scholarly journals Memorable navigation: Assessing the influence of way-finding in spatial clustering

2020 ◽  
Author(s):  
Alvaro Pastor
Keyword(s):  
Cognitive Abilities ◽  
Spatial Information ◽  
Spatial Clustering ◽  
Recall Performance ◽  
Memory Task ◽  
Correct Recall ◽  
Brain Regions ◽  
Medial Temporal Lobes ◽  
Temporal Lobes

Navigating around an environment and remembering the events that took place within it are crucial cognitive abilities that have been linked to the Hippocampus and medial temporal lobes (MTL). Scene Construction Theory (SCT) has proposed that a function of the Hippocampus is the implicit and continuous construction of scenes to help prediction of upcoming environment. Scenes, as highly efficient means of packaging information, underpin in coordination with other brain regions, episodic memory (EM), spatial navigation, future thinking and perhaps even dreaming and mind-wandering. We examined the conditions in which spatial contiguity of stimuli influences the organization of memory by examining spatial clustering (SC) phenomenon. In this research, an augmented reality (AR) system was used to test 14 participants in a spatially dependent memory task which assessed the SC differences between active navigators and passive spectators. We confirmed our hypothesis that navigators use spatial information as part of the retrieval process in free recall, as they tended to sequentially recall any two neighboring otherwise unrelated items. We also found a significant correlation between SC and correct recall performance supporting our second hypothesis. These results may be valuable for design of learning applications, especially dealing with large amounts of data. Research on Alzheimer's and other neurodegenerative diseases may also benefit from our approach. Future studies may assess the role of encoding and retrieval modality and participant's use of mnemonic strategies.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

scholarly journals Role of Glutamatergic System in Obsessive-Compulsive Disorder with Possible Therapeutic Implications

2017 ◽  
Vol 51 (06) ◽  
pp. 229-242 ◽  
Author(s):  
Přemysl Vlček ◽  
Jakub Polák ◽  
Martin Brunovský ◽  
Jiří Horáček
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Brain Regions ◽  
Glutamatergic System ◽  
Obsessive Compulsive ◽  
Therapeutic Implications ◽  
Temporal Lobes ◽  
Compulsive Disorder ◽  
Neuropsychological Evidence

AbstractObsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains unclear, the traditional model focused on alternations in the serotonin system. Selective serotonin reuptake inhibitors provide the most effective treatment; however, as much as 40–60% of patients do not respond to antidepressants therapy. Thus, attention has shifted towards other neurotransmitter systems and related neuroanatomical structures. Recently, there is extensive evidence showing a key role of glutamate pathways abnormalities within the cortico-striatal-thalamo-cortical circuitry and temporal lobes in OCD pathogenesis. In this review, we link together the existent neuroanatomical, neurophysiological, and neuropsychological evidence to argue for potential benefits of adjuvant treatment with glutamatergic agents, especially memantine. By a targeted de-excitation effect on the glutamatergic system in the temporal lobes and connected brain regions, memantine might further alleviate OCD symptoms. This effect should be even more pronounced in certain subtypes of patients with specific cognitive deficits and maladaptive compensatory memory processes (e.g., checkers).

scholarly journals Role of the medial temporal lobes in relational memory: Neuropsychological evidence from a cued recognition paradigm

2007 ◽  
Vol 45 (11) ◽  
pp. 2589-2597 ◽  
Author(s):  
Irene P. Kan ◽  
Kelly S. Giovanello ◽  
David M. Schnyer ◽  
Nikos Makris ◽  
Mieke Verfaellie
Keyword(s):  
Relational Memory ◽  
Medial Temporal Lobes ◽  
Temporal Lobes ◽  
Neuropsychological Evidence

Neuropsychological Investigations of Human Amnesia: Insights Into the Role of the Medial Temporal Lobes in Cognition

2017 ◽  
Vol 23 (9-10) ◽  
pp. 732-740 ◽  
Author(s):  
Mieke Verfaellie ◽  
Margaret M. Keane
Keyword(s):  
Long Term Memory ◽  
Medial Temporal Lobes ◽  
Theoretical Understanding ◽  
Temporal Lobes ◽  
The Past ◽  
Clinical Disorders ◽  
Nuanced Understanding ◽  
The One

