes showed that nodal stage and number of positive nodes were not significantly prognostic. CONCLUSION The number of metastatic nodes should be adopted for classification of nodal stage in gastric cancer.

scholarly journals UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy

2020 ◽  
Author(s):  
Hideki Matsuoka ◽  
Ryusuke Murakami ◽  
Kaoru Abiko ◽  
Ken Yamaguchi ◽  
Akihito Horie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Side Effects ◽  
Lymph Nodes ◽  
Progression Free Survival ◽  
Conditional Inference ◽  
Free Survival ◽  
Metastatic Lymph Nodes ◽  
Ugt1a1 Polymorphism ◽  
Metastatic Lymph ◽  
Gynecology And Obstetrics

Abstract Background : Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 (UGT1A1 ) is a predictive biomarker for the side-effects of irinotecan; irinotecan chemotherapy reduces the volume of tumors harboring UGT1A1 polymorphisms. We aimed to determine whether UGT1A1 polymorphisms can predict progression-free survival in patients with local cervical cancer treated with irinotecan. Methods : We retrospectively analyzed the data of 51 patients with cervical cancer treated at a single institution between 2010 and 2015. All patients were diagnosed with the 2009 International Federation of Gynecology and Obstetrics (FIGO) stage IB1, IB2, IIA, or IIB squamous cell carcinoma, underwent radical hysterectomy, and received irinotecan chemotherapy as neoadjuvant and/or adjuvant treatment. All patients were examined for irinotecan side effects using UGT1A1 tests. Conditional inference tree and survival analyses were performed considering stage, age, UGT1A1 status, and the number of metastatic lymph nodes to determine primary factors associated with progression-free survival. Results : The tree-structured survival model determined high recurrence-risk factors related to progression-free survival. The most relevant factor was ≥2 metastatic lymph nodes (p = 0.004). The second most relevant was UGT1A1 genotype (p = 0.024). Among patients with ≤1 metastatic lymph node, those with UGT1A1 polymorphisms benefited from irinotecan chemotherapy and demonstrated significantly longer progression-free survival (p = 0.020) than those with wild-type UGT1A1 . Conclusion : Irinotecan chemotherapy has the potential to benefit patients with cervical cancer, UGT1A1 polymorphism, and ≤1 metastatic lymph nodes.

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