Retroperitoneal Hibernoma: Exhibition of Three Case Reports and Literature Review

Hibernoma is a rare benign tumor that becomes from the vestiges of fetal brown adipose tissue. It can be located on different regions of the body, being tight the most frequent. Retroperitoneal region is approximately of 9.4%. The first person to describe this histological type was Merkel. To the present, there are only described 25 cases on this location. It has a slowly growth, so it is normally asymptomatic, and it usually presents doing compression of different structures. To diagnose the MRI is the best prove, although biopsy will provide definite diagnosis describing four possible variants. Immunochemistry of MDM2, CDK4 and p16 genes is really important to do the differential diagnosis with well-differentiated liposarcoma (WDLS). Only one extensive review of hibernoma with 170 cases on different regions is published. But there is no review on literature specifically of retroperitoneal region, so this is the purpose of the current study. Following we present three more cases of retroperitoneal hibernoma that we have treat on our Mesenchymal Tumours Unit and a revision of the previously published.

Download Full-text

A case report of lipoma-like hibernoma in axilla: A rarely benign tumor of brown adipose tissue

Case Studies in Surgery ◽

10.5430/css.v4n1p1 ◽

2018 ◽

Vol 4 (1) ◽

pp. 1

Author(s):

Ricardo Rubini Costa ◽

Antonio Torregrosa Gallud ◽

José Miguel Rayón ◽

Jerónimo Forteza Vila

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Central Nucleus ◽

Resected Specimen ◽

Axial Tomography ◽

Brown Adipose ◽

Rare Benign Tumor ◽

Computerized Axial Tomography ◽

Histological Characteristics ◽

Well Differentiated

Background: Hibernoma or lipoma of brown fat is a rare benign tumor, representing 1.6% of the neoplasms of this tissue. Because of its histological characteristics can be wrongly classified as liposarcoma, therefore a correct differential diagnosis is necessary to provide appropriate treatment.Case presentation: The patient on which this case study is based is a 44-year-old male with a painless soft mass in his axilla located by his 4th and 5th ribs. The resected specimen did not have the classic macroscopic features of lipoma or fibrolipoma. Microscopically, the report described a proliferation of unilocular adipocytes with eccentric nucleus and, in less frequency, multilocular adipocytes with central nucleus. He had no recurrence after excision.Conclusions: Despite radiology studies and other technologies such as magnetic resonance imaging, computerized axial tomography (CAT), etc., the clinical diagnosis of hibernoma could be difficult. Lipoma-like hibernoma only have a few multilocular cells and can be wrongly classified as liposarcoma. Well-differentiated liposarcoma resembles it on low-power examination. Due to this it is especially important to perform a differential diagnosis with lipoma, fibroma, and even with liposarcoma. In this study we describe the histological features, the molecular markers and cytogenetic aspects that contribute to differentiate hibernoma from others tumors.

Download Full-text

Laparoscopic Resection of a Giant Dedifferentiated Primary Retroperitoneal Mucinous Cystadenoma (PRMC) in a Young Woman: A Case Report and Literature Review

Journal of Clinical Case Studies ◽

10.16966/2471-4925.215 ◽

2021 ◽

Vol 6 (1) ◽

Author(s):

Wu L ◽

Li X ◽

Li J ◽

Lai Y

Keyword(s):

Differential Diagnosis ◽

Case Report ◽

Literature Review ◽

Benign Tumor ◽

Laparoscopic Resection ◽

Abdominal Cavity ◽

Mucinous Cystadenoma ◽

Rare Benign Tumor ◽

Primary Retroperitoneal

Background: PRMC is a very rare benign tumor of the abdominal cavity that usually occurs in women, and PRMC demonstrate no specific findings on CT. There are many reports on the differential diagnosis and discussion of PRMC imaging, but there are few reports on the treatment of dedifferentiated PRMC using laparoscopic resection and postoperative follow-up.

