scholarly journals STUDY OF THE CLINICAL CHARACTERISTICS OF INDIVIDUALS WITH CHRONIC URTICARIA: A CROSS SECTIONAL STUDY

Author(s):  
Rajeev Kumar Singh ◽  
Sanjeev Kumar Varshney

Introduction: Because of its continuous relapsing pattern and poor response to medication, chronic urticaria has a detrimental impact on sufferers' professional and social lives. Despite research improvements, the origin and cause of the varied intensity and frequency of clinical manifestation remains a mystery. Aim: The goal of this study was to look at the clinical profile of chronic urticaria in a tertiary care setting. Methods: The study comprised patients of both sexes aged 12 to 60 years old with a clinical diagnosis of chronic urticaria for which no cause could be identified using a standard technique. Results: The average age of the patients with chronic urticaria was 30.44 years, and females predominated, with a male to female ratio of 1:3. The average duration of urticaria was 27.84 months, and urticaria lesions disappeared in less than 30 minutes in 48% of patients. In 38 percent of cases, there was accompanied angioedema, and in 46 percent, there was delayed pressure urticaria. Limitations: The study's sample size was tiny, which constituted a constraint. Conclusions: Our study's clinical profile of chronic idiopathic urticaria is comparable to that of prior research. Keywords: Chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria 

Author(s):  
Sanjeev Kumar

Introduction: Owing to its persistent relapsing path and inadequate reaction to treatment, persistent urticaria has a detrimental impact on both patients' work and social life. The aetiology and the explanation for the varying severity and frequency of clinical presentation are still a problem, despite advances in science. Aim: To research a tertiary care centre 's clinical profile of chronic urticaria. Methods: The study included patients of both sexes between the ages of 14 and 55 years with a clinical diagnosis of chronic urticaria for whom a cause could not be identified under a standard protocol assessment. Results: One hundred patients with chronic urticaria were studied and the mean age was 30.22 years and the male: female ratio was 1:2.85 predominated among females. The mean period of urticaria was 27.42 months, and urticaria lesions were resolved in less than 30 minutes in 48 percent of cases. In 38 percent, there was associated angioedema and 46 percent delayed pressure urticaria. Limitations: The study's drawback was the limited sample size. Conclusions: In our research, the clinical profile for chronic idiopathic urticaria is similar to that of other studies. Keywords: Chronic urticaria, chronic idiopathic urticaria, chronic spontaneous urticaria


Author(s):  
Apurva Pawde ◽  
Rajeshree Chaurpagar ◽  
Sumit Aggarwal ◽  
Arpana Agrawal ◽  
Sandeep Dabhekar

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Hearing is necessary to learn language, speech and to develop cognitive skills. Hearing helps in developing child to learn, recognize sounds, identify objects, events and internalize concepts. Effects of hearing loss on the development of child’s ability to learn, to communicate and to socialize can be devastating. The study is planned with the aim to study clinical profile of deaf mute children and to identify ‘socio-demographic’ and ‘health’ profile of deaf mute children. This study shows distribution of various socio-demographic factors in deaf mute children and to study their clinical profile. </span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The present cross sectional descriptive study was conducted at OPD of ENT department, Government Medical College and Hospital, Akola, Maharashtra. Study was carried out for a period of two months, it’s included Deaf mute children from 2-12 years of age. 50 subjects were reported over the study of 2 months. For data collection demographic parameters, complete birth history including prenatal, perinatal and postnatal history was noted. Thorough clinical examination was carried out with special attention to branchial arch system.  </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">There were 70% males compared to 30% females. Male: female ratio was 2.33: 1. Pneumonia (10%) and hyperbilirubinemia (10%) was the commonest health problem. In the study deafness were attributed to 38% genetic causes, 28% Non-genetic and idiopathic in 34% of children. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">The age at detection of hearing loss is 0-2 yrs age at which if rehabilitation is done can benefit the child to the maximum. Delayed diagnosis of hearing loss can be explained on basis of community practices of neglecting delayed speech, lack of social awareness and partly due to absence of any active health surveillance in this aspect. Multistep protocol for hearing assessment and parental awareness about facilities of rehabilitation and accessibility of services should be emphasized.</span></p>


2019 ◽  
Vol 6 (2) ◽  
pp. 455
Author(s):  
Ashok Kumar Gudagunti ◽  
Ishwar Hasabi ◽  
Arathy S.

