scholarly journals Cytohistological correlation of conventional Papanicolaou smears in cervical neoplasia at a tertiary care hospital of Nepal

2019 ◽  
Vol 9 (1) ◽  
pp. 1475-1479
Author(s):  
Anuj Poudel ◽  
Prahar Dahal
Keyword(s):  
Uterine Cervix ◽  
Pap Smear ◽  
Cervical Screening ◽  
Tertiary Care ◽  
Cost Effective ◽  
Cervical Cytology ◽  
Pap Smears ◽  
Care Hospital ◽  
Cervical Lesions ◽  
Cervical Biopsy

Background: Conventional Cervical Cytology is the most widely used cervical cancer screening test. The incidence of cervical carcinoma is incredibly high in developing countries due to lack of proper knowledge. The extensive use of cervical screening with Papanicolau smears had considerably increased the detection of precancerous and cancerous lesion of uterine cervix. Study was conducted to evaluate cytohistological correlation and to calculate concordance and discordance of Pap smear in detection of precancerous and cancerous lesions of uterine cervix. Materials and Methods: A total of 54 samples reported in Pap smear as cervical intraepithelial lesions and suspicious for invasive malignancies were selected and correlated with corresponding histopathological findings. It was an observational study done for a period of 18 months from November 2016 to May 2018 at UCMS-TH. All the statistical evaluation was done by using SPSS version 20. Results: During the study period 54 cases were evaluated. Atypical Squamous Cell of Undetermined Significance was the common abnormal findings in the Pap smear with frequency of 26 (48.1%). Out of total 54 cases of Pap smears, 30 (55.55%) were concordant while discrepancies occurred in 24(44.44%) cases with cervical biopsy. Conclusions: The study revealed a good correlation between cervical cytology and cervical biopsy. We also concluded that conventional Pap smear is a cost effective test for the early detection of precancerous and cancerous cervical lesions.

scholarly journals A two year retrospective study of cytohistopathological correlation of cervical smear in a tertiary care hospital

2021 ◽  
Vol 12 (8) ◽  
pp. 144-148
Author(s):  
Anil Kumar Sirasagi ◽  
Arpitha K ◽  
Saara Neha ◽  
Pratima Manohar Pattar
Keyword(s):  
Cervical Cancer ◽  
Predictive Value ◽  
Pap Smear ◽  
Tertiary Care ◽  
Histopathological Diagnosis ◽  
Pap Smears ◽  
Care Hospital ◽  
Cervical Smear ◽  
Cervical Lesions ◽  
Sensitivity Specificity

Background: Cervical cancer in women is the second most common cancer and the commonest cause of mortality in developing countries. The introduction of Pap smear test changed the scenario of cervical cancer with an intense drop in the incidence and mortality due to invasive cervical cancer. Aims and Objective: To evaluate the patterns of cervical smear cytology and to correlate the cervical smear diagnosis with histopathological diagnosis and to assess the efficacy of Pap smears in diagnosing cervical lesions. Materials and Methods: This two-year retrospective study (January 2018 to December 2019) was done in the department of Pathology in a tertiary care hospital. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were calculated considering histopathological diagnosis of cervical biopsy as the gold standard. Results: A total of 316 Pap smears were studied, out of which we selected 154 cases who also undergone biopsy or hysterectomy. Epithelial cell abnormalities (ECA) were found in 28 cases (18.2%). Among this the most common ECA was Atypical squamous cells of undetermined significance (ASCUS) seen in 10 cases (6.5%) followed by LSIL (5.2%), HSIL (3.2%) and SCC of cervix (3.2%). The overall correlation between cervical cytology and histopathology was found in 125 out of 154 cases (81.16%). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pap smear was 90.57%, 62.50%, 95.41%, 43.47% and 87.66% respectively. Conclusion: Pap smear is a simple, safe, non-invasive and effective method for detection of lesions of the cervix and ECA. Hence, better awareness and periodical cytological screening programs can help in the early detection of malignant cervical lesions and thereby reducing the morbidity and mortality related to this malignancy.

scholarly journals The correlation between colposcopy, cervical cytology and histopathology in the diagnosis and management of cervical lesions: a cross sectional study

