scholarly journals Advancing the psychology of social class with large-scale replications in four countries

2021 ◽  
Author(s):  
Anatolia Batruch ◽  
Nicolas Sommet ◽  
Frederique Autin
Keyword(s):  
Social Class ◽  
Large Scale ◽  
Theoretical Models ◽  
Lower Class ◽  
Small Sample ◽  
The Self ◽  
Theoretical Frameworks ◽  
Social Scientists ◽  
Small Sample Sizes ◽  
Predictive Strength

As the topic of inequalities has gained attention in the past decade, social scientists have developed theoretical frameworks to understand how social class shapes the way individuals think, feel, and behave. These frameworks suggest that lower-class contexts nurture psychological and behavioral tendencies oriented toward others and the environment (interdependence, contextualism), whereas higher-class contexts nurture tendencies oriented toward the self (independence, solipsism). However, empirical research on social class faces obstacles that limit the generalizability of extant findings (small sample sizes, nondiverse convenience samples, measurement flexibility). We propose a large-scale (N = 36,000) and theoretically comprehensive replication of 43 key effects (from 22 studies) of social class on the self, relationships, emotions, cognition, social behavior, and decision-making. The project will also contribute to refining theoretical models by testing the predictive strength of widely (and flexibly) used measures of social class and individual, social, and structural moderators of the effects of social class.

scholarly journals Use of Antiplatelet Agents Decreases the Positive Predictive Value of Fecal Immunochemical Tests for Colorectal Cancer but Does Not Affect Their Sensitivity

2021 ◽  
Vol 11 (6) ◽  
pp. 497
Author(s):  
Yoonsuk Jung ◽  
Eui Im ◽  
Jinhee Lee ◽  
Hyeah Lee ◽  
Changmo Moon
Keyword(s):  
Colorectal Cancer ◽  
Large Scale ◽  
Screening Program ◽  
Antiplatelet Agents ◽  
Population Based ◽  
Small Sample ◽  
Antithrombotic Agents ◽  
Predictive Values ◽  
Prescription Rates ◽  
Small Sample Sizes

Previous studies have evaluated the effects of antithrombotic agents on the performance of fecal immunochemical tests (FITs) for the detection of colorectal cancer (CRC), but the results were inconsistent and based on small sample sizes. We studied this topic using a large-scale population-based database. Using the Korean National Cancer Screening Program Database, we compared the performance of FITs for CRC detection between users and non-users of antiplatelet agents and warfarin. Non-users were matched according to age and sex. Among 5,426,469 eligible participants, 768,733 used antiplatelet agents (mono/dual/triple therapy, n = 701,683/63,211/3839), and 19,569 used warfarin, while 4,638,167 were non-users. Among antiplatelet agents, aspirin, clopidogrel, and cilostazol ranked first, second, and third, respectively, in terms of prescription rates. Users of antiplatelet agents (3.62% vs. 4.45%; relative risk (RR): 0.83; 95% confidence interval (CI): 0.78–0.88), aspirin (3.66% vs. 4.13%; RR: 0.90; 95% CI: 0.83–0.97), and clopidogrel (3.48% vs. 4.88%; RR: 0.72; 95% CI: 0.61–0.86) had lower positive predictive values (PPVs) for CRC detection than non-users. However, there were no significant differences in PPV between cilostazol vs. non-users and warfarin users vs. non-users. For PPV, the RR (users vs. non-users) for antiplatelet monotherapy was 0.86, while the RRs for dual and triple antiplatelet therapies (excluding cilostazol) were 0.67 and 0.22, respectively. For all antithrombotic agents, the sensitivity for CRC detection was not different between users and non-users. Use of antiplatelet agents, except cilostazol, may increase the false positives without improving the sensitivity of FITs for CRC detection.

