scholarly journals TREATMENT OF PATIENTS WITH THE CYCLE OF THE SUPERMONTAL ARM OF THE ONTOGENIC GENESIS

Author(s):  
Mohammed Rezmak ◽  
Liliya Krynychko ◽  
Alexander Naumenko

The maxillary sinus cysts are a fairly common pathology of the paranasal sinus system, which has a multifactorial etiology that continues to be actively investigated. In recent years, particular attention of researchers has focused on the role of chronic inflammation of the root of the teeth, which are directly adjacent to the lower wall of the maxillary sinus, and accordingly involve the surrounding structures in the pathological process. One of the objective indicators of the severity of inflammation is the level of matrix metalloproteinases, in particular matrix metalloproteinase 9 (MMP-9). Аs follows, the purpose of the study is to study of efficiency of treatment of patients with cystic sinus cysts of odontogenic origin in the long term. Materials and methods. The study included 150 patients. Group 1 - 125 people (age 20-69 years, men - 58, women - 67), group 2 - 25 patients (age 21-59 years, 11 men and 14 women). All patients from the examined groups underwent surgical treatment - removal of the cyst of the maxillary sinus through the lower nasal passage, with subsequent conservative treatment; patients of the first group in the postoperative period were audited channels of the teeth of the upper jaw with replacement of the filling material, and patients of the second group this intervention was not carried out. The inclusion criterion is an increase in the level of ММП-9 in saliva. The exclusion criteria were the presence of acute disease 3 months before surgery, treatment with the dentist 3 months before surgery, normal level of MMP-9 in saliva. In the course of preoperative preparation, all patients underwent CT scan of the paranasal sinuses, endoscopic examination of the nasal cavity and nasopharynx, rhinopneumometry, determination of the index of mucociliary clearance, activity of MMP-9 in saliva. The study of MMP-9 activity in saliva was performed using ELISA kit. Statistical data processing was performed using IBM SPSS Statistics 22. Conclusion. The level of ММР-9 in the saliva of patients of the first group was 1347 (± 328) ng / ml, the second - 1410 (± 220) ng / ml. The number of recurrences of sinus cyst in group 1 was 8, accounting for 6.4% of the total. Other complications include sinus mycetoma - 4 oroantral fistula - 1, hoonal polyp - 2.. The number of relapses of the sinus cyst in group 2 was 9 cases (36%), mycetoma of the sinus cyst - 3 cases, oroantral fistula - 1, hoonal polyp - 1. Conclusion. The results obtained indicate a higher likelihood of recurrence of the maxillary sinus cyst in the absence of a subsequent revision of the root of the teeth and around the root areas immediately adjacent to the lower sinus wall.

2021 ◽  
Vol 14 (5) ◽  
pp. e241487
Author(s):  
Lukas S Fiedler ◽  
Annette Wunsch

Ameloblastoma (AM) in the maxillary sinus is rare. This benign entity shows locally invasive, destructive and aggressive behaviour and a high rate of recurrence. Therefore, the course of treatment is radical resection. We report the case of a 38-year-old man presenting with signs of recurrent sinusitis in the Ear, Nose and Throat Department. Transnasal flexible endoscopy revealed a cystic mass in the right inferior and middle nasal passage. CT scan showed an obliterated right maxillary sinus with a ballooning effect and pressure atrophy of the lateral sinus wall, without possible differentiation of the middle and low nasal turbinate. The patient was treated with transnasal functional sinus surgery; pathology stated AM. AM in the maxillary sinus is rare, locally destructive and therefore as a gold standard is resected radically to prevent recurrence. We demonstrate a conservative approach; explicitly, we combined a transvestibular and functional endoscopic sinus surgery resection of the AM to maintain function and reduce the possibility of postoperative impairments. Whether the strategy of treatment for AM is conservative, it nonetheless can result in a recurrence-free status. Nevertheless, inclusion into an oncological follow-up-programme with regularly performed MRI and CT is recommended.


