scholarly journals Antibody Response Against SARS-CoV-2 Following ChAdOx1 (Astezeneca AZD 1222) Vaccine in Health Care Workers in a Tertiary Care Hospital in India

2021 ◽  
Vol 28 (3) ◽  
pp. 307-313
Author(s):  
Felice FAIZAL ◽  
◽  
Rajneesh JOSHI ◽  
R CHATTRJEE ◽  
Ankur AHUJA ◽  
...  
Keyword(s):  
Health Care ◽  
Antibody Response ◽  
Antibody Titre ◽  
Health Care Workers ◽  
Statistical Tests ◽  
Tertiary Care ◽  
Care Hospital ◽  
Care Workers ◽  
Antibody Titres ◽  
Dose Vaccine

BACKGROUND: The ChAdOx1 nCoV-19 vaccine against COVID-19 is a two-dose vaccine spread 3 to 4 weeks apart. This study aims to ascertain the antibody response to each dose with respect to age, previous infection status etc. METHODS: Baseline total COVID-19 antibody level was ascertained using Siemens SARS‑CoV‑2 Total Antibody assay in consenting health care workers before the first dose of vaccination. Adverse effects were noted in each individual and were monitored weekly for the total antibody titre following both doses. Descriptive statistical tests were used to analyse the changes in antibodies levels weekly after both doses. Association of previous COVID infection and age with antibody levels was assessed. RESULTS: Median (range) of age of the 30 study participants was 31.5 years.23% of the participants had a history of previous COVID-19 infection. Mild adverse events following immunisation were reported by 87% participants after first dose whereas only in 7% after second dose. Median baseline antibody titres were significantly higher among those with previous COVID infection as compared to previously uninfected individuals. Antibody titres increased consistently after first dose and showed a declining trend following the second dose in all participants and showed no significant association with previous COVID-19 infection or age. CONCLUSIONS: Antibody titre response was similar amongst the various age groups. Higher response in the previously infected individuals following first dose may make them ideal candidates for a single dose vaccine regimen. Individuals showing lower levels of neutralising antibodies can be ideal candidates for a booster dose.

scholarly journals Psychological status of healthcare workers during COVID-19 pandemic: a single center observational study from Peshawar

2020 ◽  
Vol 6 (4) ◽  
pp. 03-06
Author(s):  
Wajeeha Qayyum ◽  
Asad Khalil ◽  
Mohammad Jawad ◽  
Seema Ashraf
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Psychological Status ◽  
Anxiety And Depression ◽  
Medical Institute ◽  
Care Hospital ◽  
Factors Associated ◽  
Care Workers

Introduction: Infectious pandemics are a significant health risk to the general population, but much more so for the frontline health care workers tending patients at different locations. The increased workload, stress, fear, and anxiety are the burdens to be coped with by health professionals through resort to resiliency and other mechanisms.Objective: To determine the magnitude of depression / anxiety and factors associated with it in health care workers of a tertiary care hospital during the COVID-19 pandemic in Peshawar, Khyber Pakhtunkhwa, Pakistan.Materials & Methods: This cross sectional study was conducted at Rehman Medical Institute, Peshawar after approval from Rehman Medical Institute Research Ethics Committee. A structured questionnaire consisting of two sections was distributed by convenience sampling to health care workers in the hospital, the first part containing demographic information, and the second part consisting of Hospital Anxiety and Depression Scale (HADS) comprised of 14 scales to assess anxiety and depression. Scoring for Normal, Borderline Abnormal, and Definitive Disorder was done as per standard criteria. Data were analyzed for descriptive statistics by SPSS 22. Results: Total 327 participants were included in the study, having mean age of 30.19 ± 7.82 years, of which 230(70.3%) were males. The majority of health care workers 226(69.1%) were suffering from disturbed mental status either in the form of Anxiety (19.9%), Depression (8%) or Mixed Disorder (41.3%). Factors associated with high disease frequency were female gender, age group 21-30 years, nursing staff, workers of ICU and Hostel residence (p value <0.05). Conclusion: COVID-19 related psychological disturbances significantly affected healthcare staff of a tertiary care hospital of Peshawar, being more evident in females, younger age groups, nurses, and ICU staff on duty.

scholarly journals Risk analysis of needle stick and sharp object injuries among health care workers in a tertiary care hospital (Saudi Arabia)

2013 ◽  
Vol 3 (3) ◽  
pp. 123 ◽  
Author(s):  
Ziad A. Memish ◽  
Abdullah M. Assiri ◽  
Mervat M. Eldalatony ◽  
Hanan M. Hathout ◽  
Hend Alzoman ◽  
...  
Keyword(s):  
Health Care ◽  
Saudi Arabia ◽  
Risk Analysis ◽  
Health Care Workers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Needle Stick ◽  
Sharp Object ◽  
Care Workers
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