scholarly journals DEPENDENCE OF CHANGES IN THE HYGIENIC CONDITION OF THE ORAL CAVITY AND PERIODONTIUM IN CHILDREN WITH MALIGNANT TUMORS ON THE DURATION OF POLYCHEMYTHERAPY AND QUANTITIES OF CYTOSTATIC DRUGS

2021 ◽  
pp. 65-69
Author(s):  
Yu.V. Popelo
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Abdominal Cavity ◽  
Visual Fields ◽  
Dental Status ◽  
Observation Group ◽  
Cytostatic Drugs ◽  
Prevention Measures ◽  
Scientific Publications ◽  
Hygienic Condition

It is known that the course of cancer and chemotherapy adversely affect the components of homeostasis of the oral cavity, which causes stomatotoxicity. However, scientific publications have not yet provided generalized results of research on the pathogenetic mechanisms of the dental pathology formation during chemotherapy, which constitutes the relevance of this publication. The aim of the research was to study the effect of different regimens of the second course of chemo- therapy on the hygienic condition of the oral cavity and periodontium in children with malignant tumors of the abdominal cavity. The dissatisfaction with our results obtained after the first course of chemotherapy on various regimens prompted us to further research. A survey of two previously formed clinical groups was performed. All of them resumed the treatment in the oncohematology department of the Poltava Children's City Clinical Hospital following a 3-4 week break between courses. Each patient was treated according to an individual program but in the absence of dental care. The dental status was assessed using the Green-Vermillion, Papillary-Marginal-Alveolar (PMA), and Pa- pilla Bleeding Index. The study of cytograms from the surface of the gingival margin of the frontal part of the mandible was carried out taking into account the methodology developed by our department's staff. The calculation was per- formed in 10 visual fields. Statistical processing was performed according to standard conditions. Research results and their discussion. It should be noted that in the comparative aspect, the indexes of Green-Vermillion, PMA, and RВI at the end of the first year were 1,8, 1,3, and 1,6 times worse than in the second observation group which received more cytostatic drugs. At the end of the second course of chemotherapy, the dryness of the mucous membrane accompanied by a decrease in oral fluid, which became viscous, was observed in 14 children (70,0%) of the first and 18 of the second group (85.7%). In addition, 15 people in the first group (75,0%) and 19 in the second one (90,4%) complained of pain and bleeding gums, which worsened when eating. At the same time, all children noted pain in the muscles that are adjacent to the lower jaw and involved in articulation. On external examination, only 2 children of the first (10,0%) and 1 of the second group (5%) had a red normal-coloured lip border, while the rest had exfoliation, cracks, and angular cheilitis. The oral mucosa mostly looked pale and pasty, except for 7 people of the second group (35,0%), who had manifestations of erythema. Localized erosions covered with fibrinous plaque were detected in 4 of these patients (20,0%) on the background of erythema. In addition, 12 children (60,0%) of the first group and 19 children of the second one (85.7%) showed swelling and redness of the gingival marginal edge, and the probing of the gingival sulcus provoked bleeding in all children of both groups. Green-Vermillion indexes increased by 1,5 and 1,7 times in the first and second groups, PMA increased by 1,4 times in both groups, and RВI was 1,4 and 1,5 times higher in the respective compared groups. The examination of cytograms revealed more pronounced changes in the second group where the epithelium with signs of intermediate stages of the differentiation prevailed. There was increased desquamation of the superficial layer of the gums and the increased number of peripheral blood elements, especially destroyed neutrophils. Thus, the generalization of the results obtained at the end of the second course of chemotherapy showed that the Green-Vermillion index was 1,8 times higher, and PMA and SВI indices were 1,4 times higher in the second observation group which received more cytostatics. That is, the severity of the manifestations of dental status disorders is directly proportional to the severity of the regimen. Conclusion. The prolongation of the second course of chemotherapy in children with abdominal malignant tumors provoked a significant deterioration of dental status. Major changes occurred in the group of children who received more cytostatic drugs simultaneously, which requires a balanced approach to designing differentiated treatment plans and prevention measures depending on the complexity of antitumor therapy regimens. Prospects for further research. The obtained results indicate the need to develop a set of differentiated treatment and prevention measures aimed at eliminating or improving changes in children that occur in the oral cavity under the influence of polychemotherapy.

