The Impact Of Dentistry On Recent Advances In The Management Of Hypertension-A Review

2020 ◽  
Vol 13 (01) ◽  
Keyword(s):  
Recent Advances ◽  
The Impact

scholarly journals Platelets in Healthy and Disease States: From Biomarkers Discovery to Drug Targets Identification by Proteomics

2020 ◽  
Vol 21 (12) ◽  
pp. 4541 ◽  
Author(s):  
Erica Gianazza ◽  
Maura Brioschi ◽  
Roberta Baetta ◽  
Alice Mallia ◽  
Cristina Banfi ◽  
...  
Keyword(s):  
Drug Targets ◽  
Disease Diagnosis ◽  
Post Translational Modifications ◽  
Disease States ◽  
Recent Advances ◽  
Health And Disease ◽  
Proteome Changes ◽  
Platelet Proteomics ◽  
The Impact ◽  
Platelet Functions

Platelets are a heterogeneous small anucleate blood cell population with a central role both in physiological haemostasis and in pathological states, spanning from thrombosis to inflammation, and cancer. Recent advances in proteomic studies provided additional important information concerning the platelet biology and the response of platelets to several pathophysiological pathways. Platelets circulate systemically and can be easily isolated from human samples, making proteomic application very interesting for characterizing the complexity of platelet functions in health and disease as well as for identifying and quantifying potential platelet proteins as biomarkers and novel antiplatelet therapeutic targets. To date, the highly dynamic protein content of platelets has been studied in resting and activated platelets, and several subproteomes have been characterized including platelet-derived microparticles, platelet granules, platelet releasates, platelet membrane proteins, and specific platelet post-translational modifications. In this review, a critical overview is provided on principal platelet proteomic studies focused on platelet biology from signaling to granules content, platelet proteome changes in several diseases, and the impact of drugs on platelet functions. Moreover, recent advances in quantitative platelet proteomics are discussed, emphasizing the importance of targeted quantification methods for more precise, robust and accurate quantification of selected proteins, which might be used as biomarkers for disease diagnosis, prognosis and therapy, and their strong clinical impact in the near future.

scholarly journals Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

2020 ◽  
Vol 45 (7) ◽  
pp. 1086-1096 ◽  
Author(s):  
Jonathan A. Hollander ◽  
Deborah A. Cory-Slechta ◽  
Felice N. Jacka ◽  
Steven T. Szabo ◽  
Tomás R. Guilarte ◽  
...  
Keyword(s):  
Environmental Exposures ◽  
Neuropsychiatric Disease ◽  
Recent Advances ◽  
The Impact ◽  
Looking Glass

scholarly journals The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry

2020 ◽  
Vol 37 (11) ◽  
pp. 1511-1531
Author(s):  
Zhi-Chen Wu ◽  
Dale L. Boger
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Medicinal Chemistry ◽  
Recent Advances ◽  
The Impact

This review summarizes and highlights recent advances in medicinal chemistry of natural products enabled by total synthesis that provide “supernatural products” with improved properties superseding the natural products themselves.

scholarly journals Artificial Intelligence: The Ambiguous Labor Market Impact of Automating Prediction

2019 ◽  
Vol 33 (2) ◽  
pp. 31-50 ◽  
Author(s):  
Ajay Agrawal ◽  
Joshua S. Gans ◽  
Avi Goldfarb
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Decision Making ◽  
Labor Market ◽  
Market Impact ◽  
Recent Advances ◽  
The Impact ◽  
Decision Tasks

Recent advances in artificial intelligence are primarily driven by machine learning, a prediction technology. Prediction is useful because it is an input into decision-making. In order to appreciate the impact of artificial intelligence on jobs, it is important to understand the relative roles of prediction and decision tasks. We describe and provide examples of how artificial intelligence will affect labor, emphasizing differences between when the automation of prediction leads to automating decisions versus enhancing decision-making by humans.

Measuring the Welfare Loss of Pension Mandates: A Methodology and Example

1985 ◽  
Vol 13 (1) ◽  
pp. 47-62
Author(s):  
Kathy Hayes ◽  
Shawna Grosskopf
Keyword(s):  
Approximation Method ◽  
Local Governments ◽  
Order Approximation ◽  
Second Order ◽  
Welfare Loss ◽  
Compensating Variation ◽  
Second Order Approximation ◽  
Price Distortion ◽  
Recent Advances ◽  
The Impact

In this article we employ recent advances in measuring consumer's surplus (and the related Hicksian compensation measures) to measure the impact of state mandates requiring local governments to establish minimum pensions for their employees. We measure the Hicksian compensating variation of the price distortion caused by such mandates and compare those losses to those calculated using a Harberger-type second-order approximation method.

Corticosteroids in ARDS: The Never-Ending Story

2007 ◽  
Vol 42 (8) ◽  
pp. 691-701 ◽  
Author(s):  
Zachariah Thomas ◽  
Katarzyna Kimborowicz
Keyword(s):  
Health Care ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Drug Therapy ◽  
Critically Ill ◽  
Economic Outcomes ◽  
Critically Ill Patient ◽  
Adult Intensive Care Unit ◽  
Recent Advances ◽  
The Impact

This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient — an area of health care that has become increasingly complex. Recent advances in drug therapy (including evolving and controversial data) for adult intensive-care-unit patients will be reviewed and assessed in terms of clinical, humanistic, and economic outcomes.

The Impact of Lossless Information on Algorithms

2014 ◽  
Vol 644-650 ◽  
pp. 1714-1716
Author(s):  
Xiao Peng Wang
Keyword(s):  
Information Retrieval ◽  
Fault Tolerance ◽  
Byzantine Fault Tolerance ◽  
Retrieval Systems ◽  
Byzantine Fault ◽  
Recent Advances ◽  
Information Retrieval Systems ◽  
Np Complete ◽  
The Impact ◽  
Pervasive Communication

Recent advances in semantic algorithms and pervasive communication are based entirely on the assumption that DHTs and hierarchical databases are not in conflict with write-back caches. Here, we argue the emulation of the partition table that would allow for further study into information retrieval systems. Our focus in this paper is not on whether the famous embedded algorithm for the study of e-business by Harris et al. is NP-complete, but rather on motivating an application for Byzantine fault tolerance (Mesophryon).

Behavioral Effects of ICU Medications

2005 ◽  
Vol 40 (5) ◽  
pp. 387-392
Author(s):  
Gil Fraser ◽  
Richard R. Riker
Keyword(s):  
Health Care ◽  
Drug Therapy ◽  
Critically Ill ◽  
Economic Outcomes ◽  
Behavioral Effects ◽  
Critically Ill Patient ◽  
Icu Patients ◽  
Recent Advances ◽  
The Impact

This feature examines the impact of pharmacologic interventions on the treatment of the critically ill patient — an area of health care that has become increasingly complex. Recent advances in drug therapy for adult ICU patients (including evolving and controversial data) will be reviewed and assessed in terms of clinical, humanistic, and economic outcomes. Direct questions or comments to Gil Fraser, PharmD, at [email protected] .

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