Use of a Medical Food in Adults Undergoing Surgery

2019 ◽  
Author(s):  
Keyword(s):  
Medical Food

scholarly journals Severe anemia in patients with Propionic acidemia is associated with branched-chain amino acid imbalance

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Sinziana Stanescu ◽  
Amaya Belanger-Quintana ◽  
Borja Manuel Fernandez-Felix ◽  
Francisco Arrieta ◽  
Victor Quintero ◽  
...  
Keyword(s):  
Amino Acids ◽  
Food Consumption ◽  
Protein Intake ◽  
Propionic Acidemia ◽  
Study Data ◽  
Metabolic Decompensation ◽  
Severe Anemia ◽  
Medical Food ◽  
Natural Protein ◽  
Branched Chain

Abstract Background Propionic acidemia (PA), an inborn error of metabolism, is caused by a deficiency in propionyl-CoA carboxylase. Patients have to follow a diet restricted in the propiogenic amino acids isoleucine (Ile), valine (Val), methionine (Met) and threonine (Thr); proper adherence can prevent and treat acute decompensation and increase life expectancy. However, chronic complications occur in several organs even though metabolic control may be largely maintained. Bone marrow aplasia and anemia are among the more common. Materials and methods In this retrospective study, data for patients with PA being monitored at the Hospital Ramón y Cajal (Madrid, Spain) (n = 10) in the past 10 years were examined to statistically detect relationships between persistent severe anemia outside of metabolic decompensation episodes and dietary practices such as natural protein intake and medical food consumption (special mixture of precursor-free amino acids) along with plasma levels of branched-chain amino acids (BCAA). High ferritin levels were deemed to indicate that a patient had received repeated transfusions for persistent anemia since data on hemoglobin levels at the moment of transfusion were not always passed on by the attending centers. Results Three patients had severe, persistent anemia that required repeated blood transfusions. Higher medical food consumption and plasma Leu levels were associated with iron overload. Notably, natural protein intake and plasma Val were negatively correlated with ferritin levels. We also observed an inverse relationship between plasma Val/Leu and Ile/Leu ratios and ferritin. Conclusion The present results suggest that severe anemia in patients with PA might be associated with low natural protein intake and BCAA imbalance.

scholarly journals Sentra PM (a Medical Food) and Trazodone in the Management of Sleep Disorders

2012 ◽  
Vol 4 ◽  
pp. JCNSD.S9381
Author(s):  
William E. Shell Md ◽  
Lawrence A. May Md ◽  
Debora H. Bullias Bs, Cra, Crc ◽  
Stephanie L. Pavlik Cra ◽  
David S. Silver Md
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Sleep Disorders ◽  
Sleep Latency ◽  
Quality Of Sleep ◽  
Autonomic Nervous System Activity ◽  
Medical Food ◽  
Autonomic Nervous ◽  
Nervous System Activity

Sleep disorders are a common and poorly treated disease state. This double blind, four arm placebo-controlled, randomized trial compared (1) low dose trazodone, (2) Sentra PM, a neurotransmitter based medical food, (3) the joint administration of trazodone and the medical food Sentra PM and (4) placebo. There were 111 subjects studied in 12 independent sites. Subjects underwent baseline screening, informed consent and an initial sleep questionnaire. After 14 days subjects underwent a second evaluation by questionnaire. At baseline and Day 14 the subjects underwent 24 hour ECG recordings that were analyzed in the frequency domain of heart rate variability. The specific high frequency parasympathetic autonomic nervous system activity was analyzed. The primary endpoints were sleep latency and parasympathetic autonomic nervous system improvement in sleeping hours. The results showed improvement in sleep latency for the Sentra PM and combination of Sentra PM and trazodone (−41 and −56 minutes P < 0.001). There was an improvement in quality of sleep for the amino acid formulation Sentra PM and the combination (3.86 and 6.48 Likert units on a 10 point scale P < 0.001). There was an activation of circadian activity percent at night in the medical food and combination groups while there was no change in parasympathetic activity in either the placebo or trazodone group. These data indicate that Sentra PM can improve the quality of sleep, the response to trazodone as a sleep medication and parasympathetic autonomic nervous system activity.

