scholarly journals Validity Of Mothers’ Caries Screening Of Their Preschool Children And Its Relationship To Sociodemographic Backgrounds

2017 ◽  
Vol 16 (2) ◽  
Author(s):  
Syarifah Haizan Sayed Kamar ◽  
Nasruddin Jaafar
Keyword(s):  
Preschool Children ◽  
Significant Relationship ◽  
Household Income ◽  
Educational Status ◽  
Caries Detection ◽  
Caries Prevalence ◽  
Predictive Values ◽  
Screening Sensitivity ◽  
Sensitivity Specificity ◽  
At Home

Introduction: Mothers can be trained to screen caries in their children. The aim of this study is to assess the validity of mothers’ caries screening of their preschool children. Materials and Methods: 81 volunteer mothers of four- and five-year-old preschool children, from four kindergartens in Pahang were included this study. All mothers were trained by a dentist to detect caries in preschoolers based on a simplified caries detection guideline by WHO (1997) in a three-hour course. Subsequently, all mothers screened their own children caries status at the workshop and 24 hour later, at home. The validity of the results was determined by comparing mothers’ to dentist’s findings; and calculating their sensitivity, specificity, positive predictive and negative predictive values at child and tooth levels. Results: Caries prevalence among the children was 88.9%, with mean dmft of 7.10 (sd 5.07). At the workshop, mothers’ screening sensitivity, specificity, positive predictive and negative predictive values at child level were 93.1%, 66.7%, 95.7%, 54.5%; and at tooth level were 76.6%, 94.0%, 90.4% and 87.8%, respectively. 24 hours post-workshop screening’s sensitivity, specificity, positive predictive and negative predictive values at tooth level were 76.1%, 93.7%, 90.7% and 87.9% respectively. The reliability of 24 hours post- workshop screening at tooth level was almost perfect (kappa=0.84). No significant relationship was reported between validity of screening and mothers' age, educational status, household income and area of residence. Conclusion(s): The validity of mothers’ screening in this sample was adequate in identifying caries in their preschool children, regardless of their sociodemographic backgrounds.

scholarly journals Inequalities In Caries Among Pre-School Italian Children With Different Background

2021 ◽  
Author(s):  
Guglielmo Campus ◽  
Fabio Cocco ◽  
Laura Strohmenger ◽  
Thomas Gerhard Wolf ◽  
Araxi Balian ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Preschool Children ◽  
Negative Binomial ◽  
Public Health Problem ◽  
Assessment System ◽  
Social Gradient ◽  
Caries Detection ◽  
Caries Prevalence ◽  
Explanatory Variables ◽  
Immigrant Background

Abstract Background: The study was aimed to describe caries prevalence and severity and health inequalities among Italian preschool children with European and non-European background and to explore the potential presence of a social gradient. Methods: The ICDAS (International Caries Detection and Assessment System) was recorded at school on 6,825 children (52.76% females). Caries frequency and severity was expressed as a proportion, recording the most severe ICDAS score observed. Socioeconomic status (SES) and behavioral habits of children/parents/caregivers were estimated by mean a standardized self-submitted questionnaire filled-in by parents. The Slope Index of Inequality (SII) based on regression of the mid-point value of caries experiences score for each SES group was calculated and a social gradient was generated as the weighted sum of the worst circumstances deriving from social explanatory variables. Children were stratified into four social gradient levels based on the number of worst options. Multivariate regression models (Zero-Inflated Negative Binomial logistic regression in children with European background and a logistic regression in children with non-European background) were used to elucidate the associations between all explanatory variables and health outcome (namely the caries prevalence). Mantel Haenszel trend of odds adjusted by immigrant background and area of living were calculated to study the existence, dimensions and direction of a social gradient in oral health. Results: Overall, 54.37% (95%CI 46.71–58.28%) of the children were caries-free; caries prevalence was statistically significant higher in children with non-European background compared to European children (72.59% vs 41.62% p<0.01). A statistically significant trend was observed for ICDAS 5/6 score and the worst social/behavioral level (Z=5.24, p<0.01). Conclusions: Data show how caries in preschool children is an unsolved public health problem especially in those with a non-European background. The proposed gradient was clearly able to identify children with the worst dental conditions.