2020 ◽  
Vol 9 (7) ◽  
pp. 2729
Author(s):  
Pooja Gupta ◽  
Mariyam Faruqi ◽  
Subrat Chandra ◽  
Sameer S. Shah ◽  
Rupita Kulshreshtha
Keyword(s):  
Tertiary Care ◽  
Cross Sectional Study ◽  
Cervical Cytology ◽  
Care Hospital ◽  
Sectional Study ◽  
Cervical Lesions ◽  
Cross Sectional ◽  
Diagnosis And Management ◽  
History Of ◽  
Excellent Tool

Background: The study was undertaken to see the correlation between cervical cytology, histopathology and colposcopy in the diagnosis and management of various cervical lesions.Methods: It is a cross sectional study conducted at a tertiary care hospital in Mumbai, in the department of obstetrics and gynecology from February 2007 to March 2008. A total 55 sexually active women were enrolled for the study who belonged to age group greater than 20 years with history of chronic leucorrhoea or post-coital bleeding/spotting, intermenstrual bleeding/spotting or examination findings of erosion, an unhealthy cervix, a lesion bleeding on touch or an abnormal or suspicious Papanicolaou smear. These women then underwent cytology, colposcopy and cervical biopsy.Results: The accuracy of cytology when compared to colposcopy was 81.82%. The accuracy of colpo-histopathology was 83.6%. The combined accuracy was 76.36%.Conclusions: The simultaneous use of cytological studies and screening colposcopy has been shown to increase the cervical cancer detection. Colposcopy offers an excellent tool in the hands of a gynaecologist to evaluate the uterine cervix and it is not possible to develop this kind of perspective by any other method.

scholarly journals A comparative study to see the effectiveness of Pap smear, visual inspection with 3-5% acetic acid and its confirmation by cervical biopsy

2020 ◽  
Vol 9 (2) ◽  
pp. 715
Author(s):  
Mili D. Choudhury ◽  
Sivaji S. Ghose ◽  
Milind Y. Dharmamer
Keyword(s):  
Acetic Acid ◽  
False Positive ◽  
Visual Inspection ◽  
Pap Smear ◽  
Histopathological Examination ◽  
Single Case ◽  
Cost Effective ◽  
Pap Smears ◽  
Severe Dysplasia ◽  
Cervical Biopsy

Background: Cancer of the cervix is a leading cause of morbidity and mortality among women worldwide. The present study was undertaken to compare the effectiveness of Pap smear and visual inspection with 3-5% acetic acid (VIA) in screening carcinoma cervix followed by its confirmation by cervical biopsy.Methods: A total of 100 patients with abnormal looking cervices or symptomatic patients having age beyond 30 years, attending the obstetrics and gynaecology OPD at Naval Hospital Powai, Mumbai from 31st December 2015 to 31st December 2017 were selected for the study. Pap smear and VIA was done on consecutive days. In positive cases cervical biopsy were done to confirm the result.Results: The sensitivity of VIA was 100% but at the same time specificity was 41% there will be unnecessary investigation and biopsy in false positive cases. The sensitivity of cytology was 75% and specificity was 97%. Not a single case was missed by Pap smear only one case of severe dysplasia on cytology had squamous cell carcinoma on HPE which was done after 90 days because of delay in patients follow up.Conclusions: Both the Pap smears and VIA is very effective screening tool for cervical cancer and histopathological examination remains the mainstay. But VIA is very cost effective and easy procedure, though it gives false positive reports but is not going to miss any case, rather leads to over diagnosis of the cases with cervicitis and hence treatment starts early and thus the progress of disease can be slowed down or even stopped.

scholarly journals Correlation of cervical pap smears with histopathological diagnosis in cervical lesions

2021 ◽  
Vol 10 (12) ◽  
pp. 4478
Author(s):  
Ruksana Farooq ◽  
Azhar-un-Nisa Quraishi ◽  
Shahida Mohammad
Keyword(s):  
Cervical Cancer ◽  
Predictive Value ◽  
Pap Smear ◽  
Screening Program ◽  
Tertiary Care ◽  
Histopathological Diagnosis ◽  
Pap Smears ◽  
Care Hospital ◽  
Incidence And Mortality ◽  
Chronic Cervicitis

