scholarly journals Potential Role of Clinical Trial Eligibility Criteria in Electronic Phenotyping

2021 ◽  
Author(s):  
Zhehuan Chen ◽  
Hao Liu ◽  
Alex Butler ◽  
Anna Ostropolets ◽  
Chunhua Weng
Keyword(s):  
Clinical Trial ◽  
Feature Selection ◽  
Potential Role ◽  
Lower Percentage ◽  
Eligibility Criteria ◽  
Study Results

2,719 distinctive phenotyping variables from 176 electronic phenotypes were compared with 57,150 distinctive clinical trial eligibility criteria concepts to assess the phenotype knowledge overlap between them. We observed a high percentage (69.5%) of eMERGE phenotype features and a lower percentage (47.6%) of OHDSI phenotype features matched to clinical trial eligibility criteria, possibly due to the relative emphasis on specificity for eMERGE phenotypes and the relative emphasis on sensitivity for OHDSI phenotypes. The study results show the potential of reusing clinical trial eligibility criteria for phenotyping feature selection and moderate benefits of using them for local cohort query implementation.

scholarly journals The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Okko Savonius ◽  
Irmeli Roine ◽  
Saeed Alassiri ◽  
Taina Tervahartiala ◽  
Otto Helve ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinases ◽  
Bacterial Meningitis ◽  
Confidence Interval ◽  
Potential Role ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Inflammatory Cascade ◽  
Disease Outcomes

Background. Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes. Methods. Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. Results. MPO correlated positively with MMP-8 (rho 0.496, P<0.001) and MMP-9 (rho 0.153, P=0.02) but negatively with TIMP-1 (rho -0.361, P<0.001). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8–12.9). Conclusions. CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.

Exploring the potential role of feature selection in global land-cover mapping

2016 ◽  
Vol 37 (23) ◽  
pp. 5491-5504 ◽  
Author(s):  
Le Yu ◽  
Haohuan Fu ◽  
Bo Wu ◽  
Nicolas Clinton ◽  
Peng Gong
Keyword(s):  
Feature Selection ◽  
Land Cover ◽  
Potential Role ◽  
Land Cover Mapping ◽  
Global Land Cover ◽  
Global Land

scholarly journals MiR-615 Agomir Encapsulated in Pluronic F-127 Alleviates Neuron Damage and Facilitates Function Recovery after Brachial Plexus Avulsion

2021 ◽  
Author(s):  
Kangzhen Chen ◽  
Lu Ding ◽  
Hua Shui ◽  
Yinru Liang ◽  
Xiaomin Zhang ◽  
...  
Keyword(s):  
Brachial Plexus ◽  
Upper Extremity ◽  
Potential Role ◽  
Functional Rehabilitation ◽  
Interacting Protein ◽  
Brachial Plexus Avulsion ◽  
Function Recovery ◽  
Study Results ◽  
Neuron Damage

Abstract Brachial plexus avulsion(BPA)is a devastating traumatic peripheral nerve injury complicated with paralysis of the upper extremity. We previously reported that leucine-rich repeat and immunoglobulin-like domain-containing NOGO receptor-interacting protein 1 (LINGO-1) has a potent role in inhibiting neuron survival and axonal regeneration after central nervous system (CNS) damage and miR-615 is a potential microRNA (miRNA) negatively regulated LINGO-1. However, the effect of miR-615 in BPA remains to be elucidated. Accumulating evidence indicates that pluronic F-127 (PF-127) hydrogel could serve as a promising vehicle for miRNA encapsulation. Thus, to further explore the potential role of hydrogel-miR-615 in BPA-reimplantation, the present study established the BPA rat model and injected miR-615 agomir encapsulated by PF-127 hydrogel into the reimplantation site using a microsyringe. In this study, results indicated that hydrogel-miR-615 agomir effectively alleviated motoneuron loss by LINGO-1 inhibition, promoted musculocutaneous nerve regeneration and myelination, reduced astrocytes activation, promoted angiogenesis and attenuated peripheral amyotrophy, leading to improved motor functional rehabilitation of the upper extremity. In conclusion, our findings demonstrate that miR-615-loaded PF-127 hydrogel may represent a novel therapeutic strategy for BPA treatment.

scholarly journals Modulation by Ozone Therapy of Oxidative Stress in Chemotherapy-Induced Peripheral Neuropathy: The Background for a Randomized Clinical Trial

2021 ◽  
Vol 22 (6) ◽  
pp. 2802
Author(s):  
Bernardino Clavo ◽  
Gregorio Martínez-Sánchez ◽  
Francisco Rodríguez-Esparragón ◽  
Delvys Rodríguez-Abreu ◽  
Saray Galván ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Peripheral Neuropathy ◽  
Potential Role ◽  
Ozone Therapy ◽  
Subsequent Increase ◽  
Action Mechanisms ◽  
Chronic Oxidative Stress

(1) Background: Chemotherapy-induced peripheral neuropathy (CIPN) decreases the quality of life of patients and can lead to a dose reduction and/or the interruption of chemotherapy treatment, limiting its effectiveness. Potential pathophysiological mechanisms involved in the pathogenesis of CIPN include chronic oxidative stress and subsequent increase in free radicals and proinflammatory cytokines. Approaches for the treatment of CIPN are highly limited in their number and efficacy, although several antioxidant-based therapies have been tried. On the other hand, ozone therapy can induce an adaptive antioxidant and anti-inflammatory response, which could be potentially useful in the management of CIPN. (2) Methods: The aims of this works are: (a) to summarize the potential mechanisms that could induce CIPN by the most relevant drugs (platinum, taxanes, vinca alkaloids, and bortezomib), with particular focus on the role of oxidative stress; (b) to summarize the current situation of prophylactic and treatment approaches; (c) to describe the action mechanisms of ozone therapy to modify oxidative stress and inflammation with its potential repercussions for CIPN; (d) to describe related experimental and clinical reports with ozone therapy in chemo-induced neurologic symptoms and CIPN; and (e) to show the main details about an ongoing focused clinical trial. (3) Results: A wide background relating to the mechanisms of action and a small number of experimental and clinical reports suggest that ozone therapy could be useful to prevent or improve CIPN. (4) Conclusions: Currently, there are no clinically relevant approaches for the prevention and treatment of stablished CIPN. The potential role of ozone therapy in this syndrome merits further research. Randomized controlled trials are ongoing.

scholarly journals Characterization of young graduates perceiving underemployement: Assessment of well-being and discomfort associated with this perception

2021 ◽  
Vol 24 (2) ◽  
pp. 23-34
Author(s):  
Juan Gabriel Ocampo-Palacio ◽  
Viviola Gómez Ortiz
Keyword(s):  
Job Satisfaction ◽  
Life Satisfaction ◽  
Comparative Study ◽  
Potential Role ◽  
Well Being ◽  
Psychological Well Being ◽  
Study Results ◽  
General Life Satisfaction

Previous research has shown that subjective underemployment is inversely associated to job satisfaction, psychological well-being and health. To our knowledge, the current is the first study that explores subjective underemployment in undergraduates in Colombia. One hundred and forty-two workers participated in a correlational, and comparative study. Results replicated previous findings: as subjective underemployment perception increased, job satisfaction and general life satisfaction decreased. Significant differences were found in the indicators of job satisfaction and general life satisfaction among those who perceive underemployment and those who do not. Finally, the potential role of subjective underemployment on employees’ health is discussed.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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