PERIODONTAL RESPONSE TO CYTOSTATIC DRUGS IN CHILDREN

2021 ◽  
Vol 74 (6) ◽  
pp. 1322-1325
Author(s):  
Yuliia V. Popelo ◽  
Pavlo I. Tkachenko ◽  
Natalia M. Lokhmatova
Keyword(s):  
Malignant Tumors ◽  
Abdominal Cavity ◽  
Inflammatory Cells ◽  
Preoperative Treatment ◽  
Cytostatic Drugs ◽  
Prevention Measures ◽  
Gingival Margin ◽  
Periodontal Tissues ◽  
Treatment And Prevention ◽  
Different Types

The aim: To study the effect of different types of cytostatic drugs on the periodontium in children with malignant tumors. Material and methods: The material for generalization was based at the results of examination of 44 patients with malignant tumors of the abdominal cavity who underwent preoperative treatment in the oncohematology department of Poltava Children’s City Clinical Hospital. Results: In the absence of proper dental care in patients of this group, under the influence of chemotherapeutic drugs, significantly worsens the level of oral hygiene and the condition of periodontal tissues. There are also changes in the process of differentiation of the epithelial structures of the gingival margin, which is accompanied by an increase in smears - reprints of the number of inflammatory cells of the peripheral blood, both with preserved structure and destructive forms. Conclusions: In children with malignant tumors, during antitumor therapy, there is a decrease in the level of hygiene of the oral cavity, accompanied by morphological destructive changes in the integumentary epithelial layer of the gingival margin. The severity of these disorders depends on the type and dose of cytostatic drugs, which should be considered in the formation of treatment and prevention measures for them.

scholarly journals IMPACT OF POLYCHEMOTHERAPY ON THE ORAL SOFT TISSUES IN CHILDREN WITH MALIGNANT ABDOMINAL TUMORS

2019 ◽  
Vol 72 (5) ◽  
pp. 978-982
Author(s):  
Yuliia V. Popelo ◽  
Pavlo I. Tkachenko ◽  
Serhii O. Bilokon
Keyword(s):  
Oral Cavity ◽  
Soft Tissues ◽  
Malignant Tumors ◽  
Dental Health ◽  
Abdominal Cavity ◽  
Scientific Work ◽  
Malignant Neoplasms ◽  
Cytotoxic Effects ◽  
Abdominal Tumors ◽  
Number Of Cells

Introduction: According to modern standards of treatment of malignant neoplasms conducting polychemotherapy requires up to 90% of cancer patients. However, in addition to the expected cytotoxic effects, it is accompanied by disorders in dental health in the vast majority of patients. The aim: To study the effect of cytostatics on soft tissues of the oral cavity in children with malignant tumors of the abdominal cavity. Materials and methods: Material for writing this scientific work served as a synthesis of results for 25 people aged 7 to 15 years with malignant tumors of the abdominal cavity, in which a comprehensive oral examination was performed to determine the manifestations of dental toxicity cytostatics. Results: At the end of the first course of chemotherapy, all patients had dry redness of the lips, 20 - (80,0%) with eruptions, in 18 - (20,0%) erosion. The Green-Vermillion, PMA, and PBI indices grew by 1,8; 7 and 3,3 times respectively. In cytograms with buccal epithelium an increase in the number of cells of polymorphic sizes and forms with signs of gidropic dystrophy was found. The nuclear-cytoplasmic ratio decreased by 1,4 times compared with the primary examination. Conclusions: This situation creates the preconditions for the development of inflammatory process in the tissues of the oral cavity and requires the use in this category of patients of a substantiated pathogenetic correction of existing disorders.

