Role of Vitamin D as an Adjuvant to Oral Hypoglycemic Drugs in Treatment of Type-2 Diabetic Patients

Background: Type 2 diabetes mellitus (T2DM) is considered as one of the nonskeletal diseases related with deficiency of vitamin D. Both T2DM and vitamin D deficiency have similar risk factors, such as obesity, aging, and sedentary lifestyle. Cardiovascular diseases (CVDs) and metabolic syndrome disorders are also associated with vitamin D deficiency. Vitamin D plays an important functional role in glucose homeostasis through its effects on insulin secretion and sensitivity. It may reduce insulin resistance (IR) indirectly through its effect on calcium and phosphate metabolism and through upregulation of the insulin receptor gene. Thus, this study was designed to evaluate role of vitamin D as an adjuvant to oral hypoglycemic drugs in treatment of Type 2 diabetic patients. Aims and Objectives : Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and the metabolic syndrome. Vitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin levels in diabetes mellitus. The aim of the study was to evaluate role of vitamin D as an adjuvant to oral hypoglycemic drugs in treatment of Type 2 diabetic patients. Materials and Methods: The study was done on 60 patients diagnosed with T2DM. A total of 60 patients, control group were type 2 Diabetic patients on oral hypoglycemic drugs without vitamin D supplementation (n=30) and study group was type 2 Diabetic patients on oral hypoglycemic drugs with vitamin D supplementation (n=30). Results: The mean aged of patients was 43.27±8.80 in control group and 47.93±8.39 in study group. The family history of diabetes mellitus was 39 patients. HbA1C, FBG, Postprandial were decreased in study group as compared to control group from baseline (0 day) to 90 days, respectively. Other parameters like hemoglobin, Serum Creatinine serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase were slight changes in study group as compared to control group from baseline (0 day) to 90 days, respectively. Conclusion: The present study demonstrated that vitamin D as an adjuvant to oral hypoglycemic drugs in treatment in diabetic patients, vitamin D levels being related to glycemic control in diabetes mellitus type 2. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2.

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SERUM VITAMIN D LEVEL IN TYPE 2 DIABETIC PATIENTS

The Professional Medical Journal ◽

10.29309/tpmj/2014.21.05.2549 ◽

2018 ◽

Vol 21 (05) ◽

pp. 992-997

Author(s):

Imran Ali Shaikh ◽

Naila Masood ◽

Shazia Memon

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Type 2 Diabetic

Objective: To find out serum vitamin D levels in type 2 DM patients in Hyderabad.Design: Cross sectional study. Setting: Private clinics, OPDs of government hospitals likeQasimabad, Latifabad and Pretabad. Duration: January to July 2013. Patients and Methods:Total 550 patients were selected, 450 patients (250 males and 200 females) taken from differentOPDs of Hyderabad and towns or Tehsils with diagnosis of type 2 Diabetes mellitus andanother 100 patients were taken as control (60 males and 40 females). The mean age was45.6 years. The written consent was obtained and demographic features were noted, 3cc ofblood was taken for estimation of vitamin D levels. The level of vitamin D was done on anElectrochemiluminescence Immuno Assay (ECLIA) at Diagnostic & Research laboratory LiaquatUniversity of Medical &Health sciences (LUMHS) Jamshoro, Sind. Results and Observations:Out of 550, 450 diabetic subjects tested for vitamin D, females were 44.4%and 55.5% weremales. The deficiency was seen in 33.7% patients (p <0.04) and Vitamin D insufficiency wasobserved in20% in both sex. In control group, the deficiency was observed in 23% in femalesand 20% in males while insufficiency noted in 5% in both sex. Conclusions: The study showedsignificant decreased levels of vitamin D in type 2 Diabetic subjects than normal individuals. Thevitamin D deficiency increased considerably in females with diabetes type 2.

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Effect of hypothyroidism on lipid profile of type 2 diabetic patients

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201522 ◽

2020 ◽

Vol 7 (5) ◽

pp. 754

Author(s):

Damanpreet Singh ◽

Gurinder Mohan ◽

Arshdeep Bansal

Keyword(s):

