scholarly journals Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats

2016 ◽  
Vol 62 (2) ◽  
pp. 114-124 ◽  
Author(s):  
Sarwat Jahan ◽  
Qurat Ul Ain ◽  
Hizb Ullah
Keyword(s):  
Bisphenol A ◽  
Therapeutic Effects ◽  
Testicular Damage ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Elemental Mapping Of Bone Strontium In Rats Treated With Strontium Ranelate And Strontium Citrate Using 2D Micro-XRF And 3D Dual Energy K-edge Subtraction X-ray Imaging

2021 ◽  
Author(s):  
Daniel Arturo Cardenas
Keyword(s):  
Strontium Ranelate ◽  
Dual Energy ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Treatment Of Osteoporosis ◽  
3D Images ◽  
X Ray ◽  
X Ray Imaging ◽  
Sprague Dawley Rats ◽  
Animal Bones

Strontium-based medications, such as strontium ranelate, have been shown to have therapeutic effects in the treatment of osteoporosis, other strontium salts are assumed to have similar effects on bone health. The objective of this study was to compare the distribution of strontium in animal bones following administration of strontium ranelate and strontium citrate. Humerus bones were collected from female Sprague-Dawley rats that were dosed daily over ten weeks with strontium ranelate and strontium citrate, and no strontium (control). Bones were imaged using 2D micro-XRF and 3D dual energy KES X-ray imaging. The 2D imaging revealed differences in strontium and calcium levels between samples from treated and non-treated animals (푝 < 0.001). 3D images obtained showed that strontium was observed to be largely present in the trabecular regions under the epiphyseal plate with concentrations of approximately 5 to 15 mg/cm3 in the bones of both strontium treated groups. The thickness of the strontium layers below the growth plate in both the strontium ranelate and strontium citrate sample were not significantly different (푝 = 0.9201). Both imaging studies performed in this work showed that strontium from both salts is heterogeneously distributed in newly formed bone during treatment.

scholarly journals Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats

2020 ◽  
Vol 33 (2) ◽  
pp. 87-95
Author(s):  
Khaled Radad ◽  
Yassmin El Amir ◽  
Ahmed Al-Emam ◽  
Mubarak Al-Shraim ◽  
Ismaeel Bin-Jaliah ◽  
...  
Keyword(s):  
Testicular Damage ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Pterostilbene Ameliorates Nephropathy Injury in Streptozotocin-Induced Diabetic Rats

Pharmacology ◽  
2019 ◽  
Vol 104 (1-2) ◽  
pp. 71-80 ◽  
Author(s):  
Ying Zhang ◽  
Shaoyu Ren ◽  
Ying Ji ◽  
Yafeng Liang
Keyword(s):  
High Fat Diet ◽  
Nuclear Factor Κb ◽  
Diabetic Rats ◽  
Inflammatory Factors ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Tnf Α ◽  
Necrosis Factor ◽  
Different Doses

Background: Our study investigated the therapeutic role and potential mechanisms of pterostilbene (PS) in diabetic nephropathy (DN) rats. Methods: DN models were established by high-fat diet after streptozotocin injection. A total of 50 Sprague-Dawley rats were randomly divided into control, DN, PS-treated groups (PS-H, PS-M, PS-L). PS was administered to rats by gavage for 8 weeks at 3 different doses (25, 10, and 5 mg/kg/day). The levels of oxidative stress activity (superoxide dismutase [SOD], malondialdehyde [MDA], glutathione peroxidase [GSH-PX]) and inflammatory factors (tumor necrosis factor [TNF]-α, interleukin (IL)-6, IL-1β, monocyte chemoattractant factor [MCP]-1) were detected by ­ELISA. TGF-β, Smad1, and fibronectin (FN) were measured through immunohistochemistry. The relative expressions of phospho-IκBα/IκBα, phospho-IκB kinases (IKK)β/IKKβ, phospho-nuclear factor-κB (NF-κB) p65/NF-κB p65 were detected by western blot. Results: Compared with DN group, the levels of TNF-α, IL-6, IL-1β, and MCP-1 were decreased in the PS-H group (p < 0.05). Meanwhile, the levels of SOD, MDA, GSH-PX improved in kidney and serum in PS-H groups (p< 0.05). PS also significantly decreased the level of phospho-NF-κB p65 and increased the levels of phospho- IKKβ and phospho-Iκ-Bα (p < 0.05). The results showed that PS treatment decreased TGF-β, Smad1, and FN expressions. Conclusion: PS had potential therapeutic effects on DN, which may be related to the regulation of NF-κB pathway.

