scholarly journals Cystatin Family Gene

2020 ◽  
Author(s):  
Keyword(s):  
Family Gene ◽  
Cystatin Family

Kinase Family Gene

2020 ◽  
Author(s):  
Keyword(s):  
Kinase Family ◽  
Family Gene

Kininogen Family Gene

2020 ◽  
Author(s):  
Keyword(s):  
Family Gene

scholarly journals A Novel Cysteine Protease Inhibitor of Naegleria fowleri That Is Specifically Expressed during Encystation and at Mature Cysts

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 388
Author(s):  
Hương Giang Lê ◽  
A-Jeong Ham ◽  
Jung-Mi Kang ◽  
Tuấn Cường Võ ◽  
Haung Naw ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Expression Profiles ◽  
Critical Role ◽  
Cyst Formation ◽  
Cysteine Proteases ◽  
Cysteine Protease Inhibitor ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri ◽  
Cystatin Family

Naegleria fowleri is a free-living amoeba that is ubiquitous in diverse natural environments. It causes a fatal brain infection in humans known as primary amoebic meningoencephalitis. Despite the medical importance of the parasitic disease, there is a great lack of knowledge about the biology and pathogenicity of N. fowleri. In this study, we identified and characterized a novel cysteine protease inhibitor of N. fowleri (NfCPI). NfCPI is a typical cysteine protease inhibitor belonging to the cystatin family with a Gln-Val-Val-Ala-Gly (QVVAG) motif, a characteristic motif conserved in the cystatin family of proteins. Bacterially expressed recombinant NfCPI has a dimeric structure and exhibits inhibitory activity against several cysteine proteases including cathespin Bs of N. fowleri at a broad range of pH values. Expression profiles of nfcpi revealed that the gene was highly expressed during encystation and cyst of the amoeba. Western blot and immunofluorescence assays also support its high level of expression in cysts. These findings collectively suggest that NfCPI may play a critical role in encystation or cyst formation of N. fowleri by regulating cysteine proteases that may mediate encystation or mature cyst formation of the amoeba. More comprehensive studies to investigate the roles of NfCPI in encystation and its target proteases are necessary to elucidate the regulatory mechanism and the biological significance of NfCPI.

TNF Family Gene Polymorphisms (TNF –308G/A and LTA +252A/G) and Alcoholic Liver Disease

2004 ◽  
Vol 38 (6) ◽  
pp. 865-867
Author(s):  
Z. A. Shangareeva ◽  
T. V. Viktorova ◽  
A. F. Sagidullin
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Gene Polymorphisms ◽  
Family Gene

scholarly journals Structure of the murine serum amyloid A gene family. Gene conversion.

1986 ◽  
Vol 261 (18) ◽  
pp. 8442-8452 ◽  
Author(s):  
C A Lowell ◽  
D A Potter ◽  
R S Stearman ◽  
J F Morrow
Keyword(s):  
Gene Family ◽  
Gene Conversion ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Family Gene

scholarly journals Association of Interleukin-6 and Interleukin-1 Family Gene Polymorphisms in Autoimmune Hepatitis

2018 ◽  
Vol 17 (6) ◽  
pp. 1021-1025 ◽  
Author(s):  
Azizollah Yousefi ◽  
Mehri Najafi ◽  
Farzaneh Motamed ◽  
Elham Mahmoudi ◽  
Alireza Zare Bidoki ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Interleukin 1 ◽  
Family Gene

scholarly journals Genome-wide characterization of MATE gene family and expression profiles in response to abiotic stresses in rice (Oryza sativa)

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhixuan Du ◽  
Qitao Su ◽  
Zheng Wu ◽  
Zhou Huang ◽  
Jianzhong Bao ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Gene Family ◽  
Tandem Repeats ◽  
Expression Profiles ◽  
Functional Divergence ◽  
Expression Patterns ◽  
Regulatory Elements ◽  
Genome Wide ◽  
Comprehensive Information ◽  
Family Gene

AbstractMultidrug and toxic compound extrusion (MATE) proteins are involved in many physiological functions of plant growth and development. Although an increasing number of MATE proteins have been identified, the understanding of MATE proteins is still very limited in rice. In this study, 46 MATE proteins were identified from the rice (Oryza sativa) genome by homology searches and domain prediction. The rice MATE family was divided into four subfamilies based on the phylogenetic tree. Tandem repeats and fragment replication contribute to the expansion of the rice MATE gene family. Gene structure and cis-regulatory elements reveal the potential functions of MATE genes. Analysis of gene expression showed that most of MATE genes were constitutively expressed and the expression patterns of genes in different tissues were analyzed using RNA-seq. Furthermore, qRT-PCR-based analysis showed differential expression patterns in response to salt and drought stress. The analysis results of this study provide comprehensive information on the MATE gene family in rice and will aid in understanding the functional divergence of MATE genes.

scholarly journals Comprehensive analysis of cystatin family genes suggests their putative functions in sexual reproduction, embryogenesis, and seed formation

2014 ◽  
Vol 65 (17) ◽  
pp. 5093-5107 ◽  
Author(s):  
Peng Zhao ◽  
Xue-mei Zhou ◽  
Jie Zou ◽  
Wei Wang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Sexual Reproduction ◽  
Comprehensive Analysis ◽  
Seed Formation ◽  
Cystatin Family
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