Type 2 Diabetes ◽

Lipid Profile ◽

Diabetic Complication ◽

Control Group ◽

P Value ◽

Diabetic Patients ◽

Study Group ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: Hypothyroidism is an endocrine disorder resulting from deficiency of thyroid hormones, and Diabetes is a metabolic disorder that share the phenotype of hyperglycaemia. Both the endocrinopathies have been found to be associated with dyslipidaemia and atherosclerosis that result into various complications. Our aim was to assess the difference of dyslipidaemia in patients suffering from hypothyroidism with diabetes as compared to diabetes alone.Methods: Study was conducted in department of medicine in SGRDIMSR, Sri Amritsar. A total of 120 patients were enrolled for the present study, the one who presented to hospital from January 2018 to August 2019 diagnosed with diabetes mellitus type 2. The patients were divided into two groups. 60 patients having type 2 diabetes without hypothyroidism (control group). 60 patients having type 2 diabetes with hypothyroidism (study group). Fasting lipid profile were performed in both the groups and were analysed for the study.Results: Dyslipidaemia was seen more in study group as compared to control group with mean cholesterol of 488.3(±144.43) and mean triglyceride levels of 354.30(±128.57) in study group as compared to control group with mean cholesterol and triglyceride levels of 179.7(±81.47) and 177.08(±118.18) with p-value of 0.001 and 0.01 respectively which were significant. Also, obesity and diabetic complication were more in patients of dual endocrinopathies as compared to diabetes alone which were also significant statistically.Conclusions: From our study it is concluded that type 2 diabetes with hypothyroidism causes more dyslipidaemia as compare to type 2 diabetes alone. So proper screening of thyroid profile of type 2 diabetic patients and its correction helps in achieving better lipidemic control which further prevent complications.

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ROLE OF VITAMIN D ON HbA1c LEVEL, AS AN ADJUVANT TO ORAL HYPOGLYCAEMIC DRUGS IN TYPE 2 DIABETIC PATIENTS

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/868 ◽

2017 ◽

Vol 6 (53) ◽

pp. 4017-4020

Author(s):

Shalini Gupta ◽

Nilam Nigam ◽

Sanjay Kumar Nigam ◽

Sunil Kumar ◽

Sugandha Garg

Keyword(s):

Vitamin D ◽

Hba1c Level ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Oral Hypoglycaemic Drugs ◽

Type 2 Diabetic

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Anti-inflammatory Role of Vitamin D among Type 2 Diabetic Patients with Infection

Canadian Journal of Clinical Nutrition ◽

10.14206/canad.j.clin.nutr.2021.01.05 ◽

2021 ◽

Vol 9 (1) ◽

pp. 34-60

Author(s):

Doha M. Abou-Zahra ◽

Keyword(s):

Vitamin D ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Anti Inflammatory ◽

Type 2 Diabetic

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Vitamin D Low-Levels and Silent Myocardial Ischemia in Type 2 Diabetes: Clinical Correlations and Prognostic Significance

10.21203/rs.3.rs-107272/v1 ◽

2020 ◽

Author(s):

Rosario Rossi ◽

Marisa Talarico ◽

Cristina Rolando ◽

Roberto Minici ◽

Giuseppe Boriani

Keyword(s):

Vitamin D ◽

Myocardial Ischemia ◽

Prognostic Significance ◽

Pain Modulation ◽

Silent Myocardial Ischemia ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Abstract BACKGROUND: Vitamin D deficiency has a pathogenetic and prognostic role in coronary artery disease. Moreover, Vitamin D has a key role in pain modulation and transmission. Diabetic patients have a high risk of silent myocardial ischemia (SMI), due to diabetic neuropathy. We aimed to evaluate the correlation between SMI and Vitamin D serum levels in a population of type 2 diabetic patients and to assess whether SMI patients had a worse survival than their symptomatic counterpart.METHODS: In this retrospective, cross-sectional, observational study, we enrolled 253 patients admitted in Policlinico of Modena Hospital and compared them with 50 healthy volunteers. We divided the 253 patients into three sub-groups: symptomatic MI group (125, 32.4%); SMI (78, 25.7%), and no-MI one (50, 41.9%). The entire population had a 25-hydroxyvitamin D (25(OH)D) measurement. RESULTS: 25(OH)D levels (nmol/l) were lower in SMI group (34.9 ± 5.8) respect to symptomatic MI (49.6 ± 6.1; p = 0.01); no MI (53.1 ± 6.2; p = 0.001) and control group (62.1 ± 6.7; p = 0.0001). 25(OH)D level was the only independent variable able to influence the development of SMI in diabetic patients, with an inverted odd-ratio of 1.11 (p = 0.01). Symptomatic MI group had better survival than SMI one (6-year survival rate: 83 vs. 69%; p = 0.01)CONCLUSIONS: Type 2 diabetic with SMI had a higher mortality risk and showed lower 25(OH)D levels than the symptomatic group. This suggests the crucial vitamin D role in the pathogenesis of SMI.

