Bilateral Blindness Due to Left Fronto-Temporal Lobe Glioblastoma Multiforme

Introduction: Glioblastoma multiforme is the most common primary malignant brain tumor, with a very poor prognosis. Direct compression of any structure in the visual pathway or chronic papilloedema is the cause of loss of vision in these patients. Case Report: 30 years old male from Dailekh was brought by his elder brother with the complaint of complete vision loss in both eyes for 45 days. He also had hearing difficulty on right side, headache, right sided weakness and abnormal body movement. His Visual acuity was no perception of Light in both eyes. Pupil was mid-dilated and not reacting to light. Fundus examination revealed bilateral Pallid disc edema. MRI brain revealed left fronto-temporal GBM compressing optic chiasm. Neurosurgical consultation was obtained and counseling was done regarding disease and its treatment. Due to poor prognosis and poverty patient choose palliative conservative treatment. Conclusion: This case highlights the possibility of bilateral Blindness in unilateral GBM. GBM has very poor outcome even after treatment.

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Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review

Current Medicinal Chemistry ◽

10.2174/0929867325666180514113136 ◽

2019 ◽

Vol 26 (31) ◽

pp. 5862-5874 ◽

Cited By ~ 3

Author(s):

Wang Liao ◽

Shengnuo Fan ◽

Yuqiu Zheng ◽

Shaowei Liao ◽

Ying Xiong ◽

...

Keyword(s):

Stem Cells ◽

Glioblastoma Multiforme ◽

Self Assembly ◽

Poor Prognosis ◽

Drug Delivery Systems ◽

Drug Carriers ◽

Therapeutic Resistance ◽

Average Survival ◽

Nano Drug Delivery ◽

New Development

Glioblastoma Multiforme (GBM) is the most frequent glioma with a poor prognosis. The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains unsatisfactory due to therapeutic resistance. Poor permeability restricted by the Blood Brain Barrier (BBB) and the presence of Glioblastoma Stem Cells (GSCs) remain as two problems for chemotherapy. Recently, nanocarriers have attracted much attention in the research of GBM, owing to their advantages in self-assembly, biosafety, release controllability, and BBB penetrability, making them promising candidates for GBM treatment. This article aims to review the biologic signatures of BBB and GSCs, as well as the new development of nano-drug delivery systems to facilitate our understanding of targeted treatment for GBM.

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Glioblastoma: Prognostic Factors and Predictive Response to Radio and Chemotherapy

Current Medicinal Chemistry ◽

10.2174/0929867327666200131095256 ◽

2020 ◽

Vol 27 (17) ◽

pp. 2814-2825

Author(s):

Francesco Fiorica ◽

Maria Colella ◽

Rosaria Taibi ◽

Andrea Bonetti ◽

Jacopo Giuliani ◽

...

Keyword(s):

Prognostic Factors ◽

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Therapeutic Strategy ◽

Biological Factors ◽

Near Future ◽

Predictive Response

: Glioblastoma multiforme (GBM) is characterized by poor prognosis despite an aggressive therapeutic strategy. In recent years, many advances have been achieved in the field of glioblastoma biology. : Here we try to summarize the main clinical and biological factors impacting clinical prognostication and therapy of GBM patients. From that standpoint, hopefully, in the near future, personalized therapies will be available.

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Suprabasin—A Review

Genes ◽

10.3390/genes12010108 ◽

2021 ◽

Vol 12 (1) ◽

pp. 108

Author(s):

Miroslav Pribyl ◽

Zdenek Hodny ◽

Iva Kubikova

Keyword(s):

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Current Knowledge ◽

Original Description ◽

Oesophageal Carcinoma ◽

Secreted Proteins ◽

Cornified Envelope ◽

Physiological Conditions ◽

Signalling Molecules ◽

Human Genes

Among the ~22,000 human genes, very few remain that have unknown functions. One such example is suprabasin (SBSN). Originally described as a component of the cornified envelope, the function of stratified epithelia-expressed SBSN is unknown. Both the lack of knowledge about the gene role under physiological conditions and the emerging link of SBSN to various human diseases, including cancer, attract research interest. The association of SBSN expression with poor prognosis of patients suffering from oesophageal carcinoma, glioblastoma multiforme, and myelodysplastic syndromes suggests that SBSN may play a role in human tumourigenesis. Three SBSN isoforms code for the secreted proteins with putative function as signalling molecules, yet with poorly described effects. In this first review about SBSN, we summarised the current knowledge accumulated since its original description, and we discuss the potential mechanisms and roles of SBSN in both physiology and pathology.

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Advances in Immunotherapy for Glioblastoma Multiforme

Journal of Immunology Research ◽

10.1155/2017/3597613 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 23

Author(s):

Boyuan Huang ◽

Hongbo Zhang ◽

Lijuan Gu ◽

Bainxin Ye ◽

Zhihong Jian ◽

...

Keyword(s):

Glioblastoma Multiforme ◽

Cancer Vaccines ◽

Immune Checkpoint Blockade ◽

First Line ◽

Specific Cancer ◽

Personalized Approach ◽

Poor Outcomes ◽

Temozolomide Chemotherapy ◽

Primary Malignant Brain Tumor ◽

First Line Treatment

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. Patients with GBM have poor outcomes, even with the current gold-standard first-line treatment: maximal safe resection combined with radiotherapy and temozolomide chemotherapy. Accumulating evidence suggests that advances in antigen-specific cancer vaccines and immune checkpoint blockade in other advanced tumors may provide an appealing promise for immunotherapy in glioma. The future of therapy for GBM will likely incorporate a combinatorial, personalized approach, including current conventional treatments, active immunotherapeutics, plus agents targeting immunosuppressive checkpoints.

