scholarly journals NAIL VARIATIONS IN PAPULO-SQUAMOUS DISORDERS: A CLINICAL INVESTIGATION

2021 ◽  
Vol 5 (9) ◽  
Author(s):  
Rajeev Kumar Singh ◽  
Sanjeev Kumar Varshney
Keyword(s):  
Lichen Planus ◽  
Clinical Investigation ◽  
Systemic Disease ◽  
Central India ◽  
Malignant Tumours ◽  
Dermatology Department ◽  
Nail Diseases ◽  
Nail Changes ◽  
Environmental Agents ◽  
Tertiary Healthcare

Background: Nail diseases account for about 10% of all dermatological conditions. Any abnormality that affects any part of the nail unit is classified as a nail condition. The plate, matrix, bed, proximal and lateral folds, hyponychium, and underlying distal phalanx are all part of the nail unit. Heredity, skin problems, infections, systemic disease, and the ageing process, as well as internal and external drugs, physical and environmental agents, trauma, and benign and malignant tumours, can all affect these tissues. Papulo-squamous disorder is one of the main causes. Nail changes in Papulo-squamous disease have received insufficient attention, with only a few research available. Aims & Objectives: This study attempts to shed some information on the frequency and patterns of nail involvement in Papulo-squamous illnesses. Methodology: This is a descriptive research project. Over the course of two years, it was conducted at the dermatology department of a tertiary healthcare centre in central India. Examinations of the general, systemic, and dermatological systems were performed. The nails were meticulously examined. In pertinent cases, special examinations such as skin biopsy and potassium hydroxide (KOH) mount were performed. Results: Papulo-squamous disorder affected 100 people. Psoriasis was the most frequent Papulo-squamous condition, followed by lichen-planus and PRP. Pitting was the most prevalent nail alteration (81%) while dorsal pterygium was the least common. Conclusion: The nail is an important appendage that affects a variety of dermatoses and serves as a diagnostic window. Knowing the normal and abnormal variations, as well as their relationship to various Papulo-squamous illnesses, aids not only in diagnosis but also in treatment. Key words: Papulo-squamous disorder, nail changes, psoriasis, lichen-planus. 

scholarly journals Evaluation of Subclinical Nail changes in Patients with Chronic Plaque Psoriasis using Dermoscopy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Sallam ◽  
K M A Elzawahry ◽  
R O M Attia
Keyword(s):  
Plaque Psoriasis ◽  
Nail Plate ◽  
Skin Surface ◽  
Invasive Technique ◽  
University Hospitals ◽  
Chronic Plaque Psoriasis ◽  
Dermatology Department ◽  
Nail Diseases ◽  
Nail Changes ◽  
The Matrix

Abstract Background Dermoscopy is a non-invasive technique that allows the visualization of subtle clinical features of the skin surface and appendages details not visible to the naked eye, allowing magnifications of up to 200x. It is widely used for evaluating and diagnosing all nail diseases, as it provides important information. As any other examination, nail dermoscopy (onychoscopy) requires a good knowledge of nail anatomy & physiology and the pathogenesis of the nail diseases, and it is helpful for the diagnosis of numerous nail diseases and tumors. Nail disorders are defined according to their appearance and the part of the nail affected (from distal to proximal): hyponychium, onychodermal band (ODB), nail bed, nail plate, lateral nail folds (perionychium), lunula (distal part of the matrix), cuticle, nail matrix and proximal nail fold. Objective To study the dermoscopic findings of subtle nail changes in patients with chronic plaque psoriasis and compare it with that nail changes in healthy controls by both polarized and non polarized mode of dermoscope, aiming to assist clinicians in correctly evaluating and diagnosing nail changes with the help of dermoscopy. Methods We conducted a comparative descriptive study on 50 patients having chronic plaque psoriasis, 26 were males (52.0%) and 24 were females (48.0%), as well as 50 normal healthy control subjects, 31 were males (62.0%) and 19 were females (38.0%). Patients and controls were randomly recruited from the outpatient clinic of dermatology department at Ain Shams University Hospitals, during the period from February 2018 till September 2018. And the age of both groups ranged from 14 to 70 years. Results Our study revealed that the most common fingernail changes found in psoriatic patients were nail plate thickening and crumbling followed by Dilated nailbed capillaries at the onychodermal band, Oncholysis, Subungual hyperkeratosis, Pitting, Longitudinal ridges, Scales, Salmon patch, Leukonychia, Splinter hemorrhage, Lunula red spot and Trachyonychia. And the most common toenail changes found in psoriatic patients were Subungual hyperkeratosis followed by Nail Plate Thickening &Crumbling, Oncholysis, Pitting, Longitudinal ridges, Scales, Salmon patch, Trachyonychia, Dilated nailbed capillaries at the onychodermal band, Splinter hemorrhage, Leukonychia and Lunula red spot. We found there was no difference between polarized and non polarized mode of dermoscope in examination of fingernails and toenails except that the non polarized mode showed the changes of the Dilated capillaries at the onychodermal band more obviously. And also, there was no difference between wet and dry method of polarized mode of dermoscope. Conclusion This study confirms that a handheld dermoscope is a very efficient and simple tool for detection of any nail abnormality.