scholarly journals Evaluation of a Parental Questionnaire to Identify Atopic Dermatitis in Infants and Preschool Children

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Laura B. von Kobyletzki ◽  
Staffan Janson ◽  
Mikael Hasselgren ◽  
Carl-Gustaf Bornehag ◽  
Åke Svensson
Keyword(s):  
Atopic Dermatitis ◽  
Preschool Children ◽  
Physical Examination ◽  
Semistructured Interview ◽  
Predictive Values ◽  
Small Children ◽  
Qualitative And Quantitative ◽  
Parental Questionnaire ◽  
Quantitative Analyses ◽  
Sensitivity Specificity

Aim. To develop and validate a questionnaire for detecting atopic dermatitis in infants and small children from the age of 2 months. Methods. Parents to 60 children answered a written questionnaire prior to a physical examination and individual semistructured interview. Qualitative and quantitative analyses of validity, sensitivity, specificity, and predictive values of the questionnaire were performed. Results. A total of 27 girls and 33 boys, aged 2 to 71 months, 35 with and 25 without physician-diagnosed eczema, participated. Validation of the questionnaire by comparisons with physicians’ diagnoses showed a sensitivity of 0.91 (95% CI 0.77–0.98) and a specificity of 1 (95% CI 0.86–1). Conclusions. Three questions in a parental questionnaire were sufficient for diagnosing eczema in infants and small children.

scholarly journals Performance of three automated SARS-CoV-2 antibody assays and relevance of orthogonal testing algorithms

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Evelyne Huyghe ◽  
Hilde Jansens ◽  
Veerle Matheeussen ◽  
Ilse Hoffbauer ◽  
Herman Goossens ◽  
...  
Keyword(s):  
Antibody Detection ◽  
Diagnostic Specificity ◽  
Predictive Values ◽  
Negative Patient ◽  
Antibody Assays ◽  
Golden Standard ◽  
Testing Algorithms ◽  
Screening Sensitivity ◽  
Testing Algorithm ◽  
Sensitivity Specificity

AbstractObjectivesDevelopment and implementation of SARS-CoV-2 serologic assays gained momentum. Laboratories keep on investigating the performance of these assays. In this study, we compared three fully automated SARS-CoV-2 antibody assays.MethodsA total of 186 samples from 84 PCR-positive COVID-19 patients and 120 control samples taken before the SARS-CoV-2 pandemic were analyzed using commercial serologic assays from Roche, Siemens and DiaSorin. Time after the positive COVID-19 PCR result and onset of symptoms was retrieved from the medical record. An extended golden standard, using the result of all three assays was defined, judging if antibodies are present or absent in a sample. Diagnostic and screening sensitivity/specificity and positive/negative predictive value were calculated.ResultsDiagnostic sensitivity (ability to detect a COVID-19 positive patient) ≥14 days after positive PCR testing was 96.7% (95% CI 88.5–99.6%) for DiaSorin, 93.3% (95% CI 83.8–98.2%) for Roche and 100% (95% CI 94.0–100%) for Siemens. Lower diagnostic sensitivities were observed <14 days after onset of symptoms for all three assay. Diagnostic specificity (ability to detect a COVID-19 negative patient) was 95.0% (95% CI 89.4–98.1%) for DiaSorin, 99.2% (95% CI 95.4–99.9%) for Roche and 100% (95% CI 97.0–100%) for Siemens. The sensitivity/specificity for detecting antibodies (ability of detecting absence (specificity) or presence (sensitivity) of COVID-19 antibodies) was 92.4% (95% CI 86.4–96.3%)/94.9% (95% CI 90.5–97.6%) for DiaSorin, 97.7% (95% CI 93.5–99.5%)/97.1% (95% CI 93.5–99.1%) for Roche and 98.5% (95% CI 94.6–99.8)/97.1 (95% CI 93.5–99.1%) for Siemens.ConclusionsThis study revealed acceptable performance for all three assays. An orthogonal testing algorithm using the Siemens and Roche assay achieved the highest positive predictive values for antibody detection in low seroprevalence settings.

