scholarly journals LIPID PROFILE AND ITS ABNORMALITIES IN NEWLY DIAGNOSED TYPE 2 DIABETICS: AN OBSERVATIONAL STUDY

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Ashok Kumar ◽  
Naresh Kumar ◽  
Bhim Ram
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Newly Diagnosed ◽  
Serum Triglycerides ◽  
Cholesterol Levels ◽  
Type 2 Diabetics ◽  
Very High

Background: Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. We aimed to research association between serum lipid profile and blood glucose, hypothesizing that early detection and treatment of lipid abnormalities can minimize the risk for atherogenic cardiovascular disorder and cerebrovascular accident in patients with type 2 diabetes mellitus. Material and methods: A cross-sectional study was carried out to determine the lipid profile levels in newly diagnosed type 2 diabetics in the Department of General Medicine in Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India from March 2019 to February 2020. A total of 200 newly diagnosed type 2 diabetics were enrolled in our study. Results: In our study, 96 (48.0%) participants had normal serum triglycerides levels which is <150 mg/dl whereas 104 (52.0%) participants had an abnormal level of serum triglycerides. Among the 104 (52.0%) participants with abnormal triglycerides, 30.5% had borderline high levels (150-199mg/dl), 19.5% had high levels (200-499 mg/dl) and 2% participants had very high triglycerides (≥500 mg/dl. In our study, among the 200 participants, 142 (71%) participants   had   desirable total   Cholesterol levels of <200mg/dl, 51 (25.5%) had borderline high levels of 200- 239mg/dl and 7 (3.5%) had high total cholesterol levels of ≥240mg/dl and 31% of participants had near optimal levels of LDL, 35.5% had borderline high levels of LDL, 12% had high levels of LDL and 1% had very high levels of LDL. Conclusions: Deranged lipid profiles are quite prevalent in type 2 diabetics with females having higher triglyceride levels. Recognition of such elevated triglyceride levels in even newly diagnosed type 2 diabetics will help in better prevention of associated cardiovascular disease. Keywords: Cardiovascular disease, Hypertriglyceridemia, Type 2 diabetes, Lipid profile

scholarly journals Lipid profile abnormalities in newly diagnosed type 2 diabetics: a cross-sectional study

2019 ◽  
Vol 6 (5) ◽  
pp. 1452
Author(s):  
Monica A. ◽  
Dhivya P.
Keyword(s):  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Cross Sectional Study ◽  
South Indian Population ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Type 2 Diabetics ◽  
Very High

Background: India is fast becoming the diabetes capital of the World. A direct atherogenic effect of triglyceride rich particles has been noted. This study assesses the lipid profile abnormalities in newly diagnosed type 2 diabetes mellitus. Since dyslipidemia is a risk factor for cardiovascular disease, such assessment will enable better recognition, prevention and management of cardiovascular mortality and morbidity.Methods: The study was conducted over a period of one year at a tertiary care hospital in South India. A cross-sectional study of 100 newly diagnosed type 2 diabetics in a rural South-Indian population was done. Results: In our study, 55 (55%) participants had high triglycerides and 45 (45%) had normal triglycerides.  Among the 55 participants with abnormal triglycerides, 34% had borderline high levels (150-199mg/dl), 18% had high levels (200-499 mg/dl) and 3% participants had very high triglycerides (≥500 mg/dl). 26% male and 29% female participants had above normal triglyceride levels. In our study, 25% had borderline high cholesterol levels and 5% had high total Cholesterol. 39% of participants had near optimal levels of LDL, 19% had borderline high levels of LDL, 7% had high levels of LDL and 4% had very high levels of LDL. Significantly higher levels of triglycerides and LDL were noted.Conclusions: Deranged lipid profiles are quite prevalent in type 2 diabetics with females having higher triglyceride levels. Recognition of such elevated triglyceride levels in even newly diagnosed type 2 diabetics will help in better prevention of associated cardiovascular disease.

scholarly journals INFLUENCE OF DYSLIPIDEMIA ON SOMATIC NEUROPATHY IN TYPE 2 DIABETES MELLITUS

