scholarly journals Epidemiological Risks: Importance when Zoning Administrative Territories and Activating the Epidemic Process during Infectious Diseases

2020 ◽  
Vol 18 (6) ◽  
pp. 81-89
Author(s):  
E. G. Yanovich ◽  
E. A. Moskvitina
Keyword(s):  
Risk Factors ◽  
Infectious Diseases ◽  
Ebola Virus ◽  
Virus Disease ◽  
Epidemiological Surveillance ◽  
Enteric Infection ◽  
West Nile Fever ◽  
Theoretical Concepts ◽  
Epidemic Process ◽  
Risk Areas

Along with the theoretical concepts and definitions of risk adopted in the epidemiological analysis of infectious diseases, the identification of «risk areas» is of great importance.The aim is to show the role of risk factors when determining the «risk areas» and in the genesis of complications of the epidemiological situation. Taking into account the multifactorial nature of the epidemic process under infectious diseases, we describe the risks used in zoning of natural focal particularly dangerous (plague, tularemia, anthrax, Ebola virus disease, Yellow fever); arbovirus (Crimean-Congo haemorrhagic fever, West Nile Fever and anthroponotic (cholera and other acute enteric infection (AEI) of norovirus, rotavirus and enterovirus etiology) infections. The importance of risk factors and conditions for their implementation in AEI with water pathogen distribution (unsatisfactory state of water supply and water use, population migration, etc.) and emergencies, in which certain risk factors can contribute to the complication of the epidemic situation, is shown.Conclusion. The use of risk factors in zoning of administrative territories is aimed at improving epidemiological surveillance. It is possible that potential risk factors can transfer to real, what results in activation of the epidemic process.

Spatial-temporal transmission dynamics and control of infectious diseases: Ebola virus disease (EVD) as a case study

2018 ◽  
Author(s):  
Cécile Viboud ◽  
Hélène Broutin ◽  
Gerardo Chowell
Keyword(s):  
Infectious Diseases ◽  
Disease Transmission ◽  
Ebola Virus ◽  
Temporal Dynamics ◽  
Virus Disease ◽  
Spatial Dynamics ◽  
Childhood Diseases ◽  
Middle Income ◽  
Theoretical Concepts ◽  
Dynamics And Control

Disentangling the spatial-temporal dynamics of infectious disease transmission is important to address issues of disease persistence, epidemic growth and optimal control. In this chapter, we review key concepts relating to the spatial-temporal dynamics of infectious diseases in meta-populations, whereby geographically separate subpopulations are connected by migration or mobility rates. We review the dynamics of colonization, persistence and extinction of emerging and recurrent pathogens in meta-populations; the role of demographic and environmental factors; and geographic heterogeneity in epidemic growth rate. We illustrate theoretical concepts by reviewing the spatial dynamics of childhood diseases and other acute infections in low- and middle-income countries, and provide a detailed description of the spatial-temporal dynamics of the 2014–16 Ebola epidemic in West Africa. We further discuss how increased availability of empirical data and recent methodological developments provide a deeper mechanistic understanding of transmission processes in space and time, and make recommendations for future work.

Treatment of ebola and other infectious diseases: melatonin “goes viral”

2020 ◽  
Vol 3 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Russel J Reiter ◽  
Qiang Ma ◽  
Ramaswamy Sharma
Keyword(s):  
Mortality Rate ◽  
Infectious Diseases ◽  
Hemorrhagic Shock ◽  
Safety Profile ◽  
Ebola Virus ◽  
Viral Infections ◽  
Virus Disease ◽  
Attractive Potential ◽  
Potential Treatment

This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.  

scholarly journals Experience in the implementation of epidemiological surveillance of West Nile fever in the Volgograd region

2015 ◽  
Vol 20 (1) ◽  
pp. 49-55
Author(s):  
M. V Monastyrskiy ◽  
N. V Shestopalov ◽  
V. G Akimkin ◽  
Yu. V Demina
Keyword(s):  
Public Health ◽  
Epidemiological Surveillance ◽  
West Nile Fever ◽  
Management Decisions ◽  
West Nile ◽  
Epidemic Process ◽  
Volgograd Region ◽  
Necessary And Sufficient ◽  
Epidemiological Situation

West Nilefever (WNF) is the most important arbovirus infectionfor the Volgograd region. The observed decrease in the WNF incidence from 2001 to 2006, in 2008 and2009, the reducing the number ofsevere forms ofdiseases only give evidence ofa temporary regression of the epidemic process in the territory of the Volgograd region. In the territory of the Volgograd region there are prerequisites and harbingers of the complication of epidemiological situation on West Nile fever. The aim of the performed in the Volgograd region epidemiological surveillance for WNF is to provide the information necessary and sufficient for the analysis of the epidemiological situation, as well as to determine the direction of policy and activities in public health and in making management decisions.

scholarly journals Ebola virus disease: Case management in the Institute of Infectious Diseases, University Hospital of Sassari, Sardinia, Italy

2016 ◽  
Vol 10 (05) ◽  
pp. 537-543 ◽  
Author(s):  
Giulia Bertoli ◽  
Marco Mannazzu ◽  
Giordano Madeddu ◽  
Riccardo Are ◽  
Alberto Muredda ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Ebola Virus ◽  
Virus Disease ◽  
Developed Countries ◽  
The United States ◽  
Ebola Virus Disease ◽  
University Hospital ◽  
Governmental Organization ◽  
Medical Division ◽  
Disease Case