Open But Segregated? Class Divisions And the Network Structure of Social Capital in Chile

Social Forces ◽  
2021 ◽  
Author(s):  
Gabriel Otero ◽  
Beate Volker ◽  
Jesper Rozer
Keyword(s):  
Social Capital ◽  
Social Class ◽  
Large Scale ◽  
Lower Class ◽  
Social Resources ◽  
Economic Capital ◽  
Economic Disadvantage ◽  
Occupational Class ◽  
Class Divisions ◽  
Heterogeneous Class

Abstract This paper studies how social capital is divided across classes in Chile, one of the most unequal countries in the world. We analyse the extent to which upper-, middle-, and lower class individuals congregate in social networks with similar others, while following Bourdieu and expecting that in particular the networks of the higher social strata are segregated in terms of social capital. We test our argument with large-scale, representative survey data for the Chilean urban population aged 18–75 years (n = 2,517) and build an integrated indicator of people’s social class that combines measures of education, occupational class, and household income. Our regression analyses show that upper-class individuals have larger networks and access to more varied and prestigious social resources than their middle- and lower class counterparts. Interestingly, however, we found a U-shaped relationship between social class and class homogeneity, indicating that network segregation is high at the top as well as at the bottom of the class-based social strata. In contrast, the classes in the middle have more heterogeneous class networks, possibly forming an important bridge between the “edges” of the class structure. These findings demonstrate that whereas social and economic capital cumulates in higher classes, the lower classes are socially deprived next to their economic disadvantage.

The Influence of Social Class on Activity Preferences of Comunidades Eclesiais de Base (CEBs) in the Archdiocese of São Paulo

1987 ◽  
Vol 19 (1) ◽  
pp. 141-156 ◽  
Author(s):  
W. E. Hewitt
Keyword(s):  
Social Class ◽  
Lower Class ◽  
Roman Catholic ◽  
Sao Paulo ◽  
The Self ◽  
São Paulo ◽  
Christian Communities ◽  
The Poor ◽  
Activity Preferences

A number of interpretations have recently emerged which attempt to explain the nature and sociopolitical implications of Roman Catholic base Christian communities (CEBs) in Brazil. Most studies have tended to describe these small, informal lay groups as a predominantly lower-class phenomenon which is facilitating the self-liberation of the poor from the weight of centuries-old political and economic oppression.

scholarly journals Collaboration and Open Science Initiatives in Primate Research

2021 ◽  
Author(s):  
ManyPrimates ◽  
Alba Motes Rodrigo ◽  
Charlotte Canteloup ◽  
Sonja J. Ebel ◽  
Christopher I Petkov ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Large Scale ◽  
Open Science ◽  
Small Sample ◽  
Primate Research ◽  
Research Model ◽  
Primate Cognition ◽  
History Of ◽  
Small Sample Sizes ◽  
Successful Collaboration

Traditionally, primate cognition research has been conducted by independent teams on small populations of a few species. Such limited variation and small sample sizes pose problems that prevent us from reconstructing the evolutionary history of primate cognition. In this chapter, we discuss how large-scale collaboration, a research model successfully implemented in other fields, makes it possible to obtain the large and diverse datasets needed to conduct robust comparative analysis of primate cognitive abilities. We discuss the advantages and challenges of large-scale collaborations and argue for the need for more open science practices in the field. We describe these collaborative projects in psychology and primatology and introduce ManyPrimates as the first, successful collaboration that has established an infrastructure for large-scale, inclusive research in primate cognition. Considering examples of large-scale collaborations both in primatology and psychology, we conclude that this type of research model is feasible and has the potential to address otherwise unattainable questions in primate cognition.

scholarly journals Age and sex dependent variability of type 2 dopamine receptors in the human brain: A large-scale PET cohort

2021 ◽  
Author(s):  
Tuulia Malén ◽  
Tomi Karjalainen ◽  
Janne Isojärvi ◽  
Aki Vehtari ◽  
Paul-Christian Bürkner ◽  
...  
Keyword(s):  
Human Brain ◽  
Large Scale ◽  
Movement Control ◽  
Heterogeneous Data ◽  
Small Sample ◽  
Cross Sectional ◽  
Psychiatric Conditions ◽  
Small Sample Sizes ◽  
Age And Sex

