scholarly journals CUTANEOUS METASTASES UNVEILING BREST CANCER – THERAPEUTIC AND DIAGNOSTIC CONSIDERATIONS

2020 ◽  
Vol 7 (1) ◽  
pp. 164-168
Author(s):  
Florica Sandru ◽  
Mihai Cristian Dumitrascu ◽  
Aida Petca ◽  
Raluca Gabriela Miulescu ◽  
Tiberiu Tebeica ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Systemic Disease ◽  
Lymph Node Biopsy ◽  
The Body ◽  
Cervical Region ◽  
Cutaneous Lesions ◽  
Dermatology Department ◽  
Efficient Treatment ◽  
Surgery Department

Metastatic cutaneous lesions are seen more commonly in breast cancer than in any other malignancy in women. Secondary breast cancer happens when cancer cells spread from the breast to other parts of the body. Sometimes breast cancer cells can spread to the skin. This can happen through the blood or lymphatic system. The presence of skin metastases signifies widespread systemic disease and a poor prognosis. The chest wall, the abdomen, the back, and the upper extremities are common sites.We present the case of a 69-year-old woman presented to our Surgery Department in June 2019, after appearing in the Dermatology Department a week ago, for the appearance of multiple subcutaneous painless, hardened, skin-colored nodules spread to the cervical region, anterior chest walls and upper limbs. Anatomopathological examination of the skin biopsy, performed on the anterior face of the left arm, showed dermal fragment with neoplastic, suggestive for lobular breast carcinoma (stage IV). The patient was referred to the oncological surgery department where our patient underwent a left total mastectomy and sentinel lymph node biopsy. The technique of mastectomy was the Madden technique. The surgery has no healing character, being more a necessity intervention that seeks to avoid the complications of the local evolution of the disease, such as ulceration, hemorrhage or suppuration, the possibility of applying the other forms of treatment (radiotherapy and / or polychemotherapy), elimination of a source of permanent metastatic sowing thus leading to more efficient treatment.

Breast Cancer Metastasis: Role of Tumor Microenvironment and Resident Macropahges

2016 ◽  
Vol 1 (1) ◽  
pp. 48
Author(s):  
Khemraj Singh Baghel ◽  
Smrati Bhadauria
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Metastatic Breast ◽  
Breast Cancer Metastasis ◽  
The Body ◽  
Tissue Remodelling ◽  
Mesenchymal Transition

Metastatic breast cancer is a stage of breast cancer wherever the disease has spread to distant parts of the body. Onset of metastasis is one of the biggest obstacles to the successful treatment of cancer. The potential of a tumor cell to metastasize profoundly depends on its microenvironment, or “niche” interactions with local components. Macrophages provide tropic support to tumors. Resident macrophages contribute a set of common functions, including their capability to defend against microbial infections, to maintain normal cell turnover and tissue remodelling, and to help repair sites of injury. Macrophages are recruited into the tumor microenvironment where they differentiate to become Tumor-associated-macrophages (TAMs). TAMs are the most abundant subpopulation of tumor-stroma and actively drive cancer cell invasion and metastasis. Cancer metastasis is not solely regulated by the deregulation of metastasis promoting or suppressing genes in cancer cells. Recently the interaction between the stromal cells and cancer cells has been demonstrated to promote cancer metastasis. TAMs can advocate epithelial-mesenchymal transition of cancer cells. Loss of e-cadherin, a major phenomenon of epithelial to mesenchymal transition (EMT), reduces adhesiveness and releases cancer cells to distant (secondary) sites. A positive correlation between tumor progression and the expression of matrix metallo proteinases (MMPs) in tumor tissues has been demonstrated in numerous human and animal studies. The dynamic interactions of cancer-cells with TAMs actively promote invasion-metastasis cascade through intercellular-signalling-networks that need better elucidation.

scholarly journals Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells

2008 ◽  
Vol 197 (3) ◽  
pp. 503-515 ◽  
Author(s):  
D Pugazhendhi ◽  
K A Watson ◽  
S Mills ◽  
N Botting ◽  
G S Pope ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
The Body ◽  
Hydroxyl Groups ◽  
Agonist Activity ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Mcf 7

