scholarly journals Replacing White Rice with Pre-Germinated Brown Rice Mildly Ameliorates Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rats

2010 ◽  
Vol 56 (5) ◽  
pp. 287-292 ◽  
Author(s):  
Mariko TORIMITSU ◽  
Ryouhei NAGASE ◽  
Megumi YANAGI ◽  
Miyuki HOMMA ◽  
Yousuke SASAI ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Brown Rice ◽  
Germinated Brown Rice ◽  
White Rice ◽  
Diabetes Model

scholarly journals Effects of White Rice, Brown Rice and Germinated Brown Rice on Antioxidant Status of Type 2 Diabetic Rats

2012 ◽  
Vol 13 (12) ◽  
pp. 12952-12969 ◽  
Author(s):  
Mustapha Umar Imam ◽  
Siti Nor Asma Musa ◽  
Nur Hanisah Azmi ◽  
Maznah Ismail
Keyword(s):  
Antioxidant Status ◽  
Brown Rice ◽  
Diabetic Rats ◽  
Germinated Brown Rice ◽  
White Rice ◽  
Type 2 Diabetic

scholarly journals The effect of a brown-rice diets on glycemic control and metabolic parameters in prediabetes and type 2 diabetes mellitus: a meta-analysis of randomized controlled trials and controlled clinical trials

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e11291
Author(s):  
Anis Farhanah Abdul Rahim ◽  
Mohd Noor Norhayati ◽  
Aida Maziha Zainudin
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Meta Analysis ◽  
Brown Rice ◽  
Hdl Cholesterol ◽  
Controlled Trials ◽  
White Rice ◽  
Randomized Controlled ◽  
Rice Diet

Background Brown rice is a whole-grain food that is often assumed to have a lower glycemic index compared to white rice. A few studies have objectively confirmed the effect of a brown-rice diet on glycemic control and metabolic parameters compared to a white-rice diet. The purpose of this study is to determine the effect of brown rice on improving glycemic control and metabolic parameters in prediabetes and type 2 diabetes. The researchers conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and controlled clinical trials. Methods PRISMA guidelines were used as the basis of this systematic review. Relevant studies were identified by searching the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (PubMed), as well as Epistemonikos for randomized controlled trials (RCTs) and controlled clinical trials published not later than January 2021 involving adults with prediabetes and diabetes mellitus who were consuming brown rice compared to those consuming white rice. The primary outcomes measured were glycated hemoglobin (HbA1c) and fasting blood glucose (FBG) levels. The secondary outcomes were body weight, waist circumference, systolic and diastolic blood pressure levels, LDL and HDL-cholesterol levels. The mean differences (MDs) with 95% confidence intervals (CIs) between brown and white-rice-diet groups were calculated using a random-effects model. Results Seven trials involving 417 adults with prediabetes or type 2 diabetes were included in this study. Brown-rice diet did not improve the glycemic control because it had no effect on the HbA1c level (p = 0.15) and the FBG level (p = 0.95) compared to white-rice diet. Brown-rice diet reduced body weight (p < 0.00001; MD −2.2 kg; 95% CI [−3.13 to −1.26]; I2 = 0%). However, it had no effect on the waist circumference (p = 0.09), systolic blood pressure (p = 0.60) and diastolic blood pressure level (p = 0.40). HDL-cholesterol level is increased in brown-rice diet (p = 0.01; MD 0.10, 95% CI [0.02 to 0.17]; I2 = 44%) but it had no effect on the LDL-cholesterol level (p = 0.81). Conclusions The available evidence indicated that consuming brown rice in substitute for white rice does not affect glycemic control (HbA1c and FBG levels) in pre-diabetes and type 2 diabetes patients. Brown rice, however, may be used as an alternative for white rice in such patients because it was found to reduce body weight and increase the HDL-cholesterol level. The benefits of a brown-rice diet on glycemic control may not be detected in short-term studies. The obtained evidence in this meta-analysis ranged from low to moderate quality. Thus, more high-quality trials with a larger sample size and a longer follow-up duration are needed to further investigate the effects of a brown-rice diet on diabetes glycemic control with stronger evidence. PROSPERO registration number: CRD42019143266

scholarly journals Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Sophie Bauer ◽  
Charlotte Wennberg Huldt ◽  
Kajsa P. Kanebratt ◽  
Isabell Durieux ◽  
Daniela Gunne ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Pancreatic Islets ◽  
Ex Vivo ◽  
Functional Coupling ◽  
Human Pancreatic Islets ◽  
Diabetes Model

scholarly journals PRM58 Long-Term Validation of the IMS CORE Diabetes Model in Type 1 and Type 2 Diabetes

2012 ◽  
Vol 15 (7) ◽  
pp. A470 ◽  
Author(s):  
V. Foos ◽  
J.L. Palmer ◽  
D. Grant ◽  
A. Lloyd ◽  
M. Lamotte ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Model

scholarly journals Significance of African Diets in Biotherapeutic Modulation of the Gut Microbiome

2021 ◽  
Vol 15 ◽  
pp. 117793222110126
Author(s):  
PO Isibor ◽  
PA Akinduti ◽  
OS Aworunse ◽  
JO Oyewale ◽  
O Oshamika ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Immune Cell ◽  
Inflammatory Responses ◽  
Brown Rice ◽  
Well Being ◽  
Population Characteristics ◽  
Sub Saharan Africa ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Diet plays an essential role in human development and growth, contributing to health and well-being. The socio-economic values, cultural perspectives, and dietary formulation in sub-Saharan Africa can influence gut health and disease prevention. The vast microbial ecosystems in the human gut frequently interrelate to maintain a healthy, well-coordinated cellular and humoral immune signalling to prevent metabolic dysfunction, pathogen dominance, and induction of systemic diseases. The diverse indigenous diets could differentially act as biotherapeutics to modulate microbial abundance and population characteristics. Such modulation could prevent stunted growth, malnutrition, induction of bowel diseases, attenuated immune responses, and mortality, particularly among infants. Understanding the associations between specific indigenous African diets and the predictability of the dynamics of gut bacteria genera promises potential biotherapeutics towards improving the prevention, control, and treatment of microbiome-associated diseases such as cancer, inflammatory bowel disease, obesity, type 2 diabetes, and cardiovascular disease. The dietary influence of many African diets (especially grain-base such as millet, maize, brown rice, sorghum, soya, and tapioca) promotes gut lining integrity, immune tolerance towards the microbiota, and its associated immune and inflammatory responses. A fibre-rich diet is a promising biotherapeutic candidate that could effectively modulate inflammatory mediators’ expression associated with immune cell migration, lymphoid tissue maturation, and signalling pathways. It could also modulate the stimulation of cytokines and chemokines involved in ensuring balance for long-term microbiome programming. The interplay between host and gut microbial digestion is complex; microbes using and competing for dietary and endogenous proteins are often attributable to variances in the comparative abundances of Enterobacteriaceae taxa. Many auto-inducers could initiate the process of quorum sensing and mammalian epinephrine host cell signalling system. It could also downregulate inflammatory signals with microbiota tumour taxa that could trigger colorectal cancer initiation, metabolic type 2 diabetes, and inflammatory bowel diseases. The exploitation of essential biotherapeutic molecules derived from fibre-rich indigenous diet promises food substances for the downregulation of inflammatory signalling that could be harmful to gut microbiota ecological balance and improved immune response modulation.

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