scholarly journals EVALUATION OF POSITIVITY OF CRP TEST IN EARLY ONSET NEONATAL SEPSIS IN RELATION TO DURATION OF PROM VS PROM DELIVERY INTERVAL (PDI)

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Samiksha Sharma ◽  
Girijanand Jha ◽  
Binod Kr Singh ◽  
Saroj Kumar
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Neonatal Intensive Care ◽  
Acute Inflammation ◽  
Antenatal Clinic ◽  
Medical College ◽  
Reactive Protein ◽  
Membrane Rupture ◽  
Early Onset Sepsis ◽  
History Of

Early onset infections are caused by organism prevalent in the maternal genital tract or in the delivery area. PROM is rupture of membranes before the onset of labour after 37 completed weeks of gestation. Intra amniotic infection is an acute inflammation of the membrane and chorion of the placenta, typically due to ascending polymicrobial bacterial infection in the setting of membrane rupture. Hence based on above conditions the present study was planned for Evaluation of Positivity of CRP test in early Onset Neonatal Sepsis in Relation to Duration of PROM vs PROM Delivery Interval (PDI). The present study was planned in Department of Pediatrics, Nalanda Medical College and Hospital, Patna, Bihar, India. The study was planned from November 2018 to June 2019. In the present study 50 mothers attended t antenatal clinic towards term pregnancy with history of leaking or confirmed PROM were enrolled. Clinical PROM was confirmed by speculum examination and the duration was recorded. All cases managed actively and the interval between PROM and delivery were recorded in obstetric unit of this hospital. The data generated from the present study concludes that even if 6 hour PROM is high risk for EONS, PDI should be considered first before PROM. So that, we will be more cautious and supportive and use of antibiotics in treatment to prevent need for neonatal intensive care without increase in perinatal morbidity and mortality. Keywords: Early onset Sepsis (EOS), C- Reactive Protein (CRP), Premature rupture of membrane( PROM) PROM delivery interval(PDI), etc.

scholarly journals Clinicobacteriological profile, antibiotic sensitivity patterns and mortality of neonatal sepsis in a tertiary care hospital in Kashmir, Jammu and Kashmir, India

2019 ◽  
Vol 6 (3) ◽  
pp. 917
Author(s):  
Gh Rasool Wani ◽  
Nazir Ahmed ◽  
Mohd Irshad ◽  
Mohd Ashraf ◽  
Bashir Ahmed Teli
Keyword(s):  
Blood Culture ◽  
Neonatal Mortality ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Antibiotic Sensitivity ◽  
Government Medical College ◽  
Gram Negative ◽  
Medical College ◽  
Early Onset Sepsis

Background: Neonatal sepsis refers to generalized bacterial blood stream infection in first 28 days of life documented by positive blood cultures. It is one of leading causes of neonatal mortality. Objectives was to study clinicobacteriological, antibiotic sensitivity patterns and mortality of neonatal sepsis.Methods: This prospective study was conducted in the Department of Pediatrics of Government Medical College Srinagar in collaboration with Department of Microbiology of same medical college after ethical clearance from ethical committee of Government Medical College Srinagar. One hundred (100) neonates out of 731 neonates admitted between octomber2007 and September 2008 with signs and symptoms of neonatal sepsis were included in our study by random sampling method. After history, examination and laboratory investigation blood culture results were analyzed by standard statistical methods.Results: The blood culture was positive in 40% of neonates. Fifty one (51) neonates were males while as 49 were females. Sixty three (63) neonates had late onset of sepsis while as 37 had early onset sepsis. The positive  blood culture was more common in males, late onset sepsis, babies born in rural areas, home born, vaginal births, preterm and other  low birth weight neonates .The gram negative isolates were most common followed by positive ones .The best sensitivity of gram negative isolates was to ciprofloxacin followed by amikacin and cephalosporins while as gram positive isolates were sensitive to imipenum followed by vancomycin. Pseudomonas was most responsive to pipercillin +tazobactum combination. The neonatal mortality was 35% being higher in early onset sepsis and low birth weights.Conclusions: This study depicts a high rate of neonatal sepsis, mainly caused by gram negative organisms followed by gram positive organisms with rising drug resistance that could bear far reaching implications to the times to come, mandating the implementation of sepsis preventive measures and administration of specific antibiotics.

scholarly journals Value of Resistin in Early Onset Neonatal Sepsis

2017 ◽  
Vol 07 (01) ◽  
pp. e146-e150
Author(s):  
Abdurrahman Ozdemir ◽  
Yusuf Elgormus
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Neonatal Intensive Care ◽  
Clinical Signs ◽  
Area Under The Curve ◽  
Scoring Systems ◽  
Diagnostic Value ◽  
Sepsis Group ◽  
Control Group ◽  
Reactive Protein