2013 ◽  
Vol 03 (03) ◽  
pp. 025-030
Author(s):  
Subbalakshmi N. K. ◽  
Sathyanarayana Rao K. N. ◽  
Adhikari P.M. R. ◽  
Sheila R. Pai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Statistical Tests ◽  
Duration Of Diabetes ◽  
Type 2 Diabetics ◽  
Significant Difference

Abstract Introduction: Dyslipidemia is an established cardiovascular risk factor. But its influence on somatic neuropathy (PNP) in diabetes mellitus is not clear. Objective of the study: This study assessed the association between lipids and PNP in diabetes mellitus. Materials and Methods: 101 type 2 diabetics with recently done fasting lipid profile were included. Lipid profile included fasting total cholesterol, LDL- cholesterol, HDL- cholesterol and triglycerides. Based on the neurological examination diabetics were divided into two groups: with PNP (n = 53) and without PNP (n = 48). Severity of PNP was quantified based on total scoring of all the definite clinical signs of PNP. 30 healthy subjects matched for age and sex with PNP group served as control. Statistical analysis was done with suitable statistical tests. Statistical significance was taken to be at p-value less than 0.05. Results: Mean total cholesterol, triglycerides, LDL cholesterol of PNP group was significantly higher compared to non-diabetic control (p < 0.05; < 0.01; < 0.001 respectively). There was no significant difference in any of the lipids between with PNP and without PNP groups. Among the lipids, correlation was observed only between triglycerides and PNP severity score (r = 0.37, p < 0.01). Mean age and duration of diabetes of PNP group was significantly higher compared to without PNP group (p < 0.01; < 0.01 respectively). Conclusion: Dyslipidemia persists in type 2 diabetics. Hypertriglyceridemia is correlated with severity of PNP. Higher age and duration of diabetes are associated with PNP in type 2 diabetes.

Lipid profile of patients newly diagnosed with type 2 diabetes in Albania

2013 ◽  
Author(s):  
Florian Toti ◽  
Aldi Shehu ◽  
Kliti Hoti ◽  
Manjola Carcani ◽  
Adriana Lapardhaja ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Newly Diagnosed

scholarly journals Correlation Between Lipid Profile with Type 2 Diabetes Mellitus Progression

2020 ◽  
Vol 8 (2) ◽  
pp. 66-72
Author(s):  
Angiesta Pinakesty ◽  
Restu Noor Azizah
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Cholesterol Levels ◽  
Type 2 Dm ◽  
Hba1c Levels

Introduction: Diabetes mellitus (DM) is a non-communicable disease that has increased from year to year. Type 2 diabetes mellitus is not caused by lack of insulin secretion, but is caused by the failure of the body's cells to respond to the hormone insulin (insulin resistance). Insulin resistance was found to be a major contributor to atherogenic dyslipidemia. Dyslipidemia in DM risks 2 to 4 times higher than non-DM. Although dyslipidemia has a great risk for people with type 2 diabetes mellitus, this conventional risk factor only explains a portion (25%) of excess cardiovascular risk in type 2 DM. Discussion: In uncontrolled type 2 DM patients, LDL oxidation occurs faster which results from an increase in chronic blood glucose levels. Glycemic control as a determinant of DM progressivity is determined through HbA1c examination. HbA1c levels are associated with blood triglyceride levels. Meanwhile, triglyceride levels are associated with total cholesterol and HDL cholesterol levels. HbA1c levels are also associated with LDL cholesterol levels. Conclusion: There is a relationship between lipid profile and the progression of type 2 diabetes mellitus.   Keywords: type 2 diabetes mellitus, dyslipidemia, HbA1c, glycemic control, lipid profile

scholarly journals The Effect of Urtica Dioica Extract on Blood Lipids Profile in Patients with Type 2 Diabetes: A Randomized Double-blinded Clinical Trial

2021 ◽  
Author(s):  
Roya Khajeh Mehrizi ◽  
Hassan Mozaffari-Khosravi ◽  
Parisa Aboee
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Clinical Trial ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Urtica Dioica ◽  
Significant Difference ◽  
The Mean ◽  
Double Blinded

