scholarly journals DIAGNOSTIC EFFICACY OF ENDOMETRIAL ASPIRATION CYTOLOGY WITH HISTOPATHOLOGICAL CORRELATION

2021 ◽  
Vol 5 (7) ◽  
Author(s):  
Swarnlata Ajmera ◽  
Seema Gupta ◽  
Rohit Ajmera
Keyword(s):  
Diagnostic Accuracy ◽  
Cost Effective ◽  
Atypical Hyperplasia ◽  
Aspiration Cytology ◽  
Diagnostic Efficacy ◽  
Outpatient Procedure ◽  
Histopathological Correlation ◽  
Dilatation And Curettage ◽  
Aspiration Technique ◽  
Malignant Lesions

Background: To assess the diagnostic accuracy of endometrial aspiration technique and to compare the cyto-morphology of aspirated smears with histopathology Methods: Endometrial aspiration was performed using Karman’s cannula in 100 cases who presented with abnormal uterine bleed, infertility and postmenopausal bleed. The endometrial specimens obtained by D&C were processed and evaluated histologically. The endometrial aspirated smears were reviewed for cytomorphological findings and were correlated with histopathological findings for diagnostic accuracy. Results: Aspiration cytology is more specific for diagnosing malignant lesions (100%) while it is more sensitive for the benign conditions (85.06%) as compared to borderline lesions (complex and atypical hyperplasia), cytology also has higher NPV, PPV and Accuracy for malignant conditions as compared to the benign conditions Conclusion: Endometrial aspiration technique with Karman’s cannula is simple, safe, cost effective and well tolerated outpatient procedure. Keywords: Endometrial aspiration cytology, Cyclic endometrium, Dilatation   and Curettage, Endometrial malignancy, Karman’s cannula.

scholarly journals A prospective study on the efficacy of Pipelle biopsy to diagnose endometrial pathology in patients with abnormal uterine bleeding

2019 ◽  
Vol 8 (11) ◽  
pp. 4238
Author(s):  
Sunitha Mary Mathew ◽  
Pramod Thomas
Keyword(s):  
Diagnostic Accuracy ◽  
Endometrial Thickness ◽  
Abnormal Uterine Bleeding ◽  
Cost Effective ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Atypical Hyperplasia ◽  
Focal Lesions ◽  
Endometrial Sampling ◽  
Endometrial Pathology

Background: Abnormal uterine bleeding is one of the most common problem encountered in gynaecology clinics. Assessment of endometrial pathology is recommended to rule out malignancy and premalignant conditions. Endometrial sampling can be done by Pipelle biopsy in outpatient units as well as by conventional dilatation and curettage in an operation theatre setup. Our study aims to find out the efficacy of office endometrial biopsy in terms of its sample adequacy, diagnostic accuracy and patient acceptability.Methods: 120 women presenting with abnormal uterine bleeding were included. A detailed history along with clinical examination findings are entered in the proforma. Ultrasound scan was done for all of them to identify pelvic pathology and endometrial thickness. Endometrial sampling was then done with Pipelle without anaesthesia. Histopathology reports are collected and sample adequacy and pattern were analysed. Patients are subsequently followed up for a period up to one year. Those who underwent hysterectomy are analysed for the endometrial pathology in hysterectomy specimen which is used as gold standard and compared with Pipelle endometrial sampling histopathology.Results: Sample adequacy for Pipelle biopsy was found to be 96%. Diagnostic accuracy for atypical hyperplasia and adenocarcinoma is 92.5% and 94% respectively. In hysterectomy specimens, carcinoma endometrium coexisted with atypical hyperplasia in 40% of cases with atypical hyperplasia in pipelle biopsy report.Conclusions: Thus, Pipelle endometrial biopsy is a cost-effective method for endometrial sampling except for focal lesions.

scholarly journals FNAC and histopathological correlation of salivary gland lesions: an observational study