The phytoestrogens genistein, daidzein and the daidzein metabolite equol have been shown previously to possess oestrogen agonist activity. However, following consumption of soya diets, they are found in the body not only as aglycones but also as metabolites conjugated at their 4′- and 7-hydroxyl groups with sulphate. This paper describes the effects of monosulphation on the oestrogen agonist properties of these three phytoestrogens in MCF-7 human breast cancer cells in terms of their relative ability to compete with [3H]oestradiol for binding to oestrogen receptor (ER), to induce a stably transfected oestrogen-responsive reporter gene (ERE-CAT) and to stimulate cell growth. In no case did sulphation abolish activity. The 4′-sulphation of genistein reduced oestrogen agonist activity to a small extent in whole-cell assays but increased the relative binding affinity to ER. The 7-sulphation of genistein, and also of equol, reduced oestrogen agonist activity substantially in all assays. By contrast, the position of monosulphation of daidzein acted in an opposing manner on oestrogen agonist activity. Sulphation at the 4′-position of daidzein resulted in a modest reduction in oestrogen agonist activity but sulphation of daidzein at the 7-position resulted in an increase in oestrogen agonist activity. Molecular modelling and docking studies suggested that the inverse effects of sulphation could be explained by the binding of daidzein into the ligand-binding domain of the ER in the opposite orientation compared with genistein and equol. This is the first report of sulphation enhancing activity of an isoflavone and inverse effects of sulphation between individual phytoestrogens.

scholarly journals ID: 1077 Overexpress of CD47 does not alter stemness of MCF-7 breast cancer cells

2017 ◽  
Vol 4 (S) ◽  
pp. 163
Author(s):  
Oanh Thi-Kieu Nguyen ◽  
Anh Nguyen Tu Bui ◽  
Ngoc Bich Vu ◽  
Phuc Van Pham
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Regulatory Protein ◽  
The Body ◽  
Mammosphere Formation ◽  
Transmembrane Glycoprotein ◽  
Tumor Drug Resistance ◽  
Solid Malignancies ◽  
Mcf 7

Background: CD47 is a transmembrane glycoprotein expressed on all cells in the body and particularly overexpressed on cancer cells and cancer stem cells of both hematologic and solid malignancies. In the immune system, CD47 acts as a "don't eat me" signal, inhibiting phagocytosis by macrophages by interaction with signal regulatory protein α (SIRPα). In cancer, CD47 promotes tumor invasion and metastasis. This study aimed to evaluate the stemness of breast cancer cells when CD47 is overexpressed. Methods: MCF-7 breast cancer cells were transfected with plasmid pcDNA3.4-CD47 containing the CD47 gene. The stemness of the transduced MCF7 cell population was evaluated by expression of CD44 and CD24 markers, anti-tumor drug resistance and mammosphere formation Results: Transfection of plasmid pcDNA3.4-CD47 significantly increased the expression of CD47 in MCF-7 cells. The overexpression of CD47 in transfected MCF-7 cells led to a significant increase in the CD44+CD24- population, but did not increase doxorubicin resistance of the cells or their capacity to form mammospheres. Conclusion: CD47 overexpression enhances the CD44+CD24- phenotype of breast cancer cells as observed by an increase in the CD44+CD24- expressing population. However, these changes are insufficient to increase the stemness of breast cancer cells.

scholarly journals Biosynthesised Drug-Loaded Silver Nanoparticles: A Vivid Agent for Drug Delivery for Human Breast Carcinoma

2021 ◽  
Vol 14 (4) ◽  
pp. 1839-1846
Author(s):  
Pradeepa Varadharajaperumal
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
The Body ◽  
Human Breast ◽  
Drug Bioavailability ◽  
Resonance Band

