Ultrasound features of peripheral angiodistonic syndrome of the upper extremities in vibration disease

2020 ◽  
Vol 60 (11) ◽  
pp. 815-817
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Olga A. Kochetova
Keyword(s):  
Blood Flow ◽  
Heart Defects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Ulnar Artery ◽  
Upper Extremities ◽  
Disease Stage ◽  
Peripheral Blood Flow ◽  
Pronounced Increase ◽  
Vibration Disease

Introduction. Vibration disease (VD) is an example of the most common pathology due to the systematic exposure of the worker to intense vibration with sufficient work experience, the main manifestation of which is peripheral angiodystonic syndrome. The aim of study was to learn the features of peripheral blood flow in the arteries of the forearm in vibration disease using the ultrasound method. Materials and methods. The radial and ulnar arteries in patients with vibration disease were examined by ultrasound in B- and PW-mode. These materials present the results of an ultrasound assessment of the speed indicators of the main arteries of the forearm in vibration disease stages 1 and 2. The selection criteria for patients in the study ware the presence of pronounced clinical manifestations of angiodystonic syndrome in vibration disease, confirmed by instrumental research methods and data on the sanitary and hygienic characteristics of working conditions, the absence of cardiovascular chronic diseases (ischemic heart disease, heart defects, rhythm and conduction disturbances), rheumatic, oncological, infectious diseases, osteo-traumatic changes in the upper extremities. Results. The groups of patients with the established diagnosis of vibration disease of 1 and 2 degrees were studied. With vibration disease stage 1 a decrease in the pulse velocity of blood flow was observed in isolation on the ulnar artery and an increase in peripheral resistance (pulsation index and resistance index) in the radial and ulnar arteries symmetrically on both upper extremities. The second stage of vibration disease differed from the first by a more significant decrease in speed indicators both on the ulnar and radial arteries on both sides, symmetrically in combination with a more pronounced increase in peripheral resistance indicators on both main arteries of the forearm (pulsation index and resistance index). The revealed changes were determined with the same frequency in men and women. Conclusions. A significant decrease in speed indicators on the ulnar artery and an increase in peripheral resistance indicators are detected already at the initial stages of vibration disease. Thus, the method of ultrasound examination of the main arteries of the middle caliber of the upper extremities is currently the only available and objective method for examining the vascular system in vibration disease.

scholarly journals Modern ultrasound methods for the diagnosing vibration disease

2021 ◽  
Vol 100 (8) ◽  
pp. 803-806
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Viktor V. Shilov
Keyword(s):  
Vascular System ◽  
Peripheral Resistance ◽  
Pulse Velocity ◽  
Pathological Process ◽  
Upper Extremities ◽  
Local Vibration ◽  
Pronounced Increase ◽  
Vibration Disease ◽  
Critical Problems ◽  
The Impact

Introduction. According to the latest statistical data analysis, vibration disease (VD) remains the leading pathology in the structure of occupational morbidity in the Russian Federation. The main symptom of VD is peripheral angiodystonic syndrome, which develops as a result of peripheral vessels angiospasm of extremities, which is clinically manifested in the form of pain in hands, temperature decrease and pallor of the skin. Materials and methods. The article presents the results of an ultrasound assessment of the velocity and anatomical parameters of the main arteries of upper extremities in patients with stage 2 VD from exposure to general and local vibration. Results. According to the data of sanitary and hygienic characteristics, in all examined patients with stage 2 VD from exposure to general and local vibration, the class of working conditions was assessed as class 3 (harmful). In contrast, the excess in local vibration along the X, Y, Z axes ranged from 1 to 7 dBA. Ultrasound of the main arteries of upper extremities shows a decrease in the velocity parameters along the radial and ulnar arteries symmetrically, a significant increase in the tone of the wall of the forearm arteries. Discussion. One of the most critical problems in solving expert questions is assessing pathological process severity due to the lack of transparent and objective methods. Ultrasound research is the most affordable and safest method for evaluating the vascular system of upper extremities in stage 2 VD. It also significantly increases the objectification of expert decisions on the connection of this disease with occupation. Conclusion. VD II from the impact of general and local vibration is characterized by decreased pulse velocity on the ulnar and radial arteries symmetrically on both sides with a pronounced increase of peripheral resistance, indicating a severe angiospastic syndrome to generalized.

