scholarly journals Congenital malformations at birth in 7,922 consecutive deliveries at Patan Hospital, Nepal

2015 ◽  
Vol 1 (2) ◽  
pp. 4-7
Author(s):  
Imran Ansari ◽  
Rateena Rajbhandari ◽  
Shiva Chilise ◽  
Ganesh Shalh ◽  
Pratistha Maskey ◽  
...  
Keyword(s):  
Congenital Malformation ◽  
Birth Defects ◽  
Congenital Malformations ◽  
Cleft Lip ◽  
Local Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Older Mothers ◽  
Cleft Lip Palate

Introductions: Congenital malformations need to be identified and intervened early to save lives and prevent sufferings. Many birth defects have well known incidence/prevalence rates but these have not been studied thoroughly in the local population of Nepal. The current study was undertaken to determine the prevalence of congenital malformation at birth, to classify them systematically, to study risk factors and immediate outcome of the newborn babies afflicted.Methods: This was a cross sectional study. All newly delivered babies were examined carefully for congenital malformation and when detected, the parents were interviewed in detail.Results: Over the 10 months of study period 7,922 babies were delivered out of which 90 were stillborn. The number of babies with malformations was 64 (0.81%). Polydactyli was observed in 12 (19%) babies whereas cleft lip/palate and malformations of ears in seven (11%) each. Musculoskeletal system was affected in 31 (35%) cases and craniofacial in 18 (21%). Nine (14%) mothers had bad obstetric history and eight (13%) had illness/medication during pregnancy.Conclusions: Congenital malformation is a significant cause of morbidity and mortality in Patan hospital. Our findings support many established thoughts like higher rates in stillbirths but also challenge some age-old beliefs like higher rates in babies born to older mothers.

Birth defects in the Brazilian side of the triple border: a population-based cross-sectional study

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
F K Nampo ◽  
S Souza ◽  
C R Pestana
Keyword(s):  
Birth Defects ◽  
Birth Defect ◽  
Cleft Lip ◽  
Maternal Education ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
Major Birth Defect

Abstract Background Major birth defects are characterized by its severity and are a public health challenge since it chronically affects the population. Foz do Iguassu is located in Brazili's largest international border and presents a birth defect rate 50% greater than the country's average. Methods Identifying factors associated to birth defects is important to guide preventive actions toward modifiable risk factors and target the most susceptible population. In this cross-sectional study we measured the prevalence of major birth defects and associated maternal sociodemographic factors in Foz do Iguassu. Data were collected from a governmental registry and included all births that occurred in the city between 2012 to 2017. The variables measured were maternal education, maternal race, country of residence, maternal parity and onset of prenatal care. Data were analyzed through logistic regression models to verify the maternal sociodemographic factors associated with major birth defects. Results 26,214 births were analyzed; among the 305 birth defects registered, 140 (46%) corresponded to a major birth defect. Cleft lip and/or palate and gastroschisis were the most prevalent major birth defect (9.5/10,000 live births and 6.83/10,000 live births, respectively). Maternal education up to 7 years was the only variable associated with the major birth defects (ORadj=1.58; CI = 1.07-2.33; p = 0.02). Maternal age was associated with gastroschisis (mean: 21.5 years; p = 0.002) and Down syndrome (mean: 33.5 years; p = 0.007). Conclusions In this area, cleft lip and/or palate and gastroschisis are the most common major birth defects, and maternal education is weakly associated with major birth defects. Key messages The epidemiology of major birth defects in this area differs from Brazil’s. Future research should focus on inherent risk factors for congenital defects and exposure to teratogens.

scholarly journals A Cross-Sectional Study: Are Myths on Cleft Lip and Palate Still Prevalent?

