scholarly journals The Impact of Parkinson’s Disease on Social Perception: Preliminary Evidence

2021 ◽  
Author(s):  
Kathrin Rothermich ◽  
Mackenzie Rountree ◽  
Julia Scott ◽  
Madeline Funke ◽  
Emily Bishop ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Social Cognition ◽  
Social Perception ◽  
Cognitive Abilities ◽  
Group Analysis ◽  
Preliminary Evidence ◽  
Attention And Memory ◽  
And Performance ◽  
The Impact

Besides motor symptoms, people with Parkinson’s Disease (PD) often exhibit social cognition difficulties. The assessment of social cognition in early PD is crucial, as these deficits may impact patients' social interactions and quality of life. The current study used naturalistic, dynamic video clips to examine the ability of individuals with idiopathic PD to perceive speaker intentions in comparison with healthy controls (HC). Neuropsychological evaluation of the PD patients was conducted using the Cognitive Linguistic Quick Test (CLQT). Video stimuli were taken from the Relational Inference in Social Communication database (RISC; Rothermich & Pell, 2015) and contained literal, sarcastic, and teasing scenes. The participant’s task was to identify the speaker’s belief, i.e., if they were sincere or insincere. The results show that in general, all participants had a harder time identifying nonliteral statements such as teasing as insincere when compared to literal statements. A group analysis demonstrated a marginally significant effect between people with PD and HCs, showing that individuals with PD were less accurate in recognizing social intent compared to HC. This difference was possibly driven by changes in cognitive abilities due to the progression of PD. Indeed, analyses for the PD group revealed positive correlations between several cognitive domains, such as attention and memory, and performance on the speaker belief task. Taken together, our study sheds light on the relationship between cognitive mechanisms and social perception impairments in PD and supports the development of targeted tools for diagnosing and treating these impairments.

scholarly journals The Role of Social Cognition Abilities in Parkinson's Disease in the Era of COVID-19 Emergency

2021 ◽  
Vol 12 ◽  
Author(s):  
Alessandra Dodich ◽  
Costanza Papagno ◽  
Luca Turella ◽  
Claudia Meli ◽  
Francesca Zappini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Social Network ◽  
Social Cognition ◽  
Social Isolation ◽  
Cognitive Abilities ◽  
Structured Interview ◽  
Parametric Analyses ◽  
Restrictive Measures

Introduction: Parkinson's Disease (PD) is characterized by motor and non-motor symptoms, among which deficits in social cognition might affect ~20% of patients. This study aims to evaluate the role of social cognitive abilities in the perceived impact of COVID-19 emergency, and the effects of lockdown measures on patients' social network and caregivers' burden.Methods: Fourteen PD patients performed a neuropsychological battery including sociocognitive tasks before the introduction of COVID-19 restrictive measures (i.e., social distancing and isolation). A structured interview through an online platform was performed in the last 2 weeks of the first lockdown phase to assess patients' health status, perception of COVID-19 emergency, changes in caregivers' burden, and patients' social isolation. Non-parametric analyses were performed to evaluate the association between social skills and patients' COVID-19 perception, as well as the effects of restrictive measures.Results: At baseline evaluation, half of the PD patients showed sociocognitive dysfunctions, mainly on mentalizing abilities. Patients with impaired social cognition skills showed a significantly lower concern on the possible effects of COVID-19 on their health. Caregiver burden and patients' social network remained stable during the lockdown.Conclusion: These preliminary results underline that PD sociocognitive dysfunctions might affect patients' abilities to estimate the effects of COVID-19 infection. However, the lack of a significant increase in caregivers' burden and social isolation suggests, in our sample, a good coping to COVID-19 emergency. Since COVID-19 pandemic can have direct and indirect severe consequences in patients with PD, the development of educational and preventive programs is recommended.

scholarly journals The Mozart effect combined with specific kinetic treatment in patients with Parkinson’s disease

2019 ◽  
Vol 10 (Vol.10, No.3) ◽  
pp. 294-299
Author(s):  
Xénia Melánia BREDA ◽  
Dana Marieta FODOR ◽  
Robert VERDEŞ ¹, ◽  
Dorina TĂRTĂMUŞ ◽  
Dorin-Alexandru MUREŞAN ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Abilities ◽  
Control Group ◽  
Mozart Effect ◽  
Before And After ◽  
Degree Of Disability ◽  
Few Data ◽  
The Impact ◽  
Kinetic Treatment