Background: Cervical cancer is the most common genital cancer in India. In India alone,almost,130000 new cases occur with the death toll of 70000 everywhere. Objective of current study was correlation of pap smear with histopathological diagnosis.Methods: A retrospective study was conducted in tertiary care hospital in 130 sexually active women. Pap smears were taken and histopathological diagnosis was performed in all such patientsResults: From pap smear findings, out of 130 patients, maximum number of cases, 74 (56.9%) were categorized as. Out of epithelial cell abnormality, ASCUS was seen in 25 patients (10.2%), LSIL in 17 patients (13.1%), HSIL in 11 patients (8.5%). SCC was seen in 2 patients (1.5%) and adenocarcinoma in 1 patient (0.8%). From cervical biopsy reports, 51 cases(39.2%) were diagnosed as chronic cervicitis, 34 cases (26.2%) were diagnosed as chronic cervicitis with squamous metaplasia, CIN I in 31 patients (23.8%), CIN II in 8 patients (6.2%) and CIN III in 3 patients (2.3%), squamous cell carcinoma in 2 patients (1.5%) and adenocarcinoma in 1 patient (0.8%). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of pap smear test was 91.1%, 82.4%,73.2%, 94.6% and 85.4%, respectively.Conclusions: Pap smear has excellent correlation with histopathological diagnosis. Therefore it should be encouraged as effective tool for cervical cancer screening program to reduce incidence and mortality caused by cervical cancer. 

scholarly journals Cost-effectiveness analysis of repeated self-sampling for HPV testing in primary cervical screening: a randomized study

2020 ◽  
Author(s):  
Riina Aarnio ◽  
Ellinor Östensson ◽  
Matts Olovsson ◽  
Inger Gustavsson ◽  
Ulf Gyllensten
Keyword(s):  
Cost Effectiveness ◽  
Pap Smear ◽  
Lower Cost ◽  
Cervical Screening ◽  
Cost Effective ◽  
Cost Effectiveness Analysis ◽  
Pap Smears ◽  
Hpv Testing ◽  
Randomized Clinical Study ◽  
Effectiveness Analysis

Abstract Background Human papillomavirus (HPV) testing is recommended in primary cervical screening to improve cancer prevention. An advantage of HPV testing is that it can be performed on self-samples, which could increase population coverage and result in a more efficient strategy to identify women at risk of developing cervical cancer. Our objective was to assess whether repeated self-sampling for HPV testing is cost-effective in comparison with Pap smear cytology for detection of cervical intraepithelial neoplasia grade 2 or more (CIN2+) in increasing participation rate in primary cervical screening.Methods A cost-effectiveness analysis (CEA) was performed on data from a previously published randomized clinical study including 36 390 women aged 30–49 years. Participants were randomized either to perform repeated self-sampling of vaginal fluid for HPV testing (n = 17 997, HPV self-sampling arm) or to midwife-collected Pap smears for cytological analysis (n = 18 393, Pap smear arm). Results Self-sampling for HPV testing led to 1633 more screened women and 107 more histologically diagnosed CIN2+ at a lower cost vs. midwife-collected Pap smears (€ 229 446 vs. € 782 772). Conclusions This study resulted in that repeated self-sampling for HPV testing increased participation and detection of CIN2+ at a lower cost than midwife-collected Pap smears in primary cervical screening. Offering women a home-based self-sampling may therefore be a more cost-effective alternative than clinic-based screening.Trial registration Not registered since this trial is a secondary analysis of an earlier published study (1).

scholarly journals Correlation of Pap smear and colposcopic findings in relation to histopathological findings among women attending a tertiary care hospital: a two year study

2019 ◽  
Vol 8 (6) ◽  
pp. 2163
Author(s):  
Jyothi Gandavaram ◽  
Bindu Reddy Pamulapati
Keyword(s):  
Negative Predictive Value ◽  
Predictive Value ◽  
Pap Smear ◽  
Demographic Data ◽  
Tertiary Care ◽  
Clinical History ◽  
Premalignant Lesions ◽  
Low Grade ◽  
Care Hospital ◽  
Cervical Lesions

