Testosterone Secretion Inhibition

AbstractCombinations of fructose- and fat-rich diets in experimental animals can model the human metabolic syndrome (MS). In rats, the increase in blood pressure (BP) after diet manipulation is sex related and highly dependent on testosterone secretion. However, the extent of the impact of diet on rodent hypophysial-testicular axis remains undefined. In the present study, rats drinking a 10% fructose solution or fed a high-fat (35%) diet for 10 weeks had higher plasma levels of luteinizing hormone (LH) and lower plasma levels of testosterone, without significant changes in circulating follicle-stimulating hormone or the weight of most reproductive organs. Diet manipulation brought about a significant increase in body weight, systolic BP, area under the curve (AUC) of glycemia after an intraperitoneal glucose tolerance test (IPGTT), and plasma low-density lipoprotein cholesterol, cholesterol, triglycerides, and uric acid levels. The concomitant administration of melatonin (25 μg/mL of drinking water) normalized the abnormally high LH levels but did not affect the inhibited testosterone secretion found in fructose- or high-fat-fed rats. Rather, melatonin per se inhibited testosterone secretion. Melatonin significantly blunted the body weight and systolic BP increase, the increase in the AUC of glycemia after an IPGTT, and the changes in circulating lipid profile and uric acid found in both MS models. The results are compatible with a primary inhibition of testicular function in diet-induced MS in rats and with the partial effectiveness of melatonin to counteract the metabolic but not the testicular sequelae of rodent MS.

Download Full-text

Psychosocial stress increases testosterone in patients with borderline personality disorder, post-traumatic stress disorder and healthy participants

Borderline Personality Disorder and Emotion Dysregulation ◽

10.1186/s40479-021-00145-x ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Christian E. Deuter ◽

Moritz Duesenberg ◽

Julian Hellmann-Regen ◽

Sophie Metz ◽

Stefan Roepke ◽

...

Keyword(s):

Borderline Personality Disorder ◽

Personality Disorder ◽

Mental Disorders ◽

Stress Disorder ◽

Gonadal Hormones ◽

Borderline Personality ◽

Adult Women ◽

Testosterone Metabolism ◽

Testosterone Secretion ◽

Healthy Control

Abstract Background The gonadal hormone testosterone not only regulates sexual behavior but is also involved in social behavior and cognition in both sexes. Changes in testosterone secretion in response to stress have been reported. In addition, stress associated mental disorders such as borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) are characterized by alterations in basal testosterone metabolism. However, testosterone changes to stress have not been investigated in mental disorders such as BPD and PTSD so far. Methods In the study described, we investigated testosterone reactivity to an acute psychosocial stressor, the Trier Social Stress Test (TSST). Our sample consisted of young adult women with BPD (n = 28), PTSD (n = 22) or both disorders (n = 22), and healthy control (n = 51). Based on previous studies on basal testosterone secretion in these disorders, we expected the stress-associated testosterone reactivity to be higher in the BPD group and lower in the PTSD group, when compared to the healthy control group. Results The study could demonstrate an increase in testosterone after acute stress exposure across all groups and independent of BPD or PTSD status. Different possible explanations for the absence of a group effect are discussed. Conclusions From the results of this study, we conclude that stress-related changes in testosterone release are not affected by BPD or PTSD status in a female patient population. This study expands the knowledge about changes in gonadal hormones and stress reactivity in these disorders.

Download Full-text

A model for the control of testosterone secretion

Journal of Theoretical Biology ◽

10.1016/s0022-5193(86)80158-8 ◽

1986 ◽

Vol 123 (2) ◽

pp. 239-250 ◽

Cited By ~ 43

Author(s):

Mark Cartwright ◽

Masud Husain

Keyword(s):

Testosterone Secretion

Download Full-text

Increases in testosterone secretion in adult rams with immunoneutralization of endogenous estradiol occur in the absence of increases in pulsatile LH release or testicular LH receptors

Acta Endocrinologica ◽

10.1530/acta.0.1200180 ◽

1989 ◽

Vol 120 (2) ◽

pp. 180-186 ◽

Cited By ~ 2

Author(s):

Lee M. Sanford

Keyword(s):

Binding Sites ◽

Cell Function ◽

Passive Immunization ◽

Serum Testosterone ◽

Experimental Period ◽

Pulse Amplitude ◽

Testicular Biopsy ◽

Binding Activity ◽

Testosterone Secretion ◽

Lh Release

Abstract. The testes of the ram become more responsive to LH stimulation following immunoneutralization of endogenous estradiol. The possibility that testosterone secretion is facilitated by increased LH-binding activity in the testes was investigated in the present study conducted with adult Dorset × Leicester × Suffolk rams during the time of testicular recrudescence. Patterns of episodic LH release and testosterone secretion (days –5, 10 and 24) and LH-binding activity in testicular biopsy samples (days –1, 14 and 28) were assessed on the days indicated relative to the onset of passive immunization and the establishment of relatively low titres (~1:200) of estradiol antiserum. During the experimental period, mean serum testosterone concentration increased by approximately 150% for the immunized rams as basal concentration and pulse amplitude increased, while all characteristics of testosterone secretion remained unchanged for the nonimmunized rams. Characteristics of LH release and the concentration of LH-binding sites in the testes, however, were always similar for both groups of rams. Further, group differences in FSH and PRL secretion and in the concentration of testicular FSH-binding sites did not occur. These results provide evidence for an estradiol direct (gonadotropin independent) negativefeedback component in the regulation of Leydig cell function in the ram.

Download Full-text

TESTOSTERONE SECRETION BY FOETAL RAT TESTES IN VITRO

Journal of Endocrinology ◽

10.1677/joe.0.0710231 ◽

1976 ◽

Vol 71 (2) ◽

pp. 231-238 ◽

Cited By ~ 67

Author(s):

RÉGINE PICON

Keyword(s):

Cyclic Amp ◽

Synthetic Medium ◽

Functional Differentiation ◽

Dibutyryl Cyclic Amp ◽

Testosterone Secretion ◽

Testosterone Production ◽

Foetal Rat

SUMMARY Testosterone secretion by foetal rat testes (13½–21½ days of gestation) explanted for 3 days in a synthetic medium was measured every 24 h by radioimmunoassay. During the first day of explantation, the foetal testis produced, respectively, 1013 ± 132, 8734 ± 1118, 9179 ± 2185 and 3886 ± 309 (s.e.m.) pg/testis when explanted at 14½, 16½, 18½ and 21½ days respectively. Testosterone production by 13½-day-old testes was not detectable on the first day of culture, but appeared on subsequent days. Daily testosterone secretion increased on the 2nd and 3rd days of culture in 14½-day-old testes and decreased in older stages. These results suggest that the functional differentiation of the testis is independent of stimulatory factors like gonadotrophins. Dibutyryl cyclic AMP was found to stimulate testosterone production significantly from 14½ days of gestation onwards.

Download Full-text