2003 ◽  
Vol 112 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Eric M. Genden ◽  
Patrick J. Gannon ◽  
Maria Deftereos ◽  
Shane Smith ◽  
Mark L. Urken

The inability to reconstruct extensive and often life-threatening tracheal defects is a clinical dilemma. The objective of this study was to achieve microvascular revascularization and transplantation of long-segment circumferential tracheal allografts in a canine model. Fifteen mongrel dogs were randomly assigned to 5 treatment groups. Twelve dogs underwent an excision of an 8-cm tracheal segment followed by transplantation and microvascular revascularization of an 8-cm cervical trachea allograft. Group 1 (n = 4) was treated with 10 mg/kg per day of cyclosporin A (CsA) and 7.5 mg/kg per day of mycophenolate mofetil (MM). Group 2 (n = 4) was treated with 5 mg/kg per day of CsA and 7.5 mg/kg per day of MM. Group 3 (n = 4) was treated with 2.5 mg/kg per day of CsA and 7.5 mg/kg per day of MM. Group 4 (n = 2) underwent an autograft tracheal transplant and received postoperative 2.5 mg/kg per day of CsA and 7.5 mg/kg per day of MM. Group 5 (n = 1) did not undergo surgery, but received postoperative 2.5 mg/kg per day of CsA and 7.5 mg/kg per day of MM. The animals were maintained for a duration of 30 days, during which time the graft was assessed by routine endoscopic examination and tracheal biopsies. Ex vivo, tracheal autografts were examined grossly for graft healing and microscopically for histologic architecture. The mean survival times were 13.25 days (group 1), 16 days (group 2), and 20 days (group 3). There was 1 early allograft failure secondary to microvascular thrombosis, and there were 4 delayed failures secondary to postoperative wound infections. Five dogs were euthanized before the end of the 30-day observation period because of failure to thrive or hypocalcemic tetany. None of the dogs in the study demonstrated endoscopic or histologic evidence of rejection before euthanasia. Postmortem examination of the surviving dogs demonstrated normal histologic architecture without evidence of rejection. For the first time, we have achieved allotransplantation of long tracheal segments based on the cranial thyroid artery and internal jugular vein. Minimal systemic immunosuppression appears to be associated with a higher survival rate and a lower complication rate.


2021 ◽  
pp. 38-42
Author(s):  
N.F. Zakharenko ◽  
S.I. Regeda ◽  
I.P. Manoliak ◽  
V.S. Solskyy

Research aim: to determine the clinical efficacy and safety of bioavailable curcumin Longimin® in the complex anti-relapse therapy of patients with extragenital endometriosis after surgery.Materials and methods. Study involved 45 women with a mean age of 29.3 ± 3.6 years with a diagnosis of extragenital endometriosis. After surgical treatment of this disease all patients were prescribed dienogest 2 mg/day for 6 months with anti-relapse purpose. After that, 22 patients did not receive drug treatment (group 1) and other 23 women started a six-month course of 400 mg bioavailable curcumin (group 2).Results. After 12 months of observation 3 cases (13.6%) of newly formed foci of endometriosis were found among patients of group 1, two of which were multi-endometriomas, and the third was retrocervical heterotopia. There were no signs of recurrence in the group of sequential use of dienogest and bioavailable curcumin. In addition, 6 months after completion of hormonal treatment the number of women with chronic pelvic pain in group 1 was increased and average score on a visual analogue scale (VAS) was increased by 80% (p ≤0.05). It was accompanied by a stable moderately high level of anxiety throughout the observation period. At the same time the number of women who complained of intermenstrual pain in group 2 decreased from 15 to 13, and the average VAS score decreased by 13% (p ≥0.05) during the treatment period. Patients in group 2 noted an improvement in emotional control during treatment, which resulted in the average score decrease on the scale of personal and situational anxiety of the Spielberg-Hanin's questionnaire (25% and 30% respectively, p ≤0.05).Conclusions. The nature of the endometriosis development and progression is multipathogenetic. Blocking only its hormonal link, especially in cases of extragenital forms, may not be sufficient to stop the pathological process and prevent recurrence in the long term. Оbtained results of sequential course of dienogest and bioavailable curcumin Longimin® with anti-relapse purpose showed the wider clinical effectiveness of this therapy, which is probably based on additional inhibition of systemic inflammation, proliferation, stroma and psychogenic component of disease.