2017 ◽  
Vol 4 (7) ◽  
pp. 2148 ◽  
Author(s):  
Sneha Kakoty ◽  
Tridip Dutta Baruah ◽  
C. P. Ganesh Babu
Keyword(s):  
Salivary Gland ◽  
Observational Study ◽  
Needle Aspiration ◽  
Age Group ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Histopathological Correlation ◽  
Neoplastic Lesions ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology (FNAC) is a sensitive and specific and yet an economically effective technique for diagnosis of salivary gland lesions. FNAC of salivary glands has achieved a pivotal role in the diagnosis and management of salivary gland lesions since its induction by Stewart et al in 1933. However, it has always been under scrutiny when compared to histopathology. Histopathology of salivary gland lesions is still the final method to establish diagnosis and predicting prognosis in these lesions.1Methods: A prospective observational study of 50 patients with salivary gland lesions was done at Gauhati Medical College and hospital from June 2011 to May 2012. 39 patients underwent histopathological confirmation. Cases with histopathological correlation were included in calculating diagnostic accuracy. The cytological findings were correlated with that of the histopathological diagnosis to obtain the accuracy of the cytological diagnosis. The parameters of diagnostic validity of the cytological technique in terms of sensitivity, specificity and predictive value were evaluated.Results: Study population included patients of age group ranging from 13-70 years with median age group being 31-40 years (30%). 54% of the affected patients were male with the parotid being the most commonly involved gland (62%). Neoplastic lesions constituted the major bulk of the lesions (39 cases, 78%) with benign tumours constituting 54%. The most commonly involved benign neoplastic lesion was pleomorphic adenoma (22cases, 44%). Among the non-neoplastic lesions (22%), the acute sialadenitis was frequently noted. Histopathological correlations were available in 39 cases with 11 cases being the malignant lesions. The acute sialadenitis lesions did not undergo histological examination. 28 cases of non-malignant lesions underwent the histological confirmation. In the present study, the specificity and the sensitivity were found to be 96.42% and 90.91% respectively. The predictive value of salivary gland cytology was 90.91% and diagnostic accuracy was 94.87%.Conclusions: Fine Needle Aspiration Cytology is thus a safe, reliable, quick, convenient and accurate method of diagnosis and should be considered as one of the first line of investigations in the evaluation of salivary gland lesions.

scholarly journals Diagnostic accuracy of fine needle aspiration cytology in thyroid swellings with histopathological correlation

2018 ◽  
Vol 5 (4) ◽  
pp. 1511
Author(s):  
Mahadeo R. Patil ◽  
Sandhyarani M. Patil
Keyword(s):  
Diagnostic Accuracy ◽  
Sensitivity And Specificity ◽  
High Specificity ◽  
Needle Aspiration ◽  
Histopathological Correlation ◽  
Malignant Lesions ◽  
Needle Aspiration Cytology ◽  
Very High ◽  
Benign Thyroid ◽  
Rule Out

Background: Thyroid swellings are common in India. It is important to differentiate malignant from benign thyroid swellings for definitive planning of appropriate surgery. This study is undertaken to study sensitivity and specificity of FNAC in diagnosis of thyroid swellings by comparing preoperative FNAC with postoperative histopathology.Methods: A total of 156 patients with thyroid swellings were evaluated for a period of three years. Pre-operatively FNAC was done and was compared with post-operative histopathology and sensitivity and specificity of FNAC was studied.Results: Thyroid swellings are more common in females. In present study of 156 thyroid swellings, 90.38% cytologies were benign while 7.05% were malignant and 2.56% were suspicious for malignancy. Sensitivity of FNAC for malignant lesions was 93.75% and specificity was 100%.Conclusions: FNAC with its very high specificity, and diagnostic accuracy approaching 100% can help to rule out malignancy in most of thyroid swellings and prevent unnecessary surgeries.

scholarly journals Comparison of EUS-guided conventional smear and liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis

2020 ◽  
Vol 08 (11) ◽  
pp. E1611-E1622
Author(s):  
Saurabh Chandan ◽  
Babu P. Mohan ◽  
Shahab R. Khan ◽  
Andrew Ofosu ◽  
Amaninder S. Dhaliwal ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Diagnostic Yield ◽  
Meta Analysis ◽  
False Negative ◽  
Final Analysis ◽  
Needle Aspiration ◽  
Diagnostic Efficacy ◽  
Malignant Lesions ◽  
Liquid Based Cytology