scholarly journals EVALUATION OF DENTAL EDUCATION AND ORAL HYGIENE OF PATIENTS UNDERGOING ORTHODONTIC TREATMENT

2017 ◽  
Vol 21 (2) ◽  
pp. 82-84
Author(s):  
S. Yu Kosyuga ◽  
D. I Botova
Keyword(s):  
Oral Cavity ◽  
Oral Hygiene ◽  
Orthodontic Treatment ◽  
Dental Education ◽  
Dental Status ◽  
Orthodontic Appliances ◽  
Hygienic Condition ◽  
Rational Use ◽  
Fixed Orthodontic Appliances

During long-term orthodontic treatment there are various complications associated with a reduction in the level of hygiene. The article is devoted to the study of the hygienic condition of the oral cavity and the level of dental education in dynamics in patients undergoing orthodontic treatment. The examination and questioning of 40 patients aged from 18 to 35 years with fixed orthodontic appliances. In patients after 12 months of use braces deteriorating hygienic condition of the oral cavity. Care should be taken to inform patients about the care products and hygiene items, and their rational use, depending on the timing of orthodontic treatment and dental status.

Application of photo and video recording in dentistry. Review

2021 ◽  
pp. 28-32
Author(s):  
E.Yu. Leontyeva ◽  
A.V. Dmitrieva ◽  
P.S. Kravchenko ◽  
G.S. Leontyev
Keyword(s):  
Oral Cavity ◽  
Science Citation Index ◽  
Web Of Science ◽  
Citation Index ◽  
Video Recording ◽  
The State ◽  
Dental Status ◽  
Science Citation ◽  
Russian Science ◽  
Russian Science Citation Index

The review conducted research of the Russian and foreign literature of recent years on the methods of using photo and video recording in dentistry in the databases of the Russian Science Citation Index, SCOPUS, Web of Science, Pubmed and others. The data of the possibilities of using the method of registration of the dental status and the state of the tissues of the oral cavity using photo and video fixation in the diagnosis, treatment and observation of patients are presented.

Integrated assessment of hygienic condition of the oral cavity

Stomatologiya ◽  
2020 ◽  
Vol 99 (4) ◽  
pp. 21
Author(s):  
M.T. Aleksandrov ◽  
V.N. Olesova ◽  
E.F. Dmitrieva ◽  
E.D. Namiot ◽  
O.A. Artyomova ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Integrated Assessment ◽  
Hygienic Condition

scholarly journals Primary Oral Malignant Melanoma: Two Case Reports and Review of Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Sharma
Keyword(s):  
Malignant Melanoma ◽  
Early Detection ◽  
Oral Cavity ◽  
Tumor Size ◽  
Malignant Tumors ◽  
Case Reports ◽  
Review Of Literature ◽  
Oral Region ◽  
Rare Neoplasm ◽  
Oral Malignant Melanoma

Primary malignant melanoma of the oral cavity is a rare neoplasm. The tumors tend to metastasize or locally invade tissue more readily than other malignant tumors in the oral region. The survival of patients with mucosal melanomas is less than for those with cutaneous melanomas. Tumor size and metastases are related to the prognosis of the disease. Early detection, therefore, is important.

scholarly journals REVIEW OF THE CURRENT STATE OF THE PROBLEM OF PRIMARY DETECTION OF MALIGNANT TUMORS OF THE CAVITY

2019 ◽  
Vol 15 (2) ◽  
pp. 50-55
Author(s):  
Наталья Нуриева ◽  
Natal'ya Nurieva ◽  
Александр Гузь ◽  
Aleksandr Guz ◽  
Александр Захаров ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Head And Neck ◽  
Malignant Tumors ◽  
Malignant Neoplasm ◽  
Diagnostic Procedures ◽  
Primary Diagnosis ◽  
Malignant Neoplasms ◽  
Dental Rehabilitation ◽  
Late Treatment ◽  
Clinically Significant