2004 ◽  
Vol 30 (6) ◽  
pp. 376-383 ◽  
Author(s):  
Marco Degidi ◽  
Maurizio Piattelli ◽  
Antonio Scarano ◽  
Giovanna Iezzi ◽  
Adriano Piattelli

Abstract Bone substitutes should be used when sufficient amounts of autologous bone cannot be harvested from intraoral donor sites. P-15 is a highly conserved linear peptide with a 15 amino acid sequence identical to the sequence contained in the residues 766 to 780 of the alpha-chain of type I collagen. PepGen P-15 (Dentsply Friadent, Mannheim, Germany) is a combination of the mineral component of bovine bone (Osteograf/N 300) with P-15. Bio-Oss (Geistlich, Mannheim, Germany) is a deproteinized sterilized bovine bone with 75% to 80% porosity and a crystal size of approximately 10 μm in the form of cortical granules. The purpose of the present histological and histomorphometrical study was to compare maxillary sinus augmentation procedures in humans performed with PepGen P-15 with procedures associated with Bio-Oss and autologous bone. Seven patients participated in this study (3 men and 4 women; ages between 48 and 69 years, mean of 58 years) and were categorized into 3 groups. In group 1, a mixture of 50% autologous bone from an intraoral source and 50% Bio-Oss was used. In group 2, the graft materials used were 50% Bio-Oss and 50% PepGen P-15. In group 3, 50% autologous bone and 50% PepGen P-15 were used. Group 1 histomorphometry showed that the percentage of newly formed bone was 38.7% ± 3.2%, marrow spaces represented 45.6% ± 5%, and residual graft particles constituted the remaining 14.4% ± 2.1%. Group 2 histomorphometry showed that newly formed bone represented 36.7% ± 3.3%, marrow spaces represented 39.7% ± 3.4%, and residual graft particles represented 19.6% ± 2.1%. In group 3, newly formed bone represented 32.2% ± 3.2%, marrow spaces represented 38% ± 2.5%, and residual graft particles represented 28.8% ± 1.1%. Nonstatistically significant differences were found in the percentage of newly formed bone in the different groups (P = .360). Statistically significant differences were found in the percentage of residual graft materials among the different groups (group 1 vs groups 2 and 3) (P = .0001). These data demonstrate that the use of bone-replacement materials, without the addition of autologous bone, could be an alternative in sinus augmentation procedures. Such treatment would increase patient satisfaction, decrease surgical complications, and save the clinician substantial operating time.


2021 ◽  
Vol 23 (5) ◽  
pp. 1151-1164
Author(s):  
E. V. Bezrukova ◽  
E. V. Vorobeychikov ◽  
V. G. Konusova ◽  
A. V. Sosunov ◽  
M. M. Shamtsyan ◽  
...  

The task in treating acute nasopharyngitis (ANP) deals with reducing the disease symptoms and the risk of complications. The lack of reliable antiviral drugs makes it important to search for appropriate medicines among other pharmacotherapeutic groups.The study involves a comparative analysis of the efficiency and estimates potential: the recombinant interferon α2b and the compound containing fungal β-D-glucans used in treat ANPThe studies involved patients with ANP from 18 to 55 years old. As many as 152 people were examined including the following: 38 were practically healthy people (group 1); and 114 patients wuth ANP: 38 people (group 2) was subject to a standard therapy (vasoconstrictor nasal drops, nasal cavity irrigation using 0.1% Miramistine solution, gargling using the Furacilin solution); forty people (group 3) were administered application of intranasal interferon α2b of 105 IU, it was delivered with a spray into each nasal passage twice a day; 36 people (group 4) were administered an immunotropic drug containing β-D-glucans orally twice a day. The duration of drug administration lasted 7 days. Polymerase chain reaction (PCR) was used to identify the ANP etiological factor. Concentrations of cytokines IL-1β, IL-1ra were estimated using enzyme immunoassay (ELISA) technique. Clinical efficiency was assessed through score approach. The following symptoms were taken into account: general malaise, sore throat, character of nasal discharge, and the difficulty of nasal breathing. The results of the study were analyzed using parametric and nonparametric statistical methods. In 60.0% the nasal secretions of patients revealed RV. The distribution of cytokine concentrations in nasal secretions in group 1 indicated that the concentration of IL-1β was in the range of 20.0-25.0 pg/ml, and the concentration of IL-1ra was about 1250.0-2500.0 pg/ml. Developing ANP stimulated an increase in IL-1β concentration up to 30.0-70.0 pg/ml in nasal secretions of patients without affecting IL-1ra concentrations. On day 7 of treatment, the cytokine concentrations among the patients treated using the immunotropic drugs were the same as in the group of healthy individuals. There were no significant changes in cytokine production on day 7 in the group of patients undergoing the standard treatment. Application of proposed immunobiological medicines to ANP does not result in overproduction of proinflammatory cytokine IL-1β in nasal secretion. This confirms that these drugs are promising in the treating strategy including reduction of the risk of developing complications.


