scholarly journals Genome-wide association studies for heat stress response in Bos taurus × Bos indicus crossbred cattle

2019 ◽  
Vol 102 (9) ◽  
pp. 8148-8158 ◽  
Author(s):  
Pamela I. Otto ◽  
Simone E.F. Guimarães ◽  
Lucas L. Verardo ◽  
Ana Luísa S. Azevedo ◽  
Jeremie Vandenplas ◽  
...  
Keyword(s):  
Heat Stress ◽  
Stress Response ◽  
Bos Taurus ◽  
Association Studies ◽  
Bos Indicus ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Crossbred Cattle ◽  
Heat Stress Response ◽  
Genome Wide

scholarly journals Genome-wide association studies for tick resistance in Bos taurus × Bos indicus crossbred cattle: A deeper look into this intricate mechanism

2018 ◽  
Vol 101 (12) ◽  
pp. 11020-11032 ◽  
Author(s):  
Pamela I. Otto ◽  
Simone E.F. Guimarães ◽  
Lucas L. Verardo ◽  
Ana Luísa S. Azevedo ◽  
Jeremie Vandenplas ◽  
...  
Keyword(s):  
Bos Taurus ◽  
Association Studies ◽  
Bos Indicus ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Crossbred Cattle ◽  
Genome Wide ◽  
Intricate Mechanism ◽  
Tick Resistance

scholarly journals Genetic Analyses and Genome-Wide Association Studies on Pathogen Resistance of Bos taurus and Bos indicus Cattle Breeds in Cameroon

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 976
Author(s):  
Babette Abanda ◽  
Markus Schmid ◽  
Archile Paguem ◽  
Hanna Iffland ◽  
Siegfried Preuß ◽  
...  
Keyword(s):  
Bos Taurus ◽  
Association Studies ◽  
Bos Indicus ◽  
Pathogen Resistance ◽  
Gastrointestinal Nematodes ◽  
Genome Wide Association ◽  
Zebu Cattle ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Northern Cameroon

Autochthonous taurine and later introduced zebu cattle from Cameroon differ considerably in their resistance to endemic pathogens with little to no reports of the underlying genetic make-up. Breed history and habitat variations are reported to contribute significantly to this diversity worldwide, presumably in Cameroon as well, where locations diverge in climate, pasture, and prevalence of infectious agents. In order to investigate the genetic background, the genotypes of 685 individuals of different Cameroonian breeds were analysed by using the BovineSNP50v3 BeadChip. The variance components including heritability were estimated and genome-wide association studies (GWAS) were performed. Phenotypes were obtained by parasitological screening and categorised in Tick-borne pathogens (TBP), gastrointestinal nematodes (GIN), and onchocercosis (ONC). Estimated heritabilities were low for GIN and TBP (0.079 (se = 0.084) and 0.109 (se = 0.103) respectively) and moderate for ONC (0.216 (se = 0.094)). Further than revealing the quantitative nature of the traits, GWAS identified putative trait-associated genomic regions on five chromosomes, including the chromosomes 11 and 18 for GIN, 20 and 24 for TBP, and 12 for ONC. The results imply that breeding for resistant animals in the cattle population from Northern Cameroon might be possible for the studied pathogens; however, further research in this field using larger datasets will be required to improve the resistance towards pathogen infections, propose candidate genes or to infer biological pathways, as well as the genetic structures of African multi-breed populations.

scholarly journals Genome-Wide Association Studies Reveal Susceptibility Loci for Digital Dermatitis in Holstein Cattle

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2009
Author(s):  
Ellen Lai ◽  
Alexa L. Danner ◽  
Thomas R. Famula ◽  
Anita M. Oberbauer
Keyword(s):  
Predictive Value ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Bos Taurus ◽  
Association Studies ◽  
Bayesian Regression ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Digital Dermatitis ◽  
Genome Wide

Digital dermatitis (DD) causes lameness in dairy cattle. To detect the quantitative trait loci (QTL) associated with DD, genome-wide association studies (GWAS) were performed using high-density single nucleotide polymorphism (SNP) genotypes and binary case/control, quantitative (average number of FW per hoof trimming record) and recurrent (cases with ≥2 DD episodes vs. controls) phenotypes from cows across four dairies (controls n = 129 vs. FW n = 85). Linear mixed model (LMM) and random forest (RF) approaches identified the top SNPs, which were used as predictors in Bayesian regression models to assess the SNP predictive value. The LMM and RF analyses identified QTL regions containing candidate genes on Bos taurus autosome (BTA) 2 for the binary and recurrent phenotypes and BTA7 and 20 for the quantitative phenotype that related to epidermal integrity, immune function, and wound healing. Although larger sample sizes are necessary to reaffirm these small effect loci amidst a strong environmental effect, the sample cohort used in this study was sufficient for estimating SNP effects with a high predictive value.

Short communication: Genome wide association study for gastrointestinal nematodes resistance in Bos taurus x Bos indicus crossbred cattle

2021 ◽  
Vol 245 ◽  
pp. 104403
Author(s):  
Pamela I. Otto ◽  
Simone E.F. Guimarães ◽  
Lucas L. Verardo ◽  
Ana Luísa S. Azevedo ◽  
Claudia A. Sevillano ◽  
...  
Keyword(s):  
Association Study ◽  
Short Communication ◽  
Genome Wide Association Study ◽  
Bos Taurus ◽  
Bos Indicus ◽  
Gastrointestinal Nematodes ◽  
Genome Wide Association ◽  
Crossbred Cattle ◽  
Genome Wide

scholarly journals Genome-wide association studies on heat stress tolerance during grain development in wheat (Triticum aestivum L.)

2020 ◽  
Author(s):  
Jie Guo ◽  
Weiping Shi ◽  
Jiahui Guo ◽  
Linqi Yue ◽  
Lei Zhuang ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Tolerance ◽  
Association Studies ◽  
Starch Content ◽  
Kernel Weight ◽  
Genome Wide Association ◽  
Phenotypic Traits ◽  
Genome Wide Association Studies ◽  
Wheat Cultivars ◽  
Genome Wide

Abstract BackgroundHeat stress at the late reproductive stages is a common problem encountered in autumn-sown wheat production regions in China with the affected area covering as much as two-thirds of the crop. In order to develop wheat cultivars with heat-tolerance, it is crucial to explore favorable alleles for use in breeding programs.ResultsIn this study, we performed a 90K iSelect SNP genotyping assay on a collection of 207 wheat cultivars subjected to heat stress during grain-fill growth stage in three years (2015-2017). Genotypic analyses of 19 phenotypic traits revealed that heat stress had major impacts on grain weight, size, and quality. Correlation analyses indicated that thousand kernel weight (TKW) was significantly correlated with grain width (GW) and grain perimeter (GP), whereas grain protein content (GPC) was negatively correlated with total starch content (TSC) (P <0.01). We applied heat susceptibility indices (HSI) for different traits to assess heat tolerance. Genome-wide association studies (GWAS) revealed a total of 125 marker-trait associations (MTAs) at 63 SNP loci on 16 chromosomes each accounting for phenotypic variation (R2) of 3.0-21.4%. 17 loci showed significant associations in three environments. The analysis of selective sweeps indicated that RAC875_c19042_2102 (2B), wsnp_Ex_c257_491667 (3B), wsnp_Ex_rep_c101323_86702413 (5A) and BS00061911_51 (7A) were selected between two subpopulations (top 5%).ConclusionsThese four key MTAs detected in the present study are candidates for further genetic dissection and development of molecular markers.

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