scholarly journals Dog: A Friendly Pathway to Zoonoses

2019 ◽  
Vol 36 ◽  
pp. 170-177
Author(s):  
A. Pathak ◽  
K. Kaphle
Keyword(s):  
Methicillin Resistant Staphylococcus Aureus ◽  
Viral Infections ◽  
Signs And Symptoms ◽  
High Cholesterol ◽  
Caninum Infection ◽  
Zoonotic Infections ◽  
Pet Owners ◽  
Dipylidium Caninum ◽  
Simple Contact ◽  
Infected Urine

   Canis lupus familaris (Dog); a companion animal or even considered man’s best friend is believed to have been living in harmony with humans since thousands of years. Recent discovery in Chauvet cave in France: foot print of 8-year-old boy alongside the paw print is believed to have been dated back to Paleolithic period. Reports even suggest that pet owners are less prone to high cholesterol and high blood pressure than the non-pet owners. However, dogs are also the major reservoir of various zoonotic infections. Several bacterial, viral or protozoal diseases that occur in human are transmitted from the dogs. Such diseases are known as zoonotic diseases. These diseases can be transmitted by simple contact with the infected dogs or by infected urine or feces, saliva or aerosols. Viral infections such as rabies and noro virus, bacterial infection such as pasteurellosis, salmonellosis, campylobacteriosis, leptospirosis and Methicillin-Resistant Staphylococcus aureus (MRSA) infections and protozoal infections like ancylostomiasis, toxocariasis and Dipylidium caninum infection are the most common zoonotic infections. This paper focuses on these diseases including information on signs and symptoms, mode of transmission and prevention of these diseases. As much as these infections are concerned, knowledge boosting of the pet owners regarding zoonotic disease along with proper hygiene and good sanitation practices could considerably decline the rate of zoonoses transmission and consequences.

Viral Encephalitis In Adults: A Narrative Review

2021 ◽  
Vol 16 ◽  
Author(s):  
Siciliano Valentina ◽  
Rosà Tommaso ◽  
Del Vecchio Pierluigi ◽  
D'Angelillo Anna ◽  
Brigida Mattia ◽  
...  
Keyword(s):  
Viral Encephalitis ◽  
Viral Infections ◽  
Direct Action ◽  
Ventilatory Support ◽  
Signs And Symptoms ◽  
Altered Mental Status ◽  
Poor Quality ◽  
Electrolyte Disorders ◽  
The Central Nervous System

: Viral infections of the central nervous system cause frequent hospitalization. The pathogenesis of viral encephalitis involves both the direct action of invading pathogens and the damage generated by the inflammatory reaction they trigger. The type of signs and symptoms presented by the patient depends on the severity and location of the ongoing inflammatory process. Most of the viral encephalitides are characterized by an acute development, fever, variable alterations in consciousness (confusion, lethargy, even coma), seizures (focal and generalized) and focal neurologic signs. The specific diagnosis of encephalitis is usually based on lumbar puncture. Cerebrospinal fluid examination should be performed in all patients unless absolutely contraindicated. Also, electroencephalogram and neuroimaging play a prominent role in diagnosis. Airway protection, ventilatory support, the management of raised intracranial pressure and correction of electrolyte disorders must be immediately considered in a patient with altered mental status. The only therapy strictly recommended is acyclovir in HSV encephalitis. The use of adjunctive glucocorticoids has poor-quality evidence in HSV, EBV, or VZV encephalitis. The role of antiviral therapy in other types of viral encephalitis is not well defined.

scholarly journals Human Neutrophil Lipocalin as a Superior Diagnostic Means To Distinguish between Acute Bacterial and Viral Infections

2015 ◽  
Vol 22 (9) ◽  
pp. 1025-1032 ◽  
Author(s):  
Per Venge ◽  
Lena Douhan-Håkansson ◽  
Daniel Garwicz ◽  
Christer Peterson ◽  
Shengyuan Xu ◽  
...  
Keyword(s):  
Whole Blood ◽  
Human Neutrophil ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Response Times ◽  
Clinical Performance ◽  
Point Of Care ◽  
Signs And Symptoms ◽  
Healthy Controls ◽  
Acute Infections