2021 ◽  
Vol 20 (2) ◽  
pp. 60-64
Author(s):  
Nurun Nahar ◽  
Tareq Hassan ◽  
Mohammed Kamal Uddin

Background: Giomer is a unique class of restorative material has been introduced as the true hybridization of Glass Ionomer (GI) and composite resin and has the distinguishing feature of a stable surface pre-reacted glass ionomer. Glass Ionomer Cements (GIC) are also unique restorative materials with many uses in clinical practice and provide for caries-protective fluoride releasing at the margins of restorations, as well as their ability to have the fluoride within their chemical matrix recharged by outside exposure to other fluoride-containing materials. The present study aim at clinically evaluate the comparison between the glass Ionomer cement and Giomer for the management of cervical caries. Materials and methods: The study was a cross sectional comparative study which was carried out from 01 December 2018 to 31 November 2019 in the Department of Conservative Dentistry and Endodontics, Bangladesh Dental College, Dhanmondi, Dhaka. Total number of cases was 80. The patients were divided into two groups, half of the patient (Group-1) was treated with Glass Ionomer cement and half of the patient (Group-2) was treated with Giomer restoration. The post-operative sensitivity discoloration, dislodgement of filling material and secondary caries formation were recorded. All the patients were assigned and the data were analyzed statistically by SPSS version 21. p-value < 0.05 was taken as significant. Results: The study reveals 60% of the study population was within 41 to 50 years of age group (Group-1) and 62.5% were 51 to 60 years (Group-2) 45% in (Group-1) and 10% in (Group-2) had history of post filling sensitivity, 12% in (Group-1) and 5% in (Group-2) had discoloration after restoration, 2.5% had history of dislodgement of the filling in (Group-1), no history of dislodgement of the filling in (Group-2), 2.5% had history of secondary caries formation in (Group-1) and no history of Secondary caries formation in (Group-2). Conclusion: Patients were more approachable for Giomer restoration than Glass ionomer for the management of cervical caries over a period of 12 month. Chatt Maa Shi Hosp Med Coll J; Vol.20 (2); July 2021; Page 60-64


2010 ◽  
Vol 11 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Ahmed M. Al-Kahtani ◽  
Hussam Al-Fawaz ◽  
Mohammed Al-Sarhan ◽  
Khalil Al-Ali

Abstract Objectives The aim of this study was to evaluate the fracture resistance of endodontically treated teeth filled with a resin-based obturation material using two different chelating agents. Methods and Materials Forty extracted singlecanal human teeth were prepared, instrumented, and randomly divided into three groups: Group 1 (n=15) received a final flush with 10 ml of neutralized 17% EDTA, followed by 10 ml of sodium hypochlorite (NaOCl), then obturated using lateral condensation with RealSeal. Group 2 (n=15) received a final flush of BioPure™ MTAD™, followed by 10 ml of NaOCl, then obturated using lateral condensation with RealSeal. Group 3, the control group (n=10), was instrumented but not obturated, then the root canal opening was sealed with a temporary filling material. The specimens were stored in 100% humidity for 10 days, mounted in polyester resin, and loaded to failure. Results The ANOVA revealed a significant difference between the control group and the experimental groups, although there was no statistically significant difference between Group 1 and Group 2 (p=0.05). The MTAD group displayed higher mean fracture load values than the EDTA group. Conclusions It can be concluded that filling the root canals with RealSeal™ increased the in vitro resistance to fracture of single-canal extracted human teeth when compared to instrumented and unobturated teeth. Teeth treated with MTAD demonstrated high fracture-resistance values when compared to teeth treated with 17% EDTA, but they were not statistically significant. Citation Al-Kahtani AM, Al-Fawaz H, Al-Sarhan


