Study of the vessels of the upper extremities and the rhythm of heart activity in patients with vibration disease in the post-СOVID period

2021 ◽  
Vol 61 (7) ◽  
pp. 431-435
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Viktor V. Shilov ◽  
Dina N. Serdyukova
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Tachycardia ◽  
Upper Extremities ◽  
Vascular Pathology ◽  
Ultra Sound ◽  
Daily Monitoring ◽  
Vibration Disease ◽  
Arterial Blood ◽  
Large Numbers ◽  
Coronavirus Infection

Currently, there are many consequences of the new coronavirus infection. We shall study the actual long-term consequences of this disease for population health in the coming years. It is necessary to consider concomitant chronic diseases in patients who are particularly dangerous in the post-COVID period. Vibration disease is one of the leading occupational pathologies in the Russian Federation. Symptoms of vibration disease are vegetative-vascular disorders, cold, cyanosis, paresthesia, violation of regional blood circulation of the extremities. As is known from numerous sources, the defeat of the cardiovascular system (CVS) against the background of COVID-19 infection occurs through angiotensin-converting enzyme (ACE-2) receptors, which presents in large numbers in the endothelium of veins and arteries. The study aims to research hemodynamics features in patients with vibration disease after a new coronavirus infection. In the clinic of occupational pathology, the researchers examined 28 patients with a previously established diagnosis of VD after a coronavirus infection. We did a Holter ECG, ultra-sound examination of the arteries and veins of the upper extremities. Arrhythmias in the form of supraventricular extrasystoles, paroxysms of atrial fibrillation, positional sinus tachycardia occur in patients with VB after a new coronavirus infection on an ECG and daily monitoring of the ECG by Holter. As is known, cardiac arrhythmias are essential in the development of acute and chronic vascular pathology, characterized by a decrease in arterial blood filling and changes. Ultrasound of the vessels of the upper extremities revealed moderate expansion of the radial and ulnar veins, insufficiency of the valve apparatus during functional tests, increased venous outflow. There was also an increase in the indicators of peripheral vascular resistance, which indicates violations of the tonic properties of the vessels of the upper extremities and violations of vasodilation. Scientists identified violations of the tonic properties of blood vessels in patients with vibration disease in the post-COVID period on ultrasound, arrhythmias in the form of supraventricular extrasys-toles, paroxysms of atrial fibrillation, positional sinus tachycardia on daily ECG monitoring.

CHANGES IN THE FOREARM VESSELS OF PATIENTS WITH VIBRATION DISEASE AFTER CORONAVIRUS INFECTION

2021 ◽  
Author(s):  
N.I. Kuprina ◽  
◽  
E.V. Ulanovskaya ◽  
V.V. Shilov
Keyword(s):  
Blood Circulation ◽  
Ultrasound Examination ◽  
Upper Extremities ◽  
Long Term Effects ◽  
Vibration Disease ◽  
Coronavirus Infection ◽  
The Russian Federation ◽  
Arteries And Veins ◽  
Cold Extremities

Abstract. A lot of scientific literature has already been written on the study of the consequences of a new coronavirus infection. The real long-term effects of this disease on population health are yet to be studied in the coming years. Vibration disease is a leading occupational pathology in the Russian Federation, characterized by vegetative-vascular disorders of the extremities and is manifested by cold extremities, cyanosis, paresthesias, and a violation of regional blood circulation. It is necessary to take into account the concomitant chronic diseases in patients who are particularly dangerous in the post-ovoid period. The aim of the study was to study the features of hemodynamics in patients with vibration disease after a new coronavirus infection. In the clinic of occupational pathology, 28 patients were examined with a previously established diagnosis of vibration disease after a coronavirus infection. Ultrasound examination of the arteries and veins of the upper extremities was performed. In patients with ultrasound of the vessels of the upper extremities, moderate expansion of the radial and ulnar veins, insufficiency of the valvular apparatus during functional tests, and increased venous outflow were revealed. There was also an increase in peripheral vascular resistance, which indicates violations of the tonic properties of the vessels of the upper extremities and violations of vasodilation. Inference. In patients with vibration disease in the post-ovoid period, ultrasound examination reveals violations of the tonic properties of blood vessels, venous dyscirculation in the veins of the forearm.

