Dietary Lactoferrin Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in J20 Mice

2020 ◽  
Vol 74 (1) ◽  
pp. 245-259
Author(s):  
Mona Abdelhamid ◽  
Cha-Gyun Jung ◽  
Chunyu Zhou ◽  
Mohammad Abdullah ◽  
Manabu Nakano ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Amyloid Β

scholarly journals Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Andre F. Batista ◽  
Tayná Rody ◽  
Leticia Forny-Germano ◽  
Suzana Cerdeiro ◽  
Maria Bellio ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mitochondrial Dysfunction ◽  
Memory Impairment ◽  
Mitochondrial Dynamics ◽  
Interleukin 1 ◽  
Amyloid Β ◽  
Mitochondrial Fusion ◽  
Synapse Loss ◽  
Cynomolgus Macaques ◽  
The Impact

Abstract Background The lack of effective treatments for Alzheimer’s disease (AD) reflects an incomplete understanding of disease mechanisms. Alterations in proteins involved in mitochondrial dynamics, an essential process for mitochondrial integrity and function, have been reported in AD brains. Impaired mitochondrial dynamics causes mitochondrial dysfunction and has been associated with cognitive impairment in AD. Here, we investigated a possible link between pro-inflammatory interleukin-1 (IL-1), mitochondrial dysfunction, and cognitive impairment in AD models. Methods We exposed primary hippocampal cell cultures to amyloid-β oligomers (AβOs) and carried out AβO infusions into the lateral cerebral ventricle of cynomolgus macaques to assess the impact of AβOs on proteins that regulate mitochondrial dynamics. Where indicated, primary cultures were pre-treated with mitochondrial division inhibitor 1 (mdivi-1), or with anakinra, a recombinant interleukin-1 receptor (IL-1R) antagonist used in the treatment of rheumatoid arthritis. Cognitive impairment was investigated in C57BL/6 mice that received an intracerebroventricular (i.c.v.) infusion of AβOs in the presence or absence of mdivi-1. To assess the role of interleukin-1 beta (IL-1β) in AβO-induced alterations in mitochondrial proteins and memory impairment, interleukin receptor-1 knockout (Il1r1−/−) mice received an i.c.v. infusion of AβOs. Results We report that anakinra prevented AβO-induced alteration in mitochondrial dynamics proteins in primary hippocampal cultures. Altered levels of proteins involved in mitochondrial fusion and fission were observed in the brains of cynomolgus macaques that received i.c.v. infusions of AβOs. The mitochondrial fission inhibitor, mdivi-1, alleviated synapse loss and cognitive impairment induced by AβOs in mice. In addition, AβOs failed to cause alterations in expression of mitochondrial dynamics proteins or memory impairment in Il1r1−/− mice. Conclusion These findings indicate that IL-1β mediates the impact of AβOs on proteins involved in mitochondrial dynamics and that strategies aimed to prevent pathological alterations in those proteins may counteract synapse loss and cognitive impairment in AD.

scholarly journals Neutralization of IL‐17 rescues amyloid‐β‐induced neuroinflammation and memory impairment

2019 ◽  
Vol 176 (18) ◽  
pp. 3544-3557 ◽  
Author(s):  
Claudia Cristiano ◽  
Floriana Volpicelli ◽  
Pellegrino Lippiello ◽  
Benedetta Buono ◽  
Federica Raucci ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Amyloid Β

scholarly journals Steamed and Fermented Ethanolic Extract fromCodonopsis lanceolataAttenuates Amyloid-β-Induced Memory Impairment in Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Jin Bae Weon ◽  
Min Rye Eom ◽  
Youn Sik Jung ◽  
Eun-Hye Hong ◽  
Hyun-Jeong Ko ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
Morris Water Maze ◽  
Water Maze ◽  
Memory Impairment ◽  
Ache Activity ◽  
Amyloid Β ◽  
Bdnf Expression ◽  
Creb Phosphorylation ◽  
Avoidance Tests ◽  
Tof Ms

Codonopsis lanceolata(C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed and fermentedC. lanceolata(SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice. The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), and extracellular signal-regulated kinase (ERK) signaling in the hippocampus of mice to determine a possible mechanism for the cognitive-enhancing effect. Saponin compounds in SFC were identified by Ultra Performance Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS). SFC extract ameliorated amyloid-β-induced memory impairment in the Morris water maze and passive avoidance tests. SFC extract inhibited AChE activity and also significantly increased the level of CREB phosphorylation, BDNF expression, and ERK activation in hippocampal tissue of amyloid-β-treated mice. Lancemasides A, B, C, D, E, and G and foetidissimoside A compounds present in SFC were determined by UPLC-Q-TOF-MS. These results indicate that SFC extract improves Aβ-induced memory deficits and that AChE inhibition and CREB/BDNF/ERK expression is important for the effect of the SFC extract. In addition, lancemaside A specifically may be responsible for efficacious effect of SFC.

scholarly journals Minocycline reduces inflammatory parameters in the brain structures and serum and reverses memory impairment caused by the administration of amyloid β (1-42) in mice

2017 ◽  
Vol 77 ◽  
pp. 23-31 ◽  
Author(s):  
Michelle Lima Garcez ◽  
Francielle Mina ◽  
Tatiani Bellettini-Santos ◽  
Franciellen Gonçalves Carneiro ◽  
Aline Pereira Luz ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Amyloid Β ◽  
Brain Structures ◽  
Inflammatory Parameters ◽  
The Brain

Dopaminergic neurotransmission dysfunction induced by amyloid-β transforms cortical long-term potentiation into long-term depression and produces memory impairment

2016 ◽  
Vol 41 ◽  
pp. 187-199 ◽  
Author(s):  
Perla Moreno-Castilla ◽  
Luis F. Rodriguez-Duran ◽  
Kioko Guzman-Ramos ◽  
Alejandro Barcenas-Femat ◽  
Martha L. Escobar ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Amyloid Β ◽  
Long Term Potentiation ◽  
Long Term Depression ◽  
Dopaminergic Neurotransmission ◽  
Term Potentiation

scholarly journals Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Paula Maria Quaglio Bellozi ◽  
Isabel Vieira de Assis Lima ◽  
Juliana Guimarães Dória ◽  
Érica Leandro Marciano Vieira ◽  
Alline Cristina Campos ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Memory Impairment ◽  
Amyloid Β ◽  
Neuroprotective Effects

Echinacoside ameliorates the memory impairment and cholinergic deficit induced by amyloid beta peptides via the inhibition of amyloid deposition and toxicology

2017 ◽  
Vol 8 (6) ◽  
pp. 2283-2294 ◽  
Author(s):  
Young-Ji Shiao ◽  
Muh-Hwan Su ◽  
Hang-Ching Lin ◽  
Chi-Rei Wu
Keyword(s):  
Amyloid Beta ◽  
Memory Impairment ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Protective Effects ◽  
Neuronal Function ◽  
Amyloid Beta Peptides ◽  
Beta Peptides ◽  
Amyloid Cascade

This study investigates the role of the amyloid cascade and central neuronal function on the protective effects of echinacoside in amyloid β peptide 1-42 (Aβ 1-42)-treated SH-SY5Y cells and an Aβ 1-42-infused rat.

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