ABSTRACTThe distinction between causes of acute infections is a major clinical challenge. Current biomarkers, however, are not sufficiently accurate. Human neutrophil lipocalin (HNL) concentrations in serum or whole blood activated by formyl-methionine-leucine-phenylalanine (fMLP) were shown to distinguish acute infections of bacterial or viral cause with high accuracy. The aim was therefore to compare the clinical performance of HNL with currently used biomarkers. Seven hundred twenty-five subjects (144 healthy controls and 581 patients with signs and symptoms of acute infections) were included in the study. C-reactive protein (CRP), the expression of CD64 on neutrophils, procalcitonin (PCT), and blood neutrophil counts were measured by established techniques, and HNL concentrations were measured in whole-blood samples after activation with fMLP. All tested biomarkers were elevated in bacterial as opposed to viral infections (P< 0.001). CRP, PCT, and CD64 expression in neutrophils was elevated in viral infections compared to healthy controls (P< 0.001). In the distinction between healthy controls and patients with bacterial infections, the areas under the receiver operating characteristic (ROC) curves were >0.85 for all biomarkers, whereas for the distinction between bacterial and viral infections, only HNL concentration in fMLP-activated whole blood showed an area under the ROC curve (AUROC) of >0.90 and superior clinical performance. The clinical performance of HNL in fMLP-activated whole blood was superior to current biomarkers and similar to previous results of HNL in serum. The procedure can be adopted for point-of-care testing with response times of <15 min.

Dipylidium caninum Infection

2019 ◽  
Vol 380 (21) ◽  
pp. e39 ◽  
Author(s):  
Catherine A. Hogan ◽  
Hayden Schwenk
Keyword(s):  
Caninum Infection ◽  
Dipylidium Caninum

scholarly journals Viral Encephalitis: A Hard Nut to Crack

2019 ◽  
Vol 55 (02) ◽  
pp. 098-109
Author(s):  
Alka Shukla ◽  
Mayank Gangwar ◽  
Sonam Rastogi ◽  
Gopal Nath
Keyword(s):  
Viral Encephalitis ◽  
Viral Infections ◽  
Neurological Complication ◽  
Clinical Signs ◽  
Geographical Location ◽  
Signs And Symptoms ◽  
Climatic Conditions ◽  
Altered Level ◽  
Level Of Consciousness ◽  
Clinical Signs And Symptoms

AbstractViral encephalitis is inflammation of brain that manifests as neurological complication of viral infections. There are quite a good number of viruses, for example, human herpes virus, Japanese encephalitis, and enteroviruses that can result in such a dreadful condition. Geographical location, age, gender, immune status, and climatic conditions also contribute to the establishment of this disease in an individual. Clinical signs and symptoms include fever, headache, altered level of consciousness, changed mental status, body ache, seizures, nausea, and vomiting. Effective management of this disease relies on timely diagnosis that in turn depends on apt and suitable investigation techniques. Traditional investigations have thinned out these days owing to the fact that advanced molecular technologies have been introduced to the diagnostic field. Treatment of viral encephalitis mainly involves symptomatic relieve from fever, malaise, myalgia along with measures to reduce viral load in the patient. This review mentions about all the possible aspects of viral encephalitis starting from etiology to the management and preventive measures that include immunization and vector control.

scholarly journals Comparison of the Level of Awareness about the Transmission of Echinococcosis and Toxocariasis between Pet Owners and Non-Pet Owners in Greece

2020 ◽  
Vol 17 (15) ◽  
pp. 5292 ◽  
Author(s):  
Christina Kantarakia ◽  
Maria E. Tsoumani ◽  
Antonis Galanos ◽  
Alexander G. Mathioudakis ◽  
Eleni Giannoulaki ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Linear Regression Analysis ◽  
Signs And Symptoms ◽  
Knowledge Score ◽  
Fisher Exact Test ◽  
Pet Ownership ◽  
Cross Sectional ◽  
Exact Test ◽  
Pet Owners ◽  
Chi Squared

Ζoonotic parasitic diseases that can occur through animal contact pose risks to pets, their owners and to their bond. This study aims to assess the level of knowledge about zoonoses, specifically echinococcosis and toxocariasis, among cat/dog owners and non-pet owners in Greece. Multiple-choice questionnaires were designed to obtain data regarding the knowledge of pet and non-pet owners on echinococcosis and toxocariasis, including signs and symptoms of these zoonoses, ways of transmission and precautions that need to be taken into account in order to avoid it. A total of 185 questionnaires were retrieved and data was expressed as absolute (Ν) and relative frequencies (%). Associations between pet ownership, residence and outcome variables were evaluated using the Fisher exact test and Chi-squared test, respectively. Multifactorial linear regression analysis was used to investigate the cross-sectional association between demographic characteristics and the awareness of helminthic zoonoses. All tests were two-sided and statistical significance was set at p < 0.05. Our study revealed a disturbing lack of awareness of echinococcosis and toxocariasis (mean zoonotic knowledge score 8.11 ± 3.18) independently of pet ownership. Surprisingly, in some cases the ignorance of pet owners exceeded that of non-pet owners. Given the progressive impact of toxocariasis in public health and the high prevalence of echinococcosis in the Mediterranean region, measures should be taken to inform people about zoonoses and eliminate their putative transmission.