Abstract Background and study aims Endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) has limitations of inadequate sampling and false-negative results for malignancy. It has been performed using conventional smear (CS) cytology with rapid on-site evaluation (ROSE) with reasonable diagnostic accuracy. An alternative to ROSE is liquid-based cytology (LBC). Commonly used LBC techniques include precipitation-based (SurePath™) and filtration-based (ThinPrep®, CellPrep®). Data regarding the diagnostic efficacy of LBC compared with CS are limited. Methods Multiple databases were searched through March 2020 to identify studies reporting diagnostic yield of EUS-guided CS and LBC in pancreatic lesions. Pooled diagnostic odds and rates of performance for the cytologic diagnoses of benign, suspicious, and malignant lesions were calculated. Diagnostic efficacy was evaluated by pooled rates of accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results Nine studies with a total of 1308 patients were included in our final analysis. Pooled diagnostic odds of CS cytology were 1.69 (CI 1.02–2.79) and 0.39 (CI 0.19–0.8) for malignant lesions when compared to filtration-based and precipitation-based LBC techniques, respectively. For CS, precipitation-based and filtration-based LBC, pooled diagnostic accuracy was 79.7 %, 85.2 %, 77.3 %, sensitivity was 79.2 %, 83.6 %, 68.3 %, and specificity was 99.4 %, 99.5 %, 99.5 %, respectively. Conclusions The precipitation-based LBC technique (SurePath™) had superior diagnostic odds for malignant pancreatic lesions compared with CS cytology in the absence of ROSE. It showed superior accuracy and sensitivity, but comparable specificity and PPV. Diagnostic odds of CS cytology in the absence of ROSE were superior to the filtration-based LBC technique (ThinPrep®, Cellprep®) for diagnosing malignant pancreatic lesions.

scholarly journals Ascitic fluid analysis with special reference to serum ascites cholesterol gradient and serum ascites albumin gradient

2017 ◽  
Vol 5 (2) ◽  
pp. 429 ◽  
Author(s):  
Anand Sankar Sastry ◽  
Subash Ch. Mahapatra ◽  
Vidyasagar Dumpula
Keyword(s):  
Diagnostic Accuracy ◽  
Ascitic Fluid ◽  
Total Protein ◽  
High Sensitivity ◽  
Cost Effective ◽  
Clinical Problem ◽  
Malignant Ascites ◽  
Diagnostic Efficacy ◽  
Fluid Analysis ◽  
Sensitivity Specificity

Background: Ascites being a common clinical problem with a vast spectrum of etiologies, less expensive and widely available biochemical parameters are required to differentiate ascites which can correlate with pathogenesis and pin point towards an etiology with high sensitivity and significant accuracy. Aims of the study were to determine the sensitivity, specificity and diagnostic efficacy of serum ascites albumin Gradient (SAAG) and that of ascitic fluid total protein (AFTP), evaluating their diagnostic role in identifying the etiology of ascites, to determine the diagnostic efficacy of Ascitic fluid cholesterol and serum ascites cholesterol gradient (SACG) in diagnosis of malignant ascites.Methods: In this study, 100 patients of ascitis were evaluated for ascitic fluid total protein, albumin, cholesterol, SAAG and SACG along with ultrasound and other required investigations.Results: Sensitivity, Specificity, and Diagnostic accuracy of SAAG for Portal hypertension were 97%, 85%, 96% respectively, whereas those of AFTP for exudative/transudative ascitis were 78.5%, 66%, 68% respectively. Ascitic fluid cholesterol and Mean SACG were significantly elevated in malignant ascites when compared with Non-Malignant Ascitis with p=0.0001. Similarly with a cut off level of 70mg% and 54 mg%, Ascitic fluid cholesterol and Mean SACG are having diagnostic accuracy of 90% and 93% respectively.Conclusions: SAAG is much more superior to AFTP in differential diagnosis of Ascitis. Ascitic fluid cholesterol and Mean SACG are simple and cost effective methods to separate malignant ascitis from non-malignant causes even in small centres with limited diagnostic facilities.