Nail changes in lichen planus may resemble those of yellow nail syndrome

2000 ◽  
Vol 142 (4) ◽  
pp. 848-849 ◽  
Author(s):  
A. Tosti ◽  
B.M. Piraccini ◽  
N. Cameli
Keyword(s):  
Lichen Planus ◽  
Yellow Nail Syndrome ◽  
Nail Changes

scholarly journals Isolated lichen planus of the lips: cases reports and literature review

2020 ◽  
Vol 26 (2) ◽  
pp. 14
Author(s):  
Maroua Garma ◽  
Wafa Hasni ◽  
Bechir Annabi ◽  
Badreddine Sriha ◽  
Souha Boudegga ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Histological Examination ◽  
Lichen Planus ◽  
Case Reports ◽  
Dermatology Department ◽  
Lower Lip ◽  
Therapeutic Modalities ◽  
Rare Lesion ◽  
Male Patients

Introduction: Lichen planus is an inflammatory mucocutaneous dermatosis involving skin, appendages and mucosa. Oral mucosa is the most commonly involved in all its sites, rarely the lips especially when isolated. The aim was to conduct a literature review about isolated lichen planus of the lips and reporting two case reports of this lesion in order to highlight epidemiologic, clinical and histological features and therapeutic modalities of this lesion. Observations: Case report 1: a 34-year-old diabetic male patient consulted for an erosive, crusted and hemorrhagic cheilitis of the lower lip. Clinical and histological examination led to the diagnosis of isolated lichen planus of the lips. Case report 2: a 33-year-old female patient was referred from dermatology department for biopsy of chronic cheilitis of the lower lip. Clinical and histological examination confirmed the diagnosis of isolated lichen planus of the lips. Discussion: The review based on 34 case reports of isolated lichen planus of the lips, in addition to literature data confirmed that it is a benign rare lesion affecting mostly male patients having middle age with preponderance of the lower lip, its erosive form is the most frequent and it presents a favorable healing with topical treatment particularly corticosteroids.

scholarly journals CUTANEOUS METASTASES UNVEILING BREST CANCER – THERAPEUTIC AND DIAGNOSTIC CONSIDERATIONS

2020 ◽  
Vol 7 (1) ◽  
pp. 164-168
Author(s):  
Florica Sandru ◽  
Mihai Cristian Dumitrascu ◽  
Aida Petca ◽  
Raluca Gabriela Miulescu ◽  
Tiberiu Tebeica ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Systemic Disease ◽  
Lymph Node Biopsy ◽  
The Body ◽  
Cervical Region ◽  
Cutaneous Lesions ◽  
Dermatology Department ◽  
Efficient Treatment ◽  
Surgery Department