AbstractThe diagnosis of neonatal sepsis is usually difficult because the sign and symptoms are nonspecific. Although C-reactive protein (CRP) and procalcitonin (PCT) are the most commonly used auxiliary tests, they are not reliable enough markers to be used for diagnosis of neonatal sepsis. This study aimed to evaluate the efficacy of resistin in diagnosing early onset neonatal sepsis and to compare its effectiveness to CRP and PCT. This prospective study was performed in the neonatal intensive care unit of Medicine Hospital between June and September 2016. Twenty-nine infants in the sepsis group and 33 infants in the control group were recruited. The Töllner scoring system was used for clinical signs. The hematologic parameters were evaluated using the Manroe and Rodwell scoring systems. The blood samples for CRP, PCT, and resistin were collected at admission (T0), and at 72 hours (T3). Mean plasma resistin level at T0 was 54.20 ± 39.3 ng/mL in the sepsis group and 34.92 ± 6.9 ng/mL in the control group. The sensitivity at T0 for resistin was 76%, and the specificity was 67%. The values of area under the curve (AUC) for CRP, PCT, and resistin were 0.84, 0.66, and 0.72, respectively. We found the diagnostic value of resistin to be lower than CRP, although its plasma levels were elevated. Therefore, we propose that resistin has limited value in diagnosis and follow-up of early-onset neonatal sepsis.

scholarly journals DIAGNOSTIC VALUE OF SIMULTANEOUS MEASUREMENT OF PROCALCITONIN, INTERLEUKIN-6 AND HS CRP IN PREDICTION OF EARLY-ONSET NEONATAL SEPSIS

2012 ◽  
Vol 4 (1) ◽  
pp. e2012028 ◽  
Author(s):  
Alireza Abdollahi ◽  
Saeed Shoar ◽  
Fatemeh Nayyeri ◽  
Mamak Shariat
Keyword(s):  
Interleukin 6 ◽  
Simultaneous Measurement ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Clinical Signs ◽  
C Reactive Protein ◽  
Maternal Risk ◽  
Reactive Protein ◽  
Early Onset Sepsis ◽  
Hs Crp

Neonatal sepsis is a major cause of morbidities and mortalities mostly remarkable in the third world nations .We aimed to assess the value of simultaneous measurement of procalcitonin (PCT) and interleukin-6 (IL-6) in association with high sensitive- C reactive protein in prediction of early neonatal sepsis.We performed a follow- up study on 95 neonates who were below 12 hours (h) of age, had clinical signs of sepsis or maternal risk factors for sepsis. Neonates were assigned to 4 groups including “proven early-onset sepsis”, “clinical early-onset sepsis”, “negative infectious status”, and “uncertain infectious status”. Blood samples were obtained within the first 12 h of birth repeated between 24 hours and 36 hours of age for determination of serum levels of PCT, IL-6, high sensitivie- C Reactive Protein (hs-CRP), and white blood cell (WBC) count.On admission, neonates with sepsis had a higher WBC count, IL-6, PCT, and hs-CRP levels compared with those neonates without sepsis. This remained significant even after 12-24 hours of admission. Also, patients with clinical evidences of sepsis had a higher serum level of PCT and IL-6 within 12-24 hours after admission compared to the patients with uncertain sepsis. In final The combination of IL-6, hs-CRP, and PCT seems to be predictive in diagnosis of early onset neonatal sepsis.

Procalcitonin and Neonatal Sepsis: Is This the Biomarker We Are Looking For?

2017 ◽  
Vol 36 (6) ◽  
pp. 380-384 ◽  
Author(s):  
Susan Givens Bell
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Diagnostic Marker ◽  
C Reactive Protein ◽  
Neonatal Deaths ◽  
Live Births ◽  
Neonatal Disease ◽  
Protein Levels ◽  
Reactive Protein ◽  
Early Onset Sepsis

AbstractResearchers estimate the incidence of early onset sepsis as 0.77–1/1,000 live births. It remains as one of the leading causes of neonatal deaths. Clinicians and researchers continue to search for biomarkers for specific neonatal disease processes. Clinicians frequently trend C-reactive protein levels during evaluation for neonatal sepsis. Recently, researchers have begun to explore procalcitonin as a potentially useful diagnostic marker for neonatal sepsis.

scholarly journals Endocan - a potential diagnostic marker for early onset sepsis in neonates