Download Full-text

Dermoid Cysts of the Floor of the Mouth: Two Case Reports

Case Reports in Medicine ◽

10.1155/2011/362170 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Christos Makos ◽

George Noussios ◽

Marinos Peios ◽

Spyridon Gougousis ◽

Pantelis Chouridis

Keyword(s):

Differential Diagnosis ◽

Sebaceous Gland ◽

Case Reports ◽

Branchial Arch ◽

Clinical Findings ◽

The Body ◽

Embryonic Cells ◽

Floor Of The Mouth ◽

Neck Tumors ◽

Gland Duct

Dermoid cysts in the floor of the mouth may be congenital or acquired. The congenital form, according to the main theory, originates from embryonic cells of the 1st and 2nd branchial arch. The acquired form may be due to traumatic or iatrogenic causes and as a result of the occlusion of a sebaceous gland duct. Its occurrence is less and is estimated to be from 1.6 to 6.4% of the dermoid cysts of the body in adults and 0.29% of the head and neck tumors occurring in children. They may also be classified as anatomical and histological. Anatomically, they are divided into median genioglossal, median geniohyoid, and lateral cysts, while histologically they are divided into epidermoid, dermoid cysts and teratomas. Clinically, a distinction between supra and inferior type as well as between central and lateral type is proposed in relation to themylohyoidmuscle and themidline, respectively. Histologically, an estimation of dermoid, epidermoid, and teratoid cysts is reported. Enucleation via intraoral and/or extraoral approach is the method of treatment. Two case reports of dermoid cysts in the floor of the mouth are presented in this paper, and an evaluation with regard to pathology, clinical findings, differential diagnosis, and treatment is discussed.

Download Full-text

Voluminous Extracardiac Adult Rhabdomyoma of the Neck: A Case Presentation

Case Reports in Surgery ◽

10.1155/2012/984789 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 4

Author(s):

Riccardo Maglio ◽

Scicchitano Francesco ◽

Magistri Paolo ◽

Valabrega Stefano ◽

D'Angelo Francesco ◽

...

Keyword(s):

Head And Neck ◽

Benign Tumor ◽

The Body ◽

Differential Diagnoses ◽

Mesenchymal Tumors ◽

Adult Type ◽

Case Presentation ◽

Italian Patient ◽

First Case ◽

Rare Benign Tumor

Introduction. Rhabdomyomas of the head and neck are exceptionally rare benign mesenchymal tumors. Rare cases have been reported to involve other sites of the body including the head and neck regions.Case Presentation. We report a case of voluminous extracardiac adult rhabdomyoma affecting adult patients and initially seen as slowly growing, indolent neoplasms. The patient is a seventy-year old male Italian patient.Conclusion. Adult extracardiac rhabdomyoma is a rare benign tumor that may present with symptoms that vary from aerodigestive tract obstruction to remaining asymptomatic for many years. Although histology is very characteristic, several differential diagnoses have to be considered. To our knowledge, this is the first case of voluminous adult-type symptomless rhabdomyoma.

Download Full-text

First Report of a Lipoblastoma of the Parapharyngeal Space

Ear Nose & Throat Journal ◽

10.1177/014556130208100819 ◽

2002 ◽

Vol 81 (8) ◽

pp. 564-568 ◽

Cited By ~ 8

Author(s):

Kalpana DePasquale ◽

Daniel G. Deschler

Keyword(s):

Differential Diagnosis ◽

Head And Neck ◽

Benign Tumor ◽

Parapharyngeal Space ◽

First Report ◽

Parotid Region ◽

Rare Benign Tumor ◽

A Site

Lipoblastoma is a rare benign tumor that occurs primarily in children younger than 3 years of age. Fewer than 100 cases have been reported in the literature, and only eight cases have been previously reported in the head and neck; two of them occurred in the parotid region, where the differential diagnosis becomes quite extensive. We report a new case of head and neck lipoblastoma—one that occurred in the parapharyngeal space, a site that has not been previously reported. By doing so, we hope to promote awareness and consideration of lipoblastoma in the differential diagnosis of deep-parotid and para-pharyngeal-space neoplasms.

Download Full-text

Giant Lymphoid Hyperplasia Presenting as a Highly Vascularized Parapharyngeal Mass

Otolaryngology ◽

10.1177/019459988209000411 ◽

1982 ◽

Vol 90 (4) ◽

pp. 426-430 ◽

Cited By ~ 11

Author(s):

Brent J. Lanier ◽

Charles W. Cummings

Keyword(s):

Benign Tumor ◽

Lymphoid Hyperplasia ◽

The Body ◽

Preoperative Embolization ◽

Radiographic Evidence ◽

Giant Lymph Node Hyperplasia ◽

Rare Benign Tumor ◽

Work Up ◽

Lymph Node Hyperplasia

Giant lymph node hyperplasia is a rare, benign tumor infrequently occurring in the head and neck. A 31-year-old woman with this disorder, present as a large submucosal parapharyngeal mass, is presented and the literature reviewed. Radiographic evidence of the extreme vascularity of this lesion was remarkable, emphasizing the value of arteriographic evaluation of masses located in this region. Preoperative embolization facilitated its complete resection, and follow-up examination has shown no evidence of recurrence, which is commonly the course of the disease elsewhere in the body. Consideration of this rare entity is warranted in the work-up of parapharyngeal masses.

