scholarly journals Pitavastatin Calcium

2020 ◽  
Author(s):  
Keyword(s):  
Pitavastatin Calcium

Ultra-High Performance Method on Superficially Porous Stationary Phase for the Determination of Related Substances in Pitavastatin Calcium by HPLC

2015 ◽  
Vol 78 (15-16) ◽  
pp. 1017-1029 ◽  
Author(s):  
B. Hariram ◽  
R. Suresh Kumar ◽  
Anireddy Jaya Shree ◽  
Dama Venugopala Rao ◽  
L. Kalyanaraman ◽  
...  
Keyword(s):  
Stationary Phase ◽  
High Performance ◽  
Related Substances ◽  
Pitavastatin Calcium

Development of simple spectrophotometry method to determinate pitavastatin calcium in bulk and pharmaceutical preparations

2020 ◽  
Vol 13 (12) ◽  
pp. 6206-6211
Author(s):  
Nazira Sarkis ◽  
Saad Antakli ◽  
Rita Keshishian
Keyword(s):  
Pharmaceutical Preparations ◽  
Pitavastatin Calcium

scholarly journals LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin therapy on bioactive lipids and dense LDL

2020 ◽  
Vol 61 (6) ◽  
pp. 911-932 ◽  
Author(s):  
M. John Chapman ◽  
Alexina Orsoni ◽  
Ricardo Tan ◽  
Natalie A. Mellett ◽  
Anh Nguyen ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Statin Therapy ◽  
Single Phase ◽  
Cardiometabolic Risk ◽  
Plasma Concentrations ◽  
Statin Treatment ◽  
Atherogenic Dyslipidemia ◽  
Bioactive Lipids ◽  
Ldl Particles ◽  
Pitavastatin Calcium

Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDL subclasses, and thus potential atherogenicity? What is the effect of statin treatment? Obese hypertriglyceridemic hypercholesterolemic males [n = 12; lipoprotein (a) <10 mg/dl] received pitavastatin calcium (4 mg/day) for 180 days in a single-phase unblinded study. The lipidomic profiles (23 lipid classes) of five LDL subclasses fractionated from baseline and post-statin plasmas were determined by LC-MS. At baseline and on statin treatment, very small dense LDL (LDL5) was preferentially enriched (up to 3-fold) in specific lysophospholipids {LPC, lysophosphatidylinositol (LPI), lysoalkylphosphatidylcholine [LPC(O)]; 9, 0.2, and 0.14 mol per mole of apoB, respectively; all P < 0.001 vs. LDL1-4}, suggesting elevated inflammatory potential per particle. In contrast, lysophosphatidylethanolamine was uniformly distributed among LDL subclasses. Statin treatment markedly reduced absolute plasma concentrations of all LDL subclasses (up to 33.5%), including LPC, LPI, and LPC(O) contents (up to −52%), consistent with reduction in cardiovascular risk. Despite such reductions, lipotoxic ceramide load per particle in LDL1-5 (1.5–3 mol per mole of apoB; 3–7 mmol per mole of PC) was either conserved or elevated. Bioactive lipids may constitute biomarkers for the cardiometabolic risk associated with specific LDL subclasses in atherogenic dyslipidemia at baseline, and with residual risk on statin therapy.

scholarly journals Method Development and Validation of Pitavastatin Calcium and its Degradation Behavior under varied Stress Conditions by UV Spectrophotometric methods

2019 ◽  
Vol 18 (2) ◽  
pp. 159-169
Author(s):  
S Niranjani ◽  
K Venkatachalam
Keyword(s):  
Method Development ◽  
Correlation Coefficients ◽  
Pharmaceutical Formulations ◽  
Stability Study ◽  
Control Analysis ◽  
Pharmaceutical Dosage Forms ◽  
Spectrophotometric Methods ◽  
Ich Guidelines ◽  
Pitavastatin Calcium ◽  
Development And Validation

UV spectrophotometric methods for the determination of pitavastatin calcium in pure and pharmaceutical dosage forms were developed and validated as per ICH guidelines. The standard pitavastatin calcium solutions were scanned between the ranges of 200-400 nm. The maximum absorbance of pitavastatin calcium in DMF (method A), HCl (method B) and NaOH (method C) was recorded at 266 nm. They obeyed Beers law concentration in the range of 10-45 μg/ml (method A), 0.25-2.0 μg/ml (method B) and 0.25-2.0 μg/ml (method C) with correlation coefficients 0.9996, 0.9998 and 0.9998 respectively. Stability study showed high stability of pitavastatin calcium in acidic, alkaline medium and at high temperature, but undergone degradation in oxidative stress condition. The developed methods were validated for linearity, precision, accuracy, LOD, LOQ, ruggedness, robustness and recovery studies. The proposed methods can be successfully used for the routine quality control analysis of pitavastatin calcium in bulk and commercial pharmaceutical formulations. Dhaka Univ. J. Pharm. Sci. 18(2): 159-169, 2019 (December)

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction

2015 ◽  
Vol 13 (38) ◽  
pp. 9813-9819 ◽  
Author(s):  
Fangjun Xiong ◽  
Haifeng Wang ◽  
Lingjie Yan ◽  
Lingjun Xu ◽  
Yuan Tao ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Addition Reaction ◽  
Diastereoselective Synthesis ◽  
Michael Addition Reaction ◽  
Two Component ◽  
Pitavastatin Calcium

An efficient and concise asymmetric synthesis of pitavastatin calcium (1) starting from commercially available (S)-epichlorohydrin is described.

scholarly journals Adaptation of Color Reactions for Spectrophotometric Determination of Pitavastatin Calcium in Bulk Drugs and in Pharmaceutical Formulations