BACKGROUND: The dopamine system contributes to a multitude of functions ranging from reward and motivation to learning and movement control, making it a key component in goal-directed behavior. Altered dopaminergic function is observed in neurological and psychiatric conditions. Numerous factors have been proposed to influence dopamine function, but due to small sample sizes and heterogeneous data analysis methods in previous studies their specific and joint contributions remain unresolved. METHODS: In this cross-sectional register-based study we investigated how age, sex, body mass index (BMI), as well as cerebral hemisphere and regional volume influence striatal type 2 dopamine receptor (D2R) availability in the human brain. We analyzed a large historical dataset (n=156, 120 males and 36 females) of [11C]raclopride PET scans performed between 2004 and 2018. RESULTS: Striatal D2R availability decreased through age for both sexes and was higher in females versus males throughout age. BMI and striatal D2R availability were weakly associated. There was no consistent lateralization of striatal D2R. The observed effects were independent of regional volumes. These results were validated using two different spatial normalization methods, and the age and sex effects also replicated in an independent sample (n=135). CONCLUSIONS: D2R density is dependent on age and sex, which may contribute to the vulnerability of neurological and psychiatric conditions involving altering D2R expression.

scholarly journals Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

2019 ◽  
Author(s):  
Tianye Jia ◽  
Congying Chu ◽  
Yun Liu ◽  
Jenny van Dongen ◽  
Evangelos Papastergios ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Nucleus Accumbens ◽  
Large Scale ◽  
Biomarker Discovery ◽  
Association Studies ◽  
Meta Analysis ◽  
Hippocampal Volume ◽  
Small Sample ◽  
Small Sample Sizes ◽  
Meta Analyses

AbstractDNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.

scholarly journals Defining the biological bases of individual differences in musicality

2015 ◽  
Vol 370 (1664) ◽  
pp. 20140092 ◽  
Author(s):  
Bruno Gingras ◽  
Henkjan Honing ◽  
Isabelle Peretz ◽  
Laurel J. Trainor ◽  
Simon E. Fisher
Keyword(s):  
Large Scale ◽  
Twin Studies ◽  
Small Sample ◽  
Aptitude Tests ◽  
Large Scale Assessment ◽  
Genome Wide ◽  
Entry Points ◽  
High Heritability ◽  
Small Sample Sizes ◽  
Complex Human Traits

Advances in molecular technologies make it possible to pinpoint genomic factors associated with complex human traits. For cognition and behaviour, identification of underlying genes provides new entry points for deciphering the key neurobiological pathways. In the past decade, the search for genetic correlates of musicality has gained traction. Reports have documented familial clustering for different extremes of ability, including amusia and absolute pitch (AP), with twin studies demonstrating high heritability for some music-related skills, such as pitch perception. Certain chromosomal regions have been linked to AP and musical aptitude, while individual candidate genes have been investigated in relation to aptitude and creativity. Most recently, researchers in this field started performing genome-wide association scans. Thus far, studies have been hampered by relatively small sample sizes and limitations in defining components of musicality, including an emphasis on skills that can only be assessed in trained musicians. With opportunities to administer standardized aptitude tests online, systematic large-scale assessment of musical abilities is now feasible, an important step towards high-powered genome-wide screens. Here, we offer a synthesis of existing literatures and outline concrete suggestions for the development of comprehensive operational tools for the analysis of musical phenotypes.

scholarly journals Massive Factorial Design Untangles Coding Sequences Determinants of Translation Efficacy

2017 ◽  
Author(s):  
Guillaume Cambray ◽  
Joao C. Guimaraes ◽  
Adam Paul Arkin
Keyword(s):  
Large Scale ◽  
Small Sample ◽  
Translation Efficiency ◽  
E Coli ◽  
Synthetic Dna ◽  
Critical Design ◽  
Codon Composition ◽  
Expression Activity ◽  
Small Sample Sizes ◽  
Epigenetic Disruption