Cureus ◽  
2021 ◽  
Author(s):  
Sravya Turlapati ◽  
Sai Krishna ◽  
Korutla U Deepak ◽  
Baggialaxmi Kanagaraja ◽  
Kanaparthi A Gayathri ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Pilot epidemiological study of cleft lip and/or palate inh Kota Kinabalu, Sabah

2013 ◽  
Vol 4 (3) ◽  
pp. 86-91
Author(s):  
Chai Siew Cheng ◽  
SKL Jimeno ◽  
R Sasidaran ◽  
A Sergius
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Cross Sectional Study ◽  
Queen Elizabeth Hospital ◽  
Sectional Study ◽  
Medical Sciences ◽  
Cross Sectional ◽  
Tertiary Center ◽  
Secondary Palate ◽  
Male Patients

Objective: To identify number of cases and the type of cleft lip and/or palate managed in government tertiary center (Queen Elizabeth Hospital) in Kota Kinabalu; and to analyze the associative factors of cleft lip and/or palate. Methods: A retrospective cross-sectional study carried out in Hospital Queen Elizabeth, Kota Kinabalu, Sabah from January 2011 to December 2012. Data from 162 new cases, which were referred for cleft lip and/or palate, were included in the study. Result: Cleft lip and palate was the most common type. While cleft lip with or without palate had higher preponderance towards male patients, secondary palate however was more common among female patients. These results were statistically significant. Conclusion: Further and larger scale study need to be carried out to identify the incidence of cleft lip and/or palate in Sabah, and its associated genetic and environmental risk factors. Early identification and intervention for cleft lip and palate need to be emphasized. DOI: http://dx.doi.org/10.3126/ajms.v4i3.8170   Asian Journal of Medical Sciences 4(2013) 86-91

scholarly journals Association of cleft lip and palate on mother-to-infant bonding: a cross-sectional study in the Japan Environment and Children’s Study (JECS)

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shinobu Tsuchiya ◽  
◽  
Masahiro Tsuchiya ◽  
Haruki Momma ◽  
Takeyoshi Koseki ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Maternal Depression ◽  
Odds Ratio ◽  
Maternal Age ◽  
Cleft Lip ◽  
Cross Sectional Study ◽  
Advanced Age ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Abstract Background Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status and may consequently result in higher prevalence of child maltreatment. However, the association of childbirths of infants with cleft lip and/or palate with maternal emotional involvement still remains unclear. We examined the association between childbirths of infants with cleft lip and/or palate and mother-to-infant bonding, using data from the Japan Environment and Children’s Study, a nationwide birth cohort study. Methods A cross-sectional study using the jecs-an-20,180,131 dataset was performed. A total 104,065 fetuses in 15 regional centres in Japan were enrolled after obtaining informed written consent. The Mother-to-Infant Bonding Scale, a self-report scale consisting of 10 items, was used to evaluate maternal bonding at one year after childbirth. Finally, the participants consisted of 79,140 mother-infant pairs, of which 211 mothers of infants with cleft lip and/or palate were included in our analyses. Multivariable logistic regression analysis using multiple imputation for missing data was performed to calculate the odds ratio and 95% confidence interval in the estimation of the association between bonding disorders and childbirths with cleft lip and/or palate. Results No increased risk of bonding disorders was observed among all the mothers of infants with cleft lip and/or palate (odds ratio [95% confidence interval]; 0.97 [0.63–1.48], p = 0.880), however, advanced maternal age or multiple parity may adversely affect the associations between bonding disorders and cleft lip and/or palate, respectively. After stratification with a combination of maternal age and parity, a significant association of cleft lip and/or palate with bonding disorders was found only among advanced-age multiparae (odds ratio [95% confidence interval] = 2.51 [1.17–5.37], p = 0.018), but it was weakened after additional adjustment for maternal depression. Conclusions Childbirths of infants with cleft lip and/or palate may increase the risk of bonding disorders among advanced-age multiparae, possibly through maternal depression. This finding provides valuable information for the provision of multidisciplinary cleft care.

scholarly journals Closer to the Truth on National Fistula Prevalence After Unilateral Complete Cleft Lip and Palate Repair? The Cleft Care UK Study

2019 ◽  
Vol 57 (1) ◽  
pp. 5-13
Author(s):  
Arthur S. Yang ◽  
Bruce M. Richard ◽  
Andrew K. Wills ◽  
Osama Mahmoud ◽  
Jonathan R. Sandy ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cleft Lip ◽  
Outcome Measure ◽  
Cleft Lip And Palate ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Palatal Fistula ◽  
The United Kingdom ◽  
Palate Repair