AbstractThe past 30 years of research on human amnesia has yielded important changes in our understanding of the role of the medial temporal lobes (MTL) in memory. On the one hand, this body of evidence has highlighted that not all types of memory are impaired in patients with MTL lesions. On the other hand, this research has made apparent that the role of the MTL extends beyond the domain of long-term memory, to include working memory, perception, and future thinking. In this article, we review the discoveries and controversies that have characterized this literature and that set the stage for a new conceptualization of the role of the MTL in cognition. This shift toward a more nuanced understanding of MTL function has direct relevance for a range of clinical disorders in which the MTL is implicated, potentially shaping not only theoretical understanding but also clinical practice. (JINS, 2017, 23, 732–740)

scholarly journals Visuospatial working memory and the construction of a spatial situation model in listening comprehension: An examination using a spatial tapping task

2021 ◽  
Author(s):  
Yun Lin ◽  
Norio Matsumi
Keyword(s):  
Working Memory ◽  
Spatial Information ◽  
Recall Performance ◽  
Situation Model ◽  
Verbal Working Memory ◽  
Concurrent Task ◽  
Visuospatial Working Memory ◽  
Impaired Performance ◽  
Dual Task Performance

AbstractThe present study investigated how visuospatial working memory (VSWM) is involved in the construction of a spatial situation model for spatial passages presented auditorily. A simple spatial tapping condition, a complex tapping condition as a target-tracking task, and a control condition, were used to analyze the role of VSWM. To understand how individuals who differ in verbal working memory (VWM) capacity (determined with a listening span test) process spatial text during dual-task performance, individual differences in VWM capacity were analyzed. In two experiments, the participants listened to a spatial text at the same time as performing a spatial concurrent task or no concurrent task. The results of the free recall test in Experiment 1 showed that there were no differences between the tapping conditions in the high VWM capacity group; the low VWM capacity group had a lower performance in both spatial tapping tasks compared to the control condition. The results of the map drawing test in Experiment 2 showed that complex spatial tapping impaired performance in comparison to simple spatial tapping and the control condition in the high VWM capacity group; in the low VWM capacity group, both spatial tapping tasks impaired recall performance. In addition, the participants with high VWM capacity demonstrated better performance. Overall, the results suggest that individuals with high VWM capacity have more resources to process verbal and spatial information than those with low VWM capacity, indicating that VWM capacity is related to the degree of the involvement of VSWM.

scholarly journals Hippocampal Volume Influences The Correlations Between White Matter Disruption and Tau Protein in aMCI and mild AD

2020 ◽  
Author(s):  
Thamires Naela Cardoso Magalhães ◽  
Raphael Fernandes Casseb ◽  
Christian Luiz Baptista Gerbelli ◽  
Luciana Ramalho Pimentel-Silva ◽  
Mateus Henrique Nogueira ◽  
...  
Keyword(s):  
White Matter ◽  
Medial Temporal Lobe ◽  
Hippocampal Volume ◽  
Tau Proteins ◽  
Cortical Atrophy ◽  
Medial Temporal Lobes ◽  
Temporal Lobes ◽  
Prodromal Ad ◽  
Transentorhinal Cortex

Abstract Background: Alzheimer’s disease (AD) is classically considered a grey matter (GM) disease that starts in the transentorhinal cortex and spreads to limbic and neocortical regions. However, white matter (WM) damage could be more severe and widespread than expected cortical atrophy. The role of AD biomarkers and WM integrity throughout the brain is unclear, especially in amnestic Mild Cognitive Impairment (aMCI) patients, a possible prodromal AD dementia stage. If WM damage can be detected even before the development of cortical atrophy and overt dementia and in the AD process, Aβ42 Tau (and its phosphorylated form) could directly affect WM. Methods: We analyzed in this study 183 individuals - 48 aMCI in the AD continuum (altered CSF Aβ42), 30 patients with very mild or mild AD dementia and 105 normal controls. All subjects underwent neuropsychological evaluation and MRI exams. aMCI and mild AD individuals were also submitted to CSF puncture to evaluate AD biomarkers.Results: We observed several significant differences in WM integrity regarding the DTI measures between individuals and we found significant correlations between fornix and right cingulum hippocampal tracts and Tau and p-Tau proteins. Conclusions: We hypothesize that significant correlations with tracts anatomically far from more well-established GM atrophic regions, like medial temporal lobes, would support a more direct effect of pathological proteins on WM, whereas medial temporal lobe (MTL) correlations would favor WD and/or a direct spreading of pathology from the hippocampus.