Introduction & objectives: Although controversial, the Mozart effect, consisting of an improvement in cognitive abilities in healthy persons, has started to be studied in the case of patients with various neurological, even neurodegenerative diseases (dementia, treatment-refractory epilepsy). There are few data on the Mozart effect in Parkinson’s disease, but the positive results reported for other neurological pathologies have led us to study this subject. The aim of this study is to compare the results of the Mozart effect associated with specific kinetic treatment in the rehabilitation of Parkinson’s disease and the effect of standard kinesiotherapy, results reflected in the impact on the degree of disability, emotional state and quality of life. Material and method: This was a prospective case-control study, comprising patients with Parkinson’s disease, Hoehn & Yahr stages I-III, included in a motor neurorehabilitation program through the project “The power of hope for patients with Parkinson’s disease” Cluj-Napoca. The patients were assigned to two groups, a control group with specific physiotherapy and the other group receiving the same specific kinetic treatment associated with the Mozart effect, for 2 hours daily, over 14 consecutive days. The patients were assessed using the Schwab & England scale (for the degree of dependence) and the PHQ-9 scale (for depression) before and after therapy. Results: After 2 weeks of therapy, the patients in the study group had much more obvious, statistically significant improvements in both scores. Conclusions: Mozart’s music, as an adjuvant intervention to specific kinetic treatment in patients with Parkinson’s disease, had a beneficial effect, ameliorating the degree of disability and emotional status.

Characteristics of executive function impairment in Parkinson’s disease patients without dementia

2009 ◽  
Vol 16 (2) ◽  
pp. 268-277 ◽  
Author(s):  
AUDREY MCKINLAY ◽  
RANDOLPH C. GRACE ◽  
JOHN C. DALRYMPLE-ALFORD ◽  
DEREK ROGER
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Problem Solving ◽  
Cognitive Functioning ◽  
Cognitive Intervention ◽  
Attention And Memory ◽  
Function Impairment ◽  
Visuospatial Skills ◽  
The Impact

AbstractExecutive function impairments in Parkinson’s disease (PD) are well documented. However, uncertainties remain regarding the impact of these deficits on other areas of cognitive functioning. The goal of this study was to provide a comprehensive assessment of cognitive characteristics in patients with PD without dementia and to assess how any such deficits affected other areas of cognitive functioning. Forty PD patients without dementia were compared to healthy controls using measures of attention and speed of processing and a comprehensive set of executive function tests including working memory, planning, and problem solving. Measures of memory/learning and visuospatial skills were also included to examine the relationship between aspects of executive function and other areas of cognition. Patients with PD showed deficits on measures of executive function, problem solving, and visuospatial skills. However, they were unimpaired on measures of planning, attention, and memory/learning. Deficits in problem solving were only evident for tasks with a high visuospatial content and were no longer significant when visuospatial skills were controlled for. While deficits in executive function and visuospatial skills were apparent for PD patients compared to controls, many aspects of cognition remained intact. These can provide a focus for cognitive intervention strategies that can be effective in delaying decline for PD patients. (JINS, 2010, 16, 268–277.)

Piano training enhances Stroop performance and musical self-efficacy in older adults with Parkinson’s disease

2019 ◽  
pp. 030573561988857
Author(s):  
Jennifer A Bugos ◽  
Teresa Lesiuk ◽  
Shafa Nathani
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Control ◽  
Executive Functions ◽  
Training Program ◽  
Cognitive Abilities ◽  
Self Efficacy ◽  
Control Group ◽  
Group Piano ◽  
The Impact

Parkinson’s disease (PD) is commonly associated with motor symptoms; however, many patients with PD exhibit decline in executive functions. Executive functions refer to a broad array of generalized cognitive abilities such as cognitive control and working memory. The purpose of this research was to evaluate the impact of a novel intense group piano training program on executive functions in patients with PD. Forty-five patients with PD were assigned to an intense group piano training program or a waitlist control group. Group intensive piano training consisted of basic piano technique, finger dexterity exercises, basic piano repertoire, and music theory, presented over a 10-day period (30 hrs of training). Participants completed a battery of standardized cognitive measures of processing speed, cognitive control, and verbal fluency, pre- and post-training. Results of an independent samples Mann–Whitney test on composite cognitive and psychosocial variables revealed significantly enhanced Stroop performance and musical self-efficacy. Intensive piano training may serve as an effective cognitive and psychosocial intervention for those with PD.

scholarly journals Dancing With Parkinson's Disease: The SI-ROBOTICS Study Protocol

2021 ◽  
Vol 9 ◽  
Author(s):  
Roberta Bevilacqua ◽  
Marco Benadduci ◽  
Anna Rita Bonfigli ◽  
Giovanni Renato Riccardi ◽  
Giovanni Melone ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fear Of Falling ◽  
Wearable Sensors ◽  
Modern Dance ◽  
Rehabilitation Program ◽  
Scientific Meetings ◽  
And Performance ◽  
The Impact ◽  
Balance Problems