RATIONALIZATION FOR THE DIFFERENTIAL DIAGNOSIS OF OVARIAN CANCER AND CHRONIC SALPINGOOPHORITIS IN THE PARAMETERS OF DISINTEGRATION AND NETWORK MODELING CHANGES OF BLOOD FLOW IN UTERINE AND OVARIAN ARTERIES AND VEINS

2017 ◽  
Vol 63 (5) ◽  
pp. 766-769
Author(s):  
Nikolay Agarkov ◽  
Pavel Tkachenko ◽  
Dmitriy Kicha ◽  
Vitaliy Aksenov ◽  
Aleksandr Ivanov ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Blood Flow ◽  
Diagnostic Criteria ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Diagnostic Process ◽  
Venous Outflow ◽  
Flow Changes ◽  
Arteries And Veins ◽  
Selection Of

Analysis of ultrasonic blood flow changes in uterine and ovarian arteries and veins in 92 patients with ovarian cancer and 87 patients with chronic salpingoophoritis has allowed to identify the leading differential diagnostic criteria, which include minimum diastolic blood flow velocity, resistance index, while fast hyperemia, the index of venous outflow diastolic index and index of peripheral resistance. Based on a selection of leading differential diagnostic criteria for ovarian cancer and chronic salpingoophoritis developed a network model of differentiation of these groups of patients, streamlining the differential diagnostic process

scholarly journals STUDY OF HEMOMICROCIRCULATION IN UPPER- EXTREMITYSKIN IN HEALTHY MEN IN NORMAL CONDITIONS WITH ACCOUNT OF H

2020 ◽  
Vol 10 (4) ◽  
pp. 63-65
Author(s):  
Vadim Astashov ◽  
Valentin Kozlov ◽  
Victor Sidorov, ◽  
Mihail Uloga ◽  
Inna Borodina ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Peripheral Blood ◽  
Upper Extremities ◽  
Laser Doppler ◽  
Peripheral Blood Flow ◽  
Doppler Flowmetry ◽  
Healthy Men ◽  
Young Males ◽  
Blood Microcirculation

In this study we used laser doppler flowmetry to investigate the parameters of peripheral blood flow in the upper extremities in young males both right- and left-handers. Based on the data obtained we found that in right-handers (dextrals) active mechanisms of regulation of blood microcirculation prevail on the leading hand, In left-handers (sinestrals) active and passive mechanisms of its regulation are involved in the regulation of blood flow on the leading hand (left) and on the opposite (right). However, the contribution of active mechanisms is lower than that of right-handers.

scholarly journals Features of cerebral autoregulation and reactivity in patients with arterial hypertension in older age groups with orthostatic hypotensive reactions

2020 ◽  
Vol 17 (2) ◽  
pp. 48-55
Author(s):  
I. V. Atyunina ◽  
E. V. Oshchepkova ◽  
A. N. Rogoza
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Autoregulation ◽  
Age Groups ◽  
Resistance Index ◽  
Older Age ◽  
Breath Holding ◽  
Pronounced Increase ◽  
Reactivity Coefficient

