Strengthened beliefs under psychedelics (SEBUS)? A Commentary on “REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics”
In introducing a model of “relaxed beliefs under psychedelics” (REBUS), Carhart-Harris and Friston (2019) have presented a compelling account of the effects of psychedelics on brain and mind. This model is contextualized within the Free Energy Principle (Friston et al., 2006; Friston, 2010), which may represent the first unified paradigm in the mind and life sciences. By this view, mental systems adaptively regulate their actions and interactions with the world via predictive models, whose dynamics are governed by a singular objective of minimizing prediction-error, or “free energy.” According to REBUS, psychedelics flatten the depth of free energy landscapes, or the differential attracting forces associated with various (Bayesian) beliefs, so promoting flexibility in inference and learning. Here, I would like to propose an alternative account of the effects of psychedelics that is in many ways compatible with REBUS, albeit with some important differences. Based on considerations of the distributions of 5-HT2a receptors within cortical laminae and canonical microcircuits for predictive coding, I propose that 5-HT2a agonism may also involve a strengthening of beliefs, particularly at intermediate levels of abstraction associated with conscious experience (Safron, 2020).