scholarly journals Prevalence and significance of iron deficiency of anaemia among people of Mornag District of Nepal

2012 ◽  
Vol 1 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Amar Kumar Sinha ◽  
Biswajit Majumdar ◽  
Shrawan Kumar Yadav
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
World Health ◽  
Nutritional Deficiencies ◽  
Parasitic Infections ◽  
Chronic Infections ◽  
Deficiency Anaemia ◽  
Medical College ◽  
Iron Deficient ◽  
Health Organization

Iron deficiency anaemia is one of the most dangerous and devastating causative form of malnutrition in developing countries, where special care should be taken from the health community to address the problem in South East Asian countries, 1.3-2.2 billion population is affected according to world health organization. Fifty percent of women and children and 60% of gross anemic women of developing nations have been adversely affected till date. The most common cause of iron deficiency anaemia is due to inadequate intake of iron in diet, physiologic demands of pregnancy and rapid growth and loss due to parasitic infections. Other prevalent causes of anaemia include malaria, chronic infections and nutritional deficiencies of vitamin A, folic acid and Vitamin b-12. The study reveals that 25.57 % of patients have been suffering from iron deficient anemia.DOI: http://dx.doi.org/10.3126/jonmc.v1i1.7286 Journal of Nobel Medical College Vol.1(1) 2011 40-44

463 THE USE OF FERINJECT TO MANAGE IRON DEFICIENCY ANAEMIA IN PATIENTS WITH NECK OF FEMUR FRACTURES

2021 ◽  
Vol 50 (Supplement_2) ◽  
pp. ii8-ii13
Author(s):  
O Meakin ◽  
S Adejumo
Keyword(s):  
Iron Deficiency ◽  
Patient Group ◽  
Iron Deficiency Anaemia ◽  
Eligible Patient ◽  
Blood Transfusions ◽  
Neck Of Femur ◽  
Improvement Project ◽  
Deficiency Anaemia ◽  
Femur Fractures ◽  
Iron Deficient

Abstract Introduction Iron-deficiency anaemia is a condition that is regularly seen in patients admitted with neck of femur fractures (NOFF) and is associated with increased morbidity peri-operatively. Intravenous ferinject is a method of iron replacement that leads to a more rapid increase in haemoglobin than oral replacement, therefore is often more favourable in this patient group, leading to better patient outcomes. Method A quality improvement project was undertaken. An initial audit was conducted to analyse the demographic of patients with NOFF and to assess the current practice of the orthogeriatric team when managing iron deficiency anaemia. This reviewed NOFF patients admitted in July 2017. The indications and benefits of ferinject were distributed to the medical team, encouraging use clinically, and a further audit was performed 2 years later to compare outcomes and practice, reviewing patients with NOFF admitted July–September 2019. Results It was found that 87% of patients with NOFF are iron-deficient on admission, and that introducing the use of ferinject meant that 50% fewer blood transfusions were required. Additionally, it highlighted that those who received ferinject during their admission had a smaller range of discharge haemoglobin levels than those who did not. Finally, it was found that the use of ferinject did not affect the rates of readmission in the assessed patient cohort. Conclusions The introduction of the use of ferinject in NOFF patients with iron-deficiency anaemia leads to a reduction in the requirement of blood transfusions required and to a reduction of the range of discharge haemoglobin levels. Ferinject therefore aids in improved recovery of NOFF patients. It does not, however, appear to have any effect on readmission rates in this patient group. Further education is required amongst the orthogeriatric team about the indications and benefits of ferinject to ensure that all eligible patient receive ferinject, improving their recovery.

scholarly journals Safety and Efficacy of Intravenous Ferric Carboxy Maltose in Iron Deficiency Anaemia During Postpartum Period

2018 ◽  
Vol 15 (3) ◽  
pp. 208-211 ◽  
Author(s):  
Vineet Mishra ◽  
Priyankur Roy ◽  
Khushali Gandhi ◽  
Sumesh Choudhary ◽  
Rohina Aggarwal ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Binding Capacity ◽  
World Health Organisation ◽  
World Health ◽  
Serious Adverse Events ◽  
Deficiency Anaemia ◽  
Iron Stores ◽  
Mild Anaemia ◽  
High Doses