The use of nanoparticles as drug carriers has been investigated, and it offers various benefits, including the controlled and targeted release of loaded or associated drugs, as well as enhanced drug bioavailability. They do, however, have certain disadvantages, such as in vivo toxicity, which affects all organs, including healthy ones, and overall disease treatment improvement, which might be undetectable or limited. Silver nanoparticles are being studied more and more due to their unique physical, chemical, and optical properties, which allow them to be used in a variety of applications, including drug delivery to specific targets in the body. Given the constraints of traditional cancer treatment, such as low bioavailability and the resulting usage of high doses that produce side effects, attempts to address these challenges are essential. In this work, Biocompatible Silver nanoparticles (AgNps) loaded with tamoxifen have been prepared using the gelation process. Tamoxifen-loaded green synthesized AgNps are reported to be amorphous. The phytochemicals present in the extract of Hemionitis arifolia leaf were responsible for the reduction of silver nitrate to AgNPs. The functional groups existing in the particles were identified with FT-IR analysis. XRD analysis state that the particles were crystalline in nature and arranged in quartzite crystal. Particle size and shape were illustrated from SEM analysis and revealed that the particles were amorphous in nature. UV-visible spectrophotometer showed the band around 440nm which was identified as “surface Plasmon resonance band”. The synthesized AgNps loaded with tamoxifen were significantly effective against Human breast cancer cells. The silver nanoparticle loaded with tamoxifen was found to be inducing apoptotic signals in the selected cells. It inhibits the breast cancer cells even at the lower concentration of AgNPs and TAM-AgNPs. Further apoptotic studies (AO/EtBr and DAPI) reveal that cell death is due to the fragmentation of nuclear material of the treated cells.

scholarly journals Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts

Cancers ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 182 ◽  
Author(s):  
Alison Shupp ◽  
Alexus Kolb ◽  
Dimpi Mukhopadhyay ◽  
Karen Bussard
Keyword(s):  
Breast Cancer ◽  
Bone Resorption ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cells ◽  
Metastatic Cancer ◽  
The Body ◽  
Bone Homeostasis ◽  
Inflammatory Stress ◽  
Bone Gain

The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play key roles in cancer cell dissemination to bone and subsequent metastasis. Our laboratory has evidence that when osteoblasts come into contact with disseminated breast cancer cells, the osteoblasts produce factors that initially reduce breast cancer cell proliferation, yet promote cancer cell survival in bone. Other laboratories have demonstrated that osteoblasts both directly and indirectly contribute to dormant cancer cell reactivation in bone. Moreover, we have demonstrated that osteoblasts undergo an inflammatory stress response in late stages of breast cancer, and produce inflammatory cytokines that are maintenance and survival factors for breast cancer cells and osteoclasts. Advances in understanding interactions between osteoblasts, osteoclasts, and bone metastatic cancer cells will aid in controlling and ultimately preventing cancer cell metastasis to bone.

Efficient treatment of Mycoplasma hyorhinis contamination in MCF-7 breast cancer cells with doxycyclin

2007 ◽  
Vol 22 (2) ◽  
pp. 107-110
Author(s):  
W. Mnif ◽  
M.J. Duchesne ◽  
P. Balaguer ◽  
J.C. Nicolas ◽  
V. Cavaillès ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mycoplasma Hyorhinis ◽  
Efficient Treatment ◽  
Mcf 7

scholarly journals Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1717
Author(s):  
Yedi Herdiana ◽  
Nasrul Wathoni ◽  
Shaharum Shamsuddin ◽  
I Made Joni ◽  
Muchtaridi Muchtaridi
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
Efficient Treatment ◽  
Targeted Drug

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

scholarly journals Understanding the Relationship between Microbiome, Diet and Cancer Risk

2021 ◽  
pp. 503-543
Author(s):  
Ricardo Gobato ◽  
Abhijit Mitra
Keyword(s):  
Breast Cancer ◽  
Cancer Risk ◽  
Fish Oil ◽  
Cancer Cells ◽  
Gut Microbiome ◽  
The Body ◽  
Keywords Cancer ◽  
Diet And Cancer ◽  
New Research ◽  
The Relationship