Ultrasound features of peripheral angiodistonic syndrome of the upper extremities in vibration disease

2020 ◽  
Vol 60 (11) ◽  
pp. 815-817
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Olga A. Kochetova
Keyword(s):  
Blood Flow ◽  
Heart Defects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Ulnar Artery ◽  
Upper Extremities ◽  
Disease Stage ◽  
Peripheral Blood Flow ◽  
Pronounced Increase ◽  
Vibration Disease

Introduction. Vibration disease (VD) is an example of the most common pathology due to the systematic exposure of the worker to intense vibration with sufficient work experience, the main manifestation of which is peripheral angiodystonic syndrome. The aim of study was to learn the features of peripheral blood flow in the arteries of the forearm in vibration disease using the ultrasound method. Materials and methods. The radial and ulnar arteries in patients with vibration disease were examined by ultrasound in B- and PW-mode. These materials present the results of an ultrasound assessment of the speed indicators of the main arteries of the forearm in vibration disease stages 1 and 2. The selection criteria for patients in the study ware the presence of pronounced clinical manifestations of angiodystonic syndrome in vibration disease, confirmed by instrumental research methods and data on the sanitary and hygienic characteristics of working conditions, the absence of cardiovascular chronic diseases (ischemic heart disease, heart defects, rhythm and conduction disturbances), rheumatic, oncological, infectious diseases, osteo-traumatic changes in the upper extremities. Results. The groups of patients with the established diagnosis of vibration disease of 1 and 2 degrees were studied. With vibration disease stage 1 a decrease in the pulse velocity of blood flow was observed in isolation on the ulnar artery and an increase in peripheral resistance (pulsation index and resistance index) in the radial and ulnar arteries symmetrically on both upper extremities. The second stage of vibration disease differed from the first by a more significant decrease in speed indicators both on the ulnar and radial arteries on both sides, symmetrically in combination with a more pronounced increase in peripheral resistance indicators on both main arteries of the forearm (pulsation index and resistance index). The revealed changes were determined with the same frequency in men and women. Conclusions. A significant decrease in speed indicators on the ulnar artery and an increase in peripheral resistance indicators are detected already at the initial stages of vibration disease. Thus, the method of ultrasound examination of the main arteries of the middle caliber of the upper extremities is currently the only available and objective method for examining the vascular system in vibration disease.

Atrial fibrillation associated with carbon monoxide poisoning

2019 ◽  
pp. 203-206
Author(s):  
Mevlut Demir ◽  
◽  
Muslum Sahin ◽  
Ahmet Korkmaz ◽  
◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Carbon Monoxide ◽  
Sinus Rhythm ◽  
Partial Pressure ◽  
Motor Vehicle ◽  
Carbon Monoxide Poisoning ◽  
Venous Blood ◽  
Blood Gas ◽  
Arterial Blood Gas ◽  
Arterial Blood

Carbon monoxide intoxication occurs usually via inhalation of carbon monoxide that is emitted as a result of a fire, furnace, space heater, generator, motor vehicle. A 37-year-old male patient was admitted to the emergency department at about 5:00 a.m., with complaints of nausea, vomiting and headache. He was accompanied by his wife and children. His venous blood gas measures were: pH was 7.29, partial pressure of carbon dioxide (pCO2) was 42 mmHg, partial pressure of oxygen (pO2) was 28 mmHg, carboxyhemoglobin (COHb) was 12.7% (reference interval: 0.5%-2.5%) and oxygen saturation was 52.4%. Electrocardiogram (ECG) examination showed that the patient was not in sinus rhythm but had atrial fibrillation. After three hours the laboratory examination was repeated: Troponin was 1.2 pg/ml and in the arterial blood gas COHb was 3%. The examination of the findings on the monitor showed that the sinus rhythm was re-established. The repeated ECG examination confirmed the conversion to the sinus rhythm. He was monitored with the normobaric oxygen administration.

scholarly journals Association of rs3025058 polymorphism with the development of acute cerebrovascular event