Aim. To study the condition of cerebrovascular autoregulation and reactivity in different variants of orthostatic hypotensive reactions (OНR) in elderly patients with hypertension (АН). Materials and methods. 50 patients with AH were examined (80% of women) aged 60 to 82 years (68.55.3). The duration of hypertension is from 2 to 43 years (16.811.6 years).The daily blood pressure profile was evaluated by the method of daily monitoring of blood pressure (BPLab, Russia). A study of OНR was carried out using an active orthostatic test (AOP) with continuous monitoring of cerebral blood flow (CBF) and with a minute measurement of blood pressure by the oscillometric method and continuous non-invasive measurement of SBP (systolic blood pressure) and DBP (diastolic blood pressure) in the finger artery (Task Force Monitor CNSystems Austria). The CBF velocity in the middle cerebral artery (SMA) was estimated using a transcranial sensor with a frequency of 2 MHz on an Angiodin-2K ultrasound machine (BIOSS company, Russia). In SMA, systolic (Vs), diastolic (Vd), average cerebral blood flow velocity ACBF (Vm), pulsation index (Pi), and vascular resistance index (Ri) were recorded. The difference between the indicators was calculated initially and during AOP (in the first 30 seconds and for 3 minutes): Vm30s, %, Vm3m, %. Reactivity was assessed using a hypercapnic test (HCP) with breath holding. The relative change in the CBF indicators in the MCA was calculated by the formula: Kr = (Vm1Vm2)100%/Vm1, where Kr is the reactivity coefficient, Vm1 ACBF at rest; Vm2 ACBF during the test. Statistical analysis was performed using the non-parametric MannWhitney method using Statistica 6.0. Results. In 17 (34%) patients with AH, OGR was detected. In 6 (12%) examined patients, initial OHR (IOH) was detected, in 6 (12%) classic OHR (COH), in 5 (10%) there was a combination of COH+IOH. According to the ABPM data, in patients with OHR compared with patients without OHR, there were no significant differences in the daily level of blood pressure (mmHg), SBP: 131.712.2 vs 131.313.8, p0.05; DBP 74.311.8 vs 75.38.9, p0.05). In AOP, patients with OHR significantly decreased Vm in orthostasis compared with patients without OHR, both in the first30 seconds and at 3 minutes (Vm30s: 25.05.5 vs 30.44.7, p0.05; Vm3m: 27.05.2 vs 31.24.7, p0.05; Vm30s,%: 17.06.5 vs 8.34, 1, p0.05; Vm3m,%: 11.76.3 vs 5.82.4, p0.05). When performing HCТ between patients with OHR and without OHR, statistically significant differences in the indices Pi (0.790.08 vs 0.780.16, p0.05) and Ri (0.510.09 vs 0.530.07, p0.05) was not detected, however, in patients with OHR there is a tendency to a less pronounced increase in АCBF at the peak of HCT compared with patients without OHR (36.86.4 vs 40, 06.6, p=0.13). In patients with OHR, the cerebral reactivity coefficient was lower than in patients without OHR (13.43.9 vs 20.76.6, p0.05). Conclusions. In patients with AH of older age groups with OHR, a statistically significant decrease in ACBF in orthostasis was revealed. Patients with IOH showed a decrease in ACBF in the first seconds of orthostasis with its subsequent stabilization. Persons with COH have preserved the mechanisms of cerebral autoregulation in the first seconds of orthostasis, but with prolonged orthostatic load (3 minutes), the effectiveness of autoregulatory mechanisms decreases. OHR in patients with hypertension of older age groups is associated with a decrease in cerebral reactivity.

scholarly journals Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans

2021 ◽  
Vol 12 ◽  
Author(s):  
Changyang Xing ◽  
Yuan Gao ◽  
Xinpei Wang ◽  
Wenjuan Xing ◽  
Yunnan Liu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
High Performance ◽  
Cerebral Blood Flow Velocity ◽  
Blood Pressure Response ◽  
Peripheral Resistance ◽  
Arterial Occlusion ◽  
Resistance Index ◽  
Systemic Blood Pressure ◽  
Cerebral Hypoperfusion