scholarly journals Screening, Sensitivity, Specificity, and So Forth: A Second, Somewhat Skeptical, Sequel

2019 ◽  
Vol 2 (1) ◽  
pp. p60 ◽  
Author(s):  
Robert Trevethan
Keyword(s):  
Peripheral Artery Disease ◽  
Previous Article ◽  
Screening Tests ◽  
Peripheral Artery ◽  
Predictive Values ◽  
Artery Disease ◽  
Screening Sensitivity ◽  
Sensitivity Specificity ◽  
Gold Standards ◽  
Conceptual Difficulties

This article is concerned with the sensitivity, specificity, predictive values, and other metrics associated with screening tests. It has direct origins in two previous articles. In this third article, the author of the first article writes about topics and issues that were addressed only minimally in his previous article and expands on topics raised by authors of the second article. In particular, attention is turned to wording and terminology that can be idiosyncratic and confusing with regard to screening versus diagnosis as well as to issues associated with reference (“gold”) standards and screening tests, and to the importance of cutpoints and prevalence in relation to metrics associated with screening tests. The primary aims are to help readers attain clarity about topics that they might have felt unsure about; gain reassurance about conceptual difficulties in the field that, once recognized for what they are, can become less problematic because it is possible to be confident about not being confident; and, where appropriate, adopt an appropriately skeptical attitude about screening tests and their associated metrics. Examples are drawn from the use of ankle–brachial and toe–brachial indices for identifying peripheral artery disease, although wider applicability is intended.

Knowledge and Practice of Mothers Regarding the Prevention and Management of Malnutrition Among Preschool Children – A Cross Sectional Survey

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Mahfouz R. Nath ◽  
C. Kanniammal
Keyword(s):  
Preschool Children ◽  
Good Practice ◽  
Strong Association ◽  
Educational Status ◽  
Nursing Interventions ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Economic Class ◽  
Common Causes ◽  
Knowledge And Practice

Malnutrition remains one of the most common causes of morbidity and mortality among children throughout the world. Malnutrition has been responsible, directly or indirectly for 60% of the 10.9 million deaths annually among children under five. The research study was aimed to assess the knowledge and practice of mothers of preschool children regarding the prevention and management of malnutrition. The design used was descriptive cross sectional survey. The study was conducted in a coastal setting of Trivandrum district with a sample size of 115. Data collection was done by self administered structured questionnaire by conducting mothers meeting at selected Anganwadis. According to the results of the study 19.1% of mothers had good knowledge and 34.8 % of mothers had poor knowledge. Regarding practice only 24.3 % of mothers reported good practice while 36.6 % of mothers reported poor practice. There was a strong association between the knowledge and Practice of mothers and selected socio demographic variables such as educational status of mothers and socio economic class (p less than 0.01)). The study findings can be used for planning targeted nursing interventions in coastal areas for mothers of preschool children.

Discriminating Malignancy in Thyroid Nodules: The Nomogram Versus the Kwak and ACR TI-RADS

2020 ◽  
Vol 163 (6) ◽  
pp. 1156-1165
Author(s):  
Juan Xiao ◽  
Qiang Xiao ◽  
Wei Cong ◽  
Ting Li ◽  
Shouluan Ding ◽  
...  
Keyword(s):  
Thyroid Nodules ◽  
Characteristic Curve ◽  
Area Under The Curve ◽  
Diagnostic Study ◽  
Diagnostic Efficiency ◽  
Training Set ◽  
Multivariable Logistic Regression Model ◽  
Predictive Values ◽  
Validation Set ◽  
Sensitivity Specificity

