scholarly journals PRIMARY-MULTIPLE MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM (REVIEW)

2021 ◽  
pp. 33-38
Author(s):  
S. Kamyshov ◽  
K. Izrailbekova
Keyword(s):  
Reproductive System ◽  
Malignant Tumors ◽  
Full Range ◽  
Molecular Genetic ◽  
Female Reproductive System ◽  
Genetic Studies ◽  
Specific Tumor ◽  
Examination Methods ◽  
System Review

In the last decade, in the field of oncology, there has been an increasing interest in the study of issues related to the problem of primary multiple malignant tumors (PMMT). Many researchers agree that polyneoplasias are most often found in women, which is associated with an increase in the incidence of hormone-dependent tumors of the reproductive system, which is functionally represented by the mammary glands, uterus and ovaries. The development of comprehensive examination methods, including molecular genetic studies, contributes to the identification of synchronous PMMT of the female reproductive system. In our studies, metachronous tumors prevailed among PMMTs in breast cancer (65.7%). The most common metachronous cancer of the uterine body (37.1% of cases). Determination of the level of specific tumor markers allows you to monitor in advance the development of PMMT in this category of patients. Thus, each of the tumors of the female reproductive system should be considered as an indicator of the risk of the others, which should lead to a state of rapid response to the entire well-functioning system of dispensary registration, observation and use of a full range of special methods of clarifying diagnostics.

ROLE OF ULTRASOUND IN THE DETECTION OF RECURRENT OVARIAN CANCER

2020 ◽  
Vol 6 (1) ◽  
pp. 23-31
Author(s):  
M. Alisherova ◽  
◽  
M. Ismailova
Keyword(s):  
Ovarian Cancer ◽  
Surgical Treatment ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Recurrent Ovarian Cancer ◽  
Primary Diagnosis ◽  
Female Reproductive System

Currently, there are no standard approaches to monitoring patients with ovarian cancer (OC). While the role of ultrasound (US) has been identified in the primary diagnosis of OS, it is still controversial during the subsequent surgical treatment of OC. In world statistics, ovarian cancer is consistently among the four main localizations of malignant tumors of the female reproductive system, along with tumors of the breast, body and cervix.

scholarly journals Malignant Tumors of the Female Reproductive System

2012 ◽  
Vol 3 (3) ◽  
pp. 166-180 ◽  
Author(s):  
Elisabete Weiderpass ◽  
France Labrèche
Keyword(s):  
Reproductive System ◽  
Malignant Tumors ◽  
Female Reproductive System

Identification and certification of Bactrian and Arvan camels of Kazakh population using DNA technology// FUNDAMENTAL AND APPLIED SCIENTIFIC RESEARCH: сб.науч.тр./ OEAPS Inc.; редкол.: Флора Бертран (отв.ред.) [и др.]. - Берлин, Германия : OEAPS Inc., 2018. - С. 44-56.

2018 ◽  
Author(s):  
Elmira Kalybaevna Adil’bekova ◽  
Nuradin Alibaev ◽  
Arunas Svitojus
Keyword(s):  
Genetic Resources ◽  
Molecular Genetic ◽  
Structure Identification ◽  
Dna Microsatellites ◽  
Genetic Studies ◽  
Kazakh Population ◽  
Cytogenetic Monitoring ◽  
Dna Technology ◽  
First Time

Kazakhstan is the center where Bactrians and Dromedaries can be raised, and hybridization between them has become widespread. Genetic resources of interspecies camel hybrids, raised in Kazakhstan, are represented by 30 generations.The most highly valuable in the conditions of Central Asia and Kazakhstan are transboundary camel breeds such as Kazakh Bactrian, Turkmen and Kazakh Dromedary, as well as new generations of camels Arada, Bainar and Baitur.At pure breeding of Kazakh Bactrian, genetic peculiarities are not taken into account, in view of the poor knowledge of this issue. To maintain the biodiversity, molecular genetic monitoring of the state of camel populations is required. Cytogenetic monitoring and certification are one of the promising areas for reliable camel genome assessment.Deep determination of Kazakh dairy camelsallele poolwas not carried out in Kazakhstan before. Genetic studies to optimize structure, identification and certification of valuable genotypes, as well as systematization of genetic resources in dairy camel breeding in Kazakhstan are urgent task.The aim of the study is identification, systematization and certification of genetic resources of Bactrian and Dromedary camels of Kazakh population using DNA technology. Genetic analysis of the typing results of the camels studied was carried out by 7 and 8 loci of DNA microsatellites. The material for the studies was DNA samples isolated from histological samples. The microsatellite loci were selected in accordance with the recommendations of the European Society of Genetics (FAO/ISAG).Identification and certification of Arvan and Kazakh Bactrian camels’ genetic resources using the microsatellite analysis of their genotype was carried outfor the first time. Breeding significance of Bactrian and Arvan camels of Kazakh population using DNA technologies was studied and determined. The obtained results of the study allowed evaluate camels at the level of the allelic profile.

scholarly journals The role of immunotherapy in the management of metastatic/recurrent female reproductive system neoplasms

2021 ◽  
pp. 76-86
Author(s):  
A. A. Rumyantsev ◽  
A. Yu. Anokhin
Keyword(s):  
Reproductive System ◽  
Malignant Tumors ◽  
Therapeutic Option ◽  
Objective Response ◽  
High Sensitivity ◽  
Evidence Base ◽  
Current Evidence ◽  
Malignant Neoplasms ◽  
Female Reproductive System ◽  
Current Evidence Base