scholarly journals Diagnostic accuracy of contrast enhanced MRI pelvis in differentiating indeterminate adnexal lesions into benign and malignant with histopathological correlation

2021 ◽  
Vol 10 (7) ◽  
pp. 846
Author(s):  
Sorath Murtaza ◽  
Junaid Iqbal ◽  
Saad Ahmed ◽  
Ashraf Amir Ali ◽  
Marya Hameed ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Diagnostic Accuracy ◽  
Tumor Size ◽  
Resonance Imaging ◽  
Histopathological Correlation ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Malignant Lesions ◽  
Contrast Enhanced Mri

Background: The objective of our study was to determine the diagnostic accuracy of contrast-enhanced magnetic resonance imaging pelvis in differentiating indeterminate adnexal lesions into benign and malignant, while considering histopathological examinations as the gold standard.Methods: A total 880 patients who underwent contrast enhanced MRI pelvis in our institute from January 2014 to June 2016 were prospectively analyzed.Results: A total of 880 women were included in this study, of which 782 (88.8%) were younger than 50 years and 98 (11.1%) were older than 50 years. Mean patient age was 56.7 years and mean tumor size was 4.38 cm. There were 648 (73.60%) patients who had a tumor size of >4 cm, and 337 (38.29%) of these tumors were found to be malignant. Furthermore, tumors smaller than 4 cm in size were observed in 232 (26.36%) of patients, of which tumors in 225 (25.56%) patients were benign.Conclusions: The diagnostic accuracy of contrast-enhanced MRI was found to be significantly high (79.65%) in differentiating indeterminate adnexal lesions into benign and malignant lesions.

scholarly journals A comparative study of diagnostic efficacy of fine needle aspiration cytology to open biopsy in cervical lymphadenopathy in a tertiary care hospital, Kanchipuram district, India

2018 ◽  
Vol 5 (12) ◽  
pp. 3847
Author(s):  
Dhinesh Babu K. ◽  
M. Bhaskar ◽  
T. Chitra
Keyword(s):  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Needle Aspiration ◽  
Metastatic Carcinoma ◽  
Open Biopsy ◽  
Aspiration Cytology ◽  
Diagnostic Efficacy ◽  
Fine Needle ◽  
Axillary Lymphadenopathy ◽  
Needle Aspiration Cytology

Background: Lymphadenopathy is a very common clinical manifestation of many diseases, defined as an abnormality in the size or character of lymph nodes, caused by the invasion or propagation of either inflammatory cells or neoplastic cells into the node. Objectives of this study were to evaluate the diagnostic efficacy of the fine needle aspiration cytology of cervical and axillary lymphadenopathy as compared to open biopsy for histopathological examination. A comparative study of diagnostic efficacy of FNAC cervical and axillary lymphadenopathy as compared to open biopsy for histo-pathological examination was carried out on the patients with cervical and axillary lymph adenopathy coming to OPD in Karapaga Vinayaga Medical College and Hospital, Madhuranthagam.Methods: All patients selected as per inclusion and exclusion criteria underwent FNAC of lymph node followed by open biopsy of same lymph node.Results: The results revealed that, the overall diagnostic accuracy was 82.00% with accuracy of 91.70% for tuberculous lymphadenitis and 80.00% for metastatic carcinoma with positive predictive value of 100.00%. In 50.00% of the patients, enlarged tuberculous lymph nodes were matted. Cervical group of lymph nodes were the most commonly affected group of lymph nodes (79.00%). In the present study diagnostic accuracy for metastatic carcinoma was 80.00% and for squamous cell carcinoma was 100.00%. It must be stressed that when the fine needle aspirate appears purulent or when tuberculosis is clinically suspected, specimen should be stained for acid fast bacilli.Conclusions: It improves diagnostic capability of FNAC. If FNAC is positive surgeon can proceed to treat the neck without excisional biopsy of the enlarged lymph nodes. Supraclavicular lymphadenopathy rarely represents curable disease and these nodes can be excised for histological confirmation. FNAC should be followed by open biopsy if negative. The use of flow cytometry, tumour markers, immunocytochemistry of FNA specimen have excellent potential for cytological based diagnosis.

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