Who Are You? The Study of Personality in Patients With Anterograde Amnesia

2021 ◽  
pp. 095679762110074
Author(s):  
McKenna M. Garland ◽  
Jatin G. Vaidya ◽  
Daniel Tranel ◽  
David Watson ◽  
Justin S. Feinstein
Keyword(s):  
Declarative Memory ◽  
Sense Of Self ◽  
Anterograde Amnesia ◽  
Medial Temporal Lobes ◽  
Neurological Patient ◽  
Temporal Lobes ◽  
Personality Ratings ◽  
The Stability ◽  
Severe Type

Little is known about the role of declarative memory in the ongoing perception of one’s personality. Seven individuals who developed a rare and severe type of anterograde amnesia following damage to their medial temporal lobes were identified from our neurological patient registry. We examined the stability of their personality ratings on the Big Five Inventory over five retest periods and assessed the accuracy of their ratings via analyses of self–caregiver agreement. The patients portrayed a stable sense of self over the course of 1 year. However, their self-ratings differed from those provided by the caregivers. Intriguingly, these discrepancies diminished when caregivers retrospectively rated the patients’ personalities prior to their brain injury, suggesting that patients’ perceptions of themselves were stuck in the past. We interpret our findings to indicate that the ability to form new declarative memories is not required for maintaining a stable sense of self but may be important for updating one’s sense of self over time.

Does the Medial Temporal Lobe Bind Phonological Memories?

2001 ◽  
Vol 13 (5) ◽  
pp. 593-609 ◽  
Author(s):  
Raymond Knott ◽  
William Marslen-Wilson
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Lexical Representation ◽  
Phonological Memory ◽  
Distinctive Pattern ◽  
Medial Temporal Lobes ◽  
Phonological Representations ◽  
Temporal Lobes ◽  
Phonological Errors

The medial temporal lobes play a central role in the consolidation of new memories. Medial temporal lesions impair episodic learning in amnesia, and disrupt vocabulary acquisition. To investigate the role of consolidation processes in phonological memory and to understand where and how, in amnesia, these processes begin to fail, we reexamined phonological memory in the amnesic patient HM. While HM's word span performance was normal, his supraspan recall was shown to be markedly impaired, with his recall characterized by a distinctive pattern of phonological errors, where he recombined phonemes from the original list to form new response words. These were similar to errors observed earlier for patients with specifically semantic deficits. Amnesic Korsakoff's patients showed a similar, though much less marked, pattern. We interpret the data in terms of a model of lexical representation where temporal lobe damage disrupts the processes that normally bind semantic and phonological representations.

Episodic encoding and recognition of pictures and words: role of the human medial temporal lobes

2000 ◽  
Vol 105 (2-3) ◽  
pp. 159-179 ◽  
Author(s):  
Stefan Köhler ◽  
Morris Moscovitch ◽  
Gordon Winocur ◽  
Anthony R McIntosh
Keyword(s):  
Medial Temporal Lobes ◽  
Temporal Lobes ◽  
Episodic Encoding ◽  
Pictures And Words

scholarly journals Complementary Maps for Location and Environmental Structure in CA1 and Subiculum

2021 ◽  
Author(s):  
Jacob M Olson ◽  
Alexander B Johnson ◽  
Lillian Chang ◽  
Emily L Tao ◽  
Xuefei Wang ◽  
...  
Keyword(s):  
Spatial Information ◽  
Dynamic Range ◽  
Spatial Working Memory ◽  
Activity Patterns ◽  
Memory Task ◽  
Structural Features ◽  
Brain Regions ◽  
Unique Role ◽  
Path Structure ◽  
And Function

AbstractThe dorsal subiculum lies among a network of interconnected brain regions that collectively map multiple spatial and orientational relationships between an organism and the boundaries and pathways composing its environment. A unique role of the subiculum in spatial information processing has yet to be defined despite reports of small neuron subpopulations that encode relationships to specific boundaries, axes of travel, or locations. We examined the activity patterns among populations of subiculum neurons during performance of a spatial working memory task performed within a complex network of interconnected pathways. Compared to neurons in hippocampal sub-region CA1, a major source of its afferents, subiculum neurons were far more likely to exhibit multiple firing fields at locations that were analogous with respect to path structure and function. Subiculum neuron populations were also found to exhibit a greater dynamic range in scale of spatial representation and for persistent patterns of spiking activity to be aligned to transitions between maze segments. Together, the findings indicate that the subiculum plays a unique role in spatial mapping, one that complements the location-specific firing of CA1 neurons with the encoding of emergent and recurring structural features of a complex path network.

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