PP292 IN NEWLY DIAGNOSED ESOPHAGEAL CANCER PATIENTS SERUM PGE2 LEVELS ARE REDUCED AFTER NUTRITIONAL INTERVENTION WITH A MEDICAL FOOD

2010 ◽  
Vol 5 (2) ◽  
pp. 137
Author(s):  
J. Faber ◽  
V.M. Spaander ◽  
S.C. van Steenbergen ◽  
A.P. Vos ◽  
M. Berkhout ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Nutritional Intervention ◽  
Newly Diagnosed ◽  
Medical Food

scholarly journals Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen

2017 ◽  
Vol 11 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Rachelle A. Soriano ◽  
Asuncion G. Ramos-Soriano
Keyword(s):  
Ulcerative Colitis ◽  
Treatment Regimen ◽  
Pediatric Patients ◽  
Opportunistic Infections ◽  
Activity Index ◽  
Mucosal Healing ◽  
Chronic Inflammatory Bowel Disease ◽  
Medical Food ◽  
Markers Of Inflammation ◽  
Bovine Immunoglobulin

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is particularly troublesome for pediatric patients, as current therapeutic options consist of biologic agents and steroids which alter the immune response and have the harmful side effect of leaving the patient more susceptible to opportunistic infections and eventual surgery. Another option for therapy exists in the form of serum-derived bovine immunoglobulin/protein isolate (SBI), the key ingredient in a medical food, EnteraGam®. The FDA has reviewed the safety of SBI and issued a no challenge letter to the generally recognized as safe (GRAS) findings for this medical food. The product also has no known food or drug interactions, no significant adverse effects, and no contraindications, save for beef allergy. SBI has been shown to induce clinical remission in adult populations and to decrease markers of inflammation in pediatric patients. Here, we present a detailed case of pediatric UC, including documentation of mucosal healing and decrease in pediatric UC activity index in a difficult to treat pediatric patient, after the addition of SBI to this patient’s treatment regimen.

ADDRESS ON DIETETICS—MEDICAL FOOD ETHICS NOW AND TO COME.

JAMA ◽  
1993 ◽  
Vol 269 (10) ◽  
pp. 1244
Author(s):  
EPHRAIM CUTTER
Keyword(s):  
Food Ethics ◽  
Medical Food ◽  
To Come

scholarly journals Glucose Regulatory Hormones in Camel, Cow, Goat, and Human Milk (P06-034-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Wafa Almohmadi ◽  
Jonathan Allen
Keyword(s):  
Glucose Metabolism ◽  
Human Milk ◽  
Human Insulin ◽  
Bovine Milk ◽  
Goat Milk ◽  
Model Systems ◽  
Camel Milk ◽  
Insulin Concentration ◽  
Diabetic Patients ◽  
Medical Food

Abstract Objectives Diabetes Mellitus is globally predicted to affect 592 million people by 2035 with the greatest rates of increase in low and middle income countries. Various plant and animal foods are being tested as alternatives to medication to control blood glucose. Regular consumption of milk from camels has had a positive anti-diabetic effect in both type 1 and type 2 diabetics. Epidemiological studies, research in diabetic rat and mouse model systems, and clinical studies in diabetic patients support the anti-diabetic effects of camel milk, but the mechanism of action is unclear. This study investigated hormones that impact glucose metabolism in humans from milks from different species and their stability with pasteurization. We tested hypotheses in the literature that camel milk antidiabetic properties are due to a high content of insulin or insulinotropic hormones. Methods Five milk samples: Human, Bovine, Goat, and Camel from two different farms were analyzed with a multiplex panel for hormones that impact glucose metabolism in humans. Immunoreactivity to human Insulin, C-peptide, Glucagon, Ghrelin, Leptin, GIP, GLP-1, Resistin, Visfatin, and PAI-1 (total) were determined with a multiplex assay (Biorad Bioplex diabetes panel) using a Magpix analyzer. Results Insulin immunoreactivity was present in both human and goat milk at approximately 200 pg/mL. Both camel samples were below the range of detection with this anti-human insulin antibody; but 5 pg/mL of insulin was detected in bovine milk. GIP was detected in all milks but was highest in human milk. Camel milk had higher immunoreactivity to resistin, visfatin, and ghrelin than goat or bovine milk. GLP-1 and leptin were only detected in human milk. Neither HTST nor Holder pasteurization significantly reduced the immunoreactivity of these hormones in milk. Conclusions Although literature suggests camel milk is an effective medical food for diabetics, we did not find high insulin concentration in camel milk. The hypoglycemic effect of camel milk might be due to other components of camel milk. Assays using different antibodies or insulin receptors might show different results. The insulin concentration in goat milk suggests that this product should be tested as a medical food for glucose control. Funding Sources NIFA; NCSU; Saudi Cultural Mission.

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