scholarly journals Controlled environment treatment (CET): The use of a new concept of wound environment in amputation surgery and other conditions of the extremities

1980 ◽  
Vol 4 (1) ◽  
pp. 15-28 ◽  
Author(s):  
I. M. Troup
Keyword(s):  
Controlled Trial ◽  
Clinical Impression ◽  
Controlled Environment ◽  
The United Kingdom ◽  
Clinical Presentations ◽  
Routine Basis ◽  
Amputation Surgery ◽  
Continued Use ◽  
Set Up ◽  
Clinical Conditions

The use of a new method of improving certain physical aspects of the environment imposed on the extremity is discussed. This follows the use of Controlled Environment Treatment in amputation surgery and other specific conditions within a controlled trial in several Centres in the United Kingdom and United States of America. The protocol did not attempt to establish any system of controls, the results being based on observation and clinical impression. In other words it is an extension of CET use in an attempt to obtain a wider experience of its application. One hundred cases involving 128 treatments are listed over a wide variety of clinical presentations. Recordings were made of the presence or absence of oedema, infection, ischaemia and pain, amongst other relevant data. Certain conclusions proved possible and staff acceptance of the system was obtained. The evidence suggests that the continued use of CET is justified in certain carefully selected clinical conditions. Further, it appears necessary to set up controlled scientific assessments of the system particularly within vascular laboratories where many relevant investigative procedures are carried out on a routine basis.

scholarly journals Acceptance of a Symptom-Based Approach for COVID-19 rtRT-PCR Testing to Conserve Resources in a Lower Middle-Income Setting

2021 ◽  
Vol 12 ◽  
pp. 215013272098771
Author(s):  
S. M. Rashed Ul Islam ◽  
Tahmina Akther ◽  
Md. Abdullah Omar Nasif ◽  
Sharmin Sultana ◽  
Saif Ullah Munshi
Keyword(s):  
Primary Method ◽  
Chain Reaction ◽  
Middle Income ◽  
Clinical Recovery ◽  
Clinical Presentations ◽  
Long Time ◽  
Nasopharyngeal Secretion ◽  
Polymerase Chain ◽  
Set Up

SARS-CoV-2 initially emerged in Wuhan, China in late 2019. It has since been recognized as a pandemic and has led to great social and economic disruption globally. The Reverse Transcriptase Real-Time Polymerase Chain Reaction (rtRT-PCR) has become the primary method for COVID-19 testing worldwide. The method requires a specialized laboratory set up. Long-term persistence of SARS-CoV-2 RNA in nasopharyngeal secretion after full clinical recovery of the patient is regularly observed nowadays. This forces the patients to spend a longer period in isolation and test repeatedly to obtain evidence of viral clearance. Repeated COVID-19 testing in asymptomatic or mildly symptomatic cases often leads to extra workload for laboratories that are already struggling with a high specimen turnover. Here, we present 5 purposively selected cases with different patterns of clinical presentations in which nasopharyngeal shedding of SARS-CoV-2 RNA was observed in patients for a long time. From these case studies, we emphasized the adoption of a symptom-based approach for discontinuing transmission-based precautions over a test-based strategy to reduce the time spent by asymptomatic and mildly symptomatic COVID-19 patients in isolation. A symptom-based approach will also help reduce laboratory burden for COVID-19 testing as well as conserve valuable resources and supplies utilized for rtRT-PCR testing in an emerging lower-middle-income setting. Most importantly, it will also make room for critically ill COVID-19 patients to visit or avail COVID-19 testing at their convenience.

Centros Ltd—A Complete U-Turn in the Right of Establishment for Companies?