AbstractComparative analyses of natural sequences or variant libraries are often used to infer mechanisms of expression, activity and evolution. Contingent selective histories and small sample sizes can profoundly bias such approaches. Both limitations can be lifted using precise design of large-scale DNA synthesis. Here, we precisely design 5E. coligenomes worth of synthetic DNA to untangle the relative contributions of 8 interlaced sequence properties described independently as major determinants of translation inEscherichia coli. To expose hierarchical effects, we engineer an inducible translational coupling device enabling epigenetic disruption of mRNA secondary structures. We find that properties commonly believed to modulate translation generally explain less than a third of the variation in protein production. We describe dominant effects of mRNA structures over codon composition on both initiation and elongation, and previously uncharacterized relationships among factors controlling translation. These results advance our understanding of translation efficiency and expose critical design challenges.

scholarly journals Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis

2006 ◽  
Vol 50 (8) ◽  
pp. 2640-2649 ◽  
Author(s):  
Manzour Hernando Hazbón ◽  
Michael Brimacombe ◽  
Miriam Bobadilla del Valle ◽  
Magali Cavatore ◽  
Marta Inírida Guerrero ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Large Scale ◽  
Sample Selection ◽  
Multidrug Resistant ◽  
Small Sample ◽  
Inverse Association ◽  
Resistance Mutations ◽  
Isoniazid Resistance ◽  
Large Scale Analysis ◽  
Small Sample Sizes

ABSTRACT The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. However, small sample sizes and related potential biases in sample selection have precluded the development of statistically valid and significant population genetic analyses of clinical isoniazid resistance. We present the first large-scale analysis of 240 alleles previously associated with isoniazid resistance in a diverse set of 608 isoniazid-susceptible and 403 isoniazid-resistant clinical M. tuberculosis isolates. We detected 12 mutant alleles in isoniazid-susceptible isolates, suggesting that these alleles are not involved in isoniazid resistance. However, mutations in katG, ahpC, and inhA were strongly associated with isoniazid resistance, while kasA mutations were associated with isoniazid susceptibility. Remarkably, the distribution of isoniazid resistance-associated mutations was different in isoniazid-monoresistant isolates from that in multidrug-resistant isolates, with significantly fewer isoniazid resistance mutations in the isoniazid-monoresistant group. Mutations in katG315 were significantly more common in the multidrug-resistant isolates. Conversely, mutations in the inhA promoter were significantly more common in isoniazid-monoresistant isolates. We tested for interactions among mutations and resistance to different drugs. Mutations in katG, ahpC, and inhA were associated with rifampin resistance, but only katG315 mutations were associated with ethambutol resistance. There was also a significant inverse association between katG315 mutations and mutations in ahpC or inhA and between mutations in kasA and mutations in ahpC. Our results suggest that isoniazid resistance and the evolution of multidrug-resistant strains are complex dynamic processes that may be influenced by interactions between genes and drug-resistant phenotypes.

Effects of Sex, Race, and Class on Self, Ideal-Self, and Parental Ratings in Southern Adolescents

1968 ◽  
Vol 27 (1) ◽  
pp. 15-25 ◽  
Author(s):  
Robert L. Mc Donald
Keyword(s):  
Social Class ◽  
Lower Class ◽  
The Self ◽  
Upper Class ◽  
Check List ◽  
Ideal Self ◽  
Race And Class ◽  
Segregated Schools ◽  
Parental Ratings ◽  
Interpersonal Warmth

This study replicated an earlier one in evaluating the effects of sex, race, and social class on the self- and ideal-self ratings of adolescent Ss. The effects of these three factors on Ss' parental ratings and self-parental congruency were also assessed. Interpersonal Check List data were obtained from 218 Negro and 310 white high school seniors from rural segregated schools whose social class was determined from parental occupations as reported by the students. The results largely replicated the earlier findings on self- and ideal-self-ratings for the sex and race variables. In addition, lower class students obtained higher self- and ideal-self-love scores than upper-class students. The major findings involving the parental ratings and self-parental congruency pertained to the females who described (1) their fathers as possessing more interpersonal warmth than their mothers and (2) greater self-father than self-mother congruency.

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