Subject: malignant neoplasms of the oral cavity, primary detectability, appeal to specialists, terms of treatment before hospitalization. Objective: based on a five-year analysis of the medical records of patients with a verified diagnosis of malignant neoplasm of the oral cavity, to identify significant criteria for primary diagnosis, doctors of the first contact, including non-cancer profile. Methodology. Malignant neoplasms occupy one of the leading places among all medical and social problems. This is due to a number of reasons, among which are particularly high rates of morbidity and mortality, late treatment of patients and frequent disability. the Purpose of early detection of malignant tumors of the oral cavity is to increase the effectiveness and radicality of treatment, increase the possibility of dental rehabilitation, reduction of disability. To write this article, we conducted a five-year analysis of the primary detection of malignant tumors of the oral cavity in 76 patients hospitalized for treatment in the head and neck Department of the Chelyabinsk district Oncology center. All patients with histologically confirmed diagnosis. Everyone needs specialized anti-tumor treatment. In addition to standard diagnostic procedures, all patients were surveyed on the issues of primary complaints and appeals to medical specialists. Results. On the example of the received questionnaires as well as the standard medical examinations conducted upon admission to the head and neck Department, the trends of the primary referral of patients to primary contact doctors, the terms of treatment before referral to a specialized oncological institution, the stage of the process and the presence of metastasis of the primary focus during treatment, the presence of aggravating factors are analyzed. Conclusions. The results for the five-year period in patients with primary malignant neoplasm of the oral cavity were evaluated, practical recommendations on clinically significant symptoms of malignant tumors of the oral cavity, orientation on the timing of observation were given.

scholarly journals Improvement of dental health in professional athletes engaged in power sports

2017 ◽  
Vol 98 (2) ◽  
pp. 189-194
Author(s):  
F R Safaraliev ◽  
A M Safarov ◽  
F Yu Mamedov
Keyword(s):  
Oral Cavity ◽  
Periodontal Diseases ◽  
Dental Health ◽  
Dental Status ◽  
Professional Athletes ◽  
Before And After ◽  
Long Time ◽  
Dental Diseases ◽  
Anti Inflammatory ◽  
Intense Training

Aim. Evaluation of dental diseases prevalence in professional athletes engaged in power sports and of the influence of biologically neutral products based on propolis on the level of their dental health. Methods. The examination of organs and tissues of the oral cavity of professional athletes engaged for a long time in power sports was carried out. With the use of the developed specialized questionnaire dental status of the athletes was determined. Based on the analysis of the results of clinical and laboratory studies anti-inflammatory and anti-bacterial effectiveness of products based on propolis were evaluated. Results. The results of the survey showed that not all athletes are informed about the possibility of aggravation of pathological processes in soft and hard tissues of oral cavity during active training, mainly, in power sports. Lack of awareness of surveyed athletes about the need for timely individual oral hygiene procedures and regular dentist visits was revealed, especially during intense training before and after competitions. On evaluation of dental status of professional combat athletes high prevalence and intensity of inflammatory periodontal disease and caries were found. High anti-inflammatory efficiency of the product «Pomegranate Balm» for correction of dental status of professional athletes was proven. Conclusion. High incidence of inflammatory periodontal diseases of mild to moderate severity was revealed in athletes during prolonged and intense physical training; efficacy of biologically neutral products based on propolis was established.

scholarly journals Alternative Therapeutic Approach in the Treatment of Oral Pyogenic Granuloma

2015 ◽  
Vol 8 (3) ◽  
pp. 493-497 ◽  
Author(s):  
Amr Bugshan ◽  
Harsh Patel ◽  
Karen Garber ◽  
Timothy F. Meiller
Keyword(s):  
Oral Cavity ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Pyogenic Granuloma ◽  
Hormonal Imbalance ◽  
Choice Of Treatment ◽  
Chronic Irritation ◽  
Multiple Recurrences ◽  
And Behavior ◽  
Rule Out

Pyogenic granulomas (PGs) in the oral cavity present as an inflammatory hyperplasia usually caused by trauma, hormonal imbalance, chronic irritation, or as the response to a wide variety of drugs. PGs with atypical presentation and behavior may clinically mimic malignant tumors. Thus, histological examination is required to rule out cancer development. Lesions in the oral cavity have been described to be either an isolated entity or present in multiple forms and with multiple recurrences. Conservative surgical excision is the standard choice of treatment in almost every scenario. However, the severity of the lesions and the affected sites often challenge surgical treatment. In this report, we describe the clinical scenario of a recurrent PG, where surgical excision of the lesion was questioned. As an alternative, we describe a noninvasive approach with lesional steroid injections.

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