scholarly journals In silico Analysis of Alkaloids for Therapeutic Use in Treatment of Alzheimer's Disease by Targeting Acetylcholinesterase Enzyme

2021 ◽  
pp. 1-6
Author(s):  
Sidra Batool ◽  
Muhammad Sibte Hasan Mahmood ◽  
Tiyyaba Furqan ◽  
Muaaz Karim ◽  
Sidra Batool
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Loss ◽  
In Silico Analysis ◽  
Synaptic Cleft ◽  
Inhibitory Effect ◽  
Ligand Docking ◽  
Docking Approach ◽  
Acetylcholinesterase Enzyme ◽  
Silico Analysis

Alzheimer’s is a progressive mental deterioration associated with the degeneration of the cognition activities and memory loss. It is considered to be a multifactorial disease. One of the causes of the Alzheimer’s disease is the low concentration of the neurotransmitter named acetylcholine (ACh) at the synaptic cleft. Thus, inhibitor of Acetylcholinesterase (AChE), an enzyme whose function is to degrade the acetylcholine, is proved to be a promising candidate to treat this disease. Among the inhibitors are the natural alkaloids that also have an inhibitory effect on the AChE. In this study we have focused on the simple derivates of beta carbolime (a group of alkaloids) and studied their interaction with AChE via rigid protein-ligand docking approach.

Double hit viral parasitism, polymicrobial CNS residency and perturbed proteostasis in Alzheimer’s disease: A data driven, in silico analysis of gene expression data

2020 ◽  
Vol 127 ◽  
pp. 124-135
Author(s):  
George D. Vavougios ◽  
Christiane Nday ◽  
Sygliti-Henrietta Pelidou ◽  
Sotirios G. Zarogiannis ◽  
Konstantinos I. Gourgoulianis ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Expression Data ◽  
In Silico ◽  
In Silico Analysis ◽  
Data Driven ◽  
Expression Data ◽  
Double Hit ◽  
Silico Analysis

scholarly journals In silico Analysis of the Immunological Landscape of Hippocampi in Alzheimer’s Disease

2020 ◽  
Vol 49 (3) ◽  
pp. 252-254
Author(s):  
Sai Batchu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dendritic Cells ◽  
Cd8 T Cells ◽  
Immune Cells ◽  
Critical Role ◽  
In Silico Analysis ◽  
Expression Data ◽  
Immune Signature ◽  
Silico Analysis

<b><i>Introduction:</i></b> Accumulating evidence suggests a relationship between neuroinflammation and neurodegenerative pathologies such as Alzheimer’s disease (AD). This study sought to investigate the immunological composition of hippocampi in patients afflicted with AD. <b><i>Methods:</i></b> CIBERSORTx RNA deconvolution was applied on gene expression data developed from hippocampi of 38 AD patients and 17 controls to infer the relative proportions of 22 subsets of immune cells. <b><i>Results:</i></b> AD-afflicted hippocampi were found to have greater relative abundances of M2 macrophages and CD8 T cells. AD-afflicted hippocampi were also composed of significantly more active dendritic cells and significantly fewer resting dendritic cells than control samples. <b><i>Conclusion:</i></b> AD-afflicted hippocampi present with a distinct immune signature and dendritic cells may play a critical role in the pathogenesis of AD in this brain component.

scholarly journals MicroRNAs Modulate the Pathogenesis of Alzheimer’s Disease: An In Silico Analysis in the Human Brain

Genes ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 983
Author(s):  
Agnese Gugliandolo ◽  
Luigi Chiricosta ◽  
Virginia Boccardi ◽  
Patrizia Mecocci ◽  
Placido Bramanti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nervous System ◽  
In Silico ◽  
Target Genes ◽  
Amyloid Β ◽  
In Silico Analysis ◽  
Protein Translation ◽  
Mirnas Expression ◽  
Silico Analysis

MicroRNAs (miRNAs) are small RNAs involved in the post-transcriptional regulation of their target genes, causing a decrease in protein translation from the mRNA. Different miRNAs are found in the nervous system, where they are involved in its physiological functions, but altered miRNAs expression was also reported in neurodegenerative disorders, including Alzheimer’s disease (AD). AD is characterized by memory loss, cognitive function abnormalities, and various neuropsychiatric disturbances. AD hallmarks are amyloid β (Aβ) aggregates, called senile plaques, and neurofibrillary tangles (NFTs) formed by hyperphosphorylated Tau protein. In this study, we performed an in silico analysis to evaluate altered patterns of miRNAs expression in the brains of AD patients compared to healthy subjects. We found 12 miRNAs that were differentially expressed in AD compared to healthy individuals. These miRNAs have target genes involved in AD pathogenesis. In particular, some miRNAs influence Aβ production, having as target secretase and amyloid precursor protein (APP). Some miRNAs were reported to be involved in nervous system functions, and their alteration can cause neuronal dysfunction.

scholarly journals In Silico Analysis to Link Insulin Resistance, Obesity and Ageing with Alzheimer’s Disease

2021 ◽  
Author(s):  
Priyanka Sarkar ◽  
Premkumar Jayaraj ◽  
Ketaki Patwardhan ◽  
Samiksha Yeole ◽  
Sourajit Das ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
In Silico ◽  
In Silico Analysis ◽  
Silico Analysis
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