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Chernova ◽  
S Nikulina ◽  
D Nikulin
Keyword(s):  
Risk Factors ◽  
Genetic Research ◽  
Statistical Processing ◽  
Main Group ◽  
Control Group ◽  
Cerebrovascular Event ◽  
Siberian Population ◽  
Cardiovascular Pathology ◽  
Daily Monitoring ◽  
Arterial Blood

Abstract Purpose To study SNP rs3025058 association (5a/6a) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian population. Material and methods 260 patients with Acute Cerebrovascular Event participated in a research (age [57.0; 51.0–62.0]) and 272 patients of control group (age [55.0; 51.0–62.0].). Among the patients who transferred Acute Cerebrovascular Event, 157 men and 103 women. The control group included 170 men and 102 women. Inspection of the main group included: collecting complaints, anamnesis, clinical examination, computer tomography of a brain, electrocardiography, echo, ultrasonic of arteries, daily monitoring of arterial blood pressure and cardiac rhythm, analysis of a coagulant system of blood. Patients of the main group had the following cardiovascular pathology and risk factors: arterial hypertension, supraventricular tachycardia, dislipidemiya, atherosclerosis brachiocephalic of arteries, disturbances of a system of a hemostasis. The control group is examined within the international HAPIEE project. The molecular and genetic research was conducted by PCR method in real time. Statistical processing of material was carried out with use of set of the Statistica for Windows 7.0, Excel and SPSS 22 application programs. Results In all analyzed groups and subgroups of patients statistically significant connection between a genotype of 5a/5a and an allele of 5a and in subgroup of women with Acute Cerebrovascular Event, subgroups of patients with AG and hypercoagulation of significant associations of polymorphism rs3025058 (5a/6a) with Acute Cerebrovascular Eventis not revealed. Conclusion A genotype 5a/5a and an allele 5a SNP rs3025058 (5a/6a) increase risk of development of an Acute Cerebrovascular Event in persons of the east Siberian population, including with such risk factors as atherosclerosis the brachiocephalic of arteries and a dislipidemiya. FUNDunding Acknowledgement Type of funding sources: None.

scholarly journals Effect of omeprazole on the hypotensive efficacy of amlodipine depending on the genetic characteristics of patients

2018 ◽  
pp. 124-129
Author(s):  
M. N. Dorofeeva ◽  
Zh. M. Sizova ◽  
E. V. Shikh ◽  
N. I. Lapidus ◽  
K. A. Ryzhikova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Polymorphism ◽  
Blood Plasma ◽  
Arterial Blood Pressure ◽  
Genetic Characteristics ◽  
Daily Monitoring ◽  
Arterial Blood ◽  
Genetic Features ◽  
Hypertensive Therapy

Features of anti-hypertensive therapy amlodipiny at patients with the arterial hypertonia (AH) with comorbid pathology  – kislotozavisimy diseases (KZZ), accepting омепразол, depending on genetic features of the patient are studied and analysed. It is shown that a certain genetic polymorphism of an isoenzyme of P450 3A4 cytochrome can shift a metabolism of an omeprazol towards P450 3A4 cytochrome and promote more expressed oppression of activity of this enzyme. Depending on rate of a metabolism at the sick AG and KZZ receiving a combination of an amlodipin and an omeprazol various anti-hypertensive effect of an amlodipin can be observed. Reliable differences in dynamics of indicators of daily monitoring of the arterial blood pressure (ABP) at sick AG - slow metabolizator and sick AG – fast and intermediate metabolizator are received. Decrease of the activity of an isoenzyme of P450 3A4 cytochrome at patients - slow metabolizator leads to retardation of a metabolism of an amlodipin and, as a result, to rising of its concentration in a blood plasma that is clinically shown by more expressed anti-hypertensive effect.

scholarly journals CARDIOVASCULAR PATHOLOGY IN ACUTE STROKE (ISSUES ON PREVALENCE, PREVENTION AND TREATMENT)

2014 ◽  
Vol 13 (4) ◽  
pp. 47-53 ◽  
Author(s):  
S. A. Rumjantseva ◽  
R. G. Oganov ◽  
E. V. Silina ◽  
V. A. Stupin ◽  
S. B. Bolevitch ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cerebral Infarction ◽  
Negative Influence ◽  
Vascular Pathology ◽  
Comprehensive Treatment ◽  
Variable Degree ◽  
Cardiovascular Pathology ◽  
Energy Deficiency ◽  
Vascular Comorbidity