Objective To develop an easy-to-use nomogram for discrimination of malignant thyroid nodules and to compare diagnostic efficiency with the Kwak and American College of Radiology (ACR) Thyroid Imaging, Reporting and Data System (TI-RADS). Study Design Retrospective diagnostic study. Setting The Second Hospital of Shandong University. Subjects and Methods From March 2017 to April 2019, 792 patients with 1940 thyroid nodules were included into the training set; from May 2019 to December 2019, 174 patients with 389 nodules were included into the validation set. Multivariable logistic regression model was used to develop a nomogram for discriminating malignant nodules. To compare the diagnostic performance of the nomogram with the Kwak and ACR TI-RADS, the area under the receiver operating characteristic curve, sensitivity, specificity, and positive and negative predictive values were calculated. Results The nomogram consisted of 7 factors: composition, orientation, echogenicity, border, margin, extrathyroidal extension, and calcification. In the training set, for all nodules, the area under the curve (AUC) for the nomogram was 0.844, which was higher than the Kwak TI-RADS (0.826, P = .008) and the ACR TI-RADS (0.810, P < .001). For the 822 nodules >1 cm, the AUC of the nomogram was 0.891, which was higher than the Kwak TI-RADS (0.852, P < .001) and the ACR TI-RADS (0.853, P < .001). In the validation set, the AUC of the nomogram was also higher than the Kwak and ACR TI-RADS ( P < .05), each in the whole series and separately for nodules >1 or ≤1 cm. Conclusions When compared with the Kwak and ACR TI-RADS, the nomogram had a better performance in discriminating malignant thyroid nodules.

scholarly journals The Impact of Narrow-band Imaging on the Pre- and Intra- operative Assessments of Neoplastic and Preneoplastic Laryngeal Lesions. A Systematic Review

2020 ◽  
Author(s):  
Carmelo Saraniti ◽  
Enzo Chianetta ◽  
Giuseppe Greco ◽  
Norhafiza Mat Lazim ◽  
Barbara Verro
Keyword(s):  
White Light ◽  
Diagnostic Tool ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Resection Margins ◽  
Predictive Values ◽  
White Light Endoscopy ◽  
Laryngeal Lesions ◽  
Sensitivity Specificity ◽  
The Impact

Introduction Narrow-band imaging is an endoscopic diagnostic tool that, focusing on superficial vascular changes, is useful to detect suspicious laryngeal lesions, enabling their complete excision with safe and tailored resection margins. Objectives To analyze the applications and benefits of narrow-band imaging in detecting premalignant and malignant laryngeal lesions through a comparison with white-light endoscopy. Data Synthesis A literature search was performed in the PubMed, Scopus and Web of Science databases using strict keywords. Then, two authors independently analyzed the articles, read the titles and abstracts, and read completely only the relevant studies according to certain eligibility criteria. In total, 14 articles have been included in the present review; the sensitivity, specificity, positive and negative predictive values, and accuracy of pre- and/or intraoperative narrow-band imaging were analyzed. The analysis showed that narrow-band imaging is better than white-light endoscopy in terms of sensitivity, specificity, positive and negative predictive values, and accuracy regarding the ability to identify cancer and/or precancerous laryngeal lesions. Moreover, the intraoperative performance of narrow-band imaging resulted more effective than the in-office performance. Conclusion Narrow-band imaging is an effective diagnostic tool to detect premalignant and malignant laryngeal lesions and to define proper resection margins. Moreover, narrow-band imaging is useful in cases of leukoplakia that may cover a possible malignant lesion and that cannot be easily assessed with white-light endoscopy. Finally, a shared, simple and practical classification of laryngeal lesions, such as that of the European Laryngological Society, is required to identify a shared lesion management strategy. Key Points

scholarly journals Impacts of household income on beef at-home consumption: Evidence from urban China

2021 ◽  
Vol 20 (6) ◽  
pp. 1701-1715
Author(s):  
Wen-bo ZHU ◽  
Yong-fu CHEN ◽  
Jing ZHAO ◽  
Bei-bei WU
Keyword(s):  
Household Income ◽  
Urban China ◽  
Home Consumption ◽  
At Home

scholarly journals Predicting youth diabetes risk using NHANES data and machine learning