Metastatic cutaneous lesions are seen more commonly in breast cancer than in any other malignancy in women. Secondary breast cancer happens when cancer cells spread from the breast to other parts of the body. Sometimes breast cancer cells can spread to the skin. This can happen through the blood or lymphatic system. The presence of skin metastases signifies widespread systemic disease and a poor prognosis. The chest wall, the abdomen, the back, and the upper extremities are common sites.We present the case of a 69-year-old woman presented to our Surgery Department in June 2019, after appearing in the Dermatology Department a week ago, for the appearance of multiple subcutaneous painless, hardened, skin-colored nodules spread to the cervical region, anterior chest walls and upper limbs. Anatomopathological examination of the skin biopsy, performed on the anterior face of the left arm, showed dermal fragment with neoplastic, suggestive for lobular breast carcinoma (stage IV). The patient was referred to the oncological surgery department where our patient underwent a left total mastectomy and sentinel lymph node biopsy. The technique of mastectomy was the Madden technique. The surgery has no healing character, being more a necessity intervention that seeks to avoid the complications of the local evolution of the disease, such as ulceration, hemorrhage or suppuration, the possibility of applying the other forms of treatment (radiotherapy and / or polychemotherapy), elimination of a source of permanent metastatic sowing thus leading to more efficient treatment.

Nail Changes in Lichen Planus: A Single-Center Study

2020 ◽  
pp. 120347542098255
Author(s):  
Magdalena Żychowska ◽  
Małgorzata Żychowska
Keyword(s):  
Lichen Planus ◽  
Nail Plate ◽  
Hair Follicles ◽  
Common Finding ◽  
Skin Area ◽  
Nail Changes ◽  
Single Center Study ◽  
The Subject ◽  
Nail Disease ◽  
Nail Involvement

Background Lichen planus (LP) is an inflammatory condition that can affect skin, mucous membranes, hair follicles, and/or nails. Nail abnormalities are estimated to occur in around 10% of LP cases. Clinical characteristics of nail involvement have been the subject of very few studies, which have mainly focused on isolated nail LP. Objectives To identify and describe nail alterations in patients with LP. Methods Seventy-five patients with cutaneous lichen planus (CLP) were included in the study. The diagnosis of LP was histologically confirmed in each case. Onychomycosis was excluded in each patient. Results Nail lesions were present in 21 (28%) patients (mean age 58.1 ± 12.55 years) with CLP. On an average, patients had 9.38 nails affected. A slight female preponderance was noted (57%). Nail involvement was independent of age, gender, presence of pruritus, the affected skin area, or the duration of CLP. The most common finding in the fingernails ( n = 122) was longitudinal ridging (85.2%), followed by nail plate thinning (38.2%) and onycholysis (17.2%). Pterygium formation (6.6%) and red lunulae (8.2%) were limited to the fingernails. In the fingernails, matrix involvement (98.4%) was more frequent than nail bed involvement (27%). The most common finding in the toenails ( n = 75) was hyperkeratosis (82.7%) with yellowish discoloration (69.3%). No cases of trachyonychia or anonychia were noted. Conclusions Nail abnormalities in patients with CLP may be more common than initially assessed. Rare formation of pterygium and absence of anonychia in patients with predominant cutaneous involvement might point at mild course of the nail disease in such cases.

scholarly journals Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Monica Neagu ◽  
Carolina Constantin ◽  
Marinela Bostan ◽  
Constantin Caruntu ◽  
Simona Rebeca Ignat ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Clinical Investigation ◽  
Transition Process ◽  
Transformation Process ◽  
Small Samples ◽  
Malignant Tumours ◽  
Mesenchymal Transition ◽  
Proteomic Technology ◽  
Therapy Targets ◽  
New Therapy

The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years. Proteomics has identified new molecular pathways of this process and brought important insights to develop new therapy targets. Various proteomic tools and multiple combinations were developed in this area. Out of the proteomic technology armentarium, mass spectrometry and array technologies are the most used approaches. The main characteristics of the proteomic technology used in this domain are high throughput and detection of minute concentration in small samples. We present herein, using various proteomic technologies, the identification in cancer cell lines and in tumour tissue EMT-related proteins, proteins that are involved in the activation of different cellular pathways. Proteomics has brought besides standard EMT markers (e.g., cell-cell adhesion proteins and transcription factors) other future potential markers for improving diagnosis, monitoring evolution, and developing new therapy targets. Future will increase the proteomic role in clinical investigation and validation of EMT-related biomarkers.

scholarly journals Fatores Clínico-Laboratoriais Associados ao Internamento Prolongado em Doentes com Celulite/Erisipela