2000 ◽  
Vol 49 (3) ◽  
pp. 621-642 ◽  
Author(s):  
Anne Looijestijn-Clearie
Keyword(s):  
United Kingdom ◽  
Member State ◽  
European Court Of Justice ◽  
The United Kingdom ◽  
Court Of Justice ◽  
European Court ◽  
Registered Office ◽  
Set Up ◽  
The Right ◽  
A Company

InCentros Ltd and Erhvers-og Selskabsstyrelesen (hereinafter Centros),1 the European Court of Justice ruled that it is contrary to Article 52 (now Article 432) and Article 58 (now Article 48) of the EC Treaty for the authorities of a member State (in casu Denmark) to refuse to register a branch of a company formed under the law of another member State (in casu the United Kingdom) in which it has its registered office, even if the company concerned has never conducted any business in the latter State and intends to carry out its entire business in the State in which the branch is to be set up. By avoiding the need to form a company there it would thus evade the application of the rules governing the provision for and the paying-up of a minimum share capital in force in that State. According to the Court, this does not, however, prevent the authorities of the member State in which the branch is to be set up from adopting appropriate measures for preventing or penalising fraud, either with regard to the company itself, if need be in co-operation with the member State in which it was formed, or with regard to its members, where it has been determined that they are in fact attempting, by means of the formation of a company, to evade their obligations towards creditors established in the territory of the member State of the branch.

Attempting to set up a randomised controlled trial

2000 ◽  
Vol 14 (21) ◽  
pp. 32-36 ◽  
Author(s):  
Lorraine Ellis ◽  
Sue Davies ◽  
Sara Laker
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Set Up ◽  
Randomised Controlled

scholarly journals Continued Use of an Integrated Meter with Electronic Logbook Maintains Improvements in Glycemic Control Beyond a Randomized, Controlled Trial

2007 ◽  
Vol 9 (3) ◽  
pp. 254-264 ◽  
Author(s):  
Lori M.B. Laffel ◽  
William C. Hsu ◽  
Janet B. McGill ◽  
Luigi Meneghini ◽  
Lisa K. Volkening ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Glycemic Control ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Electronic Logbook ◽  
Continued Use

Pulmonary Tuberculosis Mimicking Lung Cancer and Metastasis Radiologically- A Case Report

2020 ◽  
Author(s):  
Harveen Kaur
Keyword(s):  
Lung Cancer ◽  
Pulmonary Tuberculosis ◽  
Diagnostic Procedures ◽  
Mediastinal Lymphadenopathy ◽  
Presumptive Diagnosis ◽  
Clinical Presentations ◽  
High Incidence ◽  
Pulmonary Infiltration ◽  
Low Incidence ◽  
Clinical Conditions

Tuberculosis (TB) is known to mimic several clinical conditions, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the countries having a low incidence of TB with a high incidence of lung cancer and varying clinical presentations, which results in delay in treatment initiation and unnecessary diagnostic procedures. We present a case of a 52-year old female, with a presumptive diagnosis of malignancy, which was subsequently proved as pulmonary tuberculosis with no evidence of malignancy instead.

The Reading University-industry link

1988 ◽  
Vol 2 (4) ◽  
pp. 253-254
Author(s):  
A.K. Giles
Keyword(s):  
United Kingdom ◽  
Science Parks ◽  
Science Park ◽  
The United Kingdom ◽  
Set Up ◽  
Under Construction ◽  
University Industry

The last decade has seen the emergence and growth in this country, and elsewhere, of science parks. In 1984 the United Kingdom Science Park Association (UKSPA) was set up with eight founder members. The mushrooming that followed meant that by 1986 the Association could report 28 fully operated parks, seven others under construction and a number of Associate Members, of which Reading University was one.

scholarly journals Molecular detection and clinical aspects of porcine circovirus 3 infection in pigs from Brazil

2020 ◽  
Vol 72 (5) ◽  
pp. 1731-1736
Author(s):  
A.C.M. Cruz ◽  
I.L.F. Rodrigues ◽  
A.E. Souza ◽  
F.B. Knackfuss ◽  
R.L. Silveira ◽  
...  
Keyword(s):  
Molecular Detection ◽  
Porcine Circovirus ◽  
Southeastern Brazil ◽  
Clinical Aspects ◽  
Statistical Association ◽  
Serum Samples ◽  
Clinical Presentations ◽  
Porcine Circovirus 3 ◽  
Clinical Conditions ◽  
Swine Serum