Background: Iron deficiency is the commonest treatable cause of postpartum anaemia. Parenteral iron therapy results in faster and higher replenishment of iron stores and correction of haemoglobin levels with better compliance. Ferric Carboxy Maltose is an effective and a safe option which can be administered intravenously in single total correction dose without any serious adverse effects.The study was done to evaluate the efficacy and safety of Ferric Carboxy Maltose in the treatment of iron deficiency anaemia in post-natal patients.Methods: It was an open, single arm study including 615 women with diagnosis of Iron deficiency anaemia and haemoglobin (Hb) levels between 4gm% and 11gm% from January 2013 to December 2016. Intravenous Ferric Carboxy Maltose(500-1500mg) was administered and the improvement in haemoglobin levels and iron stores were assessed after three weeks of total dose infusion.Results: Out of the 615 women, 595 women were included in the analysis. Most of the women were in the age group of 27-30 years. Most of the women had mild anaemia as per World Health Organisation guidelines. Mean hemoglobin levels significantly increased over a period of three weeks after Ferric Carboxy Maltose administration. Other parameters like total iron binding capacity, Ferritin and Iron also had a significant improvement after Ferric Carboxy Maltose administration. No serious adverse events were observed after Ferric Carboxy Maltose.Conclusions: Intravenous Ferric Carboxy Maltose was an effective and a safe treatment option for iron deficiency anaemia and has an advantage of single administration of high doses without serious adverse effects.

Audit of the prevalence and investigation of iron deficiency anaemia in patients with heart failure in hospital practice

2019 ◽  
Vol 96 (1134) ◽  
pp. 206-211
Author(s):  
Steny Simon ◽  
Adam Ioannou ◽  
Stuart Deoraj ◽  
Sofia Metaxa ◽  
Amit K J Mandal ◽  
...  
Keyword(s):  
Heart Failure ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Healthcare Professionals ◽  
Deficiency Anaemia ◽  
Heart Failure Patients ◽  
Qualitative Survey ◽  
Retrospective Audit ◽  
Iron Deficient ◽  
Iron Replacement

Purpose of the studyIron deficiency anaemia (IDA) is associated with increased morbidity and mortality in heart failure patients. The aim of our audit was to evaluate the current practice in diagnosis and assessment of IDA in patients admitted with heart failure.Study designWe conducted a retrospective audit of patients admitted to our hospital between January 2017 and June 2017 with a diagnosis of heart failure, and obtained data regarding each patient’s demographics and anaemic status. We also conducted a qualitative survey to assess healthcare professionals’ ability to diagnose IDA, and their knowledge of iron replacement in heart failure patients.ResultsOur audit identified 218 heart failure patients, nearly two-thirds (n=138, 63.3%) of which were anaemic. Of the 138 anaemic patients, only 40 had a full haematinic screen compared with 98 who had incomplete investigations (29% vs 71%, p=0.007). Iron studies were the most commonly performed haematinic investigation (n=87, 63%), and over half of these patients were iron deficient (n=49, 56.3%). Only 12 (24.5%) iron deficient patients were prescribed oral iron therapy, while 37 (75.5%) were left without iron replacement (X2=12.8, p=0.0003). Our survey demonstrated a lack of awareness among healthcare professionals with only 19.7% of participants being able to correctly define anaemia and 9.1% being aware of guidelines regarding treatment of IDA.ConclusionMany patients admitted to hospital with heart failure also have a concomitant diagnosis of anaemia. The aetiology of the underlying anaemia is often poorly investigated, and where IDA is identified it is poorly treated.

scholarly journals Low prevalence of iron-deficiency anaemia among Inuit preschool children: Nunavut Inuit Child Health Survey, 2007–2008

2010 ◽  
Vol 14 (8) ◽  
pp. 1415-1423 ◽  
Author(s):  
Angela Pacey ◽  
Hope Weiler ◽  
Grace M Egeland
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Deficiency Anaemia ◽  
Reactive Protein ◽  
Iron Deficient ◽  
Household Crowding ◽  
Low Prevalence