Download Full-text

Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis

Sarcoma ◽

10.1155/2011/638403 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 10

Author(s):

Ronald S. A. de Vreeze ◽

Frits van Coevorden ◽

Lucie Boerrigter ◽

Petra M. Nederlof ◽

Rick L. Haas ◽

...

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Soft Tissue Tumors ◽

Fish Analysis ◽

Chondroid Lipoma ◽

Molecular Biological Analysis ◽

Morphological Aspects ◽

Myxoid Liposarcomas ◽

Well Differentiated ◽

Lipomatous Tumors

Aims. Chondroid lipoma (CL) is a benign tumor that mimics a variety of soft tissue tumors and is characterized by translocationt(11;16). Here, we analyze CL and its histological mimics.Methods. CL (n=4) was compared to a variety of histological mimics (n=83) for morphological aspects and immunohistochemical features including cyclinD1(CCND1). Using FISH analysis,CCND1andFUSwere investigated as potential translocation partners.Results. All CLs were strongly positive forCCND1. One of 4 myoepitheliomas,CCND1, was positive. In well-differentiated lipomatous tumors and in chondrosarcomas,CCND1was frequently expressed, but all myxoid liposarcomas were negative. FISH analysis did not give support for direct involvement ofCCND1andFUSas translocation partners.Conclusions. Chondroid lipoma is extremely rare and has several and more prevalent histological mimics. The differential diagnosis of chondroid lipomas can be unraveled using immunohistochemical and molecular support.

Download Full-text

Hibernoma of the axillary region: a rare benign adipocytic tumor

Rare Tumors ◽

10.4081/rt.2010.e7 ◽

2010 ◽

Vol 2 (1) ◽

pp. 20-22 ◽

Cited By ~ 2

Author(s):

Kanya Honoki ◽

Kouhei Morita ◽

Takahiko Kasai ◽

Hiromasa Fujii ◽

Akira Kido ◽

...

Keyword(s):

Malignant Neoplasm ◽

Brown Fat ◽

Fetal Life ◽

Mri Findings ◽

Brown Adipose ◽

Rare Benign Tumor ◽

Axillary Region ◽

Well Differentiated ◽

Slow Growing ◽

Interscapular Region

Hibernoma is a rare benign tumor considered to arise from remnants of fetal brown adipose tissue. It tends to occur in sites where brown fat persists beyond fetal life, such as the interscapular region, but can occur in sites where brown fat is usually absent in adults. Clinically, hibernomas are slow-growing, asymptomatic tumors. However, unlike lipomas, MRI findings sometimes mislead clinicians to diagnose a malignant neoplasm. We describe a 63-year-old male with an axillary hibernoma involving the brachial neurovascular bundles and mimicking a well-differentiated liposarcoma, from which it should be distinguished.

Download Full-text

Epidermal Cysts Surgery: Case Series

Journal of Clinical Research in Dermatology ◽

10.15226/2378-1726/7/3/001120 ◽

2020 ◽

Vol 7 (3) ◽

pp. 1-6

Author(s):

Teodor Angelov ◽

Valeri Malev ◽

Georgi Tchernev

Keyword(s):

Differential Diagnosis ◽

Benign Tumor ◽

Case Series ◽

Surgical Excision ◽

Complete Removal ◽

Vascular Lesion ◽

The Body ◽

Trichilemmal Cyst ◽

The Face ◽

Risk Of Malignancy

Epidermal cysts are the most common scalp cysts in clinical practice. They are most commonly located in the region of the face, neck, and trunk, and have been reported in many other topographic areas of the body. Clinically, they are present as free-moving nodules located below the skin, ranging in size from a few millimeters to a few centimeters in diameter. Histopathologically, they are defined as benign tumor formations with a very low risk of malignancy. The differential diagnosis includes: lipoma, neurofibroma, salivary gland adenoma, vascular lesion and fibroid, and Trichilemmal cyst. The most common treatment for epidermal cysts is surgical excision with removal of all contents without compromising the integrity of the capsule. In this publication, we present five clinical cases of patients with epidermal cysts in different topographic regions of the body. The patients were treated surgically by elliptical excision and complete removal of epidermal cysts without rupture. The defects were closed with single discontinued skin sutures and the sutures were removed on an 8- / 14-postoperative day. No recurrence was observed in the postoperative period.

Download Full-text