Author(s):  
CELINE MARISSA ◽  
MUNYATI USMAN ◽  
ENDANG SUPRASTIWI ◽  
ANITA ERDIANI ◽  
RATNA MEIDYAWATI

Objective: The main objective of endodontic treatment is to remove microorganisms from the root canal space and prevents reinfection. Deep penetration of the dentinal tubule is advantageous because it increases the contact area between the root canal filling material and dentin, thereby increasing the sealing quality of the entire root canal system. Bioceramic sealers are biocompatible, nontoxic, non-shrinking, hydrophilic, and stable, do not expand during setting, and can form hydroxyapatite, which then forms chemical bonds with dentin to compare the abilities of three types of bioceramic-based sealers to penetrate the dentinal tubules.Methods: Obturation used three types of bioceramic sealers. Group 1 (calcium phosphate silicate), Group 2 (a mixture of tricalcium silicate and resin), and Group 3 (pure tricalcium silicate) were observed using a scanning electron microscope and measurement of the penetration distance with ImageJ.Results: The bioceramic sealers had statistically significant differences in penetration distance into dentinal tubules (p’s<0.001). The mean penetration value of Group 1 (calcium phosphate silicate) was 115.99 μm, Group 2 (a mixture of tricalcium silicate and resin) was 209.28 μm, and Group 3 (pure tricalcium silicate) was 84.07 μm.Conclusion: Although all three bioceramic sealers penetrated the dentinal tubules, they exhibited differences in their penetration capabilities. Group 2 had the deepest penetration, likely due to the resin content.


2002 ◽  
Vol 45 (4) ◽  
pp. 167-171 ◽  
Author(s):  
Samer Kasabah ◽  
Antonín Šimůnek ◽  
Jiří Krug ◽  
Miguel Cevallos Lecaro

The objective of this clinical study was to determine the predictability of endosseous implant placed in a maxillary sinus augmented with deproteinized bovine bone (Bio-Oss®). A total of 185 implants (109 titanium and 76 hydroxyapatite- coated) were placed in 77 patients representing 92 sinuses either a one- or two-stage surgical technique. A mixture of venous patient’s blood and Bio-Oss® was used alone within 20 sinuses (Group 1), or in combination with autogenous bone within 72 sinuses (Group 2). Thirty-nine implants were placed in Group 1 and 147 implants were inserted in Group 2. The grafted sinuses were evaluated clinically and radiographically at second stage surgery. According to certain criteria, of the implants placed, only two titanium implants (1.08 %) failed with 98.91 % implant survival. There was no statistically variable difference for the use of hydroxyapatite-coated or titanium implants. The two failed implants were from Group 2. No clinical benefit has been achieved from the combination with autogenous bone (P<0.05). All the grafted sinuses were sufficient to place dental implants of at least 12 mm length (100 % graft success). The results of this short-term study support the hypothesis that Bio-Oss® can be a suitable material for sinus augmentation.


2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Mustaffa M ◽  
Nordin N ◽  
Embong SNH ◽  
Mohd Ibrahim MS

INTRODUCTION: This study compared the obturated surface area, the extrusion of root filling material beyond the apical foramen and the duration of obturation procedure in single-rooted mandibular premolar using monocone obturation technique. MATERIALS AND METHODS: The root canal of twenty single-rooted mandibular premolars were prepared, and then divided into two groups; Group 1 (GuttaFlow Bioseal (GFB) and a gutta-percha (GP) cone) and Group 2 (RoekoSeal Automix root canal sealer and a GP cone). The obturation procedure was timed and the obturation radiograph was taken after the procedure. The roots were sectioned perpendicularly and the surfaces were observed under scanning electron microscope. The images were transferred to the SketchAndCalc Area Calculator software for evaluation of the obturated surface area. RESULTS: The median score of obturated surface area in Group 1 and 2 at the apical was 86.51 and 83.00, at the middle was 90.48 and 87.35 and at the coronal was 93.00 and 83.39, respectively. The extrusion of root filling material between two groups did not show statistically significant difference. The mean duration of obturation in Group 1 and 2 was 149.50 and 137.60, respectively. CONCLUSIONS: The obturated surface area at the apical and middle root regions in Group 1 and 2 was comparable but at the coronal region, Group 1 showed 11.5% better coverage. The extrusion of root filling material in Group 1 and 2 was equivalent. Obturation procedure in Group 1 took 8.6% longer than in the Group 2.


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