The article concerns on the problems of vascular comorbidity epidemiology and pathophysiological aspects of heart disease, which became a leading etiopathologic factor of cerebral infarctions and hemorrhages. The relationship between coronary artery disease (CAD), atrial fibrillation, hypertension and cerebral infarction types is emphasized.Aim.To analyze the role of comorbidity, attributable to cardio-vascular pathology in the initiation, course, clinical features and outcomes of cerebral infarction.Material and methods.We performed a prospective study, including 1072 patients with stroke, attributable to various cardiovascular pathology, evaluated the influence of vascular comorbidity of variable degree on the course and outcomes at an inpatient stage and at follow-up.Results.We demonstrated a negative influence of CAD, atrial fibrillation and postinfarction cardiosclerosis on the incidence of cerebral infarction, unfavorable course of the disease and functional outcomes at inpatient stage. The combination of vascular comorbidity resulted in an increased mortality in post-stroke period during 6 years of follow-up.Conclusion.Epidemiology of vascular comorbidity, its role in cerebrovascular accidents in patients with cardiac pathology justifies the need of active realization of contemporary multidisciplinary prevention programs, prolonged instrumental monitoring and implementation of energy deficiency correction therapy in comprehensive treatment programs. 

Abstract 352: Pulmonary Vein Thrombosis can make Pulmonary Vein Acidic States, which may be Associated with Atrial Fibrillation.

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Hidekazu Takeuchi
Keyword(s):  
Carbon Dioxide ◽  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Pulmonary Vein ◽  
Es Cells ◽  
Rare Complication ◽  
Arterial Blood Flow ◽  
Vein Thrombosis ◽  
Arterial Blood ◽  
Myocardial Layer

Atrial fibrillation can cause ischemic stroke. To prevent atrial fibrillation (AF) is crucial to prevent ischemic stroke. The pulmonary vein has a myocardial layer that can generate spontaneous or triggered action potentials. The myocardial layer is extended from the left atrial myocardium. Pulmonary vein myocardium sleeve is known to be associated with generating and maintaining AF. Pulmonary vein myocardium can be classified into two types. One is short and thin myocardium sleeve, which has no potential to cause atrial fibrillation (AF). And the other is long and thick myocardium sleeve, which has potential to cause AF. The mechanisms of such myocardium sleeve changes are not understood well. Pulmonary vein thrombosis (PVT) is believed to be rare, which was reported as a rare complication of chest surgeries such as lobectomy or lung cancers. But since 2012, I reported seven cases of PVT in elderly patients without such conditions, which suggests that PVT is not uncommon. That is a novel notion. PVT prevents arterial blood flow, which inhibits oxygen and nourishment supply and carbon dioxide excretion. Hypoxia activates hypoxia inducible factors (HIFs), and HIFs can modulate epigenetic changes, reprogramming and ES cells. Undernourishments may activate nuclear respiratory factor-1 (NRF-1) and the aryl hydrocarbon receptor (AhR). PVT can make pulmonary vein acidic states by inhibiting excretion of carbon dioxide and may modulate pulmonary vein myocardium. Under acidic states, pulmonary vein cells such as pulmonary vein myocardium cells may obtain some kinds of multipotency. After obtaining multipotency, the cells may turn into new cells to adapt changed surroundings. The changes of myocardium sleeve may be caused by acidic state conditions and HIFs, AhR and NRF-1, which seemed to modulate pulmonary vein myocardium functions. To clear these, more studies are needed.