Background: Chronic pulmonary obstructive disease (COPD) has been responsible for the decreased quality of life as well as increased morbidity and mortality. Globally it has been estimated that nearly three million die yearly due to COPD and more likely to occupy the third place of mortality by 2030. The objective of the present endeavour was to study clinical profile of patients with chronic pulmonary obstructive disease at a tertiary care centre.Methods: A hospital based cross sectional study was carried out among 200 cases of COPD. Their detailed history, thorough clinical examination and parameters like hemoglobin, serum creatinine, protein etc were investigated. The presence of co-morbidities was noted.Results: As the age increased the prevalence of the COPD increased and highest was found out to be in the age group of above 60 years of age. Males were more affected with COPD as compared with females. The male to female ratio was found out to be 2.4:1. The smokers were more compared to the non smokers. The prevalence of smoking among COPD was noted to be 66% compared to 34% as non smokers. Least proportion of patients of the COPD had fever i.e. in 22% of the cases. Cough was found in 83% of the cases. Breathlessness was found out to be in 98% of the cases. 15% of the cases of the COPD had diabetes only as the co-morbidity along with COPD and no other co-morbidity.Conclusions: Breathlessness was the most common symptom at presentation and diabetes and hypertension were the most common co-morbidities found.


2020 ◽  
Vol 27 (06) ◽  
pp. 1119-1123
Author(s):  
Asif Ali Khuhro ◽  
Fazal Ur Rehman ◽  
Waqas Ali ◽  
Najmi Usman ◽  
Sanam Bano Rajper

Objectives: Childhood and adolescent obesity is increasing especially in developing countries like Pakistan. It seem to affect most socio-economic classes as well as all ethnicities and geographies. We planned this study to analyze the clinical and biochemical profile of obese as well as overweight children at a tertiary care hospital for the existence of metabolic syndrome. Study Design: Cross sectional study. Setting: Department of Pediatrics Medicine, Children Hospital Chandka Medical College / Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. Period: 1st July 2018 to 31st December 2018. Material & Methods: Children, aged 5 to 16 years, both gender, having BMI > 85th percentile regarding age and gender were enrolled. Demographic characteristics along with history, lifestyle parameters and physical examination were noted for all the study participants. Metabolic syndrome (Met S) was evaluated while overall results were presented in terms of proportions, mean and standard deviations. Results: A total of 78 cases were enrolled during the study period. There were 46 (58.9%) male and 32 (41.1%) female, with a male to female ratio of 1.4:1. Mean age amongst study participants was 10.8 years. We had 56 (71.8%) children as overweight whereas 22 (28.2%) obese. Acanthosis nigricans was the most common entity seen in 55 (70.1%) children during clinical examination. Metabolic syndrome was found to be present in 31 (39.7%) participants. Conclusion: Met S is not only limited to obese children as it can also affect children who are overweight.


2022 ◽  
Vol 71 (12) ◽  
Author(s):  
Sana Javed ◽  
Muhammad Zaid ◽  
Sumera Imran ◽  
Ayesha Hai ◽  
Muhammad Junaid Patel

Objective: To estimate the frequency of patients with fibromyalgia (by using the 2010 Modified Criteria for Fibromyalgia by American College of Rheumatology ( ACR ) presenting to Internal Medicine clinics  Methods: A cross-sectional study conducted in the department of Internal Medicine, the Indus Hospital, khi, Pakistan between December 2016 and March 2018. Patients who visited internal medicine clinics, met the selection criteria, were included in the study. After taking informed consent patients were assessed for fibromyalgia according to the new 2010 Fibromyalgia Diagnostic criteria questionnaire. The patients were asked the questions in the national language, Urdu. Data analyzed using SPSS version 21. P value of < 0.05 was considered significant. Results: Of the 267 patients presenting to the internal medicine clinics and consenting for participating in the study 149 (55.80%) met at least one of the 2010 Fibromyalgia Criteria. The prevalence of fibromyalgia as estimated in this study was 56% with no difference in gender. Mean age of patients with fibromyalgia was 42.3 ± 14.6 and patients without fibromyalgia was 38.9 ± 13.7 which was statistically significant (p-value = 0.05, 10% level of significance). Of the 267 patient 197 (73.8%) were female and 70 (26.2%) were males, a male to female ratio of 1:2.81.  Conclusion: All patients with generalized pain should be evaluated for fibromyalgia and a diagnosis made to reduce the cost of further referrals and investigations and delay in the management of this debilitating disorder. Keywords: Fibromyalgia, Chronic fatigue, Generalized Pain  


