scholarly journals Can erythrocytes behavior in microcirculation help the understanding the physiopathology and improve prevention and treatment for covid-19?

2021 ◽  
pp. 1-7
Author(s):  
Paulo Luiz Farber
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
Drug Concentration ◽  
Blood Viscosity ◽  
Erythrocyte Deformability ◽  
Tissue Hypoxia ◽  
Erythrocyte Aggregation ◽  
Prevention And Treatment

Low plasma estrogens, vitamin D deficiency, obesity, diabetes, cardiovascular diseases, thromboembolism, and impaired microcirculation are linked to the severity of covid-19. Studies have suggested that these comorbidities also are related to erythrocyte factors linked to increased blood viscosity in microcirculation such as erythrocyte aggregation and erythrocyte deformability. Increased blood viscosity in microcirculation can lead to a decrease in oxygenation and nutrition of tissues. Therefore erythrocyte aggregation and erythrocyte deformability may be involved in covid-19 severity, leading to tissue hypoxia and a decrease of drug concentration in affected organs. If this relationship is demonstrated, erythrocytes factors can be used to monitor treatments for improve microcirculatory fluidity that may decrease covid-19 severity. Lifestyle improvement and treatments such as vitamin D and estrogens supplementation are some possible approaches to improve microcirculation and covid-19 prevention and treatment.

scholarly journals Guidelines on prevention and treatment of vitamin D deficiency

Reumatismo ◽  
2011 ◽  
Vol 63 (3) ◽  
Author(s):  
S. Adami ◽  
E. Romagnoli ◽  
V. Carnevale ◽  
A. Scillitani ◽  
A. Giusti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Prevention And Treatment

Vitamin D Deficiency and Cardiovascular Diseases

2020 ◽  
Vol 12 (1) ◽  
pp. 27-37
Author(s):  
Yifei Wang ◽  
Shi Zhou ◽  
Shuai Lei ◽  
Liying Hao ◽  
Deri Sun ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
Cardiovascular Events ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Hormone Effects ◽  
Peptide Expression ◽  
Novel Strategy ◽  
Underlying Mechanisms

In recent years, there are increasing evidences of epidemiology and clinic which indicate that vitamin D deficiency has relationship with cardiovascular disease. It was found the levels of vitamin D were negatively correlated with cardiovascular events such as hypertension, heart failure, atrial fibrillation and coronary heart disease. This article reviews the connection between cardiovascular diseases and vitamin D, and explains the underlying mechanisms including regulating renin-angiotensin system or endothelial function, inhibition of natriuretic peptide expression or the release of parathyroid hormone, effects on inflammation or obesity, bioenergetics, activation of extracellular Ca2+, inhibition of oxidative stress, and so on. These mechanisms provide novel strategy for the treatment of these cardiovascular diseases.

scholarly journals Vitamin D Deficiency and Cardiovascular Diseases

2018 ◽  
Author(s):  
Antonio José Lagoeiro Jorge ◽  
Jamerson Reis Cordeiro ◽  
Maria Luiza Garcia Rosa ◽  
Diego Braga Campos Bianchi
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency

scholarly journals Vitamin D, adipose tissue, and obesity

2013 ◽  
Vol 15 (3) ◽  
Author(s):  
Julie Marcotorchino ◽  
Franck Tourniaire ◽  
Jean-François Landrier
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Adipose Tissue ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
Epidemiological Studies ◽  
The Relationship ◽  
Diabetes And Obesity

AbstractEpidemiological studies have shown a link between vitamin D deficiency and numerous pathologies such as cancers, immunity diseases, cardiovascular diseases, hypertension, type 2 diabetes, and obesity. Recent studies in vitro and in animal models demonstrated an impact of vitamin D on adipose tissue and adipocyte biology. Such observations are of particular interest and provide mechanistic explanations on the relationship between vitamin D deficiency and obesity.

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