2007 ◽  
Vol 4 (2) ◽  
pp. 272-278 ◽  
Author(s):  
Marothu Vamsi Krishna ◽  
Dannana Gowri Sankar
Keyword(s):  
Cost Effective ◽  
Pharmaceutical Formulations ◽  
Reagent Blank ◽  
Colored Complex ◽  
Spectrophotometric Methods ◽  
Experimental Parameters ◽  
The Mean ◽  
Pitavastatin Calcium ◽  
Color Reactions

Three simple, sensitive and cost effective Spectrophotometric methods are described for the determination of pitavastatin calcium (PST) in bulk drugs and in pharmaceutical formulations. These methods are based on the oxidation of PST by ferric chloride in presence ofo-phenanthroline (Method A) or 2, 2’ bipyridyl (Method B) or potassium ferricyanide (Method C). The colored complex formed was measured at 510, 530 and 755 nm for method A, B and C respectively against the reagent blank prepared in the same manner. The optimum experimental parameters for the color production are selected. Beer’s law is valid with in a concentration range of 4-20 μg mL-1for method A, 7.5-37.5 μg mL-1for method B and 5 -25 μg mL-1for method C. For more accurate results, ringbom optimum concentration ranges are 5-18 μg mL-1for method A , 8.5-35.5 μg mL-1for method B and 6.0-23.0 μg mL-1for method C. The molar absorptivities are 3.55x104, 2.10x104and 3.10x104L mol-1cm-1. Where as sandell sensitivities are 0.024, 0.041 and 0.028 μg cm-22 for method A, B and C respectively. The mean percentage recoveries are 99.95 for method A, 101.35 for method B and 100.33 for method C. The developed methods were applied for the determination of PST in bulk powder and in the pharmaceutical formulations without any interference from tablet excipients.

Determination and Quantification of Pitavastatin Calcium in Tablet Dosage Formulation by HPTLC Method

2007 ◽  
Vol 40 (14) ◽  
pp. 2625-2632 ◽  
Author(s):  
Satheesh N. Kumar ◽  
J. Baghyalakshmi
Keyword(s):  
Pitavastatin Calcium ◽  
Tablet Dosage ◽  
Hptlc Method ◽  
Dosage Formulation

scholarly journals COMPARATIVE STUDY OF RP-HPLC METHOD VERSUS FOURIER TRANSFORM CONVOLUTION CHEMOMETRIC METHODS; AN APPLICATION ON PHARMACEUTICAL BINARY MIXTURES OF CANDESARTAN CILEXETIL-PITAVASTATIN CALCIUM AND CLOPIDOGREL BISULFATE-ROSUVASTATIN CALCIUM

2016 ◽  
Vol 8 (10) ◽  
pp. 125 ◽  
Author(s):  
Marwa K. El Jamal ◽  
Azza A. Gazy
Keyword(s):  
Fourier Transform ◽  
Comparative Study ◽  
Binary Mixtures ◽  
Candesartan Cilexetil ◽  
Hplc Method ◽  
Dihydrogen Phosphate ◽  
Clopidogrel Bisulfate ◽  
Rp Hplc ◽  
Pitavastatin Calcium ◽  
Rosuvastatin Calcium

<p><strong>Objective: </strong>A comparative study of smart spectrophotometric chemometric assisted techniques and RP-HPLC for the determination of candesartan cilexetil (CAN)-pitavastatin calcium (PIT) and clopidogrel bisulfate (CLO)-rosuvastatin calcium (ROS), binary co-administered drugs were developed and validated.</p><p><strong>Methods: </strong>The spectrophotometric chemometric assisted methods included two simple techniques, namely Fourier transform convolution (FF) and ratio spectra of Fourier transform convolution (FFR) methods. FFR is considered as a hybrid divisor ratio spectra method where Fourier functions are applied to divisor ratio signals. The RP-HPLC method involves a rapid separation on a C<sub>18 </sub>column using a mobile phase consisting of acetonitrile: sodium dihydrogen phosphate (adjusted to pH 2.6 using orthophosphoric acid) in the ratio of 70:30 v/v at a flow rate of 1 ml/min in isocratic mode. CLO and ROS were monitored at 220 nm however CAN and PIT were monitored at 238 nm.</p><p><strong>Results: </strong>The spectrophotometric chemometric assisted methods proved their ability to quantify each of the studied drugs in their binary mixtures, where excellent percentage recoveries were obtained. FF and FFR method proved to be linear over the concentration range of 10-50 µg/ml for CLO, 4-20 µg/ml for ROS, 8-20 µg/ml for CAN and 2-10 µg/ml for PIT. The RP-HPLC method was able to separate the drugs in the study; retention times were found to be 3.9 min and 14.4 min for ROS-CLO, 4.2 min and 14.5 min for PIT-CAN respectively. The RP-HPLC method was found to be linear in the concentration range of 0.1-0.5 µg/ml for CLO, 0.04-0.2 µg/ml for ROS, 0.5-1 µg/ml for CAN and 0.05-0.1 µg/ml for PIT. System suitability parameters proved that peaks were well resolved from each other.</p><p><strong>Conclusion: </strong>The spectrophotometric and chromatographic methods were validated according to ICH guidelines. Recovery was found to be in the range of 95.9 %-100.5 % in synthetic laboratory mixtures. The suggested spectrophotometric methods have the advantage over other methods that they do not require a preliminary separation. Statistical analysis between the suggested spectrophotometric chemometric assisted and RP-HPLC methods, using student’s t-and F-test revealed that there is no difference between the applied methods.</p>

Sign in / Sign up

Export Citation Format

Share Document