Introduction: Parkinson's disease (PD) is one of the most frequent causes of disability among older people, characterized by motor disorders, rigidity, and balance problems. Recently, dance has started to be considered an effective exercise for people with PD. In particular, Irish dancing, along with tango and different forms of modern dance, may be a valid strategy to motivate people with PD to perform physical activity. The present protocol aims to implement and evaluate a rehabilitation program based on a new system called “SI-ROBOTICS,” composed of multiple technological components, such as a social robotic platform embedded with an artificial vision setting, a dance-based game, environmental and wearable sensors, and an advanced AI reasoner module.Methods and Analysis: For this study, 20 patients with PD will be recruited. Sixteen therapy sessions of 50 min will be conducted (two training sessions per week, for 8 weeks), involving two patients at a time. Evaluation will be primarily focused on the acceptability of the SI-ROBOTICS system. Moreover, the analysis of the impact on the patients' functional status, gait, balance, fear of falling, cardio-respiratory performance, motor symptoms related to PD, and quality of life, will be considered as secondary outcomes. The trial will start in November 2021 and is expected to end by April 2022.Discussions: The study aims to propose and evaluate a new approach in PD rehabilitation, focused on the use of Irish dancing, together with a new technological system focused on helping the patient perform the dance steps and on collecting kinematic and performance parameters used both by the physiotherapist (for the evaluation and planning of the subsequent sessions) and by the system (to outline the levels of difficulty of the exercise).Ethics and Dissemination: The study was approved by the Ethics Committee of the IRCCS INRCA. It was recorded in ClinicalTrials.gov on the number NCT05005208. The study findings will be used for publication in peer-reviewed scientific journals and presentations in scientific meetings.

Coexistent Osteoarthritis and Parkinson’s Disease: Data from the Parkinson’s Foundation Outcomes Project

2020 ◽  
Vol 10 (4) ◽  
pp. 1601-1610
Author(s):  
Jaimie A. Roper ◽  
Abigail C. Schmitt ◽  
Hanzhi Gao ◽  
Ying He ◽  
Samuel Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Study Data ◽  
Functional Mobility ◽  
Quality Improvement Initiative ◽  
Timed Up And Go ◽  
Mobility Performance ◽  
Risk Of Mortality ◽  
The Impact

Background: The impact of concurrent osteoarthritis on mobility and mortality in individuals with Parkinson’s disease is unknown. Objective: We sought to understand to what extent osteoarthritis severity influenced mobility across time and how osteoarthritis severity could affect mortality in individuals with Parkinson’s disease. Methods: In a retrospective observational longitudinal study, data from the Parkinson’s Foundation Quality Improvement Initiative was analyzed. We included 2,274 persons with Parkinson’s disease. The main outcomes were the effects of osteoarthritis severity on functional mobility and mortality. The Timed Up and Go test measured functional mobility performance. Mortality was measured as the osteoarthritis group effect on survival time in years. Results: More individuals with symptomatic osteoarthritis reported at least monthly falls compared to the other groups (14.5% vs. 7.2% without reported osteoarthritis and 8.4% asymptomatic/minimal osteoarthritis, p = 0.0004). The symptomatic group contained significantly more individuals with low functional mobility (TUG≥12 seconds) at baseline (51.5% vs. 29.0% and 36.1%, p < 0.0001). The odds of having low functional mobility for individuals with symptomatic osteoarthritis was 1.63 times compared to those without reported osteoarthritis (p < 0.0004); and was 1.57 times compared to those with asymptomatic/minimal osteoarthritis (p = 0.0026) after controlling pre-specified covariates. Similar results hold at the time of follow-up while changes in functional mobility were not significant across groups, suggesting that osteoarthritis likely does not accelerate the changes in functional mobility across time. Coexisting symptomatic osteoarthritis and Parkinson’s disease seem to additively increase the risk of mortality (p = 0.007). Conclusion: Our results highlight the impact and potential additive effects of symptomatic osteoarthritis in persons with Parkinson’s disease.

A New Series Of 1,3-Dimethylxanthine Based Adenosine A2a Receptor Antagonists As A Non-Dopaminergic Treatment Of Parkinson’s Disease

2020 ◽  
Vol 17 ◽  
Author(s):  
Suman Rohilla ◽  
Ranju Bansal ◽  
Puneet Chauhan ◽  
Sonja Kachler ◽  
Karl-Norbert Klotz
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Molecular Docking ◽  
Binding Affinity ◽  
Docking Studies ◽  
Binding Modes ◽  
Molecular Docking Studies ◽  
In Silico Docking ◽  
Adenosine A2a Receptor Antagonists ◽  
The Impact