When it comes to the microbiome, people usually think of the gut, but there is also the breast microbiome, and its role in the health and risk of breast cancer is not fully understood. A microbiome is a collection of microorganisms that live in a specific environment in the body. Diet can affect the breast microbiome, which shows that like the gut microbiome, breast microbiomes can respond to diet. New research now shows that diet, including fish oil supplements, can alter not only the breast microbiome but also its cancerous tumors. Keywords: Cancer; Cells; Tissues; Tumors; Prevention; Prognosis; Diagnosis; Imaging; Screening, Treatment; Management

scholarly journals The influence of bisphenol A on the human body

2021 ◽  
Vol 11 (9) ◽  
pp. 238-245
Author(s):  
Magdalena Kozioł ◽  
Aleksandra Krasa ◽  
Anna Małgorzata Łopuszyńska ◽  
Mateusz Pawlicki ◽  
Ewa Piekarska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Endocrine System ◽  
The Body ◽  
Low Doses ◽  
Prostate Epithelial Cells ◽  
Negative Effect ◽  
Living Organisms

Introduction: Bisphenol A (BPA) is a substance commonly used in industry for the production of everyday plastic products. It is also found in thermal paper. Global pollution of the environment by BPA results in constant exposure to its harmful effects. This substance penetrates the skin, respiratory tract and food into the body. BPA, due to its structure similar to estrogens, disturbs e.g. functioning of the endocrine system and increases the risk of certain cancers. Material and methods: The PubMed and Google Scholar databases were used to review the literature. Description of knowledge: Exposure of breast cancer cells to BPA results in increased aromatase synthesis and increased proliferation of ER + cells. Moreover, BPA stimulates the growth of neoplastic breast cancer cells not only at high doses but also at low doses (<25 µg / kg / day). This substance has an affinity for the estrogen receptor. Daily doses of BPA have been found to increase the density of the mammary gland in mammography. Exposure of this substance to human prostate epithelial cells induced the potential of cancer development in prostate cells. Recent studies have shown that BPA causes increased bronchial reactivity and reduced epidermal regeneration capacity, which proves its pro-inflammatory effect. Research proves that BPA reduces the ability to learn and disrupts the Glu / GABA neurotransmitter ratio. Conclusions: The ubiquitous presence of BPA has a negative effect on living organisms. By accumulating in adipose tissue, it exposes us to constant exposure, which is dangerous even in low doses. Increases the risk of infertility and cancer. Acting pro-inflammatory, it increases the susceptibility to allergens. There are calls for the use of BPA-free packaging and for steps to be taken to reduce BPA production. Key words: bisphenol A; BPA; estrogen; mechanisms; receptors; cancer.

scholarly journals A Review on Targeted Cell Therapy for Breast Cancer, Colon Cancer and Lung Cancer

2020 ◽  
Vol 11 (3) ◽  
pp. 4767-4772
Author(s):  
Jayashree V ◽  
Shamili M ◽  
Sathish Kumar N
Keyword(s):  
Breast Cancer ◽  
Lung Cancer ◽  
Colon Cancer ◽  
Drug Discovery ◽  
Cancer Cells ◽  
Toxic Substance ◽  
The Body ◽  
Bladder Function ◽  
Substance Exposure ◽  
Abnormal Cells

Cancer mainly defined as a group of diseases lead to growth of abnormal cells anywhere in the body. Anything that potentially leads to the growth of abnormal cells in the body is called cancer. Cancer cells grow with potential to invade or spread in any parts of the body. Cancer can be caused by various agents and factors depending upon the type of cancer developed in the particular region. Chemical and toxic substance exposure, ionizing agents and genetic factors are majorly responsible for developing cancer cells in the body state or degree of disease is determined by medical uses such as biopsy which helps in diagnosis of cancer and determining its types and extent of cancer cells spread throughout the body. The molecular targets such as VEGF, oestrogen, protease activated receptor, BRAF has become major innovations towards drug discovery both naturally and chemically.Symptoms of cancer varies according to the types and extent of disease developed in body symptoms like fatigue, weight loss, change in bowel and bladder function, cough and skin tone are some of the early signs of developing cancerous cells in the body. In this study, we focussed the targets of leading cancers among male and female like breast cancer, lung cancer and colon cancer in drug discovery and development.

Sign in / Sign up

Export Citation Format

Share Document