AbstractObjectiveTo report the prevalence rates and correlates for anaemia, iron deficiency (ID) and iron-deficiency anaemia (IDA) among Inuit preschool-aged children.DesignA cross-sectional study assessed iron intake, demographic information, medical history, anthropometrics, Hb, ferritin, C-reactive protein and antibodies toHelicobacter pylori.SettingSixteen selected Inuit communities in Nunavut Territory, Canada.SubjectsInuit (n388) aged 3–5 years randomly recruited from communities.ResultsAnaemia (3–4 years: Hb < 110 g/l; 5 years: Hb < 115 g/l) was prevalent in 16·8 % of children. The prevalence of ID (ferritin < 12 μg/l) was 18·0 % and that of IDA was 5·4 %. When ID was defined as ferritin <10 μg/l, 10·8 % of children were iron deficient and 3·3 % had IDA. In multiple logistic regression, boys were more likely to be iron deficient (OR = 2·28, 95 % CI 1·17, 8·25), but no other risk factor emerged for ID. Three- to 4-year-olds were less likely than 5-year-olds to have anaemia from causes other than ID (OR = 0·11, 95 % CI 0·08, 0·58). Anaemia from other causes was more common among children residing in crowded homes (OR = 2·30, 95 % CI 1·37, 12·31) and those treated for past-year ear infection (OR = 1·35, 95 % CI 1·05, 7·21).ConclusionsThe low prevalence of ID and IDA is encouraging, but efforts are still needed to reduce rates as they continue to be higher than general population rates. Household crowding and infections may contribute to anaemia and warrant further research.

Some Properties of Human Platelet Monoamine Oxidase in Iron-Deficiency Anaemia

1976 ◽  
Vol 50 (6) ◽  
pp. 479-485 ◽  
Author(s):  
M. B. H. Youdim ◽  
D. G. Grahame-Smith ◽  
H. F. Woods
Keyword(s):  
Iron Deficiency ◽  
Monoamine Oxidase ◽  
Iron Deficiency Anaemia ◽  
Monoamine Oxidase Inhibitor ◽  
Normal Subjects ◽  
Heat Inactivation ◽  
Binding Studies ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Platelet Monoamine Oxidase

1. Monoamine oxidase activity in platelets prepared from the blood of patients with iron-deficiency anaemia was significantly lowered when compared with that in platelets from normal subjects. 2. The Km values of the platelet enzyme for the substrates dopamine, 5-hydroxytryptamine, phenylethylamine and kynuramine were similar for the platelet enzyme from iron-deficient and normal groups. 3. Heat-inactivation studies showed that the platelet monoamine oxidase from iron-deficient subjects was more labile to this treatment, when compared with the platelet enzyme from normal subjects. 4. The sensitivity of platelet monoamine oxidase to the inhibitors, clorgyline and deprenil, was increased in iron-deficiency anaemia. 5. Binding studies with the 14C-binding irreversible monoamine oxidase inhibitor, deprenil, showed that the amount of enzyme capable of binding this inhibitor was lowered by 48% in platelets from iron-deficient patients when compared with platelets from normal subjects. 6. The results show that there is a lowered amount of active enzyme in platelets from iron-deficient subjects. It is suggested that iron is necessary either for the synthesis of monoamine oxidase apoenzyme or is a cofactor for an enzyme which attaches flavin—adenine dinucleotide covalently to the monoamine oxidase apoenzyme.

scholarly journals Standardization & Development of Rat Model with Iron Deficiency Anaemia Utilising Commercial Available Iron Deficient Food

2019 ◽  
Vol 16 (1) ◽  
pp. 71-77
Author(s):  
Mansee Kapil Thakur ◽  
Smital Sameer Kulkarni ◽  
Nimain Mohanty ◽  
Nitin. N. Kadam ◽  
Niharika S. Swain
Keyword(s):  
Iron Deficiency ◽  
Rat Model ◽  
Iron Deficiency Anaemia ◽  
Test Group ◽  
Peripheral Smear ◽  
Deficient Diet ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Body Weights ◽  
Before And After

Many research centres have developed various animal models with Iron Deficiency Anaemia (IDA) by using iron deficient feeds as well as different chemicals. Model for iron deficiency anaemia (IDA) in rats has been created by the use of iron elimination from diet components as much as possible. The present study elaborates and concludes the development of IDA rat model by investigating different parameters like body weight, haematological indices, peripheral smear, immunoassay studies and histopathological studies using commercially available iron deficient diet. 12 Wistar albino female rats weighing 180-200 gm were selected with normal haemoglobin range of 12 - 15 g/dL purchased from Bombay Veterinary College, Parel and divided into two groups – Control (3 no. of rats) and Test (9 no. of rats). The test group was fed with iron deficient diet (VRK Nutritional Solutions) whereas control group was fed with standard diet. The time duration of the study was 5 weeks (35 days) and 6 weeks (42 days). Retro orbital blood for both control and treated was drawn at both time intervals so as to analyse haematological and immunoassay studies. Peripheral smear staining was carried out to observe the gross morphology of RBCs for iron deficient and control rats. The body weights were recorded before and after treatment and statistical significance was calculated. Post exposure rats were dissected and organs like heart, kidney, liver, lungs and spleen were collected for histopathological analysis. Our results showed decreased levels of hemoglobin (Hb), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), reticulocyte count, serum iron (SI), serum ferritin (SF) and an increase in total iron binding capacity (TIBC). in IDA animals exposed to 42 days of iron deficient diet. Significant difference (p<0.5) was observed in body weights of rats when compared with the data before and after treatment. The peripheral smear has indicated microcytic hypochromic RBCs in test group confirming development of IDA model. The histopathological results revealed the abnormality at cellular level like congestion of blood vessels in heart, congestion and centrilobular hepatocyte with inflammatory cell infiltration in liver, perivasculitis in lungs and decrease in white pulp in spleen whereas kidney were found normal. Our results clearly demonstrate iron deficient rat model when administered with IDA feed. This model can be used for estimation of efficiency of new food products and food supplements enriched with iron.