Background: Adenosine receptors (AR) have emerged as competent and innovative nondopaminergic targets for the development of potential drug candidates and thus constitute an effective and safer treatment approach for Parkinson’s disease (PD). Xanthine derivatives are considered as potential candidates for the treatment Parkinson’s disease due to their potent A2A AR antagonistic properties. Objective: The objectives of the work are to study the impact of substituting N7-position of 8-m/pchloropropoxyphenylxanthine structure on in vitro binding affinity of compounds with various AR subtypes, in vivo antiparkinsonian activity and binding modes of newly synthesized xanthines with A2A AR in molecular docking studies. Methods: Several new 7-substituted 8-m/p-chloropropoxyphenylxanthine analogues have been prepared. Adenosine receptor binding assays were performed to study the binding interactions with various subtypes and perphenazine induced rat catatonia model was used for antiparkinsonian activity. Molecular docking studies were performed using Schrödinger molecular modeling interface. Results: 8-para-substituted xanthine 9b bearing an N7-propyl substituent displayed the highest affinity towards A2A AR (Ki = 0.75 µM) with moderate selectivity versus other AR subtypes. 7-Propargyl analogue 9d produced significantly longlasting antiparkinsonian effects and also produced potent and selective binding affinity towards A2A AR. In silico docking studies further highlighted the crucial structural components required to develop xanthine derived potential A2A AR ligands as antiparkinsonian agents. Conclusion: A new series of 7-substituted 8-m/p-chloropropoxyphenylxanthines having good affinity for A2A AR and potent antiparkinsonian activity has been developed.

scholarly journals Is Depression or Apathy Playing a Key Role in Predicting Financial Capacity in Parkinson’s Disease with Dementia and Frontotemporal Dementia?

2021 ◽  
Vol 11 (6) ◽  
pp. 785
Author(s):  
Vaitsa Giannouli ◽  
Magda Tsolaki
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Frontotemporal Dementia ◽  
Cognitive Abilities ◽  
Short Form ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Decisive Role ◽  
Financial Capacity ◽  
Capacity Performance

(1) Background: Depression and apathy both affect cognitive abilities, such as thinking, concentration and making decisions in young and old individuals. Although apathy is claimed to be a “core” feature of Parkinson’s disease (PD) and frontotemporal dementia (FTD), it may occur in the absence of depression and vice versa. Thus, the aim of this study is to explore whether depression or apathy better predict financial capacity performance in PD and FTD as well as in nondemented participants. (2) Methods: Eighty-eight participants divided into three groups (PD, FTD and non-demented participants) were examined with the Mini-Mental State Examination (MMSE) and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS)—Full and short form. The Geriatric Depression Scale informant version (GDS-15) and the Irritability-Apathy Scale (IAS) we completed by caregivers. (3) Results: The results indicated that both PD and FTD patients’ general cognitive functioning and financial capacity performance is negatively influenced by apathy and not by depression. (4) Conclusions: Differences in financial capacity performance indicate that apathy should not be disregarded in clinical assessments. Further studies on larger PD and FTD populations are necessary in order to investigate the decisive role of mood factors on financial capacity impairment.

scholarly journals Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort

2021 ◽  
pp. 1-12
Author(s):  
Rachael A. Lawson ◽  
Caroline H. Williams-Gray ◽  
Marta Camacho ◽  
Gordon W. Duncan ◽  
Tien K. Khoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Verbal Fluency ◽  
Neuropsychological Tests ◽  
Visual Memory ◽  
Attention And Memory ◽  
Memory And Attention ◽  
Global Cognition

Background: Cognitive impairment is common in Parkinson’s disease (PD), with 80% cumulatively developing dementia (PDD). Objective: We sought to identify tests that are sensitive to change over time above normal ageing so as to refine the neuropsychological tests predictive of PDD. Methods: Participants with newly diagnosed PD (n = 211) and age-matched controls (n = 99) completed a range of clinical and neuropsychological tests as part of the ICICLE-PD study at 18-month intervals over 72 months. Impairments on tests were determined using control means (<1-2SD) and median scores. Mild cognitive impairment (PD-MCI) was classified using 1-2SD below normative values. Linear mixed effects modelling assessed cognitive decline, while Cox regression identified baseline predictors of PDD. Results: At 72 months, 46 (cumulative probability 33.9%) participants had developed PDD; these participants declined at a faster rate in tests of global cognition, verbal fluency, memory and attention (p <  0.05) compared to those who remained dementia-free. Impaired baseline global cognition, visual memory and attention using median cut-offs were the best predictors of early PDD (area under the curve [AUC] = 0.88, p <  0.001) compared to control-generated cut-offs (AUC = 0.76–0.84, p <  0.001) and PD-MCI (AUC] = 0.64–0.81, p <  0.001). Impaired global cognition and semantic fluency were the most useful brief tests employable in a clinical setting (AUC = 0.79, p <  0.001). Conclusion: Verbal fluency, attention and memory were sensitive to change in early PDD and may be suitable tests to measure therapeutic response in future interventions. Impaired global cognition, attention and visual memory were the most accurate predictors for developing a PDD. Future studies could consider adopting these tests for patient clinical trial stratification.

Sign in / Sign up

Export Citation Format

Share Document