In 2019 malignant neoplasms of the female reproductive system (ovarian cancer, (OC), endometrial carcinoma (EC) and cervical cancer (CC) were diagnosed in 58 860 patients – 17.6% of all malignant tumors in women in Russia. The morbidity and mortality rates from these neoplasms remain high over the past 10 years. This article provides a detailed review of the current evidence base for  the  use of  various immunotherapeutic agents in  mentioned malignant neoplasms. It has been demonstrated that in  relapsed OC (ROC), the  only proved indication for  immunotherapy is tumors with microsatellite instability (MSI), whereas PD-L1 does not have an independent role in this disease. MSI occurs in approximately 8% of patients with metastatic OC. A significantly higher frequency MSI — up to 25% is detected in metastatic EC. MSI-positive subtype of the disease is characterized by an extremely high sensitivity to immunotherapy - the  rate of  objective response with pembrolizumab exceeds 50%. For  MS-stable  EC, the  combination of  pembrolizumab and lenvatinib is an effective therapeutic option. In  advanced CC, on the other hand, PD-L1 has a predictive role for immunotherapy efficacy — the KEYNOTE-158 study showed that about 15% of  patients with extensively pretreated metastatic PD-L1-positive CC can achieve long-term remission with pembrolizumab compared to 0% in PD-L1 negative tumors. Current evidence shows that PD-L1 expression can be observed in ≥ 30% of patients.

EPIDEMIOLOGICAL ASPECTS OF OVARIAN CANCER IN THE STRUCTURE OF PRIMARY MULTIPLE MALIGNANT TUMORS OF THE FEMALE REPRODUCTIVE SYSTEM (ON THE EXAMPLE OF THE CHELYABINSK REGION)

2018 ◽  
Vol 64 (6) ◽  
pp. 739-744
Author(s):  
Svetlana Bekhtereva ◽  
Yevgeniy Imyanitov ◽  
Andrey Vazhenin ◽  
Alla Domozhirova ◽  
Irina Aksenova ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Reproductive System ◽  
Malignant Tumors ◽  
Female Reproductive System ◽  
Primary And Secondary Prevention ◽  
Cumulative Survival ◽  
Clinical Center ◽  
Number Of Patients ◽  
Prevention Of Cancer ◽  
Chelyabinsk Region

The problem of primary multiplicity of malignant tumors remains relevant in oncology due to the growing number of patients with polyneoplasia, especially for tumors of the female reproductive system. The analysis of the frequency and combinations of polyneoplasias of the reproductive system in women on the example of primary multiple ovarian cancer according to the data of the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine for 15 years. The calculated indicators of the adjusted cumulative survival of patients with polyneoplasia and solitary ovarian cancer were calculated. The data obtained can be used in clinical practice, as the primary and secondary prevention of cancer in women.

scholarly journals Morphological and laboratory genetic studies of muscular dystrophies

2021 ◽  
Vol 9 (3) ◽  
pp. 481-491
Author(s):  
T.M. Cherdantseva ◽  
◽  
O.V. Bakovetskaya ◽  
A.A. Nikiforov ◽  
M.S. Nekrasovа ◽  
...  
Keyword(s):  
Correct Diagnosis ◽  
Molecular Genetic ◽  
Modern Medicine ◽  
Muscular Dystrophies ◽  
Electronic Library ◽  
Biopsy Material ◽  
Genetic Studies ◽  
The Past ◽  
Comprehensive Examination

Muscular dystrophies are one of the most pressing problems of modern medicine. In the electronic library system e-Library on the topic “Muscular Dystrophies” 13,263 papers have been published, over the past 5 years — 4,221, and in PubMed, at the request of “Muscular Dystrophy”, more than 37 thousand publications have been found, over the past 5 years there are about 6,851. The interest in this problem is understandable, since the prevalence of progressive muscular dystrophies is 200 cases per 1 000,000 population, which permits to classify them as the most common forms of hereditary pathology. The article provides an overview of information on morphological and laboratory genetic. CONCLUSION: The literature review showed that despite predomination of molecular-genetic methods of examinations nowadays, morphological and immunohistological evaluation of the damaged muscles did not lose its actuality. This is because it is not always possible to perform genetic analysis in the patient due to technical complexity of the procedure, use of costly equipment, many genetic mutations. Therefore, in some forms of muscular dystrophies (for example, in dysferlinopathies) of primary importance is morphological and immunohistological analysis of biopsy material. Nevertheless, this method should not be considered as most precise due to similarity of the morphology of different kinds of muscular dystrophies. Thus, correct diagnosis always requires systemic approach including comprehensive examination of the patient with use of maximally available methods. This is necessary for genetic consultations of patient, determination of peculiarities of therapy and for inclusion of patients in clinical trials.

scholarly journals Leptin and the female reproductive system (review)

2012 ◽  
Vol 61 (5) ◽  
pp. 96-103
Author(s):  
Ekaterina Markovna Ryazantseva
Keyword(s):  
Reproductive System ◽  
Pubertal Development ◽  
Biological Properties ◽  
Ovarian Failure ◽  
Female Reproductive System ◽  
System Review

The review presents recent data on the biological properties of leptin and its involvement in the pubertal development and pathogenesis of various forms of ovarian failure

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