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The Increased Neuromedin B Is Associated with Poor Prognosis in Glioblastoma Multiforme

SSRN Electronic Journal ◽

10.2139/ssrn.3986959 ◽

2021 ◽

Author(s):

Suqin Li ◽

Qingjie Li ◽

Fei Liu ◽

Shihuan Li ◽

Wenli Liao ◽

...

Keyword(s):

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Neuromedin B

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DEVELOPMENT OF THE VISUAL PATHWAY: OPTIC CHIASM

Archives of Ophthalmology ◽

10.1001/archopht.1954.00920050449013 ◽

1954 ◽

Vol 52 (3) ◽

pp. 447-453 ◽

Cited By ~ 5

Author(s):

A. N. BARBER ◽

G. N. RONSTROM ◽

R. J. MUELLING

Keyword(s):

Visual Pathway ◽

Optic Chiasm

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A preliminary study of the clinical application of optic pathway diffusion tensor tractography in suprasellar tumor surgery: preoperative, intraoperative, and postoperative assessment

Journal of Neurosurgery ◽

10.3171/2015.6.jns1546 ◽

2016 ◽

Vol 125 (3) ◽

pp. 759-765 ◽

Cited By ~ 7

Author(s):

Mohamadreza Hajiabadi ◽

Madjid Samii ◽

Rudolf Fahlbusch

Keyword(s):

Visual Acuity ◽

Visual Field ◽

Diffusion Tensor ◽

Tumor Resection ◽

Visual Pathway ◽

Optic Chiasm ◽

Control Group ◽

Optic Pathway ◽

Dti Tractography ◽

Mass Lesions

OBJECT Visual impairments are the most common objective manifestations of suprasellar lesions. Diffusion tensor imaging (DTI) is a noninvasive MRI modality that depicts the subcortical white matter tracts in vivo. In this study the authors tested the value of visual pathway tractography in comparison with visual field and visual acuity analyses. METHODS This prospective study consisted of 25 patients with progressive visual impairment due to suprasellar mass lesions and 6 control patients with normal vision without such lesions. Visual acuity, visual field, and the optic fundus were examined preoperatively and repeated 1 week and 3 months after surgery. Visual pathway DTI tractography was performed preoperatively, intraoperatively immediately after tumor resection, and 1 week and 3 months after surgery. RESULTS In the control group, pre- and postoperative visual status were normal and visual pathway tractography revealed fibers crossing the optic chiasm without any alteration. In patients with suprasellar lesions, vision improved in 24 of 25. The mean distance between optic tracts in tractography decreased after tumor resection and detectable fibers crossing the optic chiasm increased from 12% preoperatively to 72% postoperatively 3 months after tumor resection, and undetectable fibers crossing the optic chiasm decreased from 88% preoperatively to 27% postoperatively 3 months after tumor resection. Visual improvement after tumor removal 1 week and 3 months after surgery was significantly correlated with the distance between optic tracts in intraoperative tractography (p < 0.01). CONCLUSIONS Visual pathway DTI tractography appears to be a promising adjunct to the standard clinical and paraclinical visual examinations in patients with suprasellar mass lesions. The intraoperative findings, in particular the distance between optic tract fibers, can predict visual outcome after tumor resection. Furthermore, postoperative application of this technique may be useful in following anterior optic pathway recovery.

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Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses

Asian Pacific Journal of Cancer Prevention ◽

10.31557/apjcp.2021.22.10.3075 ◽

2021 ◽

Vol 22 (10) ◽

pp. 3075-3080

Author(s):

Jellyca Anton ◽

Sudibio Sudibio ◽

Handoko Handoko ◽

Tiara Permata ◽

Henry Kodrat ◽

...

Keyword(s):

Systematic Review ◽

Glioblastoma Multiforme ◽

Poor Prognosis ◽

Meta Analyses

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Monocular Vision Loss: A Rare Cause

Clinical Practice and Cases in Emergency Medicine ◽

10.5811/cpcem.2019.6.43224 ◽

2019 ◽

Vol 3 (4) ◽

pp. 436-437

Author(s):

David Lane ◽

Kaila Pomeranz ◽

Shannon Findlay ◽

Daniel Miller

Keyword(s):

Breast Cancer ◽

Magnetic Resonance Imaging ◽

Vision Loss ◽

Metastatic Breast ◽

Optic Chiasm ◽

Monocular Vision ◽

Resonance Imaging ◽

History Of ◽

Cerebral Structures ◽

Optic Nerve Compression

A 62-year-old woman with a history of metastatic breast cancer and known meningioma presented with unilateral vision loss associated with anisocoria and an afferent pupillary defect. On magnetic resonance imaging we found the cause to be optic nerve compression by a right frontal meningioma. Monocular vision-loss etiologies are anatomically localized to structures anterior to the optic chiasm. This case serves as a reminder that cerebral structures in this location must not be forgotten in the differential.

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