scholarly journals Anti-infertility significance of aqueous extract of I pomoea batatas (L.) Lam. against exposure of bisphenol A (BPA) promoted testicular toxicity in male Sprague Dawley rats

2013 ◽  
Vol 2 (4) ◽  
pp. 263-271
Author(s):  
Rajendran Revathy ◽  
Kulanthaivel Langeswaran ◽  
Subbaraj Gowtham kumar ◽  
Shanmugam Vijayaprakash ◽  
Peranandam Tamilselvan ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Aqueous Extract ◽  
Testicular Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Beneficial effects of combined terlipressin and tetramethylpyrazine administration on portal hypertensive rats

1999 ◽  
Vol 77 (8) ◽  
pp. 618-624 ◽  
Author(s):  
Fang-Chi Chang ◽  
Yi-Tsau Huang ◽  
Han-Chieh Lin ◽  
Chuang-Ye Hong ◽  
Jaung-Geng Lin ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Venous Pressure ◽  
Peripheral Resistance ◽  
Therapeutic Effects ◽  
Portal Vein Ligation ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Beneficial Effects ◽  
Sprague Dawley Rats ◽  
Duct Ligation

The purpose of this study was to investigate the therapeutic effects of terlipressin (TP) alone or in combination with tetramethylpyrazine (TMP) on anesthetized portal hypertensive rats. Portal hypertension was induced by either partial portal vein ligation (PVL, without cirrhosis) or bile duct ligation (BDL, with cirrhosis) in Sprague-Dawley rats. Each PVL or BDL rat received only one of the two regimens: vehicle for 3 min followed by TP (0.017 mg·kg-1·min-1 for 3 min) or TMP (10 mg·kg-1·min-1 for 3 min) followed by TP. In PVL rats, infusion of vehicle followed by TP induced significant reduction of portal venous pressure (PVP, -15.0 ± 1.0%) and prominent elevation of mean arterial pressure (MAP, 57.3 ± 8.1%) as well as total peripheral resistance (TPR, 113 ± 11%) from baseline, and there was a cardiodepressant response (cardiac index, CI, -26.3 ± 1.1%). Infusion of TMP followed by TP induced significant reduction of PVP (-20.3 ± 0.4%) and CI (-9.9 ± 1.2%) and significant elevation of MAP (31.3 ± 2.5%) and TPR (46.0 ± 4.1%) from baseline. In BDL rats, infusion of vehicle followed by TP also induced significant reduction of PVP (-13.8 ± 1.7%) but an increase in MAP (57.1 ± 2.2%) and TPR (101 ± 6%) from baseline, and there also was a cardiodepressant response (CI, -21.4 ± 2.3%). Infusion of TMP followed by TP induced significant reduction of PVP (-18.9 ± 1.4%) and CI (-11.9 ± 2.1%), but an increase in MAP (36.2 ± 2.5%) and TPR (55.0 ± 5.2%). Compared with vehicle followed by TP, TMP not only significantly enhanced portal hypotensive (PVP reduction) effects of TP but also attenuated the systemic pressor (MAP and TPR elevation) and cardiodepressant (CI reduction) effects of TP in both PVL and BDL rats. Our results suggest that TP, alone or in combination with TMP, induced portal hypotensive effects in two models of portal hypertensive rats. Combination of TP and TMP was beneficial in enhancing portal hypotensive effects of TP and ameliorating the systemic pressor and cardiodepressant effects of TP.Key words: terlipressin, tetramethylpyrazine, cirrhosis, portal hypertension, hemodynamics.

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