A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF URIC ACID FOR PROGRESSION TO PREECLAMPSIA IN GESTATIONAL HYPERTENSIVE PREGNANCIES IN THE DEPARTMENT OF OBSTRETICS AND GYNECOLOGY, SMS MEDICAL COLLEGE

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Hetal More ◽  
Archana Singh ◽  
B.S. Meena
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Characteristic Curve ◽  
Initial Presentation ◽  
Medical College

Background: The purpose of this study was to study the role of serum uric acid level in progression to preeclampsia in gestational hypertensive pregnancies. Methods: Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: Uric acid level was significantly higher in with PIH (6.68±0.36 mg/dl) as compared to without PIH (4.92±0.57 mg/dl). Receiver-operator characteristic curve showed relatively poor sensitivity and specificity performance (area under the curve= 1.00) of serum uric acid level at the initial presentation of gestational hypertension for predicting the progression to preeclampsia The best cut-off revealed from the curve was 6.18 mg/dl. Conclusion: In conclusion, higher serum uric acid levels at the initial presentation of gestational hypertension may indicate heightened risk of progression to preeclampsia and development of adverse maternal/ infant conditions. Keywords: Eclampsia, Uric acid, Hypertension

scholarly journals Study of Serum Uric Acid in Different Stages of Chronic Kidney Disease

2021 ◽  
pp. 70-79
Author(s):  
Shahida Akhter ◽  
A. S. M. Rizwan
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Medical College ◽  
Bonferroni Test

Background: Hyperuricaemia is a metabolic marker of decreased renal function in chronic kidney disease (CKD). It increases cardiovascular, cerebrovascular and mortality risk in patients with CKD. Objectives: To estimate serum uric acid level in different stages of CKD. Methods: The present study was a cross sectional analytical study and was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013 on 300 participants. They were divided into group A (150 control healthy participants) and group B (150 diagnosed cases of CKD). Serum creatinine and serum uric acid levels were measured by auto analyzer in Department of Pathology, Dhaka Medical College. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine level by Modification of Diet in Renal Disease (MDRD) equation. For statistical analysis unpaired Student “t” test, one way ANOVA test, Bonferroni test, Pearson’s correlation coefficient (r) test and Linear regression were performed using SPSS for windows version 20. Result: In this study, serum uric acid level was significantly (p<0.05) higher and eGFR were significantly lower in study groups than that of control group. There was gradual rise of serum uric acid level in CKD subjects from stage I to V. A significant inverse correlation was observed between serum uric acid level and eGFR. Serum uric acid level increased 0.048 mg/dl for each ml/min/1.73m2 decrease of eGFR. Conclusion: This study concludes that serum uric acid level increases gradually in accordance with the higher stages of CKD. There is a negative correlation of serum uric acid with eGFR in all stages of CKD which was statistically significant (p<0.05). Screening of serum uric acid level in different stages of CKD may be beneficial for assessing renal damage as well as prediction of co-morbidities associated with it.

scholarly journals Examination of Pervasiveness of Elevated Serum Uric Acid Level and Microalbuminuriain Prehypertension

2020 ◽  
Vol 3 (1) ◽  
pp. 27-31
Author(s):  
Sunjay Pathak ◽  
Mahipal Singh Puri
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
Male And Female ◽  
Normotensive Subjects ◽  
The Relationship

Background: The relationship between uric acid and microalbuminuriain healthy adults without other cardiovascular risk factors may help to clarify the role of uric acid in cardiovascular disease. In this study, we examined that elevated serum uric acid level was associated with microalbuminuria.Subjects and Methods: Study was done on both male and female prehypertensive patients of age more than 18 years and less than 60, admitted in wards and attending OPD. Controls were normotensive patients admitted in wards who were matched for age, sex and confounding factors.Results: Hyperuricemia was found in 53(15.14%) patients with prehypertension compared to 32 (9.14%) patients with normal BP. Thus hyperuricemia was seen in patients of prehypertension which was highly significant as P<0.001.Conclusion:In conclusion we found that microalbuminuria and hyperuricemia are significantly more prevalent among prehypertensive subjects as compared to normotensive subjects.

Estimation of Serum Uric Acid Level in Preeclamptic Women Determine the Severity of Preeclampsia

2020 ◽  
Vol 11 (1) ◽  
pp. 35-40
Author(s):  
Khairun Nahar ◽  
Sayada Fatema Khatun ◽  
Naila Atik Khan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Severe Preeclampsia ◽  
College Hospital ◽  
Medical College ◽  
Mild Preeclampsia ◽  
Relationship Of

Background: Serum uric acid is a relatively insoluble metabolite of purine metalolism which is mainly secreted by the kidneys and the rate is dependant on renal blood flow. It increases in preeclampsia and studies show it may be a marker of severe preeclampsia. Objective: To determine the serum uric acid level in preeclampsia, to compare the serum uric acid level between mild and sever preeclampsia and to find out any relationship of the serum uric acid level with hypertension in preeclampsia. Methods and materials: This cross sectional study was conducted in Dhaka Medical College Hospital in eclampsia ward of Gynae & Obs department during the period from January 2010 to December 2011. This study group composed of 92 diagnosed case of preeclampsia patient. Out of the 92 cases, 42 were mild preeclampsia and 50 were severe preeclampsia. Result: The results of the study showed that the mean serum uric acid level was significantly high in severe preeclampsia compared to mild preeclampsia and there is a positive and significant relationship of serum uric acid level with hypertension in preeclampsia. Conclusion: There is significant association between serum uric acid level and hypertension in Preeclampsia. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 35-40

scholarly journals Serum uric acid as biomarker for mania: An exploratory prospective study

2022 ◽  
Vol 7 (4) ◽  
pp. 311-314
Author(s):  
Ambu Pandey ◽  
Kamal Narayan Kalita ◽  
Aprajeeta Baruah
Keyword(s):  
Bipolar Disorder ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Gouty Arthritis ◽  
Mental Illnesses ◽  
Control Group

Bipolar Disorder is a major mental illness characterized by episodic occurrence of mood symptoms which can be of mania, depression or a mixed episode. The role of Uric Acid in the etiopathogenesis of episodic mental illnesses might be considered recognized long back in 19th century. Lithium was used as treatment for gouty arthritis and that in some cases helped to control mental illnesses. Multiple role of uric acid in the Central Nervous System have been recognized now. In the present study 30 patients in manic episodes were included and their serum Uric Acid level was compared to age and sex matched healthy controls twice at the interval of three weeks. It was found that Uric Acid level of cases was significantly higher than in controls before the initiation of treatment. Uric Acid level of manic group showed a significant decline after three weeks of treatment initiation. There was no significant change in Uric Acid level of control group after three weeks Serum Uric Acid levels are elevated during manic phase of Bipolar Disorder and decreases after initiation of treatment. There may be more research to find whether uric acid can be considered a biomarker for Bipolar illnesses and also an indicator for treatment response.

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

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