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Alternations in serum vitamin D, calcium, phosphorus and lipid profile levels in newly diagnosed type 2 diabetic patients of North-West India

Biomedicine ◽

10.51248/.v41i2.781 ◽

2021 ◽

Vol 41 (2) ◽

pp. 189-193

Author(s):

Kuldip Singh ◽

Asha Khubchandani ◽

Sarbjot Singh

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Lipid Profile ◽

Diabetic Patients ◽

Newly Diagnosed ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetics ◽

Healthy Control ◽

Type 2 Diabetic

Introduction and Aim: Thirty-two million Indians are suffering with diabetes mellitus worldwide and predicted that this number of diabetes to be increased to 80 million by 2030. Many reports revealed a positive relationship between diabetic patients suffering with 25 (OH) D deficiency. In developing nations like India 60% adults were found showing manifestations of vitamin D deficiency and dyslipidemia, a well-known risk factor for the development of diabetes mellitus. Therefore, we designed the study to evaluate alterations in vitamin D, calcium, and phosphorus along with complete lipid profile levels in newly diagnosed type 2 diabetic patients in North-West Indians.Materials and Methods: One hundred fifty newly diagnosed type 2 diabetic patients and equal number of healthy control subjects of both genders were recruited in the study. 5ml of blood was collected by venipuncture after 12-14 hours fasting in plain and potassium oxalate: sodium fluoride vial. Serum and plasma were separated and used for the determination of 25(OH) D levels, calcium, phosphorus and complete lipid profile levels.Results: A significantly (p < 0.001) high level of glucose was observed in newly diagnosed type 2 diabetics subjects while a significant fall (p < 0.001) was recorded in vitamin D levels in newly diagnosed type 2 diabetics in comparison to healthy control subjects. The nominal changes were seen in calcium and phosphorus levels in newly diagnosed type 2 diabetics with respect to healthy control subjects. Statistically significant increase was found in total cholesterol (p < 0.05), triglyceride (p < 0.001) and VLDL-cholesterol (p < 0.001) levels while no significant changes was observed in LDL- cholesterol and HDL- cholesterol levels in newly diagnosed type 2 diabetics with respect to healthy subjects.Conclusion: Aforementioned observations suggested that a significant decrease in vitamin D levels was associated with increased glucose and lipid levels like total cholesterol, triglycerides and VLDL-cholesterol levels could be responsible for the initiation of various diseases like diabetes mellitus, cardiovascular diseases, osteoporosis etc. Hence, new interventions should be included as a part of treatment to reduce the risk of type-2 diabetics and CVDs like atherosclerosis

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Urinary Chiro- and Myo-Inositol Levels as a Biological Marker for Type 2 Diabetes Mellitus

Disease Markers ◽

10.1155/2012/734718 ◽

2012 ◽

Vol 33 (4) ◽

pp. 193-199 ◽

Cited By ~ 13

Author(s):

Jun Hwa Hong ◽

Hye Won Jang ◽

Yea Eun Kang ◽

Ju Hee Lee ◽

Koon Soon Kim ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Characteristic Curve ◽

Biological Marker ◽

Control Group ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: The aim of this study was to investigate the role of the urinary chiro- and myo-inositol levels in predicting type 2 diabetes mellitus (T2DM).Subjects and methods: A total of 212 normal controls and 101 type 2 diabetic patients were enrolled this study. The concentrations of urinary chiro- and myo-inositol were measured by high performance liquid chromatography/mass spectrometry.Results: The concentration of urinary chiro-inositol was significantly higher in the diabetic subjects (2.24 ± 5.18 ng/L) than those in the control group (0.38 ± 0.62 ng/L;p< 0.001). The urinary myo-inositol level of the diabetic subjects (36.95 ± 37.77 ng/L) was also significantly higher than that of the controls (8.17 ± 13.29 ng/L;p< 0.001). The urinary chiro-inositol multiplied by myo-inositol level of the diabetic subjects (148.10 ± 544.91) was significantly higher than in the controls (5.12 ± 24.15;p< 0.001). The area under the receiver operating characteristic curve for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 0.840 (confidence interval 0.789–0.891,p< 0.001). The cut-off value for the urinary chiro-inositol multiplied by myo-inositol level to predict T2DM was 2.20 (sensitivity 81.3%, specificity 70.3%).Conclusions: The urinary chiro- and myo-inositol concentrations were increased in the type 2 diabetic patients and the urinary chiro- times the myo-inositol was considered to be a sufficient marker in predicting T2DM.

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Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000673 ◽

2020 ◽

pp. 1-10

Author(s):

Giuseppe Derosa ◽

Angela D’Angelo ◽

Chiara Martinotti ◽

Maria Chiara Valentino ◽

Sergio Di Matteo ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Metabolic Control ◽

Vitamin D3 ◽

Therapy Group ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

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