2021 ◽  
Vol 10 (37) ◽  
pp. 3213-3219
Author(s):  
Jagaragallu Amrutha ◽  
Narasimha Rao Netha Gurram ◽  
Padmaja Pinjala ◽  
Bhumesh Kumar Katakam ◽  
Rajeev Singh Thakur

BACKGROUND Erythroderma is a clinical entity that may cause severe systemic manifestations. The difficulty with erythroderma lies in finding the underlying aetiology. It is imperative to demonstrate precise aetiology whenever possible so that distinct therapy may be initiated. At times, despite finding the aetiology, relapses constitute a great menace. The purpose of our study was to assess the clinical profile and aetiology of erythroderma. Besides, the study also illustrated factors leading to relapses; such studies are rare in literature. METHODS This hospital-based, cross-sectional study included 88 patients of erythroderma of either sex and age more than 18 years; their clinical, laboratory, histopathological findings, treatment and outcome were studied. RESULTS The mean age of onset was 47.3 ± 12.35 years with the male to female ratio being 2.38:1. The most common cause of erythroderma was pre-existing dermatoses (67 %) followed by drugs (10.2 %), infections (3.4 %), malignancies (4.54 %), and idiopathic (14.7 %). Psoriasis was the predominant aetiology (45.4 %) among the pre-existing dermatoses with a maximum number of relapses (P = 0.02). Psoriasis was significantly associated with pruritus (P = 0.001), subungual hyperkeratosis (P = 0.0001), palmoplantar keratoderma (P = 0.001). Clinicohistological association was found in 64.6 % of cases. Mortality was seen in 6.8 % of cases. CONCLUSIONS As in previous studies, pre-existing dermatoses were the most common causes in our study; albeit, a special emphasis on factors leading to relapses was given to prevent further episodes. The most common factor of relapse was uncontrolled comorbid disorders (diabetes and hypertension) followed by medication nonadherence. Hence, our study suggests a need for more effective comorbidity management and creating awareness regarding judicial use of drugs which can go far in preventing mortality and morbidity. KEY WORDS Erythroderma, Adults, Aetiology, Relapses, Comorbidities.


2019 ◽  
Vol 6 (2) ◽  
pp. 371
Author(s):  
Nilesh S. Sonawane ◽  
Chaitanya R. Patil

Background: Tuberculosis is major public health problem especially in the low and middle income countries like India. We conducted a study to assess the knowledge, attitude and practice related to tuberculosis among the patients attending our tertiary care institute.Methods: A cross sectional study was conducted in a tertiary care hospital on the patients attending OPD of tertiary care hospital in Maharashtra. The patients with debilitating illness or bed bound patients and those diagnosed and cured of tuberculosis or were on treatment of tuberculosis were excluded from the study. A pretested and designed questionnaire was used to assess the knowledge, attitude and practice about the cause, clinical features and treatment of tuberculosis.Results: The mean age of the study subjects was 43.34±11.23 years with male: female ratio of 1.45. About 16.67% of the subjects stated that cause of TB is bacteria, 51.33% reported that cough was the most common symptom, 58.67% believed that it spreads from person to person and among the people who said it spreads 58.67% said that it can be preventable.Conclusions: About 1/5th of the study subjects expressed the cause of TB is bacteria or germs, and more than ½ believed that TB spreads from person to person. About 2/3rd of the patients felt that TB was a very serious disease; more than ½ of them expressed fear if they were diagnosed with TB but more than ½ of them also expressed rejection if they have a TB patient as a closed one.


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