Exposure to acute transition from negative (−Gz) to positive (+ Gz) gravity significantly impairs cerebral perfusion in pilots of high-performance aircraft during push—pull maneuver. This push—pull effect may raise the risk for loss of vision or consciousness. The aim of the present study was to explore effective countermeasures against cerebral hypoperfusion induced by the push—pull effect. Twenty healthy young volunteers (male, 21 ± 1 year old) were tested during the simulated push–pull maneuver by tilting. A thigh cuff (TC) pressure of 200 mmHg was applied before and during simulated push—pull maneuver (−0.87 to + 1.00 Gz). Beat-to-beat cerebral and systemic hemodynamics were measured continuously. During rapid −Gz to + Gz transition, mean cerebral blood flow velocity (CBFV) was decreased, but to a lesser extent, in the TC bout compared with the control bout (−3.1 ± 4.9 vs. −7.8 ± 4.4 cm/s, P < 0.001). Similarly, brain-level mean blood pressure showed smaller reduction in the TC bout than in the control bout (−46 ± 12 vs. −61 ± 13 mmHg, P < 0.001). The systolic CBFV was lower but diastolic CBFV was higher in the TC bout. The systemic blood pressure response was blunted in the TC bout, along with similar heart rate increase, smaller decrease, and earlier recovery of total peripheral resistance index than control during the gravitational transition. These data demonstrated that restricting thigh blood flow can effectively mitigate the transient cerebral hypoperfusion induced by rapid shift from −Gz to + Gz, characterized by remarkable improvement of cerebral diastolic flow.

Predictive value of sonoelastography of secondary changed lymphous nodes in the assessment of effectiveness of immunotherapy.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e15225-e15225
Author(s):  
Fedor Vladimirovich Moiseenko ◽  
Vladimir Moiseyenko ◽  
Vera Chernobrivtceva ◽  
Vitaliy Egorenkov ◽  
Arina Zhegalina ◽  
...  
Keyword(s):  
Blood Flow ◽  
Lymph Nodes ◽  
Objective Assessment ◽  
Objective Response ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Subsequent Treatment ◽  
Response To Treatment ◽  
Rapid Progression ◽  
Neoplastic Disease

e15225 Background: With the use of existing predictors of the effectiveness of immunotherapy it is not possible to identify patients who will have a response to treatment or a rapid progression. The mechanism of the antitumor effect of the modern generation of immunotherapeutic drugs leads to significant changes in the cellular structure of the tumor and, as a consequence of this, in its physical characteristics. Sonoelastography allows to evaluate the stiffness of the tumor. Methods: The study included 17 patients with malignant neoplastic disease with the presence of secondarily affected peripheral lymph nodes (l.n.). 11/17 patients had melanoma, 2/17 - NSCLC, 3/17 - neck cancer. 8/9 - M / F, average age 61.8 years. 5/17 patients received combined immunotherapy (Ipilimumab + Nivolumab), 12/17 - anti-PD-1 (8 people Nivolumab, 4 people Pembrolizumab). Results: An ultrasound examination of the l. n. in a multimodal mode with compression elastography was performed on a Philips Epic 7 device before the first administration of the antitumor drug and every 3 weeks. Before the first objective assessment of the effect was done, in 5/17 patients was registered an increase in the size of the studied lymph nodes by 2 or more times, in 7/17 patients the size of the l. n. did not change, in 5/17 patients the affected l. n. decreased (26% - 64%).The results of control examination after 2 months of treatment: PR - 2/17, CR - 4/17, SD- 9/17, PD- 4/17.In the group with an objective response (PR, CR, SD - 13/17), the average value. St. Ratio before treatment was 5.7 ± 0.4; during treatment decreased to an average of 3.2 ± 0.5 (p < 0.05). In the group with progression during treatment, the average St. Ratio value before treatment was 4.1 ± 0.4, and during treatment increased on average to 5.7 ± 0.5 (p < 0.05).A qualitative analysis of tumor blood flow was carried out, the Resistance Index (RI) was studied. The RI in the first group of patients was 0.65 ± 0.4; after treatment, the RI increased to 0.74. In the second group of patients, the RI before and after treatment did not significantly change. Conclusions: During the immunotherapy treatment, a decrease in the stiffness of the tumor is observed, regardless of the change in size and an increase in the indices of peripheral resistance to blood flow in case of further regression or stabilization of the process. An early change in the sonographic characteristics of tumor foci can identify patients with a subsequent treatment effect, and can also distinguish true progression from pseudoprogression, which requires confirmation in larger studies.