2202Instant analysis of the ECG with a new digital technique during palpitations reduce symptoms, anxiety, depression, and increase HRQOL in women

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C Carnlof ◽  
P Insulander ◽  
M Jensen-Urstad ◽  
K Schenck-Gustafsson
Keyword(s):  
Atrial Fibrillation ◽  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Sinus Tachycardia ◽  
Normal Sinus Rhythm ◽  
Depression Scale ◽  
Heart Rhythm ◽  
Generalized Anxiety ◽  
Digital Technique ◽  
Anxiety Depression

Abstract Background Palpitation is common, particularly in women, and usually benign caused by premature atrial/ventricular beats or stress-induced sinus tachycardia. Palpitations may cause disturbing symptoms, anxiety, depression, and decreased health related quality of life (HRQOL). Uncommonly, arrhythmias of clinical importance such as atrial fibrillation or paroxysmal supraventricular or ventricular tachycardia may be the cause. Purposes To evaluate if instant analysis of underlying heart rhythm during palpitations reduce symptoms, anxiety, depression, and increase HRQOL. Methods In all, 913 women (age 56±11 years) with palpitations causing anxiety were recruited from social web sites. Coala Heart Monitor® was used by participants and ECG recorded twice a day and at symptoms for 60 days. The system uses a well-validated algorithm to analyze heart rhythm, is connected to the user's smartphone and provides immediate response to the user. In cases of non-benign arrhythmias, the result was also analyzed manually. Questionnaires addressing symptom (Symptom severity and frequency checklist (SCL), anxiety, depression Hospital anxiety and depression scale (HADS), Generalized Anxiety Disorder (GAD-7) and HRQOL (RAND-36)) were analyzed before and after two months. Exclusion criterium was known atrial fibrillation. Results Between June 2018 and November 2018, 280 474 recordings (both chest and thumbs) ECG recordings were automatically analyzed. Frequency and severity of symptoms decreased (frequency from 23.7±8.4 to 19.7±8.5 (p<0.001), severity from 22.7±4.9 to 21±4.4 (p<0.001)). Total anxiety measured by HADS decreased from 6.4±4.2 to 5.7±4.2 (p<0.001) and depression from 5.1±3.9 to 4.6±4.1 (p<0.001). Generalized anxiety disorder decreased from 5.6±4.8 to 4.7±4.6 (p<0.001) and HRQOL increased in all domains (p<0.001). In 83% of recordings during symptomatic palpitation, benign premature atrial or ventricular beats, sinus tachycardia, or normal sinus rhythm were found. Conclusions Instant analysis of the ECG with direct response to the user during palpitations reduce symptoms, anxiety, depression, and increase HRQOL in women.

scholarly journals Features of Atrial Fibrillation in Patients with Arterial Hypertension and Extracardial Disorders

2019 ◽  
Vol 15 (3) ◽  
pp. 368-373
Author(s):  
L. D. Khidirova ◽  
D. A. Yakhontov ◽  
S. A. Zenin ◽  
M. N. Mamedov
Keyword(s):  
Atrial Fibrillation ◽  
Arterial Hypertension ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Daily Monitoring ◽  
Galectin 3 ◽  
Observational Cohort ◽  
Toxic Goiter ◽  
Permanent Form

Aim. To study the features of the progression of atrial fibrillation (AF) in patients with arterial hypertension (HT) and comorbid extracardiac diseases.Material and methods. In the observational cohort study 308 men 45-65 years old with AF and HT were observed Most patients also had the following comorbid extracardiac diseases: diabetes mellitus (DM; n=40), diffuse toxic goiter (DTG; n=42); hypothyroidism (HTH; n=59), abdominal obesity (AO; n=64), and chronic obstructive pulmonary disease (COPD; n=47). The comparison group consisted of 56 patients with AF and HT only. Clinical, anthropometric, laboratory parameters, levels of NT-proBNP and galectin-3, results of ECG, daily monitoring of ECG and blood pressure wereassessed initially and after 12 months.Results. Persistent AF (29.6-65.2%) and long-term persistent AF (16-31.3%) were more common in groups with extracardiac diseases compared with the AF+HT group (20.4% and 14.2%, respectively). Permanent form of AF was statistically significantly more common in the DM (11.1%), AO (14.8%) and HTH (6.2%) groups compared with the AF+HT group (0.6%). A comparative assessment of risk factors (smoking and alcohol) did not show significant differences in prevalence in the groups (22-44%). An assessment of the levels of fibrosis and remodeling markers found a statistically significant increase in the level of galectin-3 in groups of patients with concomitant extracardiac diseases and an increase in the NT-proBNP level, relative to reference values in all groups except DTG.Conclusion. Patients with AF in combination with HT and comorbid extracardiac diseases have a more rapid AF progression.

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