Since the onset of the worst epidemic of Ebola virus disease in December 2013, 28,637 cases were reported as confirmed, probable, or suspected. Since the week of 3 January 2016, no more cases have been reported. The total number of deaths have amounted to 11,315 (39.5%). In developed countries, seven cases have been diagnosed: four in the United States, one in Spain, one in the United Kingdom, and one in Italy. On 20 July 2015, Italy was declared Ebola-free. On 9 May 2015, an Italian health worker came back to Italy after a long stay in Sierra Leone working for a non-governmental organization. Forty-eight hours after his arrival, he noticed headache, weakness, muscle pains, and slight fever. The following day, he was safely transported to the Infectious Diseases Unit of University Hospital of Sassari. The patient was hospitalized for 19 hours until an Italian Air Force medical division transferred him to Rome, to the Lazzaro Spallanzani Institute. Nineteen people who had contacts with the patient were monitored daily for 21 days by the Public Health Office of Sassari and none presented any symptoms. So far, neither vaccine nor treatment is available to be proposed on an international scale. Ebola is considered a re-emerging infectious disease which, unlike in the past, has been a worldwide emergency. This case study aimed to establish a discussion about the operative and logistic difficulties to be faced and about the discrepancy arising when protocols clash with the reality of facts.

scholarly journals Vaccines and Antibodies: Weapons in the Fight Against Ebola Virus

2021 ◽  
Vol 9 ◽  
Author(s):  
Patrice Debré ◽  
Marie Neunez ◽  
Michel Goldman
Keyword(s):  
Infectious Disease ◽  
Immune System ◽  
Infectious Diseases ◽  
Human Body ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
World Today ◽  
The World ◽  
Stimulation Of

Ebola virus disease is one of the deadliest infections in the world today. The microbe to blame is the Ebola virus. It has already caused numerous outbreaks in Africa, in the regions located south of the Sahara. This article describes the main characteristics of this infectious disease as well as the currently available treatments, namely vaccines and antibodies. Antibodies are produced by the human body when it is infected by a microbe. Antibodies can be collected from the blood of infected humans or animals and purified or manufactured in a laboratory to produce drugs. While vaccines have demonstrated their effectiveness in preventing infectious diseases, antibodies are effective in stopping the progression of several infectious diseases. In this article, you will discover that the stimulation of the immune system, either by the vaccine or by antibodies, is essential to tackle Ebola virus disease.

scholarly journals Pre-Ebola virus disease laboratory system and related challenges in Liberia

2016 ◽  
Vol 5 (3) ◽  
Author(s):  
Stephen B. Kennedy ◽  
John B. Dogba ◽  
Christine L. Wasunna ◽  
Philip Sahr ◽  
Candace B. Eastman ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Ebola Virus ◽  
Virus Disease ◽  
Emerging Infectious Diseases ◽  
Health Facilities ◽  
Sub Saharan Africa ◽  
Ebola Virus Disease ◽  
Reference Laboratory ◽  
Laboratory System ◽  
Human Resource Capacity

Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of effective and sustainablelaboratory services in Liberia. However, in a resource-limited environment such as Liberiaprogress regarding the rebuilding of the health system can be relatively slow, while efforts tosustain the transient gains remain a key challenge for the Ministry of Health. In this paper, wedescribe the pre-Ebola virus disease laboratory system in Liberia and its prevailing efforts toaddress future emerging infectious diseases, as well as current Infectious diseases, all of whichare exacerbated by poverty. We conclude that laboratory and diagnostic services in Liberiahave encountered numerous challenges regarding its efforts to strengthen the healthcaredelivery system. These challenges include limited trained human resource capacity, inadequateinfrastructure, and a lack of coordination. As with most countries in sub-Saharan Africa, whencomparing urban and rural settings, diagnostic and clinical services are generally skewedtoward urban health facilities and private, faith-based health facilities. We recommend thatstructured policy be directed at these challenges for national institutions to develop guidelinesto improve, strengthen and sustain diagnostic and curative laboratory services to effectivelyaddress current infectious diseases and prepare for future emerging and re-emerging infectiousdiseases.

Ebola virus disease in children in Conakry and Coyah Ebola treatment centers and risk factors associated with death

2020 ◽  
Vol 50 (7) ◽  
pp. 562-566 ◽  
Author(s):  
M.S. Sow ◽  
D.C. Sow ◽  
M.L. Diallo ◽  
D. Kassé ◽  
K. Sylla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Factors Associated

Doctors’ Knowledge of Viral Haemorrhagic Fevers

2015 ◽  
Vol 14 (2) ◽  
pp. 47-52
Author(s):  
Clifford Lisk ◽  
◽  
Luke Snell ◽  
Michael Haji-Coll ◽  
Jayne Ellis ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
At Risk ◽  
West Africa ◽  
Ebola Virus ◽  
Healthcare Professionals ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Poor Knowledge ◽  
Online Study

Viral Haemorrhagic Fevers (VHF) such as Ebola Virus Disease (EVD) are of increasing concern of increasing concern to clinicians and public heath bodies across Europe and America due to the on-going epidemic in West Africa. We conducted an online study to assess clinicians’ knowledge of VHF across six hospital sites in London. This showed suboptimal knowledge of Public Health England guidance, EVD epidemiology and the risk factors for acquiring VHF. Knowledge about VHF was dependent on seniority of grade with the most junior grade of doctors performing worse in several areas of the survey. Poor knowledge raises concerns that those at risk of VHF will be inappropriately risk stratified and managed. Education of doctors and other healthcare professionals about VHF is necessary to address these knowledge gaps.

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