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nita Vangeepuram ◽  
Bian Liu ◽  
Po-hsiang Chiu ◽  
Linhua Wang ◽  
Gaurav Pandey
Keyword(s):  
Machine Learning ◽  
Large Scale ◽  
Clinical Guideline ◽  
Diabetes Risk ◽  
Screening Tools ◽  
Clinical Screening ◽  
Predictive Values ◽  
Screening Guideline ◽  
Demographic Subgroups ◽  
Sensitivity Specificity

AbstractPrediabetes and diabetes mellitus (preDM/DM) have become alarmingly prevalent among youth in recent years. However, simple questionnaire-based screening tools to reliably assess diabetes risk are only available for adults, not youth. As a first step in developing such a tool, we used a large-scale dataset from the National Health and Nutritional Examination Survey (NHANES) to examine the performance of a published pediatric clinical screening guideline in identifying youth with preDM/DM based on American Diabetes Association diagnostic biomarkers. We assessed the agreement between the clinical guideline and biomarker criteria using established evaluation measures (sensitivity, specificity, positive/negative predictive value, F-measure for the positive/negative preDM/DM classes, and Kappa). We also compared the performance of the guideline to those of machine learning (ML) based preDM/DM classifiers derived from the NHANES dataset. Approximately 29% of the 2858 youth in our study population had preDM/DM based on biomarker criteria. The clinical guideline had a sensitivity of 43.1% and specificity of 67.6%, positive/negative predictive values of 35.2%/74.5%, positive/negative F-measures of 38.8%/70.9%, and Kappa of 0.1 (95%CI: 0.06–0.14). The performance of the guideline varied across demographic subgroups. Some ML-based classifiers performed comparably to or better than the screening guideline, especially in identifying preDM/DM youth (p = 5.23 × 10−5).We demonstrated that a recommended pediatric clinical screening guideline did not perform well in identifying preDM/DM status among youth. Additional work is needed to develop a simple yet accurate screener for youth diabetes risk, potentially by using advanced ML methods and a wider range of clinical and behavioral health data.

scholarly journals COVID-19 Seroprevalence among Healthcare Workers of a Large COVID-19 Hospital in Rome Reveals Strengths and Limits of Two Different Serological Tests

2021 ◽  
Vol 18 (5) ◽  
pp. 2650
Author(s):  
Giuseppe Vetrugno ◽  
Daniele Ignazio La Milia ◽  
Floriana D’Ambrosio ◽  
Marcello Di Pumpo ◽  
Roberta Pastorino ◽  
...  
Keyword(s):  
Blood Test ◽  
Healthcare Workers ◽  
Point Of Care ◽  
Venous Blood ◽  
Administrative Staff ◽  
Serological Tests ◽  
Predictive Values ◽  
Work From Home ◽  
Significant Difference ◽  
Sensitivity Specificity

Healthcare workers are at the forefront against COVID-19, worldwide. Since Fondazione Policlinico Universitario A. Gemelli (FPG) IRCCS was enlisted as a COVID-19 hospital, the healthcare workers deployed to COVID-19 wards were separated from those with limited/no exposure, whereas the administrative staff were designated to work from home. Between 4 June and 3 July 2020, an investigation was conducted to evaluate the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (IgG) antibodies among the employees of the FPG using point-of-care (POC) and venous blood tests. Sensitivity, specificity, and predictive values were determined with reverse-transcription polymerase chain reaction on nasal/oropharyngeal swabs as the diagnostic gold standard. The participants enrolled amounted to 4777. Seroprevalence was 3.66% using the POC test and 1.19% using the venous blood test, with a significant difference (p < 0.05). The POC test sensitivity and specificity were, respectively, 63.64% (95% confidence interval (CI): 62.20% to 65.04%) and 96.64% (95% CI: 96.05% to 97.13%), while those of the venous blood test were, respectively, 78.79% (95% CI: 77.58% to 79.94%) and 99.36% (95% CI: 99.07% to 99.55%). Among the low-risk populations, the POC test’s predictive values were 58.33% (positive) and 98.23% (negative), whereas those of the venous blood test were 92.86% (positive) and 98.53% (negative). According to our study, these serological tests cannot be a valid alternative to diagnose COVID-19 infection in progress.

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