Objectives: To (1) determine the prevalence of nonperialveolar palatal fistula up to age 5 following repair of unilateral cleft lip and palate (UCLP) in the United Kingdom, (2) examine the association of palatoplasty techniques with fistula occurrence, and (3) describe the frequency of fistula repairs and their success. Design: Cross-sectional study. Setting: All 11 centralized regional cleft centers in the United Kingdom. Participants: Two hundred sixty-eight children born between 2005 and 2007 recruited by Cleft Care UK, a nationwide cross-sectional study of all 5-year-old children born with nonsyndromic UCLP. Main Outcome Measure: Nonperialveolar palatal fistula prevalence up to age 5. Results: Fistulas were found in 72 children (31.3%, 95% confidence interval: 25.4%-37.7%) and had no significant association with palate repair sequences. Twenty-four fistulas were repaired by age 5, 12 of which had data showing 10 (83.3%) successful repairs. Conclusion: The prevalence of nonperialveolar fistulas following primary palatoplasty of UCLP in the United Kingdom was higher than previously reported. This information should be part of the preoperative discussion with families. Prospective collection of the presence of fistulas will be necessary before we can associate the occurrence of fistulas with a surgeon, institution, surgical technique, or protocol of care.

scholarly journals NUTRITIONAL STATUS AND NUTRITIONAL SUPPORT IN CHILDREN WITH CONGENITAL MALFORMATIONS OF BRAIN IN UKRAINE: SINGLE-CENTER OBSERVATIONAL DESCRIPTIVE CROSS-SECTIONAL STUDY

2020 ◽  
Vol 7 (2) ◽  
pp. 94-101
Author(s):  
O. Riga ◽  
N. Orlova ◽  
T. Ishchenko
Keyword(s):  
Nutritional Status ◽  
Low Income ◽  
Congenital Malformations ◽  
Nutritional Support ◽  
Protein Energy Malnutrition ◽  
Cross Sectional Study ◽  
Z Score ◽  
Sectional Study ◽  
Single Center ◽  
Cross Sectional