Atrial extract: hemodynamics in Wistar-Kyoto and spontaneously hypertensive rats

1985 ◽  
Vol 249 (2) ◽  
pp. H265-H271 ◽  
Author(s):  
B. L. Pegram ◽  
M. B. Kardon ◽  
N. C. Trippodo ◽  
F. E. Cole ◽  
A. A. MacPhee
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Vascular Resistance ◽  
Total Peripheral Resistance ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Organ Blood Flow ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto ◽  
Atrial Natriuretic

Partially purified low (LMW) and high-(HMW) molecular-weight atrial natriuretic extracts were administered intravenously (540 micrograms protein/kg) to conscious Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Both LMW and HMW atrial natriuretic extracts produced an immediate decrease in mean arterial pressure that reached maximum within 5 min and returned to control levels within 30 min. In both strains, cardiac output decreased approximately 14% following administration of LMW. Total peripheral resistance increased only in SHR. Organ blood flow was significantly decreased to skin, brain, heart, kidneys, and splanchnic organs of WKY and to skin, muscle, heart, and splanchnic organs of SHR following administration of LMW. Corresponding increases in organ vascular resistance index were observed in brain, heart, and splanchnic organs of WKY and in skin, heart, and splanchnic organs of SHR. To some extent, the changes in organ blood flow may be a reflection of the decrease in cardiac output induced by LMW. After administration of HMW, no significant changes were observed in cardiac output or total peripheral resistance, although they tended to decrease. Organ vascular resistance was decreased to skin, muscle, brain, and splanchnic organs of SHR. Little difference was observed between WKY and SHR responses to atrial natriuretic extracts. These data indicate that atrial natriuretic extracts have an effect on systemic and regional hemodynamics in conscious rats that differs markedly from those of vasodilators such as nitroglycerin or hydralazine.

scholarly journals Dynamics of characteristics of cerebral circulation during combined treatment with amlodipine and bisoprolol

2017 ◽  
Vol 94 (12) ◽  
pp. 908-914
Author(s):  
Irina L. Zapesochnaya ◽  
A. G. Avtandilov
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Flow Velocity ◽  
Combined Therapy ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Downward Trend ◽  
Hypertensive Patients ◽  
Group 2 ◽  
Group 1

Objective: to assess dynamics of cerebral blood flow when starting combined therapy with amlodipine and bisoprolol in hypertensive patients working in the Far North under various labor schedules. Material and methods. We studied 140 patients with grade 1-2 hypertension divided into two groups depending on their work schedule. Group 1 (n=72) included subjects working only at daytime; group 2 (n=68) consisted of subjects working in shifts. All patients received combined therapy with amlodipine and bisoprolol. The final mean daily dose of amlodipine/bisoprolol amounted to 8,3±1,3/9,8±1,6 mg/day and 9,5±1,5/14,5±1,2 mg/day in groups 1 and 2 respectively. Doppler ultrasound of the common carotid, internal carotid and vertebral arteries (OCA, BCA and PA, respectively) was performed before, 12 weeks, and 6 months after onset of therapy. Results. At the end-point of intervention (6 months) patients of group 1 showed an increase in peak systolic velocity (Vps) in OCA, BCA and PA (by 4,1, 5,9 and 5,5% respectively) and maximum end-diastolic flow velocity (Ved) in ОCA and ВCA (by 5,8 and 5,2% respectively). Patients of group 2 showed an increase of Vps in OCA, BCA and PA by 6,3, 8,4 and 7,1% respectively; Ved in OCA and BCA by 6,4 and 14,5% respectively. All patients exhibited a pronounced downward trend of the peripheral resistance index of in all studied arteries. The tendency to a decrease in the thickness of the intima-media complex was documented: by 4,1%, in group 1, 6,8% in group 2, without reaching the normal level. Conclusion. 6-month starting combined therapy with amlodipine and bisoprolol in hypertensive patients has positive effect on cerebral hemodynamics manifest as the increase in parameters of cerebral blood flow velocity and reduced peripheral resistance index. Pronounced downward trend in the thickness of the intima-media monitoring in both groups was apparent but without reaching the standard level.

