scholarly journals Partial Morphologic Response

2020 ◽  
Author(s):  
Keyword(s):  



1974 ◽  
Vol 3 (1) ◽  
pp. 109-126
Author(s):  
JAMES S. STEWART
Keyword(s):  


Blood ◽  
1970 ◽  
Vol 35 (4) ◽  
pp. 496-505 ◽  
Author(s):  
PETER R. DALLMAN ◽  
JOSEPH R. GOODMAN

Abstract Marked enlargement of the mitochondrial compartment is present in heart muscle, liver, and erythroblasts of iron- and copper-deficient rats. Mitochondria are increased in size, and may also be increased in number, particularly in heart muscle and erythroid cells. The enlarged mitochondria are more electron-lucent and in the hepatocyte may have sparser packing of cristae than in animals on a complete diet. Morphologic changes in the erythroid percursors of three iron-deficient patients are similar to those observed in the experimental animal. The morphologic response is not attributable to anemia or inanition but appears more specifically related to the lack of trace metals or cofactors required for the synthesis of certain mitochondrial enzymes.



2020 ◽  
Vol 8 (10) ◽  
pp. 829
Author(s):  
Rangley C. Mickey ◽  
Patricia S. Dalyander ◽  
Robert McCall ◽  
Davina L. Passeri

Antecedent topography is an important aspect of coastal morphology when studying and forecasting coastal change hazards. The uncertainty in morphologic response of storm-impact models and their use in short-term hazard forecasting and decadal forecasting is important to account for when considering a coupled model framework. This study provided a methodology to investigate uncertainty of profile response within the storm impact model XBeach related to varying antecedent topographies. A parameterized island Gaussian fit (PIGF) model generated an idealized baseline profile and a suite of idealized profiles that vary specific characteristics based on collated observed LiDAR data from Dauphin Island, AL, USA. Six synthetic storm scenarios were simulated on each of the idealized profiles with XBeach in both 1- and 2-dimensional setups and analyzed to determine the morphological response and uncertainty related to the varied antecedent topographies. Profile morphologic response tends to scale with storm magnitude but among the varied profiles there is greater uncertainty in profile response to the medium range storm scenarios than to the low and high magnitude storm scenarios. XBeach can be highly sensitive to morphologic thresholds, both antecedent and time-varying, especially with regards to beach slope.





1981 ◽  
Vol 40 (3) ◽  
pp. 230-246 ◽  
Author(s):  
DENNIS E. BULLARD ◽  
SANDRA H. BIGNER ◽  
DARELL D. BIGNER


2011 ◽  
Vol 1 (32) ◽  
pp. 89 ◽  
Author(s):  
Mohamed A Dabees ◽  
Brett D Moore

This paper describes numerical modeling of long-term evolution of inlet systems in southwest and central Florida. The paper discusses a general methodology developed following four case studies and application to the case study of Gordon Pass in southwest Florida. The case study of Gordon Pass demonstrates the importance of considering large temporal and spatial scales in evaluating morphologic response to inlet management practices. The results describe the evolution of Gordon Pass from 1930 to present. The analysis begins with natural conditions that existed before dredging or inlet modifications and investigates how inlet evolution can be influenced by navigation improvements and provide tools to evaluate alternatives.



Author(s):  
JACQUELYN R. OVERBECK ◽  
JOSEPH W. LONG ◽  
HILARY F. STOCKDON ◽  
JUSTIN J. BIRCHLER


2020 ◽  
Vol 20 (2) ◽  
pp. e66-e75 ◽  
Author(s):  
Eytan M. Stein ◽  
Courtney D. DiNardo ◽  
Daniel A. Pollyea ◽  
Andre C. Schuh


2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 743-743
Author(s):  
Satoshi Yuki ◽  
Hiroshi Nakatsumi ◽  
Hideyuki Hayashi ◽  
Hiraku Fukushima ◽  
Takashi Kato ◽  
...  

743 Background: It was reported that an optimal morphologic response to preoperative chemotherapy was associated with better overall survival (OS) in patients (pts) with colorectal liver metastases (CLM). We investigated association of morphologic response with progression free survival (PFS) in pts with unresectable CLM from HGCSG0802 observational cohort study in pts with mCRC treated with first-line bevacizumab (BV)-based chemotherapy. Methods: The objective of HGCSG0802 was to evaluate PFS, OS, time to treatment failure (TTF), response rate (RR), safety, etc. The key eligibility criteria were evaluable lesions, older than 20 years old, ECOG PS 0-2. Pts with CLM underwent contrast-enhanced CT at the start and every 8-weeks of BV-based chemotherapy. In this analysis, three blinded, independent radiologists evaluated images for morphologic response, based on metastases changing from heterogeneous masses with ill-defined margins into homogeneous hypoattenuating lesions with sharp borders. Association of morphologic response and pts characteristics, RR, and PFS were evaluated. PFS was analyzed with Kaplan-Meier method, log-rank test, and Cox proportional hazards model. Results: Of 108 pts (the full analysis set), 73 pts with CLM were evaluable for morphologic criteria. Eighteen pts (24.7%) had optimal morphologic response (OR), 31 (42.5%) had incomplete (IR), and 24 (32.9%) had no response (NR). The pts characteristics between those with OR, IR and NR were generally balanced. The median TTF was 7.2 months in NR versus 7.2 months in IR versus 6.8 months in OR (HR (OR/NR) = 0.91, HR (OR/IR) = 0.90; p = 0.93). RR was 77.8% in OR versus 64.5% in IR and 58.3% in NR (p = 0.528). The median PFS was 8.3 months in NR versus 8.5 months in IR versus 9.1 months in OR (HR (OR/NR) = 0.72, HR (OR/IR) = 1.04; p = 0.420). Conclusions: In this analysis, morphologic response might not be a prognostic marker in first-line BV-based chemotherapy in pts with CLM.



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