Background: Cervical malignancy is ranked second among the malignancies in females with breast carcinoma the first. Screening for cervical cancer by conventional cytology and supported by colposcopy and histopathology can easily identify the premalignant lesions and also other non-invasive inflammatory lesions of the cervix. Objective of this study was to find the correlation of Pap smear, colposcopic findings and colposcopic guide biopsy in evaluation of cervical lesions in women and to analyze the various risk factorsMethods: A prospective study for two years was conducted by department of obstetrics among women aged from 20-60 years. Socio demographic data, clinical history and examination were done and findings noted. Pap smear, colposcopy and colposcopic guided biopsy was done and findings were noted and analyzed foe sensitivity, specificity and compared with Pap smear.Results: In present study sensitivity of Pap smear for detecting lesions above LSIL was 28%, specificity 99.32%, PPV was 93.47%, negative predictive value 76.21% and accuracy of Pap smear was 78%. The sensitivity of colposcopy in detection of low grade lesions and above came out to be 80.2%, specificity 82.14%, positive predictive value 66.78%, negative predictive value 86.78% and accuracy of colposcopy was 84.65%.The incidence of preinvasive lesions (LSIL and HSIL) was 33.6% with LSIL (19.2%) and HSIL (14.4%) and of invasive lesions was 9.6%.Conclusions: This study suggests that accuracy of detection of cervical abnormalities is higher when cytology, colposcopic biopsy and colposcopy are used complimentarily in diagnosis of cervical lesions. Colposcopy eliminates the need for repeated follow up as in Pap smear which has low sensitivity.

scholarly journals ANALYSIS OF CERVICAL PAP SMEARS AS PER BETHESDA SYSTEM IN A TERTIARY CARE CENTRE.

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Arpita Ajmera ◽  
Dr. Mohini Kucheria ◽  
Dr. Vivek Kathed ◽  
Dr. Taiba Farooque ◽  
Dr. Nidhi Sharma ◽  
...  
Keyword(s):  
Trichomonas Vaginalis ◽  
Tertiary Care ◽  
Cost Effective ◽  
Cervical Cytology ◽  
Pap Smears ◽  
Low Grade ◽  
Squamous Intraepithelial Lesion ◽  
Tertiary Care Centre ◽  
Intraepithelial Lesion ◽  
Bethesda System

Background: The value of exfoliative cervical cytology is undisputed today.  Most studies focus on the application of pap smears to detect precancerous and cancerous lesions but pap smears are also significant in detecting inflammatory lesions and etiology wherever possible which can help the clinician in the management and prevent further dysplasias. Aim & Objectives: To find out the prevalence of various non-neoplastic and neoplastic lesions of cervix as per the Bethesda system 2014 and to find out the etiology of inflammation wherever possible. Methodology: This study was conducted over a period of one year from January 2017 to January 2018. 1518 pap smears received in the Department of Cytology were stained with pap stain & reported according to 'The 2014 Bethesda System for reporting cervical cytology'. Results: 1518 pap smears were screened in which 28 (1.8%) smears were unsatisfactory for evaluation and 1490 (98.2%) were satisfactory. NILM was the predominant finding seen in 1473(98.86%) smears. Among the specific infections, the most common was bacterial vaginosis in 128 (8.59%) smears, trichomonas vaginalis in 10 (0.67%), candida infection in 7 (0.47%) smears and 26 (1.75%) smears showed reactive changes associated with inflammation. Atrophic changes were found in 50 (3.36%) cases. Epithelial cell abnormalities were seen in 17 (1.17%) cases in which 9 (0.6%) cases were reported as ASCUS, 2 (0.13%) cases as LSIL and HSIL was seen in 1 (0.07%) case. Squamous cell carcinoma (SCC) was diagnosed in 4 (0.27%) cases and Adenocarcinoma in 1 (0.07%) case. Conclusion: Cervical cytology is a simple and cost effective test and should be established as a routine diagnostic aid. Keywords: Atypical squamous cells of undetermined significance (ASCUS), Bethesda System, High grade squamous intraepithelial lesion (HSIL), Low grade squamous intraepithelial lesion (LSIL), Negative for intraepithelial lesion or malignancy (NILM),  Papanicolaou smears.

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