scholarly journals Vegetovascular disorders in vibration disease and differential therapy using physical factors

1998 ◽  
Vol XXX (1-2) ◽  
pp. 35-37
Author(s):  
О. A. Chudinova ◽  
R. G. Obraztsova ◽  
G. N. Samokhvalova ◽  
R. I. Filatova
Keyword(s):  
Clinical Picture ◽  
Vertebral Column ◽  
Clinical Manifestations ◽  
Upper Extremities ◽  
Disease Stage ◽  
Physical Factors ◽  
Treatment Results ◽  
Differential Therapy ◽  
Vibration Disease ◽  
Magnetic Therapy

Examination and treatment results are given, concerting 205 patients with vibration disease, in the clinical picture of which the most early and most expressed are neurovascular disorders in the system of regional circulation and vegetativesensoric polyneuropathies. It was shown, that in patients with vibration disease lowering of pulse blood supply in distal parts of upper extremities is being observed, as well aS dystoniccondition of arterial bed vessels, whose expression level is correlated with the disease stage. Suggested physiotherapeutic complexes (magnetic therapy, magnetic and laser therapy, aspirin-electrophoresis on the cervical department of vertebral column and hand) favourably enfluence peripheric hemodynamics, thus contributing to regress of basic clinical manifestations of vibration disease.

WISE 2005: responses of women to sublingual nitroglycerin before and after 56 days of 6° head-down bed rest

2012 ◽  
Vol 113 (3) ◽  
pp. 434-441 ◽  
Author(s):  
K. A. Zuj ◽  
H. Edgell ◽  
J. K. Shoemaker ◽  
M. A. Custaud ◽  
P. Arbeille ◽  
...  
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Femoral Artery ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Cardiovascular Effects ◽  
Cardiovascular Responses ◽  
Bed Rest ◽  
Sublingual Nitroglycerin

This study tested the hypothesis that cardiovascular effects of sublingual nitroglycerin (NG) would be exaggerated after 56 days of 6° head-down bed rest (HDBR) in women, and that an aerobic and resistive exercise countermeasure (EX, n = 8) would reduce the effect compared with HDBR without exercise (CON, n = 7). Middle cerebral artery maximal blood flow velocity (CBFV), cardiac stroke volume (SV), and superficial femoral artery blood flow (Doppler ultrasound) were recorded at baseline rest and for 5 min following 0.3 mg sublingual NG. Post-HDBR, NG caused greater increases in heart rate (HR) in CON compared with EX (+24.9 ± 7.7 and +18.8 ± 6.6 beats/min, respectively, P < 0.0001). The increase in HR combined with reductions in SV to maintain cardiac output. Systolic, mean, and pulse pressures were reduced 5–10 mmHg by NG, but total peripheral resistance was only slightly reduced at 3 min after NG. Reductions in CBFV of −12.5 ± 3.8 cm/s were seen after NG, but a reduction in the Doppler resistance index suggested dilation of the middle cerebral artery with no differences after HDBR. The femoral artery dilated with NG and blood flow was reduced ∼50% with the appearance of large negative waves suggesting a marked increase in downstream resistance, but there were no effects of HDBR. In general, responses of women to NG were not altered by HDBR; the greater increase in HR in CON but not EX was probably a consequence of cardiovascular deconditioning. These results contrast with the hypothesis and a previous investigation of men after HDBR by revealing no change in cardiovascular responses to exogenous nitric oxide.

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