NUTRITIONAL STATUS AND NUTRITIONAL SUPPORT IN CHILDREN WITH CONGENITAL MALFORMATIONS OF BRAIN IN UKRAINE: SINGLE-CENTER OBSERVATIONAL DESCRIPTIVE CROSS-SECTIONAL STUDY Riga O., Orlova N., Ishchenko T. In Ukraine, as one of low income and middle income countries (LMICs), PEM is detected and diagnosed not quite actively especially in children with neurologic impairment. Methods: Nutritive status and energy consumption was evaluated in 17 young and preschool children with congenital malformations of brain by anthropometry, 24-hour dietary recall and questionnaire of caregivers. Results: The study demonstrate nutritional disorders: Z-score BW for age in total cohort was -3.2, H/L for age was -2.7. The moderate PEM was diagnosed in 2/17 children, severe PEM in 12/17. The late appointment of nutritional support to such children has been demonstrated, its effect on increasing growth and body weight. Conclusion. The importance of drawing up individual plans for the energetic consumption of the children with congenital malformations of brain with training of caregivers and rehabilitative and palliative team was shown. Keywords: children, protein-energy malnutrition, congenital malformations of brain, LMICs.   Резюме. ХАРЧОВИЙ СТАТУС І ХАРЧОВА ПІДТРИМКА ДІТЕЙ З ВРОДЖЕНИМИ ВАДАМИ РОЗВИТКУ МОЗКУ В УКРАЇНІ: ОДНОЦЕНТРОВЕ НАОЧНО-ОПИСОВЕ КРОС-СЕКЦІЙНЕ ДОСЛІДЖЕННЯ Ріга О.О., Орлова Н.В., Іщенко Т.Б. В Україні, як одна із країн з низьким рівнем доходу та середнього доходу (LMICs), БЕН виявляється та діагностується не досить активно, особливо у дітей з порушеннями неврології. Методи: Харчовий статус та споживання енергії було оцінено у 17 дітей молодшого та дошкільного віку з вродженими вадами розвитку головного мозку за допомогою антропометрії, цілодобової дієти та анкетування опікунів. Результати: Дослідження демонструє харчові розлади: показник Z-score BW за віком у загальній когорті становив -3,2, H/L для віку -2,7. Помірну БЕН було діагностовано у 2/17 дітей, тяжку БЕН у 12/17. Продемонстровано несвоєчасне призначення харчової підтримки таким дітям, його вплив на збільшення росту та маси тіла. Висновки. Показано важливість складання індивідуальних планів енергетичного споживання дітей з вродженими вадами розвитку мозку під час навчання опікунів та реабілітаційно-паліативного колективу. Ключові слова: діти, білково-енергетична недостатність, вроджені вади розвитку мозку, LMICs.   Резюме. ПИЩЕВОЙ СТАТУС И ПИЩЕВАЯ ПОДДЕРЖКА ДЕТЕЙ С ВРОЖДЕННЫМИ ПОРОКАМИ РАЗВИТИЯ МОЗГА В УКРАИНЕ: ОДНОЦЕНТРОВОЕ НАГЛЯДНО-ОПИСАТЕЛЬНОЕ КРОСС-СЕКЦИОННОЕ ИССЛЕДОВАНИЕ Рига Е.А., Орлова Н.В., Ищенко Т.Б. В Украине, как одна из стран с низким уровнем дохода и среднего дохода (LMICs), БЄН оказывается и диагностируется недостаточно активно, особенно у детей с нарушениями неврологии. Методы: Пищевой статус и потребления энергии было оценено у 17 детей младшего и дошкольного возраста с врожденными пороками развития головного мозга с помощью антропометрии, круглосуточной диеты и анкетирования опекунов. Результаты: Исследование демонстрирует пищевые расстройства: показатель Z-score BW по возрасту в общей когорте составил -3,2, H/L для возраста -2,7. Умеренную БЄН было диагностировано у 2/17 детей, тяжелую БЄН у 12/17. Продемонстрировано несвоевременное назначение пищевой поддержки таким детям, его влияние на увеличение роста и массы тела. Выводы. Показана важность составления индивидуальных планов энергетического потребления детей с врожденными пороками развития мозга во время обучения опекунов и реабилитационно-паллиативного коллектива. Ключевые слова: дети, белково-энергетическая недостаточность, врожденные пороки развития мозга, LMICs.

scholarly journals Clinical and epidemiological profile of cleft lip/ palate deformities in Tamil Nadu, India

2019 ◽  
Vol 6 (6) ◽  
pp. 2428
Author(s):  
S. Prabakaran
Keyword(s):  
Tamil Nadu ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Speech Pathologist ◽  
Cleft Lip Palate ◽  
Epidemiological Profile ◽  
The Right

Background: Cleft lip and palate deformities are commonly detected at the time of birth in most of the developing countries like India. The surgical management of cleft lip/ palate deformities involve multi-disciplinary approach with corrective measures from dental surgeon, plastic surgeon, speech pathologist and audiologist. The role of pediatricians in clinical management of cleft lip is often missed. This study was done to evaluate the clinical profile of cleft lip and palate deformities.Methods: This cross sectional study was carried out among 1077 patients diagnosed with cleft lip or cleft palate deformity for a period of 5 years between 2014 and 2019. A structured patient information schedule was prepared and data regarding the age, gender, antenatal details and parental history were recorded. A detailed clinical examination was carried out to evaluate the presence of complete and incomplete deformity in the lip, alveolus, hard palate and soft palate.Results: Complete cleft lip was present in 47.8% of the participants on the left side while on the right, complete cleft lip was present in 29.4% of the participants. Complete deformity of the alveolus on the left side was present in 45.4% of the participants while complete deformity on the right side of alveolus was present in 27.4% of the participants.Conclusions: It is important the pediatricians sensitize the parents regarding the clinical and supportive management and also initiate the surgical correction of this deformity with help of a multidisciplinary team.

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