Dipylidium caninum Infection in a 14-Month-Old Child

1973 ◽  
Vol 66 (9) ◽  
pp. 1060-1062 ◽  
Author(s):  
RUSSELL W. CURRIER ◽  
G. M. KINZER ◽  
EMILY DeSHIELDS
Keyword(s):  
Caninum Infection ◽  
Dipylidium Caninum

Clinical Outcomes of Linezolid vs Vancomycin in Methicillin-Resistant Staphylococcus aureus Ventilator-Associated Pneumonia

2011 ◽  
Vol 26 (6) ◽  
pp. 385-391 ◽  
Author(s):  
Jeannie D. Chan ◽  
Tam N. Pham ◽  
Jenny Wong ◽  
Michelle Hessel ◽  
Joseph Cuschieri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Clinical Cure ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Signs And Symptoms ◽  
Ventilator Associated Pneumonia ◽  
Vancomycin Therapy ◽  
Methicillin Resistant ◽  
Treatment Standard ◽  
Primary Endpoints ◽  
Days Of Therapy

Background: Vancomycin has been the treatment standard for methicillin-resistant Staphylococcus aureus (MRSA) infections, but clinical efficacy is limited. We report outcomes of a cohort with MRSA ventilator-associated pneumonia (VAP) treated with vancomycin vs linezolid. Methods: Retrospective analysis of 113 participants with MRSA VAP confirmed by bronchoscopy who have been initiated on therapy with either vancomycin or linezolid within 24 hours after bronchoscopy and completed ≥7 days of therapy during their hospitalization from July 2003 to June 2007. The primary endpoints were hospital survival and clinical cure, defined as resolution of signs and symptoms of VAP or microbiological eradication after completion of therapy along with clinical pulmonary infection score (CPIS) ≤6 at day 7 of therapy. Results: At hospital discharge, 23/27 (85.2%) of linezolid and 72/86 (83.7%) of vancomycin recipients had survived ( P = .672). In comparison to linezolid recipients, the adjusted odds ratio (OR) for survival was 0.72 (95% confidence interval [CI]: 0.16-3.27) with vancomycin therapy. Clinical cure was achieved in 24/27 (88.9%) of linezolid and 63/86 (73.3%) of vancomycin recipients ( P = .066). Compared to linezolid recipients, the adjusted OR for clinical cure was 0.24 (95% CI: 0.05-1.10) with vancomycin therapy. Survival and clinical cure did not differ significantly between vancomycin recipients with trough level ≥15 and <15 μg/mL, respectively. Conclusions: Our results suggested no survival benefit but a trend toward higher cure rate with linezolid therapy. The optimal treatment of MRSA VAP requires further study through randomized, controlled trials.

A Fatal Case of Eczema Herpeticum With Septic Shock Due to Methicillin-Resistant Staphylococcus aureus

2016 ◽  
Vol 25 (4) ◽  
pp. 379-382 ◽  
Author(s):  
Christina L. Tupe ◽  
Bethany A. Weiler ◽  
Avelino C. Verceles ◽  
Michael T. McCurdy
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Multiorgan Failure ◽  
Fatal Case ◽  
Signs And Symptoms ◽  
Methicillin Resistant ◽  
Eczema Herpeticum ◽  
Skin Biopsies ◽  
Simplex Virus ◽  
High Index Of Suspicion

A 62-year-old woman treated with several courses of corticosteroids for an undifferentiated rash came to the emergency department with progressively worsening cutaneous signs and symptoms and generalized weakness. She had scabies, and despite treatment continued to decompensate. Repeat skin biopsies revealed disseminated herpes simplex virus infection, and results of blood cultures were consistent with infection by methicillin-resistant Staphylococcus aureus. Despite antiviral and antimicrobial therapy, sepsis and multiorgan failure developed, and the patient died. This case illustrates the complications of the rare entity eczema herpeticum, which occurs most often in immunocompromised patients and is associated with a high mortality. Maintaining a high index of suspicion for this disease in decompensating patients with an unidentified rash is essential to avoid catastrophic outcomes.

scholarly journals Dipylidium caninum Infection in an Infant

2007 ◽  
Vol 81 (4) ◽  
pp. 456-458 ◽  
Author(s):  
Naoki TSUMURA ◽  
Hiroyasu KOGA ◽  
Hidenobu HIDAKA ◽  
Fumiko MUKAI ◽  
Masaaki IKENAGA ◽  
...  
Keyword(s):  
Caninum Infection ◽  
Dipylidium Caninum
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