Background: Diabetes is an endocrine disorder that is strongly associated with cardiovascular disease. The use of alternative therapy has recently increased and medicinal plants are one of the alternative therapies for diabetic patients. This study aimed to evaluate the protective effect of Urtica dioica (Nettle) on lipid profile in patients with type 2 diabetes (T2D). Method: This parallel randomized double-blinded clinical trial was conducted on 60 men and women with T2D for an 8-week period. The participants were randomly assigned to received 100mg/kg/day extract of Urtica Dioica (UG) and the placebo group (PG). Blood triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLc) and high density lipoprotein cholesterol (HDLc) were measured at baseline and end of the study. The data were analyzed using SPSS 16.0 and P < 0.05 was considered significant. Results: The mean difference of total cholesterol showed no significant difference in the UG compared to the PG which were -10.56±40.5 and -19.5± 35.9 (P = 0.14), respectively. The study also showed no significant difference between TG and LDLc in the UG compared to the PG (-39.8±171.5 vs. -23.37±72.3 (P = 0.68) and -3.16±33.4 vs. -11.2±35.6 (P = 0.15), respectively). The mean difference of HDLc in the UG and PG were -2.68±8.11 and 2.62±10.6 (P = 0.05), respectively, indicating a significant increase in the UG compared to the PG. Conclusion: The results demonstrated that consumption of 100mg/kg/day extract of UD for 8 weeks by increasing HDL concentration can decrease the risk of cardiovascular disease in patients with T2D.

scholarly journals Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: a secondary analysis from a 1-year randomized controlled trial

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
João P. Magalhães ◽  
Diana A. Santos ◽  
Inês R. Correia ◽  
Megan Hetherington-Rauth ◽  
Rogério Ribeiro ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomized Controlled Trial ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Controlled Trial ◽  
Soluble Form ◽  
Randomized Controlled ◽  
Lipid Markers ◽  
Inflammatory Profile

Abstract Background Exercise is a well-accepted strategy to improve lipid and inflammatory profile in individuals with type 2 diabetes (T2DM). However, the exercise intensity having the most benefits on lipids and inflammatory markers in patients with T2DM remains unclear. We aimed to analyse the impact of a 1-year combined high-intensity interval training (HIIT) with resistance training (RT), and a moderate continuous training (MCT) with RT on inflammatory and lipid profile in individuals with T2DM. Methods Individuals with T2DM (n = 80, aged 59 years) performed a 1-year randomized controlled trial and were randomized into three groups (control, n = 27; HIIT with RT, n = 25; MCT with RT, n = 28). Exercise sessions were supervised with a frequency of 3 days per week. Inflammatory and lipid profiles were measured at baseline and at 1-year follow-up. Changes in inflammatory and lipid markers were assessed using generalized estimating equations. Results After adjusting for sex, age and baseline moderate-to-vigorous physical activity (MVPA), we observed a time-by-group interaction for Interleukin-6 (IL-6) in both the MCT with RT (β = − 0.70, p = 0.034) and HIIT with RT (β = − 0.62, p = 0.049) groups, whereas, only the HIIT with RT group improved total cholesterol (β = − 0.03, p = 0.045) and LDL-C (β = − 0.03, p = 0.034), when compared to control. No effect was observed for C-reactive protein (CRP), cortisol, tumour necrosis factor-α (TNF-α), soluble form of the haptoglobin-hemoglobin receptor CD163 (sCD163), triglycerides and HDL-C in both groups (p > 0.05). Conclusions Favorable adaptations on IL-6 were observed in both the HIIT and MCT combined with RT groups following a long-term 1-year exercise intervention in individuals with T2DM. However, only the HIIT with RT prevented further derangement of total cholesterol and LDL-C, when compared to the control group. Therefore, in order to encourage exercise participation and improve inflammatory profile, either exercise protocols may be prescribed, however, HIIT with RT may have further benefits on the lipid profile. Trial registration Clinicaltrials.gov ID: NCT03144505

Sign in / Sign up

Export Citation Format

Share Document