2019 ◽  
Vol 32 (6) ◽  
pp. 448
Author(s):  
Ângela Roda ◽  
Ana Marcos Pinto ◽  
Ana Rita Filipe ◽  
Ana Rita Travassos ◽  
João Pedro Freitas ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Clinical Investigation ◽  
Positive Culture ◽  
Length Of Hospital Stay ◽  
Dermatology Department ◽  
Prolonged Stay ◽  
Reactive Protein ◽  
Prolonged Hospitalization ◽  
Positive Culture Result ◽  
Santa Maria

Introduction: Cellulitis and erysipelas represent the most frequent cause of hospitalization in the dermatology department of Santa Maria Hospital in Lisbon, Portugal. The aim of this study was to investigate whether patient demographics, comorbidities, previous episodes of cellulitis/erysipelas, the presence of complications, laboratory markers at admission, microbial isolation or previous use of antibiotics, are associated with prolonged stays.Material and Methods: Retrospective analysis, including patients admitted with cellulitis/erysipelas in the inpatient dermatology department of Santa Maria Hospital between July 1st 2012 and June 30th 2017.Results: There were 372 admissions, corresponding to 348 patients. The median length of stay was 11 days. Increased age (p = 0.002, OR 1.03, 95% CI 1.01 – 1.04), previous episode of cellulitis/erysipelas requiring hospitalization (p = 0.005, OR 4.81, 95% CI 1.63 – 14.23), the presence of cellulitis/erysipelas-associated complications (p = 0.001, OR 3.28, 95% CI 1.63 – 6.59), leukocytosis (p = 0.049, OR 1.81, 95% CI 1.00 – 3.30), high levels of C-reactive protein (p = 0.035, OR 1.03, 95% CI 1.00 – 1.06) and a positive culture result (p = 0.002, OR 2.59, 95% CI 1.41 – 4.79) were associated with prolonged hospitalization.Discussion: Prolonged hospitalization for cellulitis/erysipelas is associated with higher costs, additional clinical investigation, invasive treatments, prolonged courses of antibiotic therapy, risk of nosocomial infections, and delayed return to activities of daily living. Thus, the investigation of clinical-laboratory factors associated with prolonged hospitalization for cellulitis / erysipelas is essential and may beuseful for the construction of a severity score.Conclusion: The knowledge of the characteristics that are associated with prolonged stay among patients with cellulitis/erysipelas may be relevant to improve health care, by reducing the length of hospital stay and associated risks and costs.

Nail Changes in Chilblains Mimicking Lichen Planus

2018 ◽  
Vol 09 (05) ◽  
Author(s):  
Aashim Singh ◽  
Saurabh Bhatia ◽  
Somesh Gupta
Keyword(s):  
Lichen Planus ◽  
Nail Changes

scholarly journals Ultrasound elasticity imaging

2006 ◽  
Vol 9 (6) ◽  
pp. 1-7 ◽  
Author(s):  
W. E. Svensson ◽  
D. Amiras
Keyword(s):  
Clinical Investigation ◽  
Ultrasound Image ◽  
Region Of Interest ◽  
Physical Property ◽  
Elasticity Imaging ◽  
Elasticity Analysis ◽  
Imaging Data ◽  
Malignant Tumours ◽  
Before And After ◽  
Coefficient Of Elasticity

Before the advent of diagnostic imaging, palpation was one of the main methods of clinical investigation for the evaluation of tumours. Malignant tumours feel harder that benign ones and this physical property is related to their coefficient of elasticity. Direct comparison of tissue images before and after application of a force is too crude a measure of elasticity except at extremes of differences in elasticity. Analysis of the raw imaging data, which contains very much more information than can be displayed for visual perception, can detect very much smaller differences in elasticity.The radio frequency data of returning ultrasound echoes contain much more data than appears in an ultrasound image. Comparison, of the datasets of uncompressed tissue with compressed tissue, of a region of interest allows production of a strain (elasticity) image of that same region of interest. Change in tissue which is not visible on B-mode (greyscale) imaging can now be detected with real time strain imaging which is beginning to be developed on commercial ultrasound equipment. The information obtained with strain/elasticity imaging is now showing potential in influencing management of patients with breast problems.

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