scholarly journals A case study of Human iron deficiency Anaemia in different age groups from Ujjain (M.P.) India

2021 ◽  
Vol 33 (3) ◽  
pp. 12-18
Author(s):  
MANJU JUNWAL ◽  
◽  
BHAI ISMAIL ◽  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Age Groups ◽  
Public Health Problem ◽  
Socioeconomic Level ◽  
Red Cell ◽  
Deficiency Anaemia ◽  
Iron Deficient ◽  
Red Cell Count

Iron deficiency Anaemia is the most common case of nutritional Anaemia worldwide and is a public health problem in developing countries; characterized by abnormal red cell count (MCV, MCHC). Iron deficiency Anaemia associated with fatigue, skin paleness, weakness etc. The aim of the study is to determine the risk factors for iron deficiency Anaemia among population of Ujjain district (M.P.). Both male and female iron deficient patients were studied from the SS hospital and CHL applo hospitals during Jan. 2012 to Dec. 2012. A group of 6828 patients were studied for iron deficiency Anaemia in different age groups. A total of 4549 female and 2279 males were studied. Information was collected about sex, socioeconomic level. It is inferred that the percentage of anaemia is more in women compared to men.

scholarly journals Ascaris lumbricoides infection: Still a threat for iron deficiency anaemia in 2-year-old Bangladeshi slum-dwelling children

2019 ◽  
Vol 13 (10) ◽  
pp. 933-938
Author(s):  
Md. Shabab Hossain ◽  
Subhasish Das ◽  
Md. Amran Gazi ◽  
Mustafa Mahfuz ◽  
Tahmeed Ahmed
Keyword(s):  
Logistic Regression ◽  
Iron Deficiency ◽  
Ascaris Lumbricoides ◽  
Transferrin Receptor ◽  
Iron Deficiency Anaemia ◽  
Strong Association ◽  
Parasitic Infections ◽  
Soluble Transferrin Receptor ◽  
Intestinal Parasitic Infections ◽  
Deficiency Anaemia

Introduction: Although parasitic infections lead to extracorporeal iron loss resulting in iron deficiency anaemia (IDA), data associating IDA with parasitic infections in the first two years of life are limited. We sought to evaluate the prevalence and severity of anaemia and IDA during this period and to investigate the association between intestinal parasitic infections and IDA. Methodology: Data was collected under MAL-ED study protocol in Bauniabadh slum of Dhaka, Bangladesh. The presence of parasites in stool was detected using wet preparation microscopy at 7, 15, and 24 months. Anaemia was defined as serum haemoglobin < 11 g/dL and IDA was defined by serum haemoglobin < 11 g/dL, serum ferritin < 12 g/L and soluble transferrin receptor > 8.3 mg/L. Logistic regression was done to quantify the relation between stool parasite and IDA separately on samples collected at 7, 15 and 24 months. Results: 265 children were enrolled after birth and samples were collected at 7, 15 and 24 months. Anaemia was detected at 7, 15 and 24 months in 117 (48.8%), 106 (44.2%) and 67 (27.9%) cases whereas IDA was found in 15 (6.3%), 47 (19.6%) and 39 (16.3%) cases, respectively. Iron deficiency anaemia at 24 months was significantly associated with Ascaris lumbricoides infection (OR 3.76; 95 % CI, 1.08-13.11). Conclusions: The prevalence of anaemia and IDA in slum dwelling children of Dhaka is high and Ascaris lumbricoides infection was found to have a strong association with IDA at 24 months of age.

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