ABSTRACT Porcine circovirus 3 (PCV-3) DNA has been detected in serum samples from apparently healthy pigs as well as pigs with different clinical conditions. Molecular detection of PCV-3 was observed in swine serum samples from Southeastern - Brazil using a nested PCR designed specifically for this study. The epidemiology and clinical aspects of PCV-3 infection were evaluated. The samples originated from 154 pigs of both genders from different production phases and with different clinical presentations, sampled from 31 pig farms visited between 2013 and 2018. In this study, PCV-3 was detected in 26.7% of samples from all populations across varying ages. Statistical association (P=0.0285) was observed only between animals with respiratory signs and PCV-3; no PCV-3-positive animal had diarrhea. No statistical association was observed between PCV-3 and age, or gender of the pigs. Because PCV-3 is a newly discovered virus, there is very little information about its epidemiology. We hope that these data can help in future studies investigating PCV-3 epidemiology.

scholarly journals Case Report of Rare cause of Acute Hemolytic Anemia in Saudi Patient (Babesiosis)

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Khadiga Ahmed Ismail
Keyword(s):  
Case Report ◽  
Blood Transfusion ◽  
Infected Patient ◽  
Immune Status ◽  
Antimicrobial Treatment ◽  
Zoonotic Diseases ◽  
Severe Anemia ◽  
Clinical Presentations ◽  
Discharge From Hospital ◽  
Clinical Conditions

Babesiosis is one of the protozoan zoonotic diseases its presentation rang from asymptomatic to severe clinical conditions, with severe hemolysis. Immune status of the host and the species of the parasite has impact on the clinical presentations of the infected patient our patient is presented here; the patient was admitted from a countryside with severe anemia and a deterioration in his general condition, he was admitted to intense care unit and received blood transfusion, in addition to antimicrobial treatment in form of azithromycin and Ceftriaxon, his condition improve and released from ICU on the second day and discharge from hospital after improvement on the seventh day.

scholarly journals Effects of Side-Effect Risk Framing Strategies on COVID-19 Vaccine Intentions in the United States and the United Kingdom: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Nikkil Sudharsanan ◽  
Caterina Favaretti ◽  
Violetta Hachaturyan ◽  
Till Baernighausen ◽  
Alain Vandormael
Keyword(s):  
United States ◽  
Randomized Controlled Trial ◽  
Side Effect ◽  
Motor Vehicle ◽  
Controlled Trial ◽  
The United States ◽  
Randomized Controlled ◽  
The United Kingdom ◽  
Percentage Points ◽  
Framing Strategies

Vaccination rates have stagnated in the United States and the United Kingdom leading to the continuing spread of COVID-19. Fear and concern over vaccine side-effects is one of the main drivers of hesitancy. Drawing from behavioral science and health communication theory, we conducted a randomized controlled trial among 8998 adults to determine whether the way COVID-19 vaccine side-effects are framed and presented to individuals can influence their willingness to take a vaccine. We presented participants information on a hypothetical future COVID-19 vaccine -- including information on its side-effect rate -- and then examined the effect of three side-effect framing strategies on individuals stated willingness to take this vaccine: adding a qualitative risk label next to the numerical risk, adding comparison risks, and for those presented with comparisons, framing the comparison in relative rather than absolute terms. Based on a pre-registered and published analysis plan, we found that adding a simple descriptive risk label (very low risk) next to the numerical side-effect increased participants' willingness to take the COVID-19 vaccine by 3.0 percentage points (p = 0.003). Providing a comparison to motor vehicle mortality increased COVID-19 vaccine willingness by 2.4 percentage points (p = 0.051). These effects were independent and additive: participants that received both a qualitative risk label and comparison to motor-vehicle mortality were 6.1 percentage points (p < 0.001) more likely to report willingness to take a vaccine compared to those who did not receive a label or comparison. Taken together, our results reveal that despite increasingly strong vaccination hesitancy and exposure to large amounts of vaccine misinformation, low-cost side-effect framing strategies can meaningfully affect vaccination intentions at a population level.

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