2019 ◽  
Vol 13 (04) ◽  
pp. 311-317 ◽  
Author(s):  
Gabriela Ildiko Zonda ◽  
Radu Zonda ◽  
Andrei Tudor Cernomaz ◽  
Luminita Paduraru ◽  
Andreea Luciana Avasiloaiei ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Early Onset ◽  
Neonatal Intensive Care ◽  
Clinical Signs ◽  
Serum Levels ◽  
Clinical Suspicion ◽  
Low Concentrations ◽  
Early Onset Sepsis ◽  
Pregnancy And Delivery ◽  
History Of

Introduction: Neonatal early onset sepsis assessment is based on the history of pregnancy and delivery and nonspecific clinical signs. None of the biomarkers currently in use for clinical practice has adequate prognostic value, so it is not possible to clearly distinguish neonates with culture-proven sepsis from those with only risk factors or clinical suspicion. Endocan is an endothelial mediator involved in the inflammatory response that is present in low concentrations in the serum of healthy subjects, and in much higher concentrations in patients with SIRS and septic shock. The purpose of this study is to evaluate the utility of serum endocan serum levels as a biomarker for the diagnosis of neonatal early onset sepsis (EOS). Methodology: Serum endocan concentration was measured in newborns with clinical suspicion of EOS admitted to the Neonatal Intensive Care Unit on day 1, 3 and 7. Results: Serum endocan levels were significantly increased in septic compared to non-septic neonates in the early stages of sepsis (2.43 ± 0.95 vs. 1.77 ± 0.57, p = 0.004), continued to rise up to 72 hours from onset and then decreased by the seventh day under treatment. Conclusions: These results suggest a potential role for endocan as an early marker for diagnosis and follow-up in neonatal EOS. Studies on a larger number of cases are needed in order to establish the practical utility of this molecule as a diagnostic tool for clinical practice.

Interleukin-6 as a Biomarker of Early-Onset Neonatal Sepsis

2020 ◽  
Author(s):  
José S. Cortés ◽  
Paula X. Losada ◽  
Laura X. Fernández ◽  
Emilce Beltrán ◽  
Isabel DeLaura ◽  
...  
Keyword(s):  
Roc Curve ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Neonatal Intensive Care ◽  
Late Onset ◽  
Enzyme Linked Immunosorbent Assay ◽  
Roc Curve Analysis ◽  
Optimal Cutoff ◽  
Reactive Protein ◽  
Clinical Records

Objective The aim of this study is to determine the utility of C reactive protein (CRP) and interleukin (IL)-6 in the diagnosis of neonatal sepsis (NS) in a neonatal intensive care unit (NICU) in the south of Colombia. Study Design A nonmatched case–control study was conducted. Convenience sampling was performed. Data were obtained from clinical records. IL-6 levels were determined using enzyme-linked immunosorbent assay. Receiver operator characteristic (ROC) curve analysis and Youden's index were used to determine the optimal cutoffs for CRP and IL-6 levels in diagnosing NS, early-onset NS (EONS), and late-onset NS (LONS). Results Data from 31 cases and 62 controls were included. History of chorioamnionitis (infinite odds ratio [OR] [3.07-infinity]), and the presence of meconium-stained amniotic fluid during birth (OR: 9.04 [1.35–112]) were identified as risk factors for NS. Differences in CRP (p < 0.0001) and IL-6 (p < 0.0485) levels were also found, more significantly for LONS and EONS patients, respectively. In the diagnosis of LONS using CRP levels, the area under the ROC curve (AUC) was 0.8371 (p < 0.0001). The optimal cutoff was 0.53 mg/dL. For EONS diagnosis using IL-6, the AUC was 0.6869 (p = 0.0315) and the optimal cutoff was 17.75 pg/mL. Conclusion Differences between CRP and IL-6 levels were found between control and NS groups. Furthermore, CRP showed greater potential diagnostic utility in the LONS group, whereas IL-6 showed greater potential utility in the EONS group. Key Points

C-reactive protein as a predictor of meningitis in early onset neonatal sepsis: a single unit experience

2020 ◽  
Vol 48 (8) ◽  
pp. 845-851 ◽  
Author(s):  
Naveed Ur Rehman Durrani ◽  
Sourabh Dutta ◽  
Niels Rochow ◽  
Salhab el Helou ◽  
Enas el Gouhary
Keyword(s):  
Early Onset ◽  
Neonatal Intensive Care ◽  
C Reactive Protein ◽  
Likelihood Ratios ◽  
Predictive Values ◽  
Reactive Protein ◽  
Early Onset Sepsis ◽  
Polymerase Chain ◽  
Sensitivity Specificity ◽  
Serum Crp

AbstractObjectivesTo determine whether there is a cut off value of serum C-reactive protein (CRP) associated with a higher risk of meningitis in suspected early onset sepsis (EOS) (onset birth to 7 days of life).MethodsA retrospective cohort study on neonates admitted in neonatal intensive care unit at McMaster Children’s Hospital from January 2010 to 2017 and had lumbar puncture (LP) and CRP for workup of EOS. Included subjects had either (a) non-traumatic LP or (b) traumatic LP with cerebral spinal fluid (CSF) polymerase chain reaction or gram stain or culture-positive or had received antimicrobials for 21 days. Excluded were CSF done for metabolic errors, before cytomegalovirus (CMV) treatment; from ventriculo-peritoneal (VP) shunts; missing data and contamination. Neonates were classified into definite and probable meningitis and on the range of CRP. We calculated sensitivity, specificity, and likelihood ratios for CRP values; and area under the receiver operating characteristic (AUROC) curve.ResultsOut of 609 CSF samples, 184 were eligible (28 cases of definite or probable meningitis and 156 controls). Sensitivity, specificity, predictive values, likelihood ratios, and AUROC were too low to be of clinical significance to predict meningitis in EOS.ConclusionsSerum CRP values have poor discriminatory power to distinguish between subjects with and without meningitis, in symptomatic EOS.

CLINICAL PREVALENCE AND CAUSATIVE MICROBES RESPONSIBLE FOR NEONATAL SEPSIS IN NEONATES ADMITTED IN NMCH

2018 ◽  
Author(s):  
Dr. Ramjee Prasad Gupta ◽  
Dr. Mohan Kejriwal ◽  
Dr. Alka Singh
Keyword(s):  
Neonatal Sepsis ◽  
Early Onset ◽  
Late Onset ◽  
Gram Negative ◽  
Medical College ◽  
Late Onset Sepsis ◽  
Adequate Care ◽  
Early Onset Sepsis ◽  
Low Birth Weight Babies ◽  
Third Generation Cephalosporins

Neonatal sepsis is of two types; early onset sepsis and late onset sepsis. Early onset sepsis (EOS) present within first 72 hours of life. In severe cases, the neonates may be symptomatic at birth. Infants with EOS usually present with respiratory distress and pneumonia. Hence based on above findings the present study was planned to evaluate the immediate clinical outcomes of culture proven neonatal sepsis in the NICU. The study was planned by enrolling the 320 neonates admitted in Neonatal unit of Department of Paediatrics in Nalanda Medical College and Hospital, Patna, from Dec 2017 to Jun 2018. The 40 neonates were diagnosed positive for septicemia was enrolled in the present study.  The approval of the institutional committee was taken prior conduct of study. All the patients were informed consents. The data from the present study revealed that adequate care of the low birth weight babies is of utmost importance to prevent infection by Klebsiella pneumoniae. Amikacin should be used along with third-generation cephalosporins for empirical treatment of gram-negative neonatal sepsis. This empirical regimen should be modified later based on the antibiogram of the isolates. Keywords: neonatal sepsis, epidemiology, microbiology, etc.

scholarly journals Diagnostic role of interleukin-6 and quantitative C-reactive protein in suspected early onset neonatal sepsis

2020 ◽  
Vol 8 (1) ◽  
pp. 263-270
Author(s):  
Priti Chowdhary ◽  
Ritesh Ranjan ◽  
Anita Pandey
Keyword(s):  
Blood Culture ◽  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Signs And Symptoms ◽  
Care Hospital ◽  
Age Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Early Onset Sepsis

Introduction: Neonatal sepsis is a major cause of morbidity and mortality most remarkable in the third world nations. Early diagnosis and subsequent therapy for the infected infants may play a vital role in lowering such mortality and morbidity rates. Aim: To study the clinical profile of neonatal sepsis in a tertiary care hospital and to correlate the findings with quantitative C-reactive protein (CRP) and Interleukin-6 (IL-6). Settings and Design: A total of 296 neonates admitted in neonatal intensive care unit (NICU) with clinical signs and symptoms suggestive of sepsis were studied. Based on their age the study population was divided into early onset sepsis (EOS): age group less 72 hours and late onset sepsis (LOS): age group more than 72 hours. Also healthy neonates who had no signs and symptoms of sepsis were taken as control for the study. Material and Methods: Blood culture was carried out using BacT/ Alert-3D automated system. Quantitative CRP by nephelometry and IL-6 by ELISA was done in all culture positive cases and controls. Correlation of detection of cases of sepsis by quantitative CRP and IL-6 with blood culture was carried out. Statistical analysis: Statistical parameters such as sensitivity, specificity, predictive values, accuracy and significance levels were calculated Results: In EOS the sensitivity and negative predictive value (NPV) of IL-6 was 62.32% and 33.33% respectively as compared to sensitivity of 27.5% and NPV of 26.47% of CRP. Conclusions: IL-6 is a good